{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:22:11Z","timestamp":1785439331707,"version":"3.56.0"},"reference-count":461,"publisher":"Portland Press Ltd.","issue":"14","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic respiratory diseases are among the leading causes of mortality worldwide, with the major contributor, chronic obstructive pulmonary disease (COPD) accounting for approximately 3 million deaths annually. Frequent acute exacerbations (AEs) of COPD (AECOPD) drive clinical and functional decline in COPD and are associated with accelerated loss of lung function, increased mortality, decreased health-related quality of life and significant economic costs. Infections with a small subgroup of pathogens precipitate the majority of AEs and consequently constitute a significant comorbidity in COPD. However, current pharmacological interventions are ineffective in preventing infectious exacerbations and their treatment is compromised by the rapid development of antibiotic resistance. Thus, alternative preventative therapies need to be considered. Pathogen adherence to the pulmonary epithelium through host receptors is the prerequisite step for invasion and subsequent infection of surrounding structures. Thus, disruption of bacterial\u2013host cell interactions with receptor antagonists or modulation of the ensuing inflammatory profile present attractive avenues for therapeutic development. This review explores key mediators of pathogen\u2013host interactions that may offer new therapeutic targets with the potential to prevent viral\/bacterial-mediated AECOPD. There are several conceptual and methodological hurdles hampering the development of new therapies that require further research and resolution.<\/jats:p>","DOI":"10.1042\/cs20181009","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T14:05:18Z","timestamp":1564063518000},"page":"1663-1703","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways"],"prefix":"10.1042","volume":"133","author":[{"given":"Brianna","family":"Atto","sequence":"first","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-7059","authenticated-orcid":false,"given":"Mathew\u00a0Suji","family":"Eapen","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-2306","authenticated-orcid":false,"given":"Pawan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, Sydney 2037, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Frey","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Basel UKBB, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaina\u00a0J.","family":"Ammit","sequence":"additional","affiliation":[{"name":"Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, Sydney 2037, NSW, Australia"},{"name":"Discipline of Medical Sciences, School of Life Sciences, University of Technology Sydney, Sydney 2007, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Markos","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania 7250, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin","family":"Chia","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania 7250, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie","family":"Larby","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania 7250, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Haug","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Department of Respiratory Medicine, Launceston General Hospital, Launceston, Tasmania 7250, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich\u00a0C.","family":"Weber","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Department of Respiratory Medicine, Tasmanian Health Services (THS), North West Hospital, Burnie, Tasmania, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mabeza","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"},{"name":"Department of Respiratory Medicine, Tasmanian Health Services (THS), North West Hospital, Burnie, Tasmania, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tristram","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Myers","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic\u00a0P.","family":"Geraghty","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie\u00a0L.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Clinical School, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7250, Australia"},{"name":"School of Health and Biomedical Science, RMIT University, Melbourne, Victoria, Australia"},{"name":"Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia"},{"name":"Department of Infectious Disease, Launceston General Hospital, Launceston, Tasmania 7250, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip\u00a0M.","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-8613","authenticated-orcid":false,"given":"Sukhwinder\u00a0Singh","family":"Sohal","sequence":"additional","affiliation":[{"name":"Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"2021113012310847800_B1","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1128\/JCM.05476-11","article-title":"Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era","volume":"49","author":"Agrawal","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"2021113012310847800_B2","article-title":"Global Initiative for Chronic Obstructive Lung Disease (GOLD)","author":"Global Strategy for the Diagnosis, Management and Prevention of COPD","year":"2017"},{"key":"2021113012310847800_B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2001-1326-1-10","article-title":"Haemophilus influenzae and the lung (Haemophilus and the lung)","volume":"1","author":"King","year":"2012","journal-title":"Clin. Transl. Med."},{"key":"2021113012310847800_B4","volume-title":"Global Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive Approach","author":"Cruz","year":"2007"},{"key":"2021113012310847800_B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ccm.2013.10.002","article-title":"Epidemiology and prevalence of chronic obstructive pulmonary disease","volume":"35","author":"Diaz-Guzman","year":"2014","journal-title":"Clin. Chest Med."},{"key":"2021113012310847800_B6","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2016.00050","article-title":"Haemophilus haemolyticus interaction with host cells is different to nontypeable Haemophilus influenzae and prevents NTHi association with epithelial cells","volume":"6","author":"Pickering","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2021113012310847800_B7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1183\/09059180.05.00009504","article-title":"Impact of bacterial infections on airway diseases","volume":"14","author":"Toews","year":"2005","journal-title":"Eur. Resp. Rev."},{"key":"2021113012310847800_B8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/nyas.12619","article-title":"Molecular pathogenesis of cigarette smoking-induced stable COPD","volume":"1340","author":"Caramori","year":"2015","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2021113012310847800_B9","doi-asserted-by":"publisher","first-page":"e0166462","DOI":"10.1371\/journal.pone.0166462","article-title":"Burden of idiopathic pulmonary fibrosis progression: a 5-year longitudinal follow-up study","volume":"12","author":"Cottin","year":"2017","journal-title":"PLoS One"},{"key":"2021113012310847800_B10","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/resp.13032","article-title":"The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD","volume":"22","author":"Leung","year":"2017","journal-title":"Respirology"},{"key":"2021113012310847800_B11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.coph.2013.03.005","article-title":"Murine models of infectious exacerbations of airway inflammation","volume":"13","author":"Starkey","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"2021113012310847800_B12","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1136\/thx.2005.041822","article-title":"COPD exacerbations \u00b7 2: aetiology","volume":"61","author":"Sapey","year":"2006","journal-title":"Thorax"},{"key":"2021113012310847800_B13","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2147\/COPD.S2776","article-title":"Role of bacteria in acute exacerbations of chronic obstructive pulmonary disease","volume":"3","author":"Erkan","year":"2008","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/imr.12543","article-title":"Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma","volume":"278","author":"Hansbro","year":"2017","journal-title":"Immunol. Rev."},{"key":"2021113012310847800_B15","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1183\/09031936.00081409","article-title":"Infection as a comorbidity of COPD","volume":"35","author":"Sethi","year":"2010","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/2001-1326-1-10","article-title":"Haemophilus influenzae and the lung (Haemophilus and the lung)","volume":"1","author":"King","year":"2012","journal-title":"Clin. Transl. Med."},{"key":"2021113012310847800_B17","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1099\/mic.0.040451-0","article-title":"Evidence for a non-replicative intracellular stage of nontypable Haemophilus influenzae in epithelial cells","volume":"157","author":"Morey","year":"2011","journal-title":"Microbiology"},{"key":"2021113012310847800_B18","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/resp.12734","article-title":"COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species","volume":"21","author":"Simpson","year":"2016","journal-title":"Respirology"},{"key":"2021113012310847800_B19","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.resinv.2013.08.005","article-title":"Viral infections in asthma and COPD","volume":"52","author":"Matsumoto","year":"2014","journal-title":"Respir. Investig."},{"key":"2021113012310847800_B20","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1513\/pats.200707-101TH","article-title":"Diagnosis of pathogens in exacerbations of chronic obstructive pulmonary disease","volume":"4","author":"Sykes","year":"2007","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2021113012310847800_B21","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1164\/ajrccm.162.1.9911019","article-title":"Respiratory viral infections in adults with and without chronic obstructive pulmonary disease","volume":"162","author":"Greenberg","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1513\/pats.2306030","article-title":"Role of viruses in exacerbations of chronic obstructive pulmonary disease","volume":"1","author":"Wedzicha","year":"2004","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2021113012310847800_B23","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/j.1440-1843.2010.01722.x","article-title":"Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: a systematic review","volume":"15","author":"Mohan","year":"2010","journal-title":"Respirology"},{"key":"2021113012310847800_B24","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1034\/j.1399-3003.2000.16d19.x","article-title":"Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease","volume":"16","author":"Seemungal","year":"2000","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B25","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.3389\/fimmu.2018.02345","article-title":"Resolving viral-induced secondary bacterial infection in COPD: a concise review","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"2021113012310847800_B26","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1111\/resp.13021","article-title":"Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD","volume":"22","author":"Eapen","year":"2017","journal-title":"Respirology"},{"key":"2021113012310847800_B27","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/resp.12971","article-title":"Microbiomes in respiratory health and disease: an Asia-Pacific perspective","volume":"22","author":"Chotirmall","year":"2017","journal-title":"Respirology"},{"key":"2021113012310847800_B28","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1038\/cti.2017.6","article-title":"Microbiome effects on immunity, health and disease in the lung","volume":"6","author":"Shukla","year":"2017","journal-title":"Clin. Transl. Immunol."},{"key":"2021113012310847800_B29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut-lung axis","volume":"15","author":"Budden","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"2021113012310847800_B30","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1099\/mic.0.040451-0","article-title":"Evidence for a non-replicative intracellular stage of nontypable Haemophilus influenzae in epithelial cells","volume":"157","author":"Morey","year":"2011","journal-title":"Microbiology"},{"key":"2021113012310847800_B31","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1164\/rccm.201501-0188OC","article-title":"Targeting PI3K-p110\u03b1 suppresses influenza virus infection in chronic obstructive pulmonary disease","volume":"191","author":"Chen-Yu Hsu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B32","doi-asserted-by":"publisher","first-page":"e20444","DOI":"10.7554\/eLife.20444","article-title":"Suppressor of cytokine signaling (SOCS) 5 ameliorates influenza infection via inhibition of EGFR signaling","volume":"6","author":"Kedzierski","year":"2017","journal-title":"Elife"},{"key":"2021113012310847800_B33","doi-asserted-by":"publisher","first-page":"e1004549","DOI":"10.1371\/journal.ppat.1004549","article-title":"Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung","volume":"11","author":"Tay","year":"2015","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1513\/AnnalsATS.201310-350OC","article-title":"Bacterial colonization increases daily symptoms in patients with chronic obstructive pulmonary disease","volume":"11","author":"Desai","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"2021113012310847800_B35","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jinf.2013.08.010","article-title":"Antibiotics for treatment and prevention of exacerbations of chronic obstructive pulmonary disease","volume":"67","author":"Wilson","year":"2013","journal-title":"J. Infect."},{"key":"2021113012310847800_B36","doi-asserted-by":"publisher","first-page":"e0121257","DOI":"10.1371\/journal.pone.0121257","article-title":"Prophylactic use of macrolide antibiotics for the prevention of chronic obstructive pulmonary disease exacerbation: a meta-analysis","volume":"10","author":"Ni","year":"2015","journal-title":"PLoS One"},{"key":"2021113012310847800_B37","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/resp.13012","article-title":"Global strategy for the diagnosis, management and prevention of chronic obstructive lung disease 2017 report","volume":"22","author":"Vogelmeier","year":"2017","journal-title":"Respirology"},{"key":"2021113012310847800_B38","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(15)60693-6","article-title":"Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management","volume":"385","author":"Woodruff","year":"2015","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B39","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S2213-2600(18)30296-0","article-title":"Precision medicine in COPD exacerbations","volume":"6","author":"Agusti","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"2021113012310847800_B40","first-page":"1532","article-title":"Biomarkers of progression of chronic obstructive pulmonary disease (COPD)","volume":"6","author":"Shaw","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"2021113012310847800_B41","doi-asserted-by":"publisher","first-page":"e0158843","DOI":"10.1371\/journal.pone.0158843","article-title":"A systematic review of diagnostic biomarkers of COPD exacerbation","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"key":"2021113012310847800_B42","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1080\/15412555.2016.1254172","article-title":"Inhaled corticosteroid use in chronic obstructive pulmonary disease and risk of pneumonia: a nested case-control population-based study in Lazio (Italy)\u2014The OUTPUL Study","volume":"14","author":"Cascini","year":"2017","journal-title":"J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B43","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1007\/s40265-018-1001-8","article-title":"Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities","volume":"78","author":"Eapen","year":"2018","journal-title":"Drugs"},{"key":"2021113012310847800_B44","article-title":"Efficacy and safety of long-acting \u03b2-agonist\/long-acting muscarinic antagonist combinations in COPD: a network meta-analysis","author":"Oba","year":"2015","journal-title":"Thorax"},{"key":"2021113012310847800_B45","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1378\/chest.118.5.1294","article-title":"The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial","volume":"118","author":"Casaburi","year":"2000","journal-title":"Chest"},{"key":"2021113012310847800_B46","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010177.pub2","article-title":"Long-acting beta2-agonists for chronic obstructive pulmonary disease","author":"Kew","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"2021113012310847800_B47","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1136\/bmj.320.7245.1297","article-title":"Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial","volume":"320","author":"Burge","year":"2000","journal-title":"BMJ"},{"key":"2021113012310847800_B48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4104\/pcrj.2011.00102","article-title":"Beyond lung function in COPD management: effectiveness of LABA\/LAMA combination therapy on patient-centred outcomes","volume":"21","author":"van der Molen","year":"2012","journal-title":"Prim. Care Respir. J."