{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:25:04Z","timestamp":1790198704674,"version":"4.1.0"},"reference-count":216,"publisher":"Portland Press Ltd.","issue":"22","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adipose tissue is classically recognized as the primary site of lipid storage, but in recent years has garnered appreciation for its broad role as an endocrine organ comprising multiple cell types whose collective secretome, termed as adipokines, is highly interdependent on metabolic homeostasis and inflammatory state. Anatomical location (e.g. visceral, subcutaneous, epicardial etc) and cellular composition of adipose tissue (e.g. white, beige, and brown adipocytes, macrophages etc.) also plays a critical role in determining its response to metabolic state, the resulting secretome, and its potential impact on remote tissues. Compared with other tissues, the heart has an extremely high and constant demand for energy generation, of which most is derived from oxidation of fatty acids. Availability of this fatty acid fuel source is dependent on adipose tissue, but evidence is mounting that adipose tissue plays a much broader role in cardiovascular physiology. In this review, we discuss the impact of the brown, subcutaneous, and visceral white, perivascular (PVAT), and epicardial adipose tissue (EAT) secretome on the development and progression of cardiovascular disease (CVD), with a particular focus on cardiac hypertrophy and fibrosis.<\/jats:p>","DOI":"10.1042\/cs20190578","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T03:41:51Z","timestamp":1574912511000},"page":"2329-2344","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis"],"prefix":"10.1042","volume":"133","author":[{"given":"Sarah\u00a0R.","family":"Anthony","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne\u00a0R.","family":"Guarnieri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamarie","family":"Gozdiff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u00a0N.","family":"Helsley","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Albert","family":"Phillip\u00a0Owens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0609-3717","authenticated-orcid":false,"given":"Michael","family":"Tranter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati College of Medicine, Cincinnati, OH, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"2021113012333497000_B1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol. Rev."},{"key":"2021113012333497000_B2","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1111\/bph.12475","article-title":"Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy","volume":"171","author":"Fillmore","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"2021113012333497000_B3","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/j.1471-0528.2006.01004.x","article-title":"Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue","volume":"113","author":"Cancello","year":"2006","journal-title":"BJOG"},{"key":"2021113012333497000_B4","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1161\/CIRCRESAHA.115.306885","article-title":"Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease","volume":"118","author":"Fuster","year":"2016","journal-title":"Circ. Res."},{"key":"2021113012333497000_B5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/nyas.13398","article-title":"Deciphering adipose tissue heterogeneity","volume":"1411","author":"Lynes","year":"2018","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2021113012333497000_B6","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.molmed.2013.05.001","article-title":"Chronic adipose tissue inflammation: all immune cells on the stage","volume":"19","author":"Cildir","year":"2013","journal-title":"Trends Mol. Med."},{"key":"2021113012333497000_B7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2021113012333497000_B8","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.trsl.2014.04.010","article-title":"Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management","volume":"164","author":"Alpert","year":"2014","journal-title":"Transl. Res."},{"key":"2021113012333497000_B9","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.jacc.2013.10.080","article-title":"Disparate effects of metabolically healthy obesity in coronary heart disease and heart failure","volume":"63","author":"Lavie","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.mayocp.2016.11.001","article-title":"Obesity and heart failure: focus on the obesity paradox","volume":"92","author":"Carbone","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"2021113012333497000_B11","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"2021113012333497000_B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchf.2012.10.002","article-title":"Heart failure","volume":"1","author":"Braunwald","year":"2013","journal-title":"JACC Heart Fail."},{"key":"2021113012333497000_B13","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B14","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"key":"2021113012333497000_B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2014.03.009","article-title":"Cardiac fibroblasts: the good, the bad, the ugly, the beautiful","volume":"70","author":"Sadoshima","year":"2014","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B16","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"2021113012333497000_B17","doi-asserted-by":"publisher","first-page":"e000222","DOI":"10.1136\/openhrt-2014-000222","article-title":"Clinical prediction of incident heart failure risk: a systematic review and meta-analysis","volume":"2","author":"Yang","year":"2015","journal-title":"Open Heart"},{"key":"2021113012333497000_B18","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","article-title":"Cellular energy utilization and molecular origin of standard metabolic rate in mammals","volume":"77","author":"Rolfe","year":"1997","journal-title":"Physiol. Rev."