{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:40:08Z","timestamp":1784133608593,"version":"3.55.0"},"reference-count":57,"publisher":"Portland Press Ltd.","issue":"22","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eosinophilic chronic rhinosinusitis with nasal polyps (ECRS) is a condition linked with type 2 inflammation, poor treatment outcomes, and high recurrence tendency. Although \u03b3\u03b4T cells have been reported to induce type 2 immune responses and eosinophilic infiltration in several diseases, their role in ECRS has not been fully explored. We aimed to evaluate the association of \u03b3\u03b4T cells with the type 2 inflammatory profiles in ECRS. Nasal tissue samples obtained from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) (51 eosinophilic and 48 non-eosinophilic), 50 patients with chronic rhinosinusitis without nasal polyps (CRSsNP), and 58 control subjects were examined for \u03b3\u03b4T cells, inflammatory markers and eosinophils using HE, RT-qPCR, ELISA, immunofluorescence, and flow cytometry. In parallel, studies were also conducted in an ECRS murine model induced by anti-\u03b3\u03b4T cells neutralizing antibody administration. \u03b3\u03b4T cells expression was significantly increased in tissues from patients with ECRS compared with non-ECRS, CRSsNP and control subjects. Moreover, inflammatory markers including type 2 proinflammatory cytokines (IL-4, IL-5, IL-13), GATA3, eosinophil cationic protein (ECP), and eotaxin levels were also increased in nasal tissues of patients with ECRS, and V\u03b31+ \u03b3\u03b4T cells mRNA expression was positively correlated with type 2 cytokines, GATA3, and ECP. In the ECRS murine model, anti-V\u03b31+ \u03b3\u03b4T antibody treatment reduced the infiltration of eosinophils and expression of type 2 cytokines, GATA3, and ECP in nasal mucosae. In conclusion, the results of the present study suggest that \u03b3\u03b4T cells play a crucial role in the type 2 inflammatory profiles and nasal tissue eosinophilic infiltration in patients with ECRS.<\/jats:p>","DOI":"10.1042\/cs20190481","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T11:57:59Z","timestamp":1573646279000},"page":"2301-2315","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["\u03b3\u03b4T cells contribute to type 2 inflammatory profiles in eosinophilic chronic rhinosinusitis with nasal polyps"],"prefix":"10.1042","volume":"133","author":[{"given":"Xia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaixiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph\u00a0A","family":"Bellanti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Microbiology-Immunology, Georgetown University Medical Center, Washington, DC, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-4774","authenticated-orcid":false,"given":"Song\u00a0Guo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"2021113012331348600_B1","first-page":"1","article-title":"Summary health statistics for U.S. adults: national health interview survey, 2012","volume":"10","author":"Blackwell","year":"2014","journal-title":"Vital Health Stat."},{"key":"2021113012331348600_B2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/all.12577","article-title":"Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities","volume":"70","author":"Shi","year":"2015","journal-title":"Allergy"},{"key":"2021113012331348600_B3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe\u2013an underestimated disease. 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