{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:00Z","timestamp":1787004480875,"version":"build-2736575974"},"reference-count":67,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":170,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bleomycin, a widely used anti-cancer drug, may give rise to pulmonary fibrosis, a serious side effect which is associated with significant morbidity and mortality. Despite the intensive efforts, the precise pathogenic mechanisms of pulmonary fibrosis still remain to be clarified. Our previous study showed that bleomycin bound directly to annexin A2 (ANXA2, or p36), leading to development of pulmonary fibrosis by impeding transcription factor EB (TFEB)-induced autophagic flux. Here, we demonstrated that ANXA2 also played a critical role in bleomycin-induced inflammation, which represents another major cause of bleomycin-induced pulmonary fibrosis. We found that bleomycin could induce the cell surface translocation of ANXA2 in lung epithelial cells through exosomal secretion, associated with enhanced interaction between ANXA2 and p11. Knockdown of ANXA2 or blocking membrane ANXA2 mitigated bleomycin-induced activation of nuclear factor (NF)-\u03baB pathway and production of pro-inflammatory cytokine IL-6 in lung epithelial cells. ANXA2-deficient (ANXA2\u2212\/\u2212) mice treated with bleomycin exhibit reduced pulmonary fibrosis along with decreased cytokine production compared with bleomycin-challenged wild-type mice. Further, the surface ANXA2 inhibitor TM601 could ameliorate fibrotic and inflammatory response in bleomycin-treated mice. Taken together, our results indicated that, in addition to disturbing autophagic flux, ANXA2 can contribute to bleomycin-induced pulmonary fibrosis by mediating inflammatory response.<\/jats:p>","DOI":"10.1042\/cs20180687","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T13:45:13Z","timestamp":1553262313000},"page":"789-804","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice"],"prefix":"10.1042","volume":"133","author":[{"given":"Yunlong","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, P.R. China"},{"name":"The School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610083, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People\u2019s Hospital; Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuping","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhua","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-3568","authenticated-orcid":false,"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610083, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"2021113012290390800_B1","doi-asserted-by":"publisher","first-page":"L1349","DOI":"10.1152\/ajplung.00338.2001","article-title":"Bleomycin upregulates expression of gamma-glutamylcysteine synthetase in pulmonary artery endothelial cells","volume":"282","author":"Day","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012290390800_B2","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1165\/ajrcmb.25.2.4235","article-title":"Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin","volume":"25","author":"Oury","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012290390800_B3","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1164\/rccm.201002-0232OC","article-title":"Yin yang 1 is a novel regulator of pulmonary fibrosis","volume":"183","author":"Lin","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012290390800_B4","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.ejphar.2009.11.007","article-title":"Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis","volume":"627","author":"Zhao","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"2021113012290390800_B5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1189\/jlb.0610346","article-title":"Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice","volume":"89","author":"Russo","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"2021113012290390800_B6","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.freeradbiomed.2010.04.036","article-title":"Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis","volume":"49","author":"Kliment","year":"2010","journal-title":"Free Radical Biol. Med."},{"key":"2021113012290390800_B7","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"2021113012290390800_B8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1755-1536-5-11","article-title":"Molecular and cellular mechanisms of pulmonary fibrosis","volume":"5","author":"Todd","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2021113012290390800_B9","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/S0140-6736(12)61144-1","article-title":"New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis","volume":"380","author":"Fernandez","year":"2012","journal-title":"Lancet"},{"key":"2021113012290390800_B10","doi-asserted-by":"publisher","first-page":"87ra53","DOI":"10.1126\/scitranslmed.3001725","article-title":"The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis","volume":"3","author":"Pullamsetti","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"2021113012290390800_B11","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.2353\/ajpath.2006.060501","article-title":"Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration","volume":"169","author":"Yasuoka","year":"2006","journal-title":"Am. J. Pathol."},{"key":"2021113012290390800_B12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/ars.2007.1897","article-title":"The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis","volume":"10","author":"Bringardner","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"2021113012290390800_B13","doi-asserted-by":"publisher","first-page":"e0154516","DOI":"10.1371\/journal.pone.0154516","article-title":"Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis","volume":"11","author":"Balestro","year":"2016","journal-title":"PLoS ONE"},{"key":"2021113012290390800_B14","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1164\/rccm.200609-1288OC","article-title":"Inhibition of nuclear factor-kappaB in T cells suppresses lung fibrosis","volume":"176","author":"Fujimoto","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012290390800_B15","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1007\/s00018-009-0027-1","article-title":"The annexins: spatial and temporal coordination of signaling events during cellular stress","volume":"66","author":"Monastyrskaya","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"2021113012290390800_B16","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1242\/jcs.01245","article-title":"Annexins\u2013unique membrane binding proteins with diverse functions","volume":"117","author":"Rescher","year":"2004","journal-title":"J. Cell Sci."},{"key":"2021113012290390800_B17","doi-asserted-by":"publisher","first-page":"d341","DOI":"10.2741\/kim","article-title":"Annexin II: a plasminogen-plasminogen activator co-receptor","volume":"7","author":"Kim","year":"2002","journal-title":"Front. Biosci."