},{"key":"2021113012333497000_B19","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"2021113012333497000_B20","doi-asserted-by":"publisher","first-page":"e49452","DOI":"10.1371\/journal.pone.0049452","article-title":"Human BAT possesses molecular signatures that resemble beige\/brite cells","volume":"7","author":"Sharp","year":"2012","journal-title":"PLoS ONE"},{"key":"2021113012333497000_B21","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1210\/jcem-54-2-254","article-title":"Relation of body fat distribution to metabolic complications of obesity","volume":"54","author":"Kissebah","year":"1982","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113012333497000_B22","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1172\/JCI111040","article-title":"Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution","volume":"72","author":"Krotkiewski","year":"1983","journal-title":"J. Clin. Invest."},{"key":"2021113012333497000_B23","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1161\/CIRCULATIONAHA.117.029617","article-title":"Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management","volume":"137","author":"Neeland","year":"2018","journal-title":"Circulation"},{"key":"2021113012333497000_B24","doi-asserted-by":"publisher","first-page":"E1756","DOI":"10.1210\/jc.2011-0615","article-title":"Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity","volume":"96","author":"McLaughlin","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113012333497000_B25","doi-asserted-by":"publisher","first-page":"H1592","DOI":"10.1152\/ajpheart.00698.2015","article-title":"Brown adipose tissue: The heat is on the heart","volume":"310","author":"Thoonen","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113012333497000_B26","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1111\/j.1749-6632.2010.05875.x","article-title":"Adipokines as novel biomarkers and regulators of the metabolic syndrome","volume":"1212","author":"Deng","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021113012333497000_B27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tcb.2016.01.004","article-title":"Emerging complexities in adipocyte origins and identity","volume":"26","author":"Sanchez-Gurmaches","year":"2016","journal-title":"Trends Cell Biol."},{"key":"2021113012333497000_B28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnut.2016.00010","article-title":"Relationships between rodent white adipose fat pads and human white adipose fat depots","volume":"3","author":"Chusyd","year":"2016","journal-title":"Front. Nutr."},{"key":"2021113012333497000_B29","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.cmet.2013.03.008","article-title":"Mechanisms and metabolic implications of regional differences among fat depots","volume":"17","author":"Tchkonia","year":"2013","journal-title":"Cell Metab."},{"key":"2021113012333497000_B30","doi-asserted-by":"publisher","first-page":"3939","DOI":"10.1242\/dev.080549","article-title":"The developmental origins of adipose tissue","volume":"140","author":"Berry","year":"2013","journal-title":"Development"},{"key":"2021113012333497000_B31","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.2337\/db05-1439","article-title":"Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution","volume":"55","author":"Tchernof","year":"2006","journal-title":"Diabetes"},{"key":"2021113012333497000_B32","doi-asserted-by":"publisher","first-page":"E298","DOI":"10.1152\/ajpendo.00202.2006","article-title":"Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns","volume":"292","author":"Tchkonia","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021113012333497000_B33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fcvm.2017.00027","article-title":"Humans and mice display opposing patterns of \u201cBrowning\u201d gene expression in visceral and subcutaneous white adipose tissue depots","volume":"4","author":"Zuriaga","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"2021113012333497000_B34","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1038\/nm.3324","article-title":"Tracking adipogenesis during white adipose tissue development, expansion and regeneration","volume":"19","author":"Wang","year":"2013","journal-title":"Nat. Med."},{"key":"2021113012333497000_B35","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/ajcn\/84.3.483","article-title":"Body fat distribution and risk of type 2 diabetes in the general population: are there differences between men and women? The MONICA\/KORA Augsburg cohort study","volume":"84","author":"Meisinger","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"2021113012333497000_B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1259\/bjr\/38447238","article-title":"The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis","volume":"85","author":"Shuster","year":"2012","journal-title":"Br. J. Radiol."