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In the article published recently in Clinical Science (vol 132 (16) 1779-1796), Poulson and colleagues investigated the role of adenylyl cyclase 6 (AC6) in acid-base homeostasis. They uncovered a complex role of AC6, specifically affecting acid-base balance during HCO3\u2212 load, which causes pronounced alkalosis in AC6-deficient mice. However, the phenotype of AC6-deficient mice appears much more complex, involving systemic effects associated with increased energy expenditure. These observations remind us that there is much to be learned about the intricate signaling pathways involved in renal control of acid-base balance and the complex ramifications of acid-base regulation.<\/jats:p>","DOI":"10.1042\/cs20180572","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T08:56:30Z","timestamp":1537088190000},"page":"1995-1997","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenylyl cyclase 6 in acid-base balance \u2013 adding complexity"],"prefix":"10.1042","volume":"132","author":[{"given":"Jakob","family":"Voelkl","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Augustenburgerplatz 1, Berlin 13353, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Hessische Str. 3-4, Berlin 10115, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Physiology I, Eberhard-Karls University, Wilhelmstr. 56, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"2021113011022444700_B1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000335111","article-title":"The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis","volume":"28","author":"Wagner","year":"2011","journal-title":"Cell. 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