},{"key":"2021113012310847800_B49","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1016\/j.drudis.2014.08.004","article-title":"Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping","volume":"19","author":"Montuschi","year":"2014","journal-title":"Drug Discov. Today"},{"key":"2021113012310847800_B50","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1164\/rccm.201606-1179PP","article-title":"Current controversies in the pharmacological treatment of chronic obstructive pulmonary disease","volume":"194","author":"Singh","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1517\/13543784.2013.732997","article-title":"Th2 cytokine antagonists: potential treatments for severe asthma","volume":"22","author":"Hansbro","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"2021113012310847800_B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s41030-017-0043-5","article-title":"A review on the safety and efficacy of inhaled corticosteroids in the management of asthma","volume":"3","author":"Ye","year":"2017","journal-title":"Pulmon. Ther."},{"key":"2021113012310847800_B53","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1517\/14656566.2015.1067682","article-title":"A re-evaluation of the role of inhaled corticosteroids in the management of patients with chronic obstructive pulmonary disease","volume":"16","author":"D\u2019Urzo","year":"2015","journal-title":"Expert Opin. Pharmacother."},{"key":"2021113012310847800_B54","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4104\/pcrj.2009.00072","article-title":"Pneumonia among COPD patients using inhaled corticosteroids and long-acting bronchodilators","volume":"19","author":"Mapel","year":"2010","journal-title":"Prim. Care Respir. J."},{"key":"2021113012310847800_B55","article-title":"Effect of fluticasone propionate on induced sputum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with COPD","author":"Culpitt","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B56","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1164\/ajrccm.155.2.9032192","article-title":"Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD","volume":"155","author":"Keatings","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B57","article-title":"Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease","author":"Barnes","year":"2000"},{"key":"2021113012310847800_B58","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1016\/S0140-6736(98)10019-3","article-title":"Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial","volume":"353","author":"Vestbo","year":"1999","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B59","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1136\/thx.53.6.477","article-title":"Randomised controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary disease","volume":"53","author":"Bourbeau","year":"1998","journal-title":"Thorax"},{"key":"2021113012310847800_B60","first-page":"1902","article-title":"Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease","volume":"2000","author":"Group","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B61","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1046\/j.1365-2222.1999.00021.x","article-title":"A double-blind placebo-controlled study of the effect of inhaled beclomethasone dipropionate for 2 years in patients with nonasthmatic chronic obstructive pulmonary disease","volume":"29","author":"Weir","year":"1999","journal-title":"Clin. Exp. Allergy"},{"key":"2021113012310847800_B62","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0140-6736(97)03471-5","article-title":"Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease","volume":"351","author":"Paggiaro","year":"1998","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B63","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1164\/rccm.200508-1338PP","article-title":"Statistical treatment of exacerbations in therapeutic trials of chronic obstructive pulmonary disease","volume":"173","author":"Suissa","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B64","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1183\/09031936.03.00031402","article-title":"Efficacy and safety of budesonide\/formoterol in the management of chronic obstructive pulmonary disease","volume":"21","author":"Szafranski","year":"2003","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B65","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1183\/09031936.03.00027003","article-title":"Maintenance therapy with budesonide and formoterol in chronicobstructive pulmonary disease","volume":"22","author":"Calverley","year":"2003","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B66","first-page":"130","article-title":"Efficacy and safety of inhaler steroids in COPD patients: Systematic review and meta-analysis of randomized placebo-controlled trials","volume":"5","author":"Karbasi-Afshar","year":"2014","journal-title":"Caspian J. Intern. Med."},{"key":"2021113012310847800_B67","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1513\/pats.200707-096ET","article-title":"Inhaled and systemic corticosteroids in chronic obstructive pulmonary disease","volume":"5","author":"Falk","year":"2008","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2021113012310847800_B68","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1465-9921-11-79","article-title":"Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations","volume":"11","author":"Glaab","year":"2010","journal-title":"Respir. Res."},{"key":"2021113012310847800_B69","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1164\/rccm.200611-1630OC","article-title":"Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumonia","volume":"176","author":"Ernst","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B70","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1164\/rccm.201509-1869OC","article-title":"Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen General Population Study","volume":"193","author":"Vedel-Krogh","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B71","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.rmed.2018.03.016","article-title":"Blood eosinophil levels as a biomarker in COPD","volume":"138","author":"Brusselle","year":"2018","journal-title":"Respir. Med."},{"key":"2021113012310847800_B72","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.2147\/COPD.S175017","article-title":"Blood eosinophils and inhaled corticosteroids in patients with COPD: systematic review and meta-analysis","volume":"13","author":"Cheng","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B73","doi-asserted-by":"publisher","first-page":"13451","DOI":"10.1038\/s41598-017-13745-x","article-title":"Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis","volume":"7","author":"Ho","year":"2017","journal-title":"Sci. Rep."},{"key":"2021113012310847800_B74","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S2213-2600(15)00106-X","article-title":"Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials","volume":"3","author":"Pascoe","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"2021113012310847800_B75","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1136\/thoraxjnl-2015-207021","article-title":"Blood eosinophils and inhaled corticosteroid\/long-acting \u03b2-2 agonist efficacy in COPD","volume":"71","author":"Pavord","year":"2016","journal-title":"Thorax"},{"key":"2021113012310847800_B76","article-title":"Global Initiative for Chronic Obstructive Lung Disease (GOLD)","author":"Global Strategy for the Diagnosis, Management and Prevention of COPD","year":"2019"},{"key":"2021113012310847800_B77","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02257-2017","article-title":"Inhaled corticosteroids and increased microbial load in COPD: potential role of epithelial adhesion molecules","volume":"51","author":"Sohal","year":"2018","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B78","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1164\/rccm.201808-1553LE","article-title":"Dysfunctional immunity and microbial adhesion molecules in smoking-induced pneumonia","volume":"199","author":"Eapen","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B79","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/17476348.2017.1360769","article-title":"Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox","volume":"11","author":"Eapen","year":"2017","journal-title":"Expert Rev. Respir. Med."},{"key":"2021113012310847800_B80","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00289-2017","article-title":"Airway inflammation and inhaled corticosteroids in COPD","volume":"49","author":"Sohal","year":"2017","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B81","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.2147\/COPD.S154897","article-title":"Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent?","volume":"12","author":"Sohal","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B82","doi-asserted-by":"publisher","first-page":"e64833","DOI":"10.1371\/journal.pone.0064833","article-title":"Changes in airway histone deacetylase2 in smokers and COPD with inhaled corticosteroids: a randomized controlled trial","volume":"8","author":"Sohal","year":"2013","journal-title":"PLoS One"},{"key":"2021113012310847800_B83","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.2147\/COPD.S113176","article-title":"Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD","volume":"11","author":"Soltani","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B84","doi-asserted-by":"publisher","first-page":"13392","DOI":"10.1038\/s41598-017-13888-x","article-title":"Abnormal M1\/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)","volume":"7","author":"Eapen","year":"2017","journal-title":"Sci. Rep."},{"key":"2021113012310847800_B85","article-title":"Dysfunctional immunity and microbial adhesion molecules in smoking-induced pneumonia","author":"Eapen","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B86","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/1753465816630208","article-title":"Inhaled corticosteroids and the increased risk of pneumonia: what\u2019s new? A 2015 updated review","volume":"10","author":"Iannella","year":"2016","journal-title":"Ther. Adv. Respir. Dis."},{"key":"2021113012310847800_B87","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1164\/rccm.201012-2070OC","article-title":"Observational study of inhaled corticosteroids on outcomes for COPD patients with pneumonia","volume":"184","author":"Chen","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B88","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1056\/NEJMoa1713901","article-title":"Once-daily single-inhaler triple versus dual therapy in patients with COPD","volume":"378","author":"Lipson","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B89","first-page":"6","article-title":"Withdrawal of inhaled corticosteroids and exacerbations of COPD: the wisdom phenotyping substudy","volume":"5","author":"Rodriguez-Roisin","journal-title":"Management"},{"key":"2021113012310847800_B90","doi-asserted-by":"publisher","first-page":"174","DOI":"10.4049\/jimmunol.1402217","article-title":"Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function","volume":"195","author":"Stolberg","year":"2015","journal-title":"J. Immunol."},{"key":"2021113012310847800_B91","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1465-9921-13-40","article-title":"Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice","volume":"13","author":"Patterson","year":"2012","journal-title":"Respir. Res."},{"key":"2021113012310847800_B92","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1038\/s41467-018-04574-1","article-title":"Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations","volume":"9","author":"Singanayagam","year":"2018","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B93","doi-asserted-by":"publisher","first-page":"1800120","DOI":"10.1183\/13993003.00120-2018","article-title":"Blood eosinophil count and risk of pneumonia hospitalisations in individuals with COPD","volume":"51","author":"Vedel-Krogh","year":"2018","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B94","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/ACI.0000000000000251","article-title":"Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: evidence and unmet needs","volume":"16","author":"Varricchi","year":"2016","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"2021113012310847800_B95","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1183\/20734735.026318","article-title":"Precision medicine in COPD: review of mepolizumab for eosinophilic COPD","volume":"14","author":"Long","year":"2018","journal-title":"Breathe"},{"key":"2021113012310847800_B96","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S2213-2600(14)70187-0","article-title":"Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study","volume":"2","author":"Brightling","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"2021113012310847800_B97","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2147\/COPD.S152291","article-title":"Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease","volume":"13","author":"Tashkin","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B98","doi-asserted-by":"publisher","first-page":"1700853","DOI":"10.1183\/13993003.00853-2017","article-title":"Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort","volume":"50","author":"Kim","year":"2017","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B99","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12931-017-0570-5","article-title":"Blood and sputum eosinophils in COPD; relationship with bacterial load","volume":"18","author":"Kolsum","year":"2017","journal-title":"Respir. Res."},{"key":"2021113012310847800_B100","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.2147\/COPD.S143656","article-title":"Scientific rationale for the possible inhaled corticosteroid intraclass difference in the risk of pneumonia in COPD","volume":"12","author":"Janson","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B101","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pupt.2014.05.002","article-title":"Antibiotic prophylaxis in COPD: Why, when, and for whom?","volume":"32","author":"Miravitlles","year":"2015","journal-title":"Pulmon. Pharmacol. Ther."},{"key":"2021113012310847800_B102","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.2147\/COPD.S135338","article-title":"ampicillin resistance in Haemophilus influenzae from COPD patients in the UK","volume":"12","author":"Maddi","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B103","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1056\/NEJMoa1104623","article-title":"Azithromycin for prevention of exacerbations of COPD","volume":"365","author":"Albert","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B104","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1503\/cmaj.121573","article-title":"Long-term macrolide therapy in chronic obstructive pulmonary disease","volume":"186","author":"Parameswaran","year":"2014","journal-title":"Can. Med. Assoc. J."