},{"key":"2021113012333497000_B37","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.2337\/dc08-2280","article-title":"Abdominal subcutaneous adipose tissue: a protective fat depot?","volume":"32","author":"Porter","year":"2009","journal-title":"Diabetes Care"},{"key":"2021113012333497000_B38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00125-004-1637-7","article-title":"Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study","volume":"48","author":"Snijder","year":"2005","journal-title":"Diabetologia"},{"key":"2021113012333497000_B39","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12933-015-0302-4","article-title":"High visceral fat with low subcutaneous fat accumulation as a determinant of atherosclerosis in patients with type 2 diabetes","volume":"14","author":"Bouchi","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"2021113012333497000_B40","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/0735-1097(88)90467-6","article-title":"Relation of blood pressure and body build to left ventricular mass in normotensive and hypertensive employed adults","volume":"12","author":"Hammond","year":"1988","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1001\/jama.1991.03470020057032","article-title":"The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study","volume":"266","author":"Lauer","year":"1991","journal-title":"JAMA."},{"key":"2021113012333497000_B42","doi-asserted-by":"publisher","first-page":"757","DOI":"10.7326\/0003-4819-99-6-757","article-title":"Dimorphic cardiac adaptation to obesity and arterial hypertension","volume":"99","author":"Messerli","year":"1983","journal-title":"Ann. Intern. Med."},{"key":"2021113012333497000_B43","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.echo.2019.05.018","article-title":"Changes in left ventricular mass and geometry in the older adults: role of body mass and central obesity","volume":"32","author":"Lee","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"2021113012333497000_B44","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1172\/JCI20514","article-title":"Obesity-induced inflammatory changes in adipose tissue","volume":"112","author":"Wellen","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2021113012333497000_B45","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1253\/circj.68.975","article-title":"Adiponectin as a biomarker of the metabolic syndrome","volume":"68","author":"Ryo","year":"2004","journal-title":"Circ. J."},{"key":"2021113012333497000_B46","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1253\/circj.CJ-17-0458","article-title":"Role of adipokines in cardiovascular disease","volume":"81","author":"Lau","year":"2017","journal-title":"Circ. J."},{"key":"2021113012333497000_B47","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/nm1295","article-title":"Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms","volume":"11","author":"Shibata","year":"2005","journal-title":"Nat. Med."},{"key":"2021113012333497000_B48","doi-asserted-by":"publisher","first-page":"e68697","DOI":"10.1371\/journal.pone.0068697","article-title":"Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes","volume":"8","author":"Essick","year":"2013","journal-title":"PLoS ONE"},{"key":"2021113012333497000_B49","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bbrc.2015.02.081","article-title":"FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism","volume":"459","author":"Joki","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113012333497000_B50","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1038\/nm1137","article-title":"Adiponectin-mediated modulation of hypertrophic signals in the heart","volume":"10","author":"Shibata","year":"2004","journal-title":"Nat. Med."},{"key":"2021113012333497000_B51","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1161\/ATVBAHA.107.156687","article-title":"Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha","volume":"28","author":"Fujita","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113012333497000_B52","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/HYPERTENSIONAHA.106.079509","article-title":"Adiponectin level and left ventricular hypertrophy in Japanese men","volume":"49","author":"Mitsuhashi","year":"2007","journal-title":"Hypertension"},{"key":"2021113012333497000_B53","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/CIRCRESAHA.115.307856","article-title":"Mutual regulation of epicardial adipose tissue and myocardial redox state by PPAR- \u03b3\/adiponectin signalling","volume":"118","author":"Antonopoulos","year":"2016","journal-title":"Circ. Res."},{"key":"2021113012333497000_B54","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1161\/ATVBAHA.114.303828","article-title":"Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease","volume":"34","author":"Antonopoulos","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113012333497000_B55","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1038\/s41598-018-37137-x","article-title":"The significance of the effect of visceral adiposity on left ventricular diastolic function in the general population","volume":"9","author":"Sawada","year":"2019","journal-title":"Sci. Rep."},{"key":"2021113012333497000_B56","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1046\/j.1365-2796.1999.00571.x","article-title":"Leptin is associated with increased risk of myocardial infarction","volume":"246","author":"S\u00f6derberg","year":"1999","journal-title":"J. Intern. Med."},{"key":"2021113012333497000_B57","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.amjcard.2007.02.088","article-title":"Relation of increased leptin concentrations to history of myocardial infarction and stroke in the United States population","volume":"100","author":"Sierra-Johnson","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"2021113012333497000_B58","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/08037050410021405","article-title":"Serum leptin and myocardial infarction in hypertension","volume":"13","author":"Wallerstedt","year":"2004","journal-title":"Blood Press."