},{"key":"2021113012290390800_B18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2172-12-59","article-title":"Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis","volume":"12","author":"Damazo","year":"2011","journal-title":"BMC Immunol."},{"key":"2021113012290390800_B19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jcb.22529","article-title":"Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis","volume":"110","author":"Zhang","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"2021113012290390800_B20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12185-009-0356-8","article-title":"Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myeloma","volume":"90","author":"Bao","year":"2009","journal-title":"Int. J. Hematol."},{"key":"2021113012290390800_B21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11010-007-9649-5","article-title":"Involvement of Annexin A2 in p53 induced apoptosis in lung cancer","volume":"309","author":"Huang","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"2021113012290390800_B22","doi-asserted-by":"publisher","first-page":"12595","DOI":"10.1074\/jbc.M800189200","article-title":"Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells","volume":"283","author":"Hastie","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113012290390800_B23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s12307-011-0064-9","article-title":"The role of annexin A2 in tumorigenesis and cancer progression","volume":"4","author":"Lokman","year":"2011","journal-title":"Cancer Microenviron."},{"key":"2021113012290390800_B24","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1002\/jcp.23026","article-title":"Interferon-gamma stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis","volume":"227","author":"Fang","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"2021113012290390800_B25","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/S1357-2725(97)00057-5","article-title":"Extracellular annexin II","volume":"29","author":"Siever","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021113012290390800_B26","doi-asserted-by":"publisher","first-page":"30911","DOI":"10.1074\/jbc.M111.271155","article-title":"Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2","volume":"286","author":"Valapala","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2021113012290390800_B27","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1182\/blood-2009-06-226944","article-title":"Annexin A2 tetramer activates human and murine macrophages through TLR4","volume":"115","author":"Swisher","year":"2010","journal-title":"Blood"},{"key":"2021113012290390800_B28","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11010-007-9477-7","article-title":"Regulation of nucleo-cytoplasmic shuttling of human annexin A2: a proposed mechanism","volume":"303","author":"Liu","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"2021113012290390800_B29","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1091\/mbc.e08-12-1204","article-title":"Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina","volume":"20","author":"Law","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"2021113012290390800_B30","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/15548627.2017.1409405","article-title":"Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux","volume":"14","author":"Wang","year":"2018","journal-title":"Autophagy"},{"key":"2021113012290390800_B31","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.017988","article-title":"Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis","volume":"11","author":"Zhou","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"2021113012290390800_B32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1465-9921-11-31","article-title":"Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1\/Th2 balance","volume":"11","author":"Kikuchi","year":"2010","journal-title":"Respir. Res."},{"key":"2021113012290390800_B33","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J. Clin. Pathol."},{"key":"2021113012290390800_B34","doi-asserted-by":"publisher","first-page":"21652","DOI":"10.1074\/jbc.271.35.21652","article-title":"Interaction of the fibrinolytic receptor, annexin II, with the endothelial cell surface. Essential role of endonexin repeat 2","volume":"271","author":"Hajjar","year":"1996","journal-title":"J. Biological Chem."},{"key":"2021113012290390800_B35","doi-asserted-by":"publisher","first-page":"966","DOI":"10.4161\/auto.7.9.15863","article-title":"Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling","volume":"7","author":"Wang","year":"2011","journal-title":"Autophagy"},{"key":"2021113012290390800_B36","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.molimm.2009.11.019","article-title":"Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies","volume":"47","author":"Fang","year":"2010","journal-title":"Mol. Immunol."},{"key":"2021113012290390800_B37","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1053\/j.gastro.2010.08.054","article-title":"Annexin A2 mediates up-regulation of NF-kappaB, beta-catenin, and stem cell in response to progastrin in mice and HEK-293 cells","volume":"140","author":"Sarkar","year":"2011","journal-title":"Gastroenterology"},{"key":"2021113012290390800_B38","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1164\/rccm.200506-947OC","article-title":"A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice","volume":"173","author":"Inayama","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012290390800_B39","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1681\/ASN.2011111123","article-title":"Tissue plasminogen activator activates NF-kappaB through a pathway involving annexin A2\/CD11b and integrin-linked kinase","volume":"23","author":"Lin","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113012290390800_B40","doi-asserted-by":"publisher","first-page":"L772","DOI":"10.1152\/ajplung.00553.2016","article-title":"Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity","volume":"312","author":"Schuliga","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012290390800_B41","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1183\/09031936.03.00011903","article-title":"Bleomycin induces cellular senescence in alveolar epithelial cells","volume":"22","author":"Aoshiba","year":"2003","journal-title":"Eur. Respir. J."},{"key":"2021113012290390800_B42","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1189\/jlb.0307154","article-title":"Annexin A2 is a soluble mediator of macrophage activation","volume":"82","author":"Swisher","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"2021113012290390800_B43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.micpath.2004.10.002","article-title":"Expression of IL-6 and TNF-alpha in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumophila","volume":"37","author":"Chang","year":"2004","journal-title":"Microb. Pathog."},{"key":"2021113012290390800_B44","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1038\/emboj.2013.90","article-title":"Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response","volume":"32","author":"Radovanac","year":"2013","journal-title":"EMBO J."