{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:28:11Z","timestamp":1791638891802,"version":"4.3.4"},"reference-count":61,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Persistent inflammatory response in the diabetic wound impairs the healing process, resulting in significant morbidity and mortality. Mounting evidence indicate that the activation of Nod-like receptor protein (NLRP) 3 inflammasome in macrophages (M\u03a6) contributes to the sustained inflammatory response and impaired wound healing associated with diabetes. However, the main trigger of NLRP3 inflammasome in the wounds is not known. Neutrophils, as sentinels of the innate immune system and key stimulators of M\u03a6, are immune cells that play the main role in the early phase of healing. Neutrophils release extracellular traps (NETs) as defense against pathogens. On the other hand, NETs induce tissue damage. NETs have been detected in the diabetic wound and implicated in the impaired healing process, but the mechanism of NETs suspend wound healing and its role in fostering inflammatory dysregulation are elusive. Here, we report that NLRP3 and NETs production are elevated in human and rat diabetic wounds. NETs overproduced in the diabetic wounds triggered NLRP3 inflammasome activation and IL-1\u03b2 release in M\u03a6. Furthermore, NETs up-regulated NLRP3 and pro-IL-1\u03b2 levels via the TLR-4\/TLR-9\/NF-\u03baB signaling pathway. They also elicited the generation of reactive oxygen species, which facilitated the association between NLRP3 and thioredoxin-interacting protein, and activated the NLRP3 inflammasome. In addition, NET digestion by DNase I alleviated the activation of NLRP3 inflammasome, regulated the immune cell infiltration, and accelerated wound healing in diabetic rat model. These findings illustrate a new mechanism by which NETs contribute to the activation of NLRP3 inflammasome and sustained inflammatory response in the diabetic wound.<\/jats:p>","DOI":"10.1042\/cs20180600","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T17:55:34Z","timestamp":1547056534000},"page":"565-582","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":199,"title":["NLRP3 activation induced by neutrophil extracellular traps sustains inflammatory response in the diabetic wound"],"prefix":"10.1042","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-3512","authenticated-orcid":false,"given":"Dan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Shanghai Ninth People\u2019s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Burns Institution, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"2021113011094422700_B1","volume-title":"International Diabetes Federation","author":"IDF DIABETES ATLAS","year":"2017"},{"key":"2021113011094422700_B2","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1111\/dme.13054","article-title":"Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom","volume":"33","author":"Walsh","year":"2016","journal-title":"Diabetic Med.: A J. Br. Diab. Asso."},{"key":"2021113011094422700_B3","doi-asserted-by":"publisher","first-page":"17S","DOI":"10.1016\/j.jvs.2010.06.003","article-title":"The costs of diabetic foot: the economic case for the limb salvage team","volume":"52","author":"Driver","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"2021113011094422700_B4","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"2021113011094422700_B5","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet North Am. Ed."},{"key":"2021113011094422700_B6","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.2337\/db12-0227","article-title":"Mechanisms involved in the development and healing of diabetic foot ulceration","volume":"61","author":"Dinh","year":"2012","journal-title":"Diabetes"},{"key":"2021113011094422700_B7","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2021113011094422700_B8","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.2337\/db17-0194","article-title":"The histone methyltransferase MLL1 directs macrophage-mediated inflammation in wound healing and is altered in a murine model of obesity and type 2 diabetes","volume":"66","author":"Kimball","year":"2017","journal-title":"Diabetes"},{"key":"2021113011094422700_B9","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.2353\/ajpath.2009.090248","article-title":"Selective and specific macrophage ablation is detrimental to wound healing in mice","volume":"175","author":"Mirza","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2021113011094422700_B10","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential roles of macrophages in diverse phases of skin repair","volume":"184","author":"Lucas","year":"2010","journal-title":"J. Immunol."},{"key":"2021113011094422700_B11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4049\/jimmunol.1700223","article-title":"Macrophage-mediated inflammation in normal and diabetic wound healing","volume":"199","author":"Boniakowski","year":"2017","journal-title":"J. Immunol."