},{"key":"2021113012333497000_B59","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1161\/hc5001.101061","article-title":"Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)","volume":"104","author":"Wallace","year":"2001","journal-title":"Circulation"},{"key":"2021113012333497000_B60","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1016\/j.jacc.2004.07.050","article-title":"Plasma leptin and prognosis in patients with established coronary atherosclerosis","volume":"44","author":"Wolk","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrcardio.2009.224","article-title":"Cardiovascular effects of leptin","volume":"7","author":"Sweeney","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"key":"2021113012333497000_B62","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/jcp.21883","article-title":"Leptin attenuates hypoxia\/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells","volume":"221","author":"Shin","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"2021113012333497000_B63","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1111\/j.1742-4658.2008.06465.x","article-title":"Leptin protects H9c2 rat cardiomyocytes from H2O2-induced apoptosis","volume":"275","author":"Eguchi","year":"2008","journal-title":"FEBS J."},{"key":"2021113012333497000_B64","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1093\/cvr\/cvp071","article-title":"Leptin attenuates cardiac apoptosis after chronic ischaemic injury","volume":"83","author":"McGaffin","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"2021113012333497000_B65","doi-asserted-by":"publisher","first-page":"560","DOI":"10.4161\/cc.7.5.5529","article-title":"Decreased p110alpha catalytic activity accompanies increased myocyte apoptosis and cardiac hypertrophy in leptin deficient ob\/ob mice","volume":"7","author":"Trivedi","year":"2008","journal-title":"Cell Cycle"},{"key":"2021113012333497000_B66","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/sj.bjp.0706834","article-title":"Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects","volume":"149","author":"Smith","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"2021113012333497000_B67","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/FJC.0b013e31819d6152","article-title":"The cardioprotective actions of leptin are lost in the Zucker obese (fa\/fa) rat","volume":"53","author":"Dixon","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021113012333497000_B68","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.yjmcc.2006.05.001","article-title":"An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1","volume":"41","author":"Rajapurohitam","year":"2006","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B69","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.cardiores.2005.11.022","article-title":"Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes","volume":"69","author":"Madani","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"2021113012333497000_B70","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1161\/01.RES.0000089255.37804.72","article-title":"The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes","volume":"93","author":"Rajapurohitam","year":"2003","journal-title":"Circ. Res."},{"key":"2021113012333497000_B71","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/01.CIR.0000140766.52771.6D","article-title":"Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes","volume":"110","author":"Xu","year":"2004","journal-title":"Circulation"},{"key":"2021113012333497000_B72","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/dmrr.964","article-title":"Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease","volume":"25","author":"Majumdar","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"2021113012333497000_B73","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.cardiores.2006.06.024","article-title":"Essential role of Rho\/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes","volume":"72","author":"Zeidan","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"2021113012333497000_B74","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/cvr\/cvm020","article-title":"Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA\/ROCK-dependent p38 MAPK translocation to nuclei","volume":"77","author":"Zeidan","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"2021113012333497000_B75","doi-asserted-by":"crossref","first-page":"H2387","DOI":"10.1152\/ajpheart.00579.2006","article-title":"Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation","volume":"292","author":"Abe","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113012333497000_B76","doi-asserted-by":"crossref","first-page":"H441","DOI":"10.1152\/ajpheart.91537.2007","article-title":"A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart","volume":"295","author":"Purdham","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113012333497000_B77","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.yjmcc.2008.03.005","article-title":"Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts","volume":"44","author":"Schram","year":"2008","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B78","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1745-7254.2007.00503.x","article-title":"Improvement of chronic heart failure by dexamethasone is not associated with downregulation of leptin in rats","volume":"28","author":"Xia","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"2021113012333497000_B79","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0022-2275(20)32133-7","article-title":"Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels","volume":"40","author":"Coe","year":"1999","journal-title":"J. Lipid Res."},{"key":"2021113012333497000_B80","doi-asserted-by":"publisher","first-page":"R173","DOI":"10.1530\/JOE-17-0031","article-title":"Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease","volume":"233","author":"Rodr\u00edguez-Calvo","year":"2017","journal-title":"J. Endocrinol."