{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:42:30Z","timestamp":1787686950323,"version":"build-2784847793"},"reference-count":43,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":198,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine if terlipressin or direct portacaval shunting can modulate these effects. Pigs were randomized (n=8\/group) to undergo 80% hepatectomy alone (control); terlipressin (2 mg bolus + 0.5\u20131 mg\/h) + 80% hepatectomy; or portacaval shunt (PCS) + 80% hepatectomy, and were maintained under terminal anesthesia for 8 h. The primary outcome was changed in PVP. Secondary outcomes included portal venous flow (PVF), hepatic arterial flow (HAF), and biochemical and histological markers of liver injury. Hepatectomy increased PVP (9.3 \u00b1 0.4 mmHg pre-hepatectomy compared with 13.0 \u00b1 0.8 mmHg post-hepatectomy, P&amp;lt;0.0001) and PVF\/g liver (1.2 \u00b1 0.2 compared with 6.0 \u00b1 0.6 ml\/min\/g, P&amp;lt;0.0001) and decreased HAF (70.8 \u00b1 5.0 compared with 41.8 \u00b1 5.7 ml\/min, P=0.002). Terlipressin and PCS reduced PVP (terlipressin = 10.4 \u00b1 0.8 mmHg, P=0.046 and PCS = 8.3 \u00b1 1.2 mmHg, P=0.025) and PVF (control = 869.0 \u00b1 36.1 ml\/min compared with terlipressin = 565.6 \u00b1 25.7 ml\/min, P&amp;lt;0.0001 and PCS = 488.4 \u00b1 106.4 ml\/min, P=0.002) compared with control. Treatment with terlipressin increased HAF (73.2 \u00b1 11.3 ml\/min) compared with control (40.3 \u00b1 6.3 ml\/min, P=0.026). The results of the present study suggest that terlipressin and PCS may have a role in the prevention and treatment of post-resection liver failure.<\/jats:p>","DOI":"10.1042\/cs20180858","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T13:45:19Z","timestamp":1546523119000},"page":"153-166","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig"],"prefix":"10.1042","volume":"133","author":[{"given":"John\u00a0S.","family":"Hammond","sequence":"first","affiliation":[{"name":"Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, Nottingham, U.K."},{"name":"Department of Hepato-Pancreatico-Biliary Surgery and Transplantation, Freeman Hospital, Newcastle upon Tyne, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Godtliebsen","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Steigen","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Department of Clinical Pathology, The University Hospital of North Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.\u00a0Neil","family":"Guha","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, Nottingham, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Revhaug","sequence":"additional","affiliation":[{"name":"Surgical Research Laboratory, Institute of Clinical Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Department of Gastrointestinal Surgery, The University Hospital of North Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-5796","authenticated-orcid":false,"given":"Dileep\u00a0N.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, Nottingham, U.K."},{"name":"MRC\/ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen\u2019s Medical Centre, Nottingham, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim\u00a0E.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Surgical Research Laboratory, Institute of Clinical Medicine, UiT \u2013 The Arctic University of Norway, Troms\u00f8, Norway"},{"name":"Department of Gastrointestinal Surgery, The University Hospital of North Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"2021113010063717100_B1","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00423-009-0518-4","article-title":"The costs of postoperative liver failure and the economic impact of liver function capacity after extended liver resection\u2014a single-center experience","volume":"394","author":"Lock","year":"2009","journal-title":"Langenbecks Arch. Surg."},{"key":"2021113010063717100_B2","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1002\/bjs.7630","article-title":"Prediction, prevention and management of postresection liver failure","volume":"98","author":"Hammond","year":"2011","journal-title":"Br. J. Surg."},{"key":"2021113010063717100_B3","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/gut.2004.046524","article-title":"The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection","volume":"54","author":"Schindl","year":"2005","journal-title":"Gut"},{"key":"2021113010063717100_B4","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1097\/SLA.0b013e3182a64b38","article-title":"Posthepatectomy portal vein pressure predicts liver failure and mortality after major liver resection on noncirrhotic liver","volume":"258","author":"Allard","year":"2013","journal-title":"Ann. Surg."},{"key":"2021113010063717100_B5","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/S0016-5085(96)70070-7","article-title":"Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure","volume":"111","author":"Bruix","year":"1996","journal-title":"Gastroenterology"},{"key":"2021113010063717100_B6","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1007\/s00268-005-0294-4","article-title":"Effect of portocaval shunt on residual extreme small liver after extended hepatectomy in porcine","volume":"30","author":"Wang","year":"2006","journal-title":"World J. Surg."