},{"key":"2021113012290390800_B45","doi-asserted-by":"publisher","first-page":"43411","DOI":"10.1074\/jbc.M408078200","article-title":"An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface","volume":"279","author":"Deora","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021113012290390800_B46","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1242\/jcs.00434","article-title":"Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2","volume":"116","author":"Peterson","year":"2003","journal-title":"J. Cell Sci."},{"key":"2021113012290390800_B47","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1513\/pats.200601-004TK","article-title":"Epithelial origin of myofibroblasts during fibrosis in the lung","volume":"3","author":"Willis","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2021113012290390800_B48","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1128\/MCB.01247-07","article-title":"Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin activation","volume":"28","author":"de Graauw","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"2021113012290390800_B49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1172\/JCI19684","article-title":"Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo","volume":"113","author":"Ling","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2021113012290390800_B50","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/jcp.22296","article-title":"Agents that bind annexin A2 suppress ocular neovascularization","volume":"225","author":"Lima e Silva","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"2021113012290390800_B51","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.18632\/oncotarget.375","article-title":"Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis","volume":"2","author":"Madureira","year":"2011","journal-title":"Oncotarget"},{"key":"2021113012290390800_B52","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.1038\/sj.onc.1207555","article-title":"Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis","volume":"23","author":"Tanaka","year":"2004","journal-title":"Oncogene"},{"key":"2021113012290390800_B53","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ydbio.2003.08.026","article-title":"Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart","volume":"265","author":"Krishnan","year":"2004","journal-title":"Dev. Biol."},{"key":"2021113012290390800_B54","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.yexmp.2006.03.003","article-title":"Angiogenesis-associated protein annexin II in breast cancer: selective expression in invasive breast cancer and contribution to tumor invasion and progression","volume":"81","author":"Sharma","year":"2006","journal-title":"Exp. Mol. Pathol."},{"key":"2021113012290390800_B55","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jdermsci.2008.03.008","article-title":"Equine ANXA2 and MMP1 expression analyses in an experimental model of normal and pathological wound repair","volume":"51","author":"Miragliotta","year":"2008","journal-title":"J. Dermatol. Sci."},{"key":"2021113012290390800_B56","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1111\/j.1365-2362.2006.01729.x","article-title":"Protein biomarkers associated with acute renal failure and chronic kidney disease","volume":"36","author":"Perco","year":"2006","journal-title":"Eur. J. Clin. Invest."},{"key":"2021113012290390800_B57","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/abbs\/gmq108","article-title":"Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease","volume":"43","author":"Zhang","year":"2011","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"2021113012290390800_B58","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1091\/mbc.e07-02-0126","article-title":"The formation of the cAMP\/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function","volume":"18","author":"Borthwick","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"2021113012290390800_B59","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1021\/pr1009355","article-title":"Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs","volume":"10","author":"Korfei","year":"2011","journal-title":"J. Proteome Res."},{"key":"2021113012290390800_B60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1755-1536-5-21","article-title":"Multiplex transcriptional analysis of paraffin-embedded liver needle biopsy from patients with liver fibrosis","volume":"5","author":"Staten","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2021113012290390800_B61","doi-asserted-by":"publisher","first-page":"L968","DOI":"10.1152\/ajplung.00327.2001","article-title":"Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice","volume":"282","author":"Hubbard","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012290390800_B62","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1183\/09031936.00050211","article-title":"DNA damage as a molecular link in the pathogenesis of COPD in smokers","volume":"39","author":"Aoshiba","year":"2012","journal-title":"Eur. Respir. J."},{"key":"2021113012290390800_B63","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1248\/bpb.33.1261","article-title":"Gemcitabine resistance induced by interaction between alternatively spliced segment of tenascin-C and annexin A2 in pancreatic cancer cells","volume":"33","author":"Gong","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"2021113012290390800_B64","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00428-010-0976-7","article-title":"Integrin-linked kinase (ILK) in pulmonary fibrosis","volume":"457","author":"Kavvadas","year":"2010","journal-title":"Virchows Arch."},{"key":"2021113012290390800_B65","doi-asserted-by":"publisher","first-page":"9824","DOI":"10.1073\/pnas.171320598","article-title":"An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer","volume":"98","author":"Brichory","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012290390800_B66","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/cdd.2008.168","article-title":"Autophagy and multivesicular bodies: two closely related partners","volume":"16","author":"Fader","year":"2009","journal-title":"Cell Death Differ."},{"key":"2021113012290390800_B67","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3389\/fimmu.2014.00403","article-title":"Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness","volume":"5","author":"Baixauli","year":"2014","journal-title":"Front. Immunol."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/7\/789\/863374\/cs-2018-0687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/7\/789\/863374\/cs-2018-0687.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T22:09:08Z","timestamp":1721081348000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/133\/7\/789\/218854\/Cell-surface-translocation-of-annexin-A2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,4,15]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20180687","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,4]]}}}