{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:47:28Z","timestamp":1761896848857,"version":"3.37.3"},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"20","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin\u2013angiotensin\u2013aldosterone system (RAAS) activation, leading to endothelial dysfunction. In the present study, we investigated the associations between habitual sodium intake and RAAS blockade on endothelial function by measuring circulating microparticles (MPs) in individuals with T2D. Methods: We conducted a prospective, cross-sectional study in 74 individuals with T2D. Habitual dietary sodium intake was estimated by using the mean of three corrected 24-h urine sodium excretion measurements (24hUNa). MP subtypes in platelet-free plasma were quantitated using flow cytometry. Results: No associations between 24hUNa with levels of endothelial MPs were observed. Instead, a trend toward higher diabetes related CD36+\/CD235a+ MP levels was associated with lower 24hUNa (rho = \u22120.23, P=0.05). When stratified according to tertiles of 24hUNa, platelet-derived CD42b+\/CD41+ and CD42+\/CD41+\/Annexin V+ MPs were higher in the lowest tertile (24hUNa &amp;lt; 157 mmol\/24 h) (P=0.02 respectively). Despite RAAS blockade being associated with lower levels of most MP subsets, it was not associated with lower MPs, in the setting of low sodium intake. Conclusion: Lower sodium intake is associated with higher circulating procoagulant MPs, but not with evidence of endothelial dysfunction in individuals with T2D.<\/jats:p>","DOI":"10.1042\/cs20180472","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T11:55:46Z","timestamp":1537790146000},"page":"2207-2220","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes"],"prefix":"10.1042","volume":"132","author":[{"given":"Sara","family":"Baqar","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Medicine (Austin Health), The University of Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa\u00a0F.","family":"Lincz","sequence":"additional","affiliation":[{"name":"Hunter Haematology Research Group, Calvary Mater Newcastle Hospital, Waratah, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee\u00a0Wen","family":"Kong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Jerums","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Medicine (Austin Health), The University of Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-395X","authenticated-orcid":false,"given":"Elif\u00a0I.","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia"},{"name":"Department of Medicine (Austin Health), The University of Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"2021113011043018800_B1","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1007\/s00125-003-1116-6","article-title":"Mortality from heart disease in a cohort of 23,000 patients with insulin-treated diabetes","volume":"46","author":"Laing","year":"2003","journal-title":"Diabetologia"},{"key":"2021113011043018800_B2","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1161\/CIR.0b013e31820d0793","article-title":"The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association","volume":"123","author":"Appel","year":"2011","journal-title":"Circulation"},{"key":"2021113011043018800_B3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/jhh.2008.144","article-title":"A comprehensive review on salt and health and current experience of worldwide salt reduction programmes","volume":"23","author":"He","year":"2009","journal-title":"J. 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