},{"key":"2021113010063717100_B7","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.3748\/wjg.v19.i31.5076","article-title":"Impact of mesocaval shunt on safe minimal liver remnant: porcine model","volume":"19","author":"Tu","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"2021113010063717100_B8","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3748\/wjg.v20.i4.1021","article-title":"Portal inflow preservation during portal diversion in small-for-size syndrome","volume":"20","author":"Wang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"2021113010063717100_B9","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/SLA.0000000000002146","article-title":"Modulating portal hemodynamics with vascular ring allows efficient regeneration after partial hepatectomy in a porcine model","volume":"268","author":"Bucur","year":"2018","journal-title":"Ann. Surg."},{"key":"2021113010063717100_B10","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1056\/NEJM196403052701003","article-title":"A controlled trial of prophylactic portacaval-shunt surgery","volume":"270","author":"Garceau","year":"1964","journal-title":"N. Engl. J. Med."},{"key":"2021113010063717100_B11","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1002\/hep.510280508","article-title":"Portosystemic hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: clinical, laboratory, psychometric, and electroencephalographic investigations","volume":"28","author":"Nolte","year":"1998","journal-title":"Hepatology"},{"key":"2021113010063717100_B12","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver regeneration","volume":"213","author":"Michalopoulos","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"2021113010063717100_B13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0168-8278(99)80112-3","article-title":"Splanchnic haemodynamics after intravenous terlipressin in anaesthetised healthy pigs","volume":"30","author":"Hansen","year":"1999","journal-title":"J. Hepatol."},{"key":"2021113010063717100_B14","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1053\/jhep.2000.16601","article-title":"Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: the test study","volume":"32","author":"Escorsell","year":"2000","journal-title":"Hepatology"},{"key":"2021113010063717100_B15","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0140-6736(95)92708-5","article-title":"Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients","volume":"346","author":"Levacher","year":"1995","journal-title":"Lancet"},{"key":"2021113010063717100_B16","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/hep.27709","article-title":"Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: a randomized trial","volume":"62","author":"Cavallin","year":"2015","journal-title":"Hepatology"},{"key":"2021113010063717100_B17","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1002\/hep.23286","article-title":"Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome","volume":"51","author":"Gluud","year":"2010","journal-title":"Hepatology"},{"key":"2021113010063717100_B18","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1053\/j.gastro.2008.02.024","article-title":"Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study","volume":"134","author":"Martin-Llahi","year":"2008","journal-title":"Gastroenterology"},{"key":"2021113010063717100_B19","doi-asserted-by":"publisher","first-page":"e107466","DOI":"10.1371\/journal.pone.0107466","article-title":"Terlipressin versus norepinephrine in the treatment of hepatorenal syndrome: a systematic review and meta-analysis","volume":"9","author":"Nassar","year":"2014","journal-title":"PLoS ONE"},{"key":"2021113010063717100_B20","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1053\/j.gastro.2008.02.014","article-title":"A randomized, prospective, double-blind, placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome","volume":"134","author":"Sanyal","year":"2008","journal-title":"Gastroenterology"},{"key":"2021113010063717100_B21","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jcrc.2013.02.016","article-title":"Effect of perioperative terlipressin infusion on systemic, hepatic, and renal hemodynamics during living donor liver transplantation","volume":"28","author":"Fayed","year":"2013","journal-title":"J. Crit. Care"},{"key":"2021113010063717100_B22","doi-asserted-by":"publisher","first-page":"118","DOI":"10.4174\/astr.2018.94.3.118","article-title":"Effects of splanchnic vasoconstrictors on liver regeneration and survival after 90% rat hepatectomy","volume":"94","author":"Kim","year":"2018","journal-title":"Ann. Surg. Treat. Res."},{"key":"2021113010063717100_B23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S1499-3872(17)60036-5","article-title":"Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats","volume":"16","author":"Ulmer","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"2021113010063717100_B24","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1097\/TP.0000000000000045","article-title":"Elevated liver regeneration in response to pharmacological reduction of elevated portal venous pressure by terlipressin after partial hepatectomy","volume":"97","author":"Fahrner","year":"2014","journal-title":"Transplantation"},{"key":"2021113010063717100_B25","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals","year":"2011","edition":"8th"},{"key":"2021113010063717100_B26","doi-asserted-by":"publisher","first-page":"H1345","DOI":"10.1152\/ajpheart.2000.278.4.H1345","article-title":"Myocardial substrate metabolism influences left ventricular energetics in vivo","volume":"278","author":"Korvald","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010063717100_B27","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jss.2006.11.020","article-title":"Improvement of morphological changes after 70% hepatectomy with portocaval shunt: preclinical study in porcine model","volume":"143","author":"Iida","year":"2007","journal-title":"J. Surg. Res."