},{"key":"2021113011094422700_B12","doi-asserted-by":"publisher","first-page":"766e12","DOI":"10.1016\/j.jvs.2012.11.095","article-title":"Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing","volume":"58","author":"Pradhan Nabzdyk","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"2021113011094422700_B13","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cyto.2011.06.016","article-title":"Dysregulation of monocyte\/macrophage phenotype in wounds of diabetic mice","volume":"56","author":"Mirza","year":"2011","journal-title":"Cytokine"},{"key":"2021113011094422700_B14","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.biopha.2014.10.020","article-title":"Suppressed recruitment of alternatively activated macrophages reduces TGF-beta1 and impairs wound healing in streptozotocin-induced diabetic mice","volume":"70","author":"Okizaki","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"2021113011094422700_B15","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.2337\/db13-0927","article-title":"Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice","volume":"63","author":"Mirza","year":"2014","journal-title":"Diabetes"},{"key":"2021113011094422700_B16","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1159\/000480367","article-title":"Autophagy inhibition contributes to ROS-producing NLRP3-dependent inflammasome activation and cytokine secretion in high glucose-induced macrophages","volume":"43","author":"Dai","year":"2017","journal-title":"Cell. Physiol. Biochem.: Int. J. Exp. Cell. Physiol. Biochemis. Pharmacol."},{"key":"2021113011094422700_B17","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2337\/db12-0420","article-title":"Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"key":"2021113011094422700_B18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol. Rev."},{"key":"2021113011094422700_B19","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1111\/bph.12557","article-title":"Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice","volume":"171","author":"Bitto","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"2021113011094422700_B20","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat. Immunol."},{"key":"2021113011094422700_B21","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"2021113011094422700_B22","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/nm.4332","article-title":"Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation","volume":"23","author":"Toussaint","year":"2017","journal-title":"Nat. Med."},{"key":"2021113011094422700_B23","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.4049\/jimmunol.1202388","article-title":"Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages","volume":"190","author":"Kahlenberg","year":"2013","journal-title":"J. Immunol."},{"key":"2021113011094422700_B24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.it.2009.07.011","article-title":"NETs: a new strategy for using old weapons","volume":"30","author":"Papayannopoulos","year":"2009","journal-title":"Trends Immunol."},{"key":"2021113011094422700_B25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J. Cell Biol."},{"key":"2021113011094422700_B26","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"2021113011094422700_B27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021113011094422700_B28","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.chom.2012.06.011","article-title":"Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis","volume":"12","author":"McDonald","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2021113011094422700_B29","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1161\/ATVBAHA.111.242859","article-title":"Neutrophil extracellular trap (NET) impact on deep vein thrombosis","volume":"32","author":"Fuchs","year":"2012","journal-title":"Arteriosclerosis Thrombosis Vasc. Biol."},{"key":"2021113011094422700_B30","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.autrev.2017.09.012","article-title":"Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review","volume":"16","author":"Lee","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"2021113011094422700_B31","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jim.2007.06.004","article-title":"Immunochemical assay for deoxyribonuclease activity in body fluids","volume":"325","author":"Cherepanova","year":"2007","journal-title":"J. Immunol. Methods"},{"key":"2021113011094422700_B32","doi-asserted-by":"publisher","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113011094422700_B33","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1126\/science.aam8897","article-title":"Host DNases prevent vascular occlusion by neutrophil extracellular traps.","volume":"358","author":"Jim\u00e9nez-Alc\u00e1zar","year":"2017","journal-title":"Science"},{"key":"2021113011094422700_B34","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"2021113011094422700_B35","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat. Med."},{"key":"2021113011094422700_B36","doi-asserted-by":"publisher","first-page":"3.20.1","DOI":"10.1002\/0471142735.im0320s110","article-title":"Isolation of mouse neutrophils","volume":"110","author":"Swamydas","year":"2015","journal-title":"Curr. Protoc. Immunol."},{"key":"2021113011094422700_B37","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"2021113011094422700_B38","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"2021113011094422700_B39","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1038\/s41564-017-0015-4","article-title":"Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation","volume":"2","author":"Chen","year":"2017","journal-title":"Nat. Microbiol."