},{"key":"2021113012310847800_B105","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009764.pub2","article-title":"Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD)","author":"Herath","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"2021113012310847800_B106","doi-asserted-by":"publisher","first-page":"e105609","DOI":"10.1371\/journal.pone.0105609","article-title":"The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial","volume":"9","author":"Simpson","year":"2014","journal-title":"PLoS One"},{"key":"2021113012310847800_B107","doi-asserted-by":"crossref","first-page":"00031","DOI":"10.1183\/23120541.00031-2018","article-title":"Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD","volume":"4","author":"Baines","year":"2018","journal-title":"ERJ Open Res"},{"key":"2021113012310847800_B108","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/462934","article-title":"Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD","volume":"2013","author":"Simpson","year":"2013","journal-title":"Mediators Inflamm."},{"key":"2021113012310847800_B109","first-page":"1","article-title":"Nontypeable Haemophilus influenzae and chronic obstructive pulmonary disease: a review for clinicians","author":"Sriram","year":"2017","journal-title":"Crit. Rev. Microbiol."},{"key":"2021113012310847800_B110","first-page":"104","article-title":"Emerging opportunities for inhaled antibiotic therapy","volume":"1","author":"Cipolla","year":"2015","journal-title":"J Antimicrob. Agents"},{"key":"2021113012310847800_B111","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.1128\/AAC.00301-16","article-title":"Effect of fluoroquinolones and macrolides on eradication and resistance of Haemophilus influenzae in chronic obstructive pulmonary disease","volume":"60","author":"Pettigrew","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"2021113012310847800_B112","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3109\/15412555.2010.510162","article-title":"Antibiotic resistance in sputum isolates of Streptococcus pneumoniae in chronic obstructive pulmonary disease is related to antibiotic exposure","volume":"7","author":"Desai","year":"2010","journal-title":"J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B113","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1465-9921-11-10","article-title":"Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial","volume":"11","author":"Sethi","year":"2010","journal-title":"Respir. Res."},{"key":"2021113012310847800_B114","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1128\/AAC.04005-14","article-title":"Molecular characterization of fluoroquinolone resistance in nontypeable Haemophilus influenzae clinical isolates","volume":"59","author":"Puig","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"2021113012310847800_B115","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1128\/AAC.43.1.161","article-title":"Increase in quinolone resistance in a Haemophilus influenzae strain isolated from a patient with recurrent respiratory infections treated with ofloxacin","volume":"43","author":"Vila","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"2021113012310847800_B116","article-title":"Levofloxacin treatment failure in Haemophilus influenzae pneumonia","author":"Bastida","year":"2003"},{"key":"2021113012310847800_B117","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207194","article-title":"Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised controlled trial","author":"Brill","year":"2015","journal-title":"Thorax"},{"key":"2021113012310847800_B118","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2174\/1872213X09666150223114958","article-title":"Vaccines for patients with COPD","volume":"9","author":"Moreno","year":"2015","journal-title":"Recent Patents Inflammation Allergy Drug Discov"},{"key":"2021113012310847800_B119","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001390.pub4","article-title":"Pneumococcal vaccines for preventing pneumonia in chronic obstructive pulmonary disease","author":"Walters","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"2021113012310847800_B120","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1136\/thx.2005.043323","article-title":"Clinical efficacy of anti-pneumococcal vaccination in patients with COPD","volume":"61","author":"Alfageme","year":"2006","journal-title":"Thorax"},{"key":"2021113012310847800_B121","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1056\/NEJMoa1408544","article-title":"Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults","volume":"372","author":"Bonten","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B122","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12890-017-0420-8","article-title":"Seasonal influenza vaccination in patients with COPD: a systematic literature review","volume":"17","author":"Bekkat-Berkani","year":"2017","journal-title":"BMC Pulm. Med."},{"key":"2021113012310847800_B123","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002733.pub3","article-title":"Influenza vaccine for chronic obstructive pulmonary disease (COPD)","author":"Kopsaftis","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"2021113012310847800_B124","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002733.pub2","article-title":"Influenza vaccine for patients with chronic obstructive pulmonary disease","author":"Poole","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"2021113012310847800_B125","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1111\/j.1440-1843.2012.02200.x","article-title":"Innate immunity to influenza in chronic airways diseases","volume":"17","author":"Hsu","year":"2012","journal-title":"Respirology"},{"key":"2021113012310847800_B126","first-page":"51","article-title":"Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease","volume":"9","author":"Nath","year":"2014","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B127","article-title":"Evaluation of immune responses to influenza vaccination in chronic obstructive pulmonary disease","volume":"4","author":"Burel","year":"2013","journal-title":"J. Vaccin. Vaccination"},{"key":"2021113012310847800_B128","first-page":"A6340","article-title":"Inefficiency of influenza vaccination In COPD patients is associated with defect Of B cell differentiation and decrease of IFN\u03b3 CD4+ T cells production, in C107. Immunity, exacerbation and immune cell function in COPD","author":"Parpaleix","year":"2016","journal-title":"Am. Thorac. Soc."},{"key":"2021113012310847800_B129","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00040","article-title":"Defining the binding region in factor H to develop a therapeutic factor H-Fc fusion protein against non-typeable Haemophilus influenzae","volume":"6","author":"Wong","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2021113012310847800_B130","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.antiviral.2015.08.010","article-title":"Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia","volume":"123","author":"Mastromarino","year":"2015","journal-title":"Antiviral Res."},{"key":"2021113012310847800_B131","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1089\/ars.2011.4307","article-title":"Respiratory syncytial virus infection: mechanisms of redox control and novel therapeutic opportunities","volume":"18","author":"Garofalo","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"2021113012310847800_B132","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3390\/ijms18081717","article-title":"Respiratory syncytial virus: the influence of serotype and genotype variability on clinical course of infection","volume":"18","author":"Vandini","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2021113012310847800_B133","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/rmv.1856","article-title":"Toward antiviral therapy\/prophylaxis for rhinovirus-induced exacerbations of chronic obstructive pulmonary disease: challenges, opportunities, and strategies","volume":"26","author":"Thibaut","year":"2016","journal-title":"Rev. Med. Virol."},{"key":"2021113012310847800_B134","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.antiviral.2013.12.006","article-title":"Experimental rhinovirus infection in COPD: implications for antiviral therapies","volume":"102","author":"Gunawardana","year":"2014","journal-title":"Antiviral Res."},{"key":"2021113012310847800_B135","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1073\/pnas.1119817109","article-title":"Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase","volume":"109","author":"Muratore","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B136","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1086\/429694","article-title":"Inhibition of influenza A virus replication by resveratrol","volume":"191","author":"Palamara","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2021113012310847800_B137","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1056\/NEJM199709253371302","article-title":"Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections","volume":"337","author":"Hayden","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B138","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1471-4914(02)00010-2","article-title":"Influenza-virus-induced signaling cascades: targets for antiviral therapy?","volume":"9","author":"Ludwig","year":"2003","journal-title":"Trends Mol. Med."},{"key":"2021113012310847800_B139","first-page":"2000","article-title":"Study of the impact of oseltamivir on the risk for pneumonia and other outcomes of influenza","volume":"10","author":"Peters","year":"2008","journal-title":"Medscape J. Med."},{"key":"2021113012310847800_B140","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/00006454-200005000-00005","article-title":"Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial","volume":"19","author":"Hedrick","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"2021113012310847800_B141","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/jac\/44.suppl_2.23","article-title":"Randomized, placebo-controlled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis","volume":"44","author":"Monto","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"2021113012310847800_B142","doi-asserted-by":"publisher","first-page":"337","DOI":"10.2165\/00044011-200020050-00005","article-title":"Efficacy and safety of inhaled zanamivir for the treatment of influenza in patients with asthma or chronic obstructive pulmonary disease","volume":"20","author":"Murphy","year":"2000","journal-title":"Clin. Drug Investig."},{"key":"2021113012310847800_B143","first-page":"55","article-title":"Influenza infection and COPD","volume":"2","author":"Mallia","year":"2007","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B144","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF03256597","article-title":"Neuraminidase inhibitors in patients with underlying airways disease","volume":"1","author":"Williamson","year":"2002","journal-title":"Am. J. Respir. Med."},{"key":"2021113012310847800_B145","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1001\/archinte.163.14.1667","article-title":"Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations","volume":"163","author":"Kaiser","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"2021113012310847800_B146","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1128\/AAC.47.7.2264-2272.2003","article-title":"Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir","volume":"47","author":"McKimm-Breschkin","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"2021113012310847800_B147","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofx105","article-title":"A review of clinical influenza A and B infections with reduced susceptibility to both oseltamivir and zanamivir","volume-title":"Open Forum Infectious Diseases","author":"Abed","year":"2017"},{"key":"2021113012310847800_B148","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1086\/314440","article-title":"Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus","volume":"178","author":"Gubareva","year":"1998","journal-title":"J. Infect. Dis."},{"key":"2021113012310847800_B149","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1056\/NEJMp0900648","article-title":"Global transmission of oseltamivir-resistant influenza","volume":"360","author":"Moscona","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B150","first-page":"357","article-title":"Combined therapy of influenza with antiviral drugs with a different mechanism of action in comparison with monotherapy","volume":"10","author":"Popov","year":"2018","journal-title":"J. Pharm. Sci. Res."},{"key":"2021113012310847800_B151","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ejps.2017.10.027","article-title":"Oseltamivir-zanamivir combination therapy suppresses drug-resistant H1N1 influenza A viruses in the hollow fiber infection model (HFIM) system","volume":"111","author":"de Mello","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"2021113012310847800_B152","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s00705-007-0974-5","article-title":"Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo","volume":"152","author":"Shi","year":"2007","journal-title":"Arch. Virol."},{"key":"2021113012310847800_B153","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/infdis\/jiv245","article-title":"Emergence of multidrug-resistant influenza A (H1N1) pdm09 virus variants in an immunocompromised child treated with oseltamivir and zanamivir","volume":"212","author":"Tamura","year":"2015","journal-title":"J. Infect. Dis."},{"key":"2021113012310847800_B154","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2174\/138920307779941523","article-title":"Human rhinovirus 3C protease as a potential target for the development of antiviral agents","volume":"8","author":"May Wang","year":"2007","journal-title":"Curr. Protein Pept. Sci."},{"key":"2021113012310847800_B155","doi-asserted-by":"publisher","first-page":"505","DOI":"10.2217\/fvl-2018-0016","article-title":"Antiviral therapeutic approaches for human rhinovirus infections","volume":"13","author":"Casanova","year":"2018","journal-title":"Future Virol"},{"key":"2021113012310847800_B156","first-page":"13","article-title":"Non-pharmacological management of chronic obstructive pulmonary disease","volume":"84","author":"Safka","year":"2015","journal-title":"Ulster Med. J."},{"key":"2021113012310847800_B157","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.pcrj.2005.11.003","article-title":"International Primary Care Respiratory Group (IPCRG) Guidelines: management of chronic obstructive pulmonary disease (COPD)","volume":"15","author":"Bellamy","year":"2006","journal-title":"Prim. Care Respir. J."},{"key":"2021113012310847800_B158","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1001\/jama.1994.03520190043033","article-title":"Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: the Lung Health Study","volume":"272","author":"Anthonisen","year":"1994","journal-title":"JAMA"},{"key":"2021113012310847800_B159","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1136\/thorax.55.9.746","article-title":"Pulmonary function, smoking cessation and 30 year mortality in middle aged Finnish men","volume":"55","author":"Pelkonen","year":"2000","journal-title":"Thorax"},{"key":"2021113012310847800_B160","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1164\/ajrccm.161.2.9901044","article-title":"Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease: the Lung Health Study","volume":"161","author":"Scanlon","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B161","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1164\/rccm.2112096","article-title":"Smoking and lung function of Lung Health Study participants after 11 years","volume":"166","author":"Anthonisen","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B162","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.rmed.2009.02.013","article-title":"Smoking cessation in chronic obstructive pulmonary disease","volume":"103","author":"Tashkin","year":"2009","journal-title":"Respir. Med."},{"key":"2021113012310847800_B163","article-title":"Smoking cessation in chronic obstructive pulmonary disease","author":"Tashkin","year":"2015","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"2021113012310847800_B164","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ccm.2013.11.002","article-title":"Smoking cessation","volume":"35","author":"Rennard","year":"2014","journal-title":"Clin. Chest Med."