},{"key":"2021113010063717100_B28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jss.2003.08.007","article-title":"Subtotal hepatectomy: a porcine model for the study of liver regeneration","volume":"116","author":"Court","year":"2004","journal-title":"J. Surg. Res."},{"key":"2021113010063717100_B29","first-page":"601","article-title":"Extended hepatectomy with segments i and vii as resection remnant: A simple model for small-for-size injuries in pigs","volume":"7","author":"Xia","year":"2008","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"2021113010063717100_B30","doi-asserted-by":"publisher","first-page":"G819","DOI":"10.1152\/ajpgi.00179.2007","article-title":"Regenerative response in the pig liver remnant varies with the degree of resection and rise in portal pressure","volume":"294","author":"Mortensen","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2021113010063717100_B31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1476-5926-9-2","article-title":"Increased sinusoidal flow is not the primary stimulus to liver regeneration","volume":"9","author":"Mortensen","year":"2010","journal-title":"Comp. Hepatol."},{"key":"2021113010063717100_B32","doi-asserted-by":"publisher","first-page":"H3012","DOI":"10.1152\/ajpheart.00168.2006","article-title":"Scale-space analysis of time series in circulatory research","volume":"291","author":"Mortensen","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010063717100_B33","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1097\/00000478-200608000-00009","article-title":"Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome","volume":"30","author":"Demetris","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"2021113010063717100_B34","first-page":"G549","article-title":"Mechanism and role of intrinsic regulation of hepatic arterial blood flow: Hepatic arterial buffer response","volume":"249","author":"Lautt","year":"1985","journal-title":"Am. J. Physiol."},{"key":"2021113010063717100_B35","first-page":"G253","article-title":"Shear-induced modulation of vasoconstriction in the hepatic artery and portal vein by nitric oxide","volume":"274","author":"Macedo","year":"1998","journal-title":"Am. J. Physiol."},{"key":"2021113010063717100_B36","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1161\/01.RES.43.4.496","article-title":"The effects of intra-arterial and intraportal injections of vasopressin on the simultaneously perfused hepatic arterial and portal venous vascular beds of the dog","volume":"43","author":"Richardson","year":"1978","journal-title":"Circ. Res."},{"key":"2021113010063717100_B37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1113\/jphysiol.1978.sp012475","article-title":"Pressure-flow relationships and effects of noradrenaline and isoprenaline on the hepatic arterial and portal venous vascular beds of the dog","volume":"282","author":"Richardson","year":"1978","journal-title":"J. Physiol."},{"key":"2021113010063717100_B38","doi-asserted-by":"publisher","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","article-title":"Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning","volume":"284","author":"Jaeschke","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2021113010063717100_B39","first-page":"831","article-title":"Splenic arterial ligation prevents liver injury after a major hepatectomy by a reduction of surplus portal hypertension in hepatocellular carcinoma patients with cirrhosis","volume":"48","author":"Sato","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"2021113010063717100_B40","first-page":"625","article-title":"The impact of splenectomy or splenic artery ligation on the outcome of a living donor adult liver transplantation using a left lobe graft","volume":"51","author":"Shimada","year":"2004","journal-title":"Hepatogastroenterology"},{"key":"2021113010063717100_B41","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1111\/j.1432-2277.2010.01079.x","article-title":"Splenectomy improves survival by increasing arterial blood supply in a rat model of reduced-size liver","volume":"23","author":"Eipel","year":"2010","journal-title":"Transpl. Int."},{"key":"2021113010063717100_B42","first-page":"1652","article-title":"Splenectomy for reduction of excessive portal hypertension after adult living-related donor liver transplantation","volume":"49","author":"Sato","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"2021113010063717100_B43","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/liv.12562","article-title":"Characteristic haemodynamic changes of cirrhosis may influence the diagnosis of portopulmonary hypertension","volume":"35","author":"Chiva","year":"2015","journal-title":"Liver Int."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/1\/153\/841543\/cs-2018-0858.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/1\/153\/841543\/cs-2018-0858.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T10:06:53Z","timestamp":1638266813000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/133\/1\/153\/163\/The-effects-of-terlipressin-and-direct-portacaval"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,15]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20180858","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2019,1]]}}}