},{"key":"2021113011094422700_B40","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"2021113011094422700_B41","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nature04517","article-title":"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin\/Nalp3","volume":"440","author":"Kanneganti","year":"2006","journal-title":"Nature"},{"key":"2021113011094422700_B42","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1111\/febs.14076","article-title":"Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation\u2026 or is it sterile?","volume":"284","author":"Lupfer","year":"2017","journal-title":"FEBS J."},{"key":"2021113011094422700_B43","doi-asserted-by":"publisher","first-page":"e2518","DOI":"10.1038\/cddis.2016.410","article-title":"Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation","volume":"7","author":"Marsman","year":"2016","journal-title":"Cell Death Dis."},{"key":"2021113011094422700_B44","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00109-014-1148-z","article-title":"Extracellular histones in tissue injury and inflammation","volume":"92","author":"Allam","year":"2014","journal-title":"J. Mol. Med."},{"key":"2021113011094422700_B45","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2021113011094422700_B46","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"2021113011094422700_B47","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1038\/ncomms3958","article-title":"The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein","volume":"5","author":"Hwang","year":"2014","journal-title":"Nat. Commun."},{"key":"2021113011094422700_B48","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/iwj.12404","article-title":"The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review","volume":"13","author":"Jupiter","year":"2016","journal-title":"Int. Wound J."},{"key":"2021113011094422700_B49","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3892\/ijmm.2017.2870","article-title":"Neutrophil extracellular traps induce IL-1\u03b2 production by macrophages in combination with lipopolysaccharide","volume":"39","author":"Hu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"2021113011094422700_B50","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1073\/pnas.1320294111","article-title":"IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113011094422700_B51","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1399-302X.2008.00432.x","article-title":"The role of Toll-like receptors 2 and 4 on reactive oxygen species and nitric oxide production by macrophage cells stimulated with root canal pathogens","volume":"23","author":"Marcato","year":"2008","journal-title":"Oral. Microbiol. Immunol."},{"key":"2021113011094422700_B52","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.4049\/jimmunol.173.6.3589","article-title":"Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF- B","volume":"173","author":"Park","year":"2004","journal-title":"J. Immunol."},{"key":"2021113011094422700_B53","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.4049\/jimmunol.1003930","article-title":"Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury","volume":"187","author":"Xu","year":"2011","journal-title":"J. Immunol."},{"key":"2021113011094422700_B54","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat. Med."},{"key":"2021113011094422700_B55","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1172\/JCI23025","article-title":"Human lupus autoantibody\u2013DNA complexes activate DCs through cooperation of CD32 and TLR9","volume":"115","author":"Means","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2021113011094422700_B56","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.4049\/jimmunol.1202733","article-title":"Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury","volume":"191","author":"Huang","year":"2013","journal-title":"J. Immunol."},{"key":"2021113011094422700_B57","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat. Immunol."},{"key":"2021113011094422700_B58","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1007\/s10753-017-0542-4","article-title":"Quercetin and ascorbic acid suppress fructose-induced NLRP3 inflammasome activation by blocking intracellular shuttling of TXNIP in human macrophage cell lines","volume":"40","author":"Choe","year":"2017","journal-title":"Inflammation"},{"key":"2021113011094422700_B59","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00125-017-4462-5","article-title":"Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes","volume":"61","author":"Szpigel","year":"2018","journal-title":"Diabetologia"},{"key":"2021113011094422700_B60","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1126\/science.1195491","article-title":"Intravascular danger signals guide neutrophils to sites of sterile inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"2021113011094422700_B61","doi-asserted-by":"publisher","first-page":"e0119106","DOI":"10.1371\/journal.pone.0119106","article-title":"Nod-like receptor protein-3 inflammasome plays an important role during early stages of wound healing","volume":"10","author":"Weinheimer-Haus","year":"2015","journal-title":"PLoS One"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/4\/565\/842822\/cs-2018-0600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/4\/565\/842822\/cs-2018-0600.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:08:45Z","timestamp":1638274125000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/133\/4\/565\/218745\/NLRP3-activation-induced-by-neutrophil"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,2,28]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20180600","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2019,2]]}}}