},{"key":"2021113012310847800_B165","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1056\/NEJMoa1604344","article-title":"A randomized trial of long-term oxygen for COPD with moderate desaturation","volume":"375","author":"Group TL-TOTTR. Long-Term Oxygen Treatment Trial Research Group","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B166","article-title":"A randomized trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease patients","volume":"14","author":"Chaouat","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B167","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1136\/thx.52.8.674","article-title":"Effect of long-term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia","volume":"52","author":"Gorecka","journal-title":"Thorax"},{"key":"2021113012310847800_B168","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1513\/AnnalsATS.201705-374SD","article-title":"The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: rationale, design, and lessons learned","volume":"15","author":"Yusen","year":"2018","journal-title":"Ann. Am. Thorac. Soc."},{"key":"2021113012310847800_B169","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12931-018-0778-z","article-title":"Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes","volume":"19","author":"Staudt","year":"2018","journal-title":"Respir. Res."},{"key":"2021113012310847800_B170","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12931-016-0369-9","article-title":"Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2, 5-dimethypyrazine","volume":"17","author":"Sherwood","year":"2016","journal-title":"Respir. Res."},{"key":"2021113012310847800_B171","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.tiv.2014.04.012","article-title":"Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells","volume":"28","author":"Cervellati","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"2021113012310847800_B172","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12931-016-0368-x","article-title":"Electronic cigarette exposure triggers neutrophil inflammatory responses","volume":"17","author":"Higham","year":"2016","journal-title":"Respir. Res."},{"key":"2021113012310847800_B173","doi-asserted-by":"publisher","first-page":"e0116732","DOI":"10.1371\/journal.pone.0116732","article-title":"Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung","volume":"10","author":"Lerner","year":"2015","journal-title":"PLoS One"},{"key":"2021113012310847800_B174","doi-asserted-by":"publisher","first-page":"e0116861","DOI":"10.1371\/journal.pone.0116861","article-title":"Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model","volume":"10","author":"Sussan","year":"2015","journal-title":"PLoS One"},{"key":"2021113012310847800_B175","doi-asserted-by":"publisher","first-page":"E1560","DOI":"10.1073\/pnas.1718185115","article-title":"E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B176","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1165\/rcmb.2015-0306OC","article-title":"Impaired antiviral stress granule and IFN-\u03b2 enhanceosome formation enhances susceptibility to influenza infection in chronic obstructive pulmonary disease epithelium","volume":"55","author":"Hsu","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B177","first-page":"51","article-title":"E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells","author":"Miyashita","year":"2018","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B178","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1183\/09031936.00103408","article-title":"Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia","volume":"33","author":"Giebelen","year":"2009","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B179","doi-asserted-by":"publisher","first-page":"6518","DOI":"10.4049\/jimmunol.167.11.6518","article-title":"Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine","volume":"167","author":"Matsunaga","year":"2001","journal-title":"J. Immunol."},{"key":"2021113012310847800_B180","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/pr.2012.55","article-title":"In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages","volume":"72","author":"Wongtrakool","year":"2012","journal-title":"Pediatr. Res."},{"key":"2021113012310847800_B181","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.chom.2010.03.009","article-title":"Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production","volume":"7","author":"Radek","year":"2010","journal-title":"Cell Host Microbe"},{"key":"2021113012310847800_B182","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.intimp.2010.12.020","article-title":"Alteration of immune functions and Th1\/Th2 cytokine balance in nicotine-induced murine macrophages: immunomodulatory role of eugenol and N-acetylcysteine","volume":"11","author":"Mahapatra","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"2021113012310847800_B183","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/ajim.20151","article-title":"Effects of theatrical smokes and fogs on respiratory health in the entertainment industry","volume":"47","author":"Varughese","year":"2005","journal-title":"Am. J. Ind. Med."},{"key":"2021113012310847800_B184","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00159-2018","article-title":"IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette","volume":"5","author":"Sohal","year":"2019","journal-title":"ERJ Open Res"},{"key":"2021113012310847800_B185","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1152\/physrev.00040.2016","article-title":"Bacterial-host interactions: physiology and pathophysiology of respiratory infection","volume":"98","author":"Hakansson","year":"2018","journal-title":"Physiol. Rev."},{"key":"2021113012310847800_B186","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/706376","article-title":"The lung immune response to nontypeable Haemophilus influenzae (lung immunity to NTHi)","volume":"2015","author":"King","year":"2015","journal-title":"J. Immunol. Res."},{"key":"2021113012310847800_B187","first-page":"473","article-title":"Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target","volume":"9","author":"Shukla","year":"2015","journal-title":"Expert Rev. Respir. Med."},{"key":"2021113012310847800_B188","doi-asserted-by":"publisher","first-page":"6182","DOI":"10.4049\/jimmunol.177.9.6182","article-title":"Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology","volume":"177","author":"Fillon","year":"2006","journal-title":"J. Immunol."},{"key":"2021113012310847800_B189","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1042\/bj2920617","article-title":"Platelet-activating factor: receptors and signal transduction","volume":"292","author":"Chao","year":"1993","journal-title":"Biochem. J."},{"key":"2021113012310847800_B190","first-page":"191","article-title":"The role of platelet-activating factor in chronic inflammation, immune activation, and comorbidities associated with HIV infection","volume":"17","author":"Kelesidis","year":"2015","journal-title":"AIDS Rev."},{"key":"2021113012310847800_B191","doi-asserted-by":"publisher","first-page":"3840","DOI":"10.1002\/1873-3468.12351","article-title":"Host-pathogen interactions of nontypeable Haemophilus influenzae: from commensal to pathogen","volume":"590","author":"Duell","year":"2016","journal-title":"FEBS Lett."},{"key":"2021113012310847800_B192","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1128\/IAI.01168-12","article-title":"Microbial modulation of host immunity with the small molecule phosphorylcholine","volume":"81","author":"Clark","year":"2013","journal-title":"Infect. Immun."},{"key":"2021113012310847800_B193","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1046\/j.1462-5822.2002.00180.x","article-title":"Molecular and cellular determinants of non-typeable Haemophilus influenzae adherence and invasion","volume":"4","author":"Geme","year":"2002","journal-title":"Cell. Microbiol."},{"key":"2021113012310847800_B194","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1046\/j.1365-2958.2000.01952.x","article-title":"Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor","volume":"37","author":"Swords","year":"2000","journal-title":"Mol. Microbiol."},{"key":"2021113012310847800_B195","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1136\/thoraxjnl-2011-200835","article-title":"Cigarette smoke and platelet-activating factor receptor dependent adhesion of Streptococcus pneumoniae to lower airway cells","volume":"67","author":"Grigg","year":"2012","journal-title":"Thorax"},{"key":"2021113012310847800_B196","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.2147\/COPD.S108698","article-title":"An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke","volume":"11","author":"Shukla","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B197","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/resp.12709","article-title":"Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients","volume":"21","author":"Shukla","year":"2016","journal-title":"Respirology"},{"key":"2021113012310847800_B198","doi-asserted-by":"publisher","first-page":"853","DOI":"10.2147\/COPD.S67044","article-title":"Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease","volume":"9","author":"Shukla","year":"2014","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B199","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.chest.2017.05.024","article-title":"Potential mechanisms of microbial pathogens in idiopathic interstitial lung disease","volume":"152","author":"Sohal","year":"2017","journal-title":"Chest"},{"key":"2021113012310847800_B200","first-page":"A1029","article-title":"The effect of E-cigarettes (EC) on nasal platelet activating factor receptor (PAFR) expression, in A16. Why should we be concerned about E-cigarettes?","author":"Miyashita","year":"2017","journal-title":"Am. Thorac. Soc."},{"key":"2021113012310847800_B201","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1128\/IAI.00864-13","article-title":"Internalization and trafficking of nontypeable Haemophilus influenzae in human respiratory\u02da epithelial cells and roles of IgA1 proteases for optimal invasion and persistence","volume":"82","author":"Clementi","year":"2014","journal-title":"Infect. Immun."},{"key":"2021113012310847800_B202","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1128\/IAI.74.2.830-838.2006","article-title":"Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression","volume":"74","author":"Avadhanula","year":"2006","journal-title":"Infect. Immun."},{"key":"2021113012310847800_B203","doi-asserted-by":"publisher","first-page":"14553","DOI":"10.1074\/jbc.M005067200","article-title":"Intercellular adhesion molecule-1 (ICAM-1) gene expression in human T cells is regulated by phosphotyrosyl phosphatase activity involvement of NF-\u03baB, Ets, and palindromic interferon-\u03b3-responsive element-binding sites","volume":"276","author":"Roy","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B204","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/0092-8674(89)90689-2","article-title":"A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses","volume":"56","author":"Staunton","year":"1989","journal-title":"Cell"},{"key":"2021113012310847800_B205","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1111\/cmi.12575","article-title":"Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae","volume":"18","author":"Novotny","year":"2016","journal-title":"Cell. Microbiol."},{"key":"2021113012310847800_B206","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1128\/JVI.78.7.3663-3674.2004","article-title":"VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds","volume":"78","author":"Ledford","year":"2004","journal-title":"J. Virol."},{"key":"2021113012310847800_B207","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1046\/j.1365-2249.2000.01301.x","article-title":"Expression of intercellular adhesion molecule-1 (ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection?","volume":"121","author":"Bianco","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"2021113012310847800_B208","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12931-016-0483-8","article-title":"The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)","volume":"18","author":"Shukla","year":"2017","journal-title":"Respir. Res."},{"key":"2021113012310847800_B209","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1096\/fj.06-5806fje","article-title":"H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression","volume":"20","author":"Sajjan","year":"2006","journal-title":"FASEB J."},{"key":"2021113012310847800_B210","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/resp.12285","article-title":"Intercellular adhesion molecule-1 as a drug target in asthma and rhinitis","volume":"19","author":"Mukhopadhyay","year":"2014","journal-title":"Respirology"},{"key":"2021113012310847800_B211","doi-asserted-by":"publisher","first-page":"e1003520","DOI":"10.1371\/journal.ppat.1003520","article-title":"An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation","volume":"9","author":"Traub","year":"2013","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B212","first-page":"1","article-title":"Classification and evolution of human rhinoviruses","author":"Palmenberg","year":"2015","journal-title":"Rhinoviruses"},{"key":"2021113012310847800_B213","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/j.1365-2958.2007.05864.x","article-title":"The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract","volume":"65","author":"Jurcisek","year":"2007","journal-title":"Mol. Microbiol."},{"key":"2021113012310847800_B214","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/IAI.67.1.187-192.1999","article-title":"Fimbria-mediated enhanced attachment of nontypeableHaemophilus influenzae to respiratory syncytial virus-infected respiratory epithelial cells","volume":"67","author":"Jiang","year":"1999","journal-title":"Infect. Immun."},{"key":"2021113012310847800_B215","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/mi.2011.6","article-title":"Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae","volume":"4","author":"Novotny","year":"2011","journal-title":"Mucosal Immunol"},{"key":"2021113012310847800_B216","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/ni.1661","article-title":"CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells","volume":"9","author":"Slevogt","year":"2008","journal-title":"Nat. Immunol."},{"key":"2021113012310847800_B217","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1465-9921-14-85","article-title":"Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons","volume":"14","author":"Klaile","year":"2013","journal-title":"Respir. Res."},{"key":"2021113012310847800_B218","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1099\/mic.0.000434","article-title":"Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease","volume":"163","author":"Kc","year":"2017","journal-title":"Microbiology"},{"key":"2021113012310847800_B219","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1016\/j.celrep.2016.05.036","article-title":"CEACAM1-mediated inhibition of virus production","volume":"15","author":"Vitenshtein","year":"2016","journal-title":"Cell Rep."},{"key":"2021113012310847800_B220","doi-asserted-by":"publisher","first-page":"6217","DOI":"10.1038\/ncomms7217","article-title":"CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production","volume":"6","author":"Khairnar","year":"2015","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B221","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1038\/s41467-018-04832-2","article-title":"CEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection","volume":"9","author":"Khairnar","year":"2018","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B222","doi-asserted-by":"publisher","first-page":"8173","DOI":"10.1128\/JVI.75.17.8173-8186.2001","article-title":"Targeted disruption of the Ceacam1 (MHVR) gene leads to reduced susceptibility of mice to mouse hepatitis virus infection","volume":"75","author":"Blau","year":"2001","journal-title":"J. Virol."},{"key":"2021113012310847800_B223","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1007\/s000180050258","article-title":"Structure, function and metabolism of sialic acids","volume":"54","author":"Traving","year":"1998","journal-title":"Cell Mol. Life Sci."