{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:19:08Z","timestamp":1784575148752,"version":"3.55.0"},"reference-count":43,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Activation of the sympathetic nervous system is a hallmark of heart failure (HF) and is positively correlated with disease progression. Catecholaminergic (C1) neurons located in the rostral ventrolateral medulla (RVLM) are known to modulate sympathetic outflow and are hyperactivated in volume overload HF. However, there is no conclusive evidence showing a contribution of RVLM-C1 neurons to the development of cardiac dysfunction in the setting of HF. Therefore, the aim of this study was to determine the role of RVLM-C1 neurons in cardiac autonomic control and deterioration of cardiac function in HF rats. A surgical arteriovenous shunt was created in adult male Sprague-Dawley rats to induce HF. RVLM-C1 neurons were selectively ablated using cell-specific immunotoxin (dopamine-\u03b2 hydroxylase saporin [D\u03b2H-SAP]) and measures of cardiac autonomic tone, function, and arrhythmia incidence were evaluated. Cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction were present in HF rats and improved after D\u03b2H-SAP toxin treatment. Most importantly, the progressive decline in fractional shortening observed in HF rats was reduced by D\u03b2H-SAP toxin. Our results unveil a pivotal role played by RVLM-C1 neurons in cardiac autonomic imbalance, arrhythmogenesis and cardiac dysfunction in volume overload-induced HF.<\/jats:p>","DOI":"10.1042\/cs20180589","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T17:55:03Z","timestamp":1547056503000},"page":"393-405","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure"],"prefix":"10.1042","volume":"133","author":[{"given":"David\u00a0C.","family":"Andrade","sequence":"first","affiliation":[{"name":"Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Centro de Investigaci\u00f3n en Fisiolog\u00eda del Ejercicio, Universidad Mayor, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Toledo","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE-UC), Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo\u00a0S.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lucero","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, 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