},{"key":"2021113012310847800_B224","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/ijdr.IJDR_106_16","article-title":"Comparative analysis of salivary sialic acid levels in patients with chronic obstructive pulmonary disease and chronic periodontitis patients: a biochemical study","volume":"29","author":"Rathod","year":"2018","journal-title":"Indian J. Dent. Res."},{"key":"2021113012310847800_B225","first-page":"1209","article-title":"Elevated levels of serum sialic acid and C-reactive protein: markers of systemic inflammation in patients with chronic obstructive pulmonary disease","volume":"4","author":"Pinnelli","year":"2016","journal-title":"Int. J. Res. Med. Sci."},{"key":"2021113012310847800_B226","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.coi.2011.07.016","article-title":"The pathogenesis of influenza virus infections: the contributions of virus and host factors","volume":"23","author":"Fukuyama","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"2021113012310847800_B227","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.micinf.2004.05.002","article-title":"Endocytosis of influenza viruses","volume":"6","author":"Lakadamyali","year":"2004","journal-title":"Microbes Infect."},{"key":"2021113012310847800_B228","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nsmb769","article-title":"Assembly of endocytic machinery around individual influenza viruses during viral entry","volume":"11","author":"Rust","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2021113012310847800_B229","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.biomaterials.2015.11.034","article-title":"Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: a dramatic multivalent effect","volume":"78","author":"Xiao","year":"2016","journal-title":"Biomaterials"},{"key":"2021113012310847800_B230","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801999115","article-title":"A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin","author":"Kadam","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B231","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1128\/JVI.02344-12","article-title":"Identification and structural characterization of a broadly neutralizing antibody targeting a novel conserved epitope on the influenza virus H5N1 hemagglutinin","volume":"87","author":"Du","year":"2013","journal-title":"J. Virol."},{"key":"2021113012310847800_B232","doi-asserted-by":"publisher","first-page":"e0138426","DOI":"10.1371\/journal.pone.0138426","article-title":"New influenza A virus entry inhibitors derived from the viral fusion peptides","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"2021113012310847800_B233","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1128\/JVI.01225-13","article-title":"New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion","volume":"88","author":"Basu","year":"2014","journal-title":"J. Virol."},{"key":"2021113012310847800_B234","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.ejphar.2011.04.013","article-title":"CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry","volume":"660","author":"Liu","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"2021113012310847800_B235","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M510233200","article-title":"Membrane accumulation of influenza a virus hemagglutinin triggers nuclear export of the viral genome via PKC\u03b1 mediated activation of ERK signaling","author":"Marjuki","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B236","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1177\/2040206615622920","article-title":"Molecular basis of influenza hemagglutinin inhibition with an entry-blocker peptide by computational docking and mass spectrometry","volume":"24","author":"Lu","year":"2015","journal-title":"Antivir. Chem. Chemother."},{"key":"2021113012310847800_B237","doi-asserted-by":"publisher","first-page":"5428","DOI":"10.3390\/v7102883","article-title":"Perspective of use of antiviral peptides against influenza virus","volume":"7","author":"Skalickova","year":"2015","journal-title":"Viruses"},{"key":"2021113012310847800_B238","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.antiviral.2014.04.006","article-title":"Arbidol as a broad-spectrum antiviral: an update","volume":"107","author":"Blaising","year":"2014","journal-title":"Antiviral Res."},{"key":"2021113012310847800_B239","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1073\/pnas.1617020114","article-title":"Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol","volume":"114","author":"Kadam","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B240","doi-asserted-by":"publisher","first-page":"215","DOI":"10.17816\/KMJ2018-215","article-title":"Study of effectiveness of antiviral drugs (umifenovir, triazavirin) against acute respiratory viral infections","volume":"99","author":"Tikhonova","year":"2018","journal-title":"Kazan Med. J."},{"key":"2021113012310847800_B241","doi-asserted-by":"publisher","DOI":"10.26442\/terarkh201890848-52","article-title":"Afficacy of Arbidol in the prevention of virus-induced exacerbations of bronchial asthma and chronic obstructive pulmonary disease","volume":"90","author":"Titova","year":"2018","journal-title":"Ther. Arch."},{"key":"2021113012310847800_B242","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijid.2016.01.001","article-title":"Virus susceptibility and clinical effectiveness of anti-influenza drugs during the 2010-2011 influenza season in Russia","volume":"43","author":"Leneva","year":"2016","journal-title":"Int. J. Infect. Dis."},{"key":"2021113012310847800_B243","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/17512433.2017.1255550","article-title":"The pharmacological management of severe influenza infection-\u2018existing and emerging therapies\u2019","volume":"10","author":"McMahon","year":"2017","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"2021113012310847800_B244","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.antiviral.2013.03.021","article-title":"Broadly neutralizing antibodies against influenza viruses","volume":"98","author":"Laursen","year":"2013","journal-title":"Antiviral Res."},{"key":"2021113012310847800_B245","doi-asserted-by":"publisher","first-page":"e3942","DOI":"10.1371\/journal.pone.0003942","article-title":"Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells","volume":"3","author":"Throsby","year":"2008","journal-title":"PLoS One"},{"key":"2021113012310847800_B246","first-page":"1204839","article-title":"A highly conserved neutralizing epitope on group 2 influenza A viruses","author":"Ekiert","year":"2011","journal-title":"Science"},{"key":"2021113012310847800_B247","doi-asserted-by":"publisher","first-page":"e1003150","DOI":"10.1371\/journal.ppat.1003150","article-title":"Human monoclonal antibodies broadly neutralizing against influenza B virus","volume":"9","author":"Yasugi","year":"2013","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B248","first-page":"1205669","article-title":"A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins","author":"Corti","year":"2011","journal-title":"Science"},{"key":"2021113012310847800_B249","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nsmb.1566","article-title":"Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses","volume":"16","author":"Sui","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2021113012310847800_B250","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1073\/pnas.1218509110","article-title":"Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B251","doi-asserted-by":"publisher","first-page":"e1003657","DOI":"10.1371\/journal.ppat.1003657","article-title":"New world bats harbor diverse influenza A viruses","volume":"9","author":"Tong","year":"2013","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B252","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1099\/jgv.0.000509","article-title":"The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone","volume":"97","author":"Zhao","year":"2016","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B253","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1038\/ncomms5448","article-title":"An infectious bat-derived chimeric influenza virus harbouring the entry machinery of an influenza A virus","volume":"5","author":"Juozapaitis","year":"2014","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B254","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/cei.12289","article-title":"Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages","volume":"176","author":"Metcalfe","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"2021113012310847800_B255","doi-asserted-by":"crossref","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"2021113012310847800_B256","doi-asserted-by":"publisher","first-page":"e0156402","DOI":"10.1371\/journal.pone.0156402","article-title":"TLR2, TLR4 and MyD88 mediate allergic airway disease (AAD) and Streptococcus pneumoniae-induced suppression of AAD","volume":"11","author":"Thorburn","year":"2016","journal-title":"PLoS One"},{"key":"2021113012310847800_B257","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3390\/ijms19020582","article-title":"Lung macrophage phenotypes and functional responses: role in the pathogenesis of COPD","volume":"19","author":"Yamasaki","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021113012310847800_B258","doi-asserted-by":"publisher","first-page":"13392","DOI":"10.1038\/s41598-017-13888-x","article-title":"Abnormal M1\/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)","volume":"7","author":"Eapen","year":"2017","journal-title":"Sci. Rep."},{"key":"2021113012310847800_B259","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Front. Immunol."},{"key":"2021113012310847800_B260","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1086\/508428","article-title":"Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease","volume":"194","author":"Berenson","year":"2006","journal-title":"J. Infect. Dis."},{"key":"2021113012310847800_B261","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1046\/j.1440-1711.2003.t01-1-01170.x","article-title":"Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells","volume":"81","author":"Hodge","year":"2003","journal-title":"Immunol. Cell Biol."},{"key":"2021113012310847800_B262","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1165\/rcmb.2007-0025OC","article-title":"Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease","volume":"37","author":"Hodge","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B263","doi-asserted-by":"publisher","first-page":"7657","DOI":"10.4049\/jimmunol.176.12.7657","article-title":"Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease","volume":"176","author":"Morimoto","year":"2006","journal-title":"J. Immunol."},{"key":"2021113012310847800_B264","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1280347","article-title":"Low-dose oxygen enhances macrophage-derived bacterial clearance following cigarette smoke exposure","volume":"2016","author":"Bain","year":"2016","journal-title":"J. Immunol. Res."},{"key":"2021113012310847800_B265","doi-asserted-by":"publisher","first-page":"e0176073","DOI":"10.1371\/journal.pone.0176073","article-title":"Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure","volume":"12","author":"Serban","year":"2017","journal-title":"PLoS One"},{"key":"2021113012310847800_B266","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2466-8-17","article-title":"Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice","volume":"8","author":"Martorana","year":"2008","journal-title":"BMC Pulm. Med."},{"key":"2021113012310847800_B267","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1111\/j.1440-1843.2012.02135.x","article-title":"Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophagesin chronic obstructive pulmonary disease subjects","volume":"17","author":"Hodge","year":"2012","journal-title":"Respirology"},{"key":"2021113012310847800_B268","first-page":"1548","article-title":"Targeting pro-resolution pathways to combat chronic inflammation in COPD","volume":"6","author":"Bozinovski","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"2021113012310847800_B269","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving lipid mediators and mechanisms in the resolution of acute inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"2021113012310847800_B270","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1038\/cdd.2016.19","article-title":"Influenza A virus enhances its propagation through the modulation of Annexin-A1 dependent endosomal trafficking and apoptosis","volume":"23","author":"Arora","year":"2016","journal-title":"Cell Death Differ."},{"key":"2021113012310847800_B271","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8239258","article-title":"Annexin A1 and the resolution of inflammation: modulation of neutrophil recruitment, apoptosis, and clearance","volume":"2016","author":"Sugimoto","year":"2016","journal-title":"J. Immunol. Res."},{"key":"2021113012310847800_B272","doi-asserted-by":"publisher","first-page":"40.e2","DOI":"10.1016\/j.jalz.2013.12.024","article-title":"Resolution of inflammation is altered in Alzheimer\u2019s disease","volume":"11","author":"Wang","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2021113012310847800_B273","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.004","article-title":"The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution","author":"Serhan","year":"2015","journal-title":"Semin. Immunol."},{"key":"2021113012310847800_B274","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3748\/wjg.v20.i1.64","article-title":"Inflammatory pathways of importance for management of inflammatory bowel disease","volume":"20","author":"Pedersen","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"2021113012310847800_B275","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12967-018-1435-5","article-title":"Defective formyl peptide receptor 2\/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease","volume":"16","author":"Chen","year":"2018","journal-title":"J. Transl. Med."},{"key":"2021113012310847800_B276","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2147\/COPD.S149766","article-title":"Annexin A1 is elevated in patients with COPD and affects lung fibroblast function","volume":"13","author":"Lai","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B277","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1513\/pats.200603-072MS","article-title":"State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease","volume":"3","author":"Henson","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"2021113012310847800_B278","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1016\/j.rmed.2012.08.020","article-title":"Defective efferocytosis by alveolar macrophages in IPF patients","volume":"106","author":"Morimoto","year":"2012","journal-title":"Respir. Med."},{"key":"2021113012310847800_B279","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1124\/pr.111.004622","article-title":"Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease","volume":"64","author":"Bezemer","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"2021113012310847800_B280","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.2147\/COPD.S105156","article-title":"Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants","volume":"11","author":"Pomerenke","year":"2016","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B281","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2147\/COPD.S97071","article-title":"The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages","volume":"13","author":"Lea","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B282","doi-asserted-by":"publisher","first-page":"6097","DOI":"10.4049\/jimmunol.179.9.6097","article-title":"Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-\u03baB in alveolar macrophages stimulated with TLR2 and TLR4 agonists","volume":"179","author":"Chen","year":"2007","journal-title":"J. Immunol."},{"key":"2021113012310847800_B283","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cyto.2008.02.001","article-title":"Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages","volume":"42","author":"Kent","year":"2008","journal-title":"Cytokine"},{"key":"2021113012310847800_B284","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1365-2249.2009.03986.x","article-title":"Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages","volume":"158","author":"Armstrong","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"2021113012310847800_B285","doi-asserted-by":"publisher","first-page":"C260","DOI":"10.1152\/ajpcell.1989.256.2.C260","article-title":"Cigarette smoking decreases interleukin 1 release by human alveolar macrophages","volume":"256","author":"Brown","year":"1989","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2021113012310847800_B286","doi-asserted-by":"publisher","first-page":"L471","DOI":"10.1152\/ajplung.1992.263.4.L471","article-title":"Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages","volume":"263","author":"Soliman","year":"1992","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012310847800_B287","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S0954-6111(98)90191-3","article-title":"Cigarette smoking decreases interleukin-8 secretion by human alveolar macrophages","volume":"92","author":"Ohta","year":"1998","journal-title":"Respir. Med."},{"key":"2021113012310847800_B288","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1164\/rccm.200509-1461OC","article-title":"Impaired alveolar macrophage response to Haemophilus antigens in chronic obstructive lung disease","volume":"174","author":"Berenson","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B289","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1165\/rcmb.2004-0309OC","article-title":"Interleukin-1\u03b2 causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung","volume":"32","author":"Lappalainen","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B290","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/SHK.0000000000000294","article-title":"Predictive value of IL-8 for sepsis and severe infections after burn injury-A clinical study","volume":"43","author":"Kraft","year":"2015","journal-title":"Shock"},{"key":"2021113012310847800_B291","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1517\/13543776.2011.569494","article-title":"Toll-like receptor modulators: a patent review (2006-2010)","volume":"21","author":"Basith","year":"2011","journal-title":"Expert Opin. Ther. Pat."},{"key":"2021113012310847800_B292","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1165\/rcmb.2009-0342TR","article-title":"Harnessing regulatory T cells to suppress asthma: from potential to therapy","volume":"43","author":"Thorburn","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B293","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1038\/s41598-019-38864-5","article-title":"Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice","volume":"9","author":"To","year":"2019","journal-title":"Sci. Rep."},{"key":"2021113012310847800_B294","doi-asserted-by":"publisher","first-page":"L425","DOI":"10.1152\/ajplung.00038.2010","article-title":"Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice","volume":"299","author":"Duong","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012310847800_B295","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.tips.2011.09.001","article-title":"Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy","volume":"33","author":"Vlahos","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"2021113012310847800_B296","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.pharmthera.2015.08.005","article-title":"Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities","volume":"155","author":"Bernardo","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"2021113012310847800_B297","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1378\/chest.12-2664","article-title":"Oxidative stress in COPD","volume":"144","author":"Kirkham","year":"2013","journal-title":"Chest"},{"key":"2021113012310847800_B298","doi-asserted-by":"publisher","first-page":"20983","DOI":"10.1038\/srep20983","article-title":"Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice","volume":"6","author":"Oostwoud","year":"2016","journal-title":"Sci. Rep."},{"key":"2021113012310847800_B299","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1179\/1351000213Y.0000000053","article-title":"Glutathione peroxidase-1 as a novel therapeutic target for COPD","volume":"18","author":"Vlahos","year":"2013","journal-title":"Redox Rep."},{"key":"2021113012310847800_B300","doi-asserted-by":"crossref","DOI":"10.1136\/thx.2005.049502","volume-title":"Why Does Airway Inflammation Persist After the Smoking Stops?","author":"Hogg","year":"2006"},{"key":"2021113012310847800_B301","doi-asserted-by":"publisher","first-page":"e1001271","DOI":"10.1371\/journal.ppat.1001271","article-title":"Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation","volume":"7","author":"Vlahos","year":"2011","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B302","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13524","article-title":"Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice","author":"To","year":"2019","journal-title":"Respirology"},{"key":"2021113012310847800_B303","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fimmu.2014.00435","article-title":"Role of alveolar macrophages in chronic obstructive pulmonary disease","volume":"5","author":"Vlahos","year":"2014","journal-title":"Front. Immunol."},{"key":"2021113012310847800_B304","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"2021113012310847800_B305","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41467-017-00057-x","article-title":"Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy","volume":"8","author":"To","year":"2017","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B306","article-title":"Bronchial epithelial gene expression of NOX isoforms are related to important clinical characteristics in COPD","author":"Russell","year":"2016","journal-title":"Eur. Respir. Soc."},{"key":"2021113012310847800_B307","doi-asserted-by":"crossref","DOI":"10.3934\/molsci.2016.3.439","article-title":"Cigarette smoke extract is a Nox agonist and regulates ENaC in alveolar type 2 cells","author":"Downs","year":"2016"},{"key":"2021113012310847800_B308","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3389\/fncel.2016.00301","article-title":"NOX activation by subunit interaction and underlying mechanisms in disease","volume":"10","author":"Rastogi","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"2021113012310847800_B309","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1089\/ars.2014.5862","article-title":"NOX2 as a target for drug development: indications, possible complications, and progress","volume":"23","author":"Diebold","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"2021113012310847800_B310","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","article-title":"Residual NADPH oxidase and survival in chronic granulomatous disease","volume":"363","author":"Kuhns","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B311","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12890-018-0680-y","article-title":"NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD","volume":"18","author":"Guo","year":"2018","journal-title":"BMC Pulm. Med."},{"key":"2021113012310847800_B312","article-title":"The expression of NOX4 in smooth muscles of small airway correlates with the disease severity of COPD","volume":"2016","author":"Liu","year":"2016","journal-title":"BioMed Res. Int."},{"key":"2021113012310847800_B313","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1124\/mol.114.095216","article-title":"NADPH oxidases as novel pharmacologic targets against influenza A virus infection","volume":"86","author":"Vlahos","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"2021113012310847800_B314","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"2021113012310847800_B315","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1164\/rccm.200804-549OC","article-title":"Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations","volume":"178","author":"Dahl","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B316","article-title":"The association between oxidative stress and obstructive lung impairment in patients with COPD","volume":"56","author":"Kluchova","year":"2007","journal-title":"Physiol. Res."},{"key":"2021113012310847800_B317","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.freeradbiomed.2011.05.008","article-title":"Smoking and COPD increase sputum levels of extracellular superoxide dismutase","volume":"51","author":"Regan","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"2021113012310847800_B318","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1165\/rcmb.2011-0345OC","article-title":"Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation","volume":"48","author":"Yatmaz","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B319","doi-asserted-by":"publisher","first-page":"15571","DOI":"10.1073\/pnas.1007625107","article-title":"Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM","volume":"107","author":"Yao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B320","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1164\/rccm.200509-1387OC","article-title":"Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease","volume":"173","author":"Juul","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B321","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1099\/jgv.0.000627","article-title":"Viral-bacterial interactions in the respiratory tract","volume":"97","author":"Bellinghausen","year":"2016","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B322","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0140-6736(14)61136-3","article-title":"The role of the microbiome in exacerbations of chronic lung diseases","volume":"384","author":"Dickson","year":"2014","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B323","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1513\/AnnalsATS.201503-133AW","article-title":"The gut-lung axis in respiratory disease","volume":"12","author":"Marsland","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"2021113012310847800_B324","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1038\/emm.2017.7","article-title":"The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"2021113012310847800_B325","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1513\/AnnalsATS.201506-319AW","article-title":"The sputum microbiome in chronic obstructive pulmonary disease exacerbations","volume":"12","author":"Huang","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"2021113012310847800_B326","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01406-2015","article-title":"Lung microbiome dynamics in chronic obstructive pulmonary disease exacerbations","author":"Wang","year":"2016","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B327","doi-asserted-by":"crossref","DOI":"10.1136\/thoraxjnl-2017-210408","article-title":"Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations","author":"Mayhew","year":"2018","journal-title":"Thorax"},{"key":"2021113012310847800_B328","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01967-14","article-title":"Severity-related changes of bronchial microbiome in Copd","author":"Garcia-Nu\u00f1ez","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"2021113012310847800_B329","doi-asserted-by":"publisher","first-page":"20140294","DOI":"10.1098\/rstb.2014.0294","article-title":"The role of the local microbial ecosystem in respiratory health and disease","volume":"370","author":"de Steenhuijsen Piters","year":"2015","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"2021113012310847800_B330","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1089\/omi.2009.0100","article-title":"A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations","volume":"14","author":"Huang","year":"2010","journal-title":"OMICS"},{"key":"2021113012310847800_B331","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/2049-2618-1-19","article-title":"Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation","volume":"1","author":"Segal","year":"2013","journal-title":"Microbiome"},{"key":"2021113012310847800_B332","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1164\/rccm.201502-0223OC","article-title":"Host response to the lung microbiome in chronic obstructive pulmonary disease","volume":"192","author":"Sze","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B333","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.gpb.2014.06.001","article-title":"Human pharyngeal microbiome may play a protective role in respiratory tract infections","volume":"12","author":"Gao","year":"2014","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"2021113012310847800_B334","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00408-011-9297-0","article-title":"Association between pneumonia and oral care in nursing home residents","volume":"189","author":"El-Solh","year":"2011","journal-title":"Lung"},{"key":"2021113012310847800_B335","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4037\/ajcc2015102","article-title":"Nasal colonization and lower respiratory tract infections with methicillin-resistant Staphylococcus aureus","volume":"24","author":"Tilahun","year":"2015","journal-title":"Am. J. Crit. Care"},{"key":"2021113012310847800_B336","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.4049\/jimmunol.1403169","article-title":"No vacancy: how beneficial microbes cooperate with immunity to provide colonization resistance to pathogens","volume":"194","author":"Sassone-Corsi","year":"2015","journal-title":"J. Immunol."},{"key":"2021113012310847800_B337","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1164\/rccm.201111-2075OC","article-title":"The lung tissue microbiome in chronic obstructive pulmonary disease","volume":"185","author":"Sze","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B338","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1096\/fj.201500172R","article-title":"Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells","volume":"30","author":"Heinrich","year":"2016","journal-title":"FASEB J."},{"key":"2021113012310847800_B339","doi-asserted-by":"publisher","first-page":"e4176","DOI":"10.1371\/journal.pone.0004176","article-title":"Augmented lung inflammation protects against influenza A pneumonia","volume":"4","author":"Tuvim","year":"2009","journal-title":"PLoS One"},{"key":"2021113012310847800_B340","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1038\/ncomms3106","article-title":"Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B341","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1165\/rcmb.2012-0498OC","article-title":"Toll-like receptor-2\/6 and Toll-like receptor-9 agonists suppress viral replication but not airway hyperreactivity in guinea pigs","volume":"48","author":"Drake","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B342","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1073\/pnas.1019378108","article-title":"Microbiota regulates immune defense against respiratory tract influenza A virus infection","volume":"108","author":"Ichinohe","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B343","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/751068","article-title":"Probiotics in the management of lung diseases","volume":"2013","author":"Mortaz","year":"2013","journal-title":"Mediators Inflamm."},{"key":"2021113012310847800_B344","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/721782","article-title":"Increased numbers of NK cells, NKT-like cells, and NK inhibitory receptors in peripheral blood of patients with chronic obstructive pulmonary disease","volume":"2013","author":"Tang","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"2021113012310847800_B345","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1365-2567.2009.03167.x","article-title":"Natural killer cells in infection and inflammation of the lung","volume":"128","author":"Culley","year":"2009","journal-title":"Immunology"},{"key":"2021113012310847800_B346","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1164\/ajrccm.163.7.2002015","article-title":"Defective natural killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glycophosphopeptical (inmunoferon)","volume":"163","author":"Prieto","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B347","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1164\/rccm.201702-0311PP","article-title":"The \u201ciron\u201d-y of iron overload and iron deficiency in chronic obstructive pulmonary disease","volume":"196","author":"Cloonan","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B348","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1016\/j.jmb.2016.03.018","article-title":"Heme synthesis and acquisition in bacterial pathogens","volume":"428","author":"Choby","year":"2016","journal-title":"J. Mol. Biol."},{"key":"2021113012310847800_B349","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/2211-5463.12324","article-title":"Covalent bonding of heme to protein prevents heme capture by nontypeable Haemophilus influenzae","volume":"7","author":"Sgheiza","year":"2017","journal-title":"FEBS Open Bio"},{"key":"2021113012310847800_B350","doi-asserted-by":"publisher","first-page":"e1003709","DOI":"10.1371\/journal.ppat.1003709","article-title":"Haemophilus responses to nutritional immunity: epigenetic and morphological contribution to biofilm architecture, invasion, persistence and disease severity","volume":"9","author":"Szelestey","year":"2013","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B351","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.biocel.2017.05.003","article-title":"Role of iron in the pathogenesis of respiratory disease","volume":"88","author":"Ali","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021113012310847800_B352","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1164\/rccm.200802-334OC","article-title":"Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect","volume":"178","author":"Ghio","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B353","doi-asserted-by":"publisher","first-page":"L1178","DOI":"10.1152\/ajplung.00290.2014","article-title":"Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF\/c-Met and TGF-\u03b1\/EGFR signaling","volume":"308","author":"Ito","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012310847800_B354","doi-asserted-by":"publisher","first-page":"40760","DOI":"10.1038\/srep40760","article-title":"Inhibition of influenza a virus infection by Fucoidan targeting viral neuraminidase and cellular EGFR pathway","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"2021113012310847800_B355","doi-asserted-by":"publisher","first-page":"9977","DOI":"10.1074\/jbc.M710257200","article-title":"Epidermal growth factor receptor signaling to Erk1\/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection","volume":"283","author":"Liu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B356","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s40248-015-0031-2","article-title":"The role of iron in pulmonary pathology","volume":"10","author":"Khiroya","year":"2015","journal-title":"Multidiscip. Respir. Med."},{"key":"2021113012310847800_B357","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1182\/blood-2007-07-102335","article-title":"Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications","volume":"111","author":"Sohn","year":"2008","journal-title":"Blood"},{"key":"2021113012310847800_B358","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.bcmd.2013.04.002","article-title":"Long-term treatment with deferiprone enhances left ventricular ejection function when compared to deferoxamine in patients with thalassemia major","volume":"51","author":"Filosa","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"key":"2021113012310847800_B359","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0010-8545(02)00050-4","article-title":"Design of iron chelators with therapeutic application","volume":"232","author":"Liu","year":"2002","journal-title":"Coord. Chem. Rev."},{"key":"2021113012310847800_B360","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1128\/jb.85.4.842-850.1963","article-title":"Hemin biosynthesis in Haemophilus","volume":"85","author":"White","year":"1963","journal-title":"J. Bacteriol."},{"key":"2021113012310847800_B361","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.micpath.2003.08.007","article-title":"Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin\/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media","volume":"36","author":"Morton","year":"2004","journal-title":"Microb. Pathog."},{"key":"2021113012310847800_B362","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1128\/JCM.00345-15","article-title":"Comparative profile of heme acquisition genes in disease-causing and colonizing nontypeable Haemophilus influenzae and Haemophilus haemolyticus","volume":"53","author":"Hariadi","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"2021113012310847800_B363","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ijmm.2009.03.004","article-title":"The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant","volume":"299","author":"Morton","year":"2009","journal-title":"Int. J. Med. Microbiol."},{"key":"2021113012310847800_B364","doi-asserted-by":"publisher","first-page":"6213","DOI":"10.1128\/IAI.00744-06","article-title":"Complex role of hemoglobin and hemoglobin-haptoglobin binding proteins in Haemophilus influenzae virulence in the infant rat model of invasive infection","volume":"74","author":"Seale","year":"2006","journal-title":"Infect. Immun."},{"key":"2021113012310847800_B365","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftx042","article-title":"Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease","volume":"75","author":"Ahearn","year":"2017","journal-title":"Pathog. Dis."},{"key":"2021113012310847800_B366","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1164\/ajrccm.160.3.9811018","article-title":"Increased concentrations of iron and isoferritins in the lower respiratory tract of patients with stable cystic fibrosis","volume":"160","author":"Stites","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B367","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1086\/509824","article-title":"Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae","volume":"195","author":"Murphy","year":"2007","journal-title":"J. Infect. Dis."},{"key":"2021113012310847800_B368","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ijantimicag.2016.12.010","article-title":"An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae","volume":"49","author":"Latham","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"2021113012310847800_B369","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1124\/pr.116.012518","article-title":"Kinases as novel therapeutic targets in asthma and chronic obstructive pulmonary disease","volume":"68","author":"Barnes","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"2021113012310847800_B370","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1164\/rccm.201610-2074PP","article-title":"New therapies for asthma and chronic obstructive pulmonary disease","volume":"195","author":"Gross","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B371","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.4049\/jimmunol.166.4.2681","article-title":"Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase","volume":"166","author":"Monick","year":"2001","journal-title":"J. Immunol."},{"key":"2021113012310847800_B372","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0014-5793(91)80826-O","article-title":"Effects of protein kinase C inhibitors on viral entry and infectivity","volume":"292","author":"Constantinescu","year":"1991","journal-title":"FEBS Lett."},{"key":"2021113012310847800_B373","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1099\/0022-1317-81-11-2697","article-title":"Entry of influenza viruses into cells is inhibited by a highly specific protein kinase C inhibitor","volume":"81","author":"Root","year":"2000","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B374","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1128\/JVI.77.1.460-469.2003","article-title":"Role of protein kinase C \u03b2II in influenza virus entry via late endosomes","volume":"77","author":"Sieczkarski","year":"2003","journal-title":"J. Virol."},{"key":"2021113012310847800_B375","doi-asserted-by":"publisher","first-page":"13717","DOI":"10.1128\/JVI.78.24.13717-13726.2004","article-title":"Protein kinase C-\u03b1 activity is required for respiratory syncytial virus fusion to human bronchial epithelial cells","volume":"78","author":"San-Juan-Vergara","year":"2004","journal-title":"J. Virol."},{"key":"2021113012310847800_B376","doi-asserted-by":"publisher","first-page":"242","DOI":"10.4062\/biomolther.2017.172","article-title":"Towards the application of human defensins as antivirals","volume":"26","author":"Park","year":"2018","journal-title":"Biomol. Ther."},{"key":"2021113012310847800_B377","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1086\/521027","article-title":"\u03b2-defensin inhibits influenza virus replication by cell-mediated mechanism (s)","volume":"196","author":"Salvatore","year":"2007","journal-title":"J. Infect. Dis."},{"key":"2021113012310847800_B378","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710415200","article-title":"Role of human beta defensin-2 during tumor necrosis factor-\u03b1\/NF-\u03baB mediated innate anti-viral response against human respiratory syncytial virus","author":"Kota","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B379","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.3390\/v6031237","article-title":"Construction of eukaryotic expression vector with mBD1-mBD3 fusion genes and exploring its activity against influenza A virus","volume":"6","author":"Li","year":"2014","journal-title":"Viruses"},{"key":"2021113012310847800_B380","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1164\/rccm.201205-0806OC","article-title":"Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease","volume":"186","author":"Mallia","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B381","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/407271","article-title":"Airway \u03b2-defensin-1 protein is elevated in COPD and severe asthma","volume":"2015","author":"Baines","year":"2015","journal-title":"Mediators Inflamm."},{"key":"2021113012310847800_B382","doi-asserted-by":"publisher","first-page":"e21898","DOI":"10.1371\/journal.pone.0021898","article-title":"Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease","volume":"6","author":"Andresen","year":"2011","journal-title":"PLoS One"},{"key":"2021113012310847800_B383","doi-asserted-by":"publisher","first-page":"e33601","DOI":"10.1371\/journal.pone.0033601","article-title":"Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients","volume":"7","author":"Pace","year":"2012","journal-title":"PLoS One"},{"key":"2021113012310847800_B384","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1183\/09031936.98.12051200","article-title":"Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium","volume":"12","author":"Hiemstra","year":"1998","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B385","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fimmu.2015.00115","article-title":"An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses","volume":"6","author":"Machado","year":"2015","journal-title":"Front. Immunol."},{"key":"2021113012310847800_B386","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cytogfr.2014.12.005","article-title":"Defensins: \u201cSimple\u201d antimicrobial peptides or broad-spectrum molecules?","volume":"26","author":"Suarez-Carmona","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"2021113012310847800_B387","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1742-4690-8-45","article-title":"Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment","volume":"8","author":"Rapista","year":"2011","journal-title":"Retrovirology"},{"key":"2021113012310847800_B388","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/184241","article-title":"Antiviral activity of resveratrol against human and animal viruses","volume":"2015","author":"Abba","year":"2015","journal-title":"Adv. Virol."},{"key":"2021113012310847800_B389","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0925-4439(02)00214-4","article-title":"Inhibition of protein kinase C by resveratrol","volume":"1637","author":"Slater","year":"2003","journal-title":"Biochim. Biophys. Acta."},{"key":"2021113012310847800_B390","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3390\/v1030523","article-title":"Activation of the antiviral kinase PKR and viral countermeasures","volume":"1","author":"Dauber","year":"2009","journal-title":"Viruses"},{"key":"2021113012310847800_B391","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.1128\/JVI.74.13.6203-6206.2000","article-title":"Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication","volume":"74","author":"Bergmann","year":"2000","journal-title":"J. Virol."},{"key":"2021113012310847800_B392","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1099\/vir.0.2008\/004606-0","article-title":"The multifunctional NS1 protein of influenza A viruses","volume":"89","author":"Hale","year":"2008","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B393","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.virol.2007.01.038","article-title":"A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis","volume":"363","author":"Min","year":"2007","journal-title":"Virology"},{"key":"2021113012310847800_B394","doi-asserted-by":"publisher","first-page":"11667","DOI":"10.1128\/JVI.01142-06","article-title":"Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha\/beta interferon","volume":"80","author":"Dauber","year":"2006","journal-title":"J. Virol."},{"key":"2021113012310847800_B395","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.virol.2006.01.005","article-title":"Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA","volume":"349","author":"Li","year":"2006","journal-title":"Virology"},{"key":"2021113012310847800_B396","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1128\/JVI.00978-07","article-title":"A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens","volume":"82","author":"Zhu","year":"2008","journal-title":"J. Virol."},{"key":"2021113012310847800_B397","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1128\/JVI.01920-08","article-title":"Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza","volume":"83","author":"Steel","year":"2009","journal-title":"J. Virol."},{"key":"2021113012310847800_B398","first-page":"8188","article-title":"A genetically engineered influenza A virus with ras-dependent oncolytic properties","volume":"61","author":"Bergmann","year":"2001","journal-title":"Cancer Res."},{"key":"2021113012310847800_B399","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1128\/JVI.80.8.3957-3965.2006","article-title":"The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target","volume":"80","author":"Twu","year":"2006","journal-title":"J. Virol."},{"key":"2021113012310847800_B400","doi-asserted-by":"publisher","first-page":"13093","DOI":"10.1073\/pnas.0805213105","article-title":"Structural basis for suppression of a host antiviral response by influenza A virus","volume":"105","author":"Das","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B401","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1128\/JVI.01805-08","article-title":"Novel influenza virus NS1 antagonists block replication and restore innate immune function","volume":"83","author":"Basu","year":"2009","journal-title":"J. Virol."},{"key":"2021113012310847800_B402","doi-asserted-by":"publisher","first-page":"14659","DOI":"10.1074\/jbc.RA118.004012","article-title":"Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds","volume":"293","author":"Kleinpeter","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B403","doi-asserted-by":"publisher","first-page":"L931","DOI":"10.1152\/ajplung.00150.2009","article-title":"Elastase-and LPS-exposed mice display altered responses to rhinovirus infection","volume":"297","author":"Sajjan","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113012310847800_B404","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.antiviral.2013.06.005","article-title":"The influenza virus NS1 protein as a therapeutic target","volume":"99","author":"Engel","year":"2013","journal-title":"Antiviral Res."},{"key":"2021113012310847800_B405","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1164\/rccm.201006-0833OC","article-title":"Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation","volume":"183","author":"Mallia","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B406","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.1128\/JVI.01714-06","article-title":"Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes","volume":"81","author":"Mel\u00e9n","year":"2007","journal-title":"J. Virol"},{"key":"2021113012310847800_B407","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.virol.2010.09.012","article-title":"Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-\u03b2 transcription","volume":"408","author":"Kuo","year":"2010","journal-title":"Virology"},{"key":"2021113012310847800_B408","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.micinf.2017.08.011","article-title":"The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses","volume":"19","author":"Mok","year":"2017","journal-title":"Microbes Infect."},{"key":"2021113012310847800_B409","doi-asserted-by":"publisher","first-page":"10708","DOI":"10.1128\/JVI.00610-10","article-title":"Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein","volume":"84","author":"Zielecki","year":"2010","journal-title":"J. Virol."},{"key":"2021113012310847800_B410","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1165\/rcmb.2010-0157OC","article-title":"Human influenza is more effective than avian influenza at antiviral suppression in airway cells","volume":"44","author":"Hsu","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113012310847800_B411","doi-asserted-by":"publisher","first-page":"e33354","DOI":"10.7554\/eLife.33354","article-title":"IFN-\u03bb prevents influenza virus spread from the upper airways to the lungs and limits virus transmission","volume":"7","author":"Klinkhammer","year":"2018","journal-title":"eLife"},{"key":"2021113012310847800_B412","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1128\/JVI.02453-08","article-title":"Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets","volume":"83","author":"Kugel","year":"2009","journal-title":"J. Virol."},{"key":"2021113012310847800_B413","doi-asserted-by":"publisher","first-page":"e29255","DOI":"10.1371\/journal.pone.0029255","article-title":"Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques","volume":"6","author":"Matzinger","year":"2011","journal-title":"PLoS One"},{"key":"2021113012310847800_B414","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1128\/JVI.01732-09","article-title":"Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment","volume":"84","author":"Steel","year":"2010","journal-title":"J. Virol."},{"key":"2021113012310847800_B415","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1465-9921-14-15","article-title":"Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD","volume":"14","author":"Baines","year":"2013","journal-title":"Respir. Res."},{"key":"2021113012310847800_B416","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/irv.12173","article-title":"Advances in antivirals for non-influenza respiratory virus infections","volume":"7","author":"Hayden","year":"2013","journal-title":"Influenza Other Respir. Viruses"},{"key":"2021113012310847800_B417","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","article-title":"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus","volume":"139","author":"Brass","year":"2009","journal-title":"Cell"},{"key":"2021113012310847800_B418","doi-asserted-by":"publisher","first-page":"e1002337","DOI":"10.1371\/journal.ppat.1002337","article-title":"IFITM3 inhibits influenza A virus infection by preventing cytosolic entry","volume":"7","author":"Feeley","year":"2011","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B419","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-virology-031413-085537","article-title":"IFITM-family proteins: the cell\u2019s first line of antiviral defense","volume":"1","author":"Bailey","year":"2014","journal-title":"Annu. Rev. Virol."},{"key":"2021113012310847800_B420","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1038\/ncomms4864","article-title":"Pathogenic potential of interferon \u03b1\u03b2 in acute influenza infection","volume":"5","author":"Davidson","year":"2014","journal-title":"Nat. Commun."},{"key":"2021113012310847800_B421","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/nm1765","article-title":"Inhibition of pulmonary antibacterial defense by interferon-\u03b3 during recovery from influenza infection","volume":"14","author":"Sun","year":"2008","journal-title":"Nat. Med."},{"key":"2021113012310847800_B422","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/j.1462-5822.2009.01309.x","article-title":"A new player in a deadly game: influenza viruses and the PI3K\/Akt signalling pathway","volume":"11","author":"Ehrhardt","year":"2009","journal-title":"Cell. Microbiol."},{"key":"2021113012310847800_B423","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1099\/vir.0.82483-0","article-title":"Effect of the phosphatidylinositol 3-kinase\/Akt pathway on influenza A virus propagation","volume":"88","author":"Shin","year":"2007","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B424","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1111\/j.1462-5822.2006.00713.x","article-title":"Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence","volume":"8","author":"Ehrhardt","year":"2006","journal-title":"Cell. Microbiol."},{"key":"2021113012310847800_B425","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1099\/vir.0.018465-0","article-title":"The PI3K\/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1","volume":"91","author":"Lu","year":"2010","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B426","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1128\/JVI.02082-06","article-title":"Influenza A virus NS1 protein activates the PI3K\/Akt pathway to mediate antiapoptotic signaling responses","volume":"81","author":"Ehrhardt","year":"2007","journal-title":"J. Virol."},{"key":"2021113012310847800_B427","doi-asserted-by":"publisher","first-page":"12730","DOI":"10.1128\/JVI.01427-07","article-title":"SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K\/Akt signaling pathway activation","volume":"81","author":"Shin","year":"2007","journal-title":"J. Virol."},{"key":"2021113012310847800_B428","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1099\/vir.0.82419-0","article-title":"Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)\/Akt pathway by direct interaction with the p85 subunit of PI3K","volume":"88","author":"Shin","year":"2007","journal-title":"J. Gen. Virol."},{"key":"2021113012310847800_B429","doi-asserted-by":"publisher","first-page":"14194","DOI":"10.1073\/pnas.0606109103","article-title":"Influenza A virus NS1 protein binds p85\u03b2 and activates phosphatidylinositol-3-kinase signaling","volume":"103","author":"Hale","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113012310847800_B430","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00705-016-2966-9","article-title":"A naturally truncated NS1 protein of influenza A virus impairs its interferon-antagonizing activity and thereby confers attenuation in vitro","volume":"162","author":"Lee","year":"2017","journal-title":"Arch. Virol."},{"key":"2021113012310847800_B431","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1183\/09031936.00036707","article-title":"Increased activation of p38 MAPK in COPD","volume":"31","author":"Renda","year":"2008","journal-title":"Eur. Respir. J."},{"key":"2021113012310847800_B432","doi-asserted-by":"publisher","first-page":"L230","DOI":"10.1152\/ajplung.00382.2016","article-title":"Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD","volume":"313","author":"Yanagisawa","year":"2017","journal-title":"Am. J. Physiol Lung Cell. Mol. Physiol."},{"key":"2021113012310847800_B433","doi-asserted-by":"publisher","first-page":"e1005508","DOI":"10.1371\/journal.ppat.1005508","article-title":"PI3K\u03b3 is critical for dendritic cell-mediated CD8+ T cell priming and viral clearance during influenza virus infection","volume":"12","author":"Nobs","year":"2016","journal-title":"PLoS Pathog."},{"key":"2021113012310847800_B434","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-60327-538-5","volume-title":"Guide to Signal Pathways in Immune Cells","author":"Wardle","year":"2009"},{"key":"2021113012310847800_B435","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1136\/thx.2003.018879","article-title":"Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium","volume":"59","author":"Burgel","year":"2004","journal-title":"Thorax"},{"key":"2021113012310847800_B436","doi-asserted-by":"publisher","first-page":"31736","DOI":"10.1074\/jbc.M803732200","article-title":"Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway","volume":"283","author":"Bergin","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B437","first-page":"13","article-title":"The significance of serum interleukin-8 in acute exacerbations of chronic obstructive pulmonary disease","volume":"17","author":"Zhang","year":"2018","journal-title":"Tanaffos"},{"key":"2021113012310847800_B438","article-title":"Elevated serum IL-8: a biomarker indicating exacerbation-prone COPD","author":"Zhang","year":"2017","journal-title":"Eur. Respir. Soc."},{"key":"2021113012310847800_B439","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1136\/thoraxjnl-2012-201719","article-title":"Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A","volume":"68","author":"Ganesan","year":"2013","journal-title":"Thorax"},{"key":"2021113012310847800_B440","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1136\/thx.2004.028043","article-title":"Expression of ErbB receptors and mucins in the airways of long term current smokers","volume":"59","author":"O\u2019donnell","year":"2004","journal-title":"Thorax"},{"key":"2021113012310847800_B441","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.cyto.2011.09.010","article-title":"Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke","volume":"56","author":"Zhang","year":"2011","journal-title":"Cytokine"},{"key":"2021113012310847800_B442","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1172\/JCI25167","article-title":"Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals","volume":"116","author":"Tyner","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2021113012310847800_B443","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1067134","article-title":"The EGFR-ADAM17 axis in chronic obstructive pulmonary disease and cystic fibrosis lung pathology","volume":"2018","author":"Stolarczyk","year":"2018","journal-title":"Mediators Inflamm."},{"key":"2021113012310847800_B444","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3109\/15412555.2016.1168391","article-title":"Regulation of viral infection-induced airway remodeling cytokine production by the TLR3-EGFR signaling pathway in human bronchial epithelial cells","volume":"13","author":"Jiang","year":"2016","journal-title":"J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B445","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1084\/jem.20121401","article-title":"Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon \u03bb and antiviral defense in airway epithelium","volume":"210","author":"Ueki","year":"2013","journal-title":"J. Exp. Med."},{"key":"2021113012310847800_B446","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.bbrc.2014.06.102","article-title":"The Moraxella catarrhalis-induced pro-inflammatory immune response is enhanced by the activation of the epidermal growth factor receptor in human pulmonary epithelial cells","volume":"450","author":"N\u2019Guessan","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113012310847800_B447","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/sj.bjc.6603885","article-title":"Targeting EGFR and HER-2 with cetuximab-and trastuzumab-mediated immunotherapy in oesophageal squamous cell carcinoma","volume":"97","author":"Kawaguchi","year":"2007","journal-title":"Br. J. Cancer"},{"key":"2021113012310847800_B448","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1093\/annonc\/mdp496","article-title":"Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts","volume":"21","author":"Larbouret","year":"2009","journal-title":"Ann. Oncol."},{"key":"2021113012310847800_B449","doi-asserted-by":"publisher","first-page":"7038","DOI":"10.1074\/jbc.M408575200","article-title":"Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling","volume":"280","author":"Kario","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021113012310847800_B450","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.3945\/jn.113.179036","article-title":"Supplementation of elderly Japanese men and women with Fucoidan from seaweed increases immune responses to seasonal influenza vaccination, 2","volume":"143","author":"Negishi","year":"2013","journal-title":"J. Nutr."},{"key":"2021113012310847800_B451","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.fct.2008.01.025","article-title":"Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells","volume":"46","author":"Lee","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"2021113012310847800_B452","doi-asserted-by":"publisher","first-page":"00119","DOI":"10.1183\/23120541.00119-2017","article-title":"Single-inhaler triple therapy in symptomatic COPD patients: FULFIL subgroup analyses","volume":"4","author":"Halpin","year":"2018","journal-title":"ERJ Open Res."},{"key":"2021113012310847800_B453","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S0140-6736(16)31354-X","article-title":"Single inhaler triple therapy versus inhaled corticosteroid plus long-acting \u03b22-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial","volume":"388","author":"Singh","year":"2016","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B454","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/S0140-6736(18)30206-X","article-title":"Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B455","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1056\/NEJMoa1516385","article-title":"Indacaterol-glycopyrronium versus salmeterol-fluticasone for COPD","volume":"374","author":"Wedzicha","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2021113012310847800_B456","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.2147\/COPD.S133307","article-title":"The effect of indacaterol\/glycopyrronium versus tiotropium or salmeterol\/fluticasone on the prevention of clinically important deterioration in COPD","volume":"12","author":"Anzueto","year":"2017","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B457","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2147\/COPD.S146189","article-title":"The impact of indacaterol\/glycopyrronium fixed-dose combination versus tiotropium monotherapy on lung function and treatment preference: a randomized crossover study - the FAVOR study","volume":"13","author":"Kardos","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"2021113012310847800_B458","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1164\/rccm.201607-1349OC","article-title":"Effect of Roflumilast and Inhaled Corticosteroid\/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A randomized clinical tria","volume":"194","author":"Martinez","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021113012310847800_B459","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0140-6736(14)62410-7","article-title":"Articles: Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial","volume":"385","author":"Martinez","year":"2015","journal-title":"Lancet North Am. Ed."},{"key":"2021113012310847800_B460","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(18)30331-X","article-title":"Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial","author":"Rabe","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"2021113012310847800_B461","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.conctc.2015.12.008","article-title":"Effects of simvastatin in chronic obstructive pulmonary disease: Results of a pilot, randomized, placebo-controlled clinical trial","volume":"2","author":"Balaguer","year":"2016","journal-title":"Contemp. Clin. Trials Commun."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/14\/1663\/845350\/cs-2018-1009c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/14\/1663\/845350\/cs-2018-1009c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T15:43:23Z","timestamp":1664034203000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/133\/14\/1663\/219056\/New-therapeutic-targets-for-the-prevention-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":461,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,31]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20181009","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,7]]}}}