},{"key":"2021113012333497000_B81","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.1073\/pnas.96.10.5528","article-title":"Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein","volume":"96","author":"Shen","year":"1999","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021113012333497000_B82","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1136\/heartjnl-2013-303735","article-title":"Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women","volume":"99","author":"Engeli","year":"2013","journal-title":"Heart"},{"key":"2021113012333497000_B83","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1042\/CS20120004","article-title":"Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure","volume":"124","author":"Liu","year":"2013","journal-title":"Clin. Sci."},{"key":"2021113012333497000_B84","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1016\/S0021-9258(18)89059-7","article-title":"Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes","volume":"260","author":"Bernlohr","year":"1985","journal-title":"J. Biol. Chem."},{"key":"2021113012333497000_B85","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1073\/pnas.86.10.3629","article-title":"Mechanism of regulation of the 422(aP2) gene by cAMP during preadipocyte differentiation","volume":"86","author":"Yang","year":"1989","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021113012333497000_B86","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0022-2275(20)32363-4","article-title":"Oxidized LDL induces the expression of ALBP\/aP2 mRNA and protein in human THP-1 macrophages","volume":"41","author":"Fu","year":"2000","journal-title":"J. Lipid Res."},{"key":"2021113012333497000_B87","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1006\/bbrc.1999.1071","article-title":"PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes","volume":"261","author":"Pelton","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113012333497000_B88","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.cmet.2013.12.017","article-title":"Irisin and FGF21 are cold- induced endocrine activators of brown fat function in humans","volume":"19","author":"Lee","year":"2014","journal-title":"Cell Metab."},{"key":"2021113012333497000_B89","doi-asserted-by":"publisher","first-page":"18465","DOI":"10.1074\/jbc.M110.200022","article-title":"Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase\/mammalian target of rapamycin (AMPK\/mTOR) and c-Jun N-terminal kinase\/insulin receptor substrate 1 (JNK\/IRS1) pathways","volume":"286","author":"Kang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2021113012333497000_B90","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.yjmcc.2011.04.006","article-title":"Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats","volume":"51","author":"Chemaly","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B91","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2014.12.044","article-title":"The association of resistin with cardiovascular disease in the multi-ethnic study of atherosclerosis","volume":"239","author":"Muse","year":"2015","journal-title":"Atherosclerosis"},{"key":"2021113012333497000_B92","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jacc.2005.04.022","article-title":"Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease","volume":"46","author":"Ohmori","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B93","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/oby.2005.215","article-title":"Association of plasma resistin levels with coronary heart disease in women","volume":"13","author":"Pischon","year":"2005","journal-title":"Obes. Res."},{"key":"2021113012333497000_B94","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1253\/circj.71.460","article-title":"Serum resistin is associated with high risk in patients with congestive heart failure\u2013a novel link between metabolic signals and heart failure","volume":"71","author":"Takeishi","year":"2007","journal-title":"Circ. J."},{"key":"2021113012333497000_B95","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1530\/JME-18-0242","article-title":"Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice","volume":"63","author":"Xu","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"2021113012333497000_B96","doi-asserted-by":"publisher","first-page":"946427","DOI":"10.1155\/2013\/946427","article-title":"Visfatin\/Nampt: an adipokine with cardiovascular impact","volume":"2013","author":"Romacho","year":"2013","journal-title":"Mediators Inflamm."},{"key":"2021113012333497000_B97","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/jcp.24257","article-title":"A novel adipocytokine visfatin protects against H(2)O(2) -induced myocardial apoptosis: a missing link between obesity and cardiovascular disease","volume":"228","author":"Xiao","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"2021113012333497000_B98","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1111\/j.1582-4934.2008.00332.x","article-title":"The novel adipocytokine visfatin exerts direct cardioprotective effects","volume":"12","author":"Lim","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"2021113012333497000_B99","doi-asserted-by":"publisher","first-page":"e0148273","DOI":"10.1371\/journal.pone.0148273","article-title":"Visfatin destabilizes atherosclerotic plaques in apolipoprotein E-deficient mice","volume":"11","author":"Li","year":"2016","journal-title":"PLoS ONE"},{"key":"2021113012333497000_B100","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.tcm.2010.12.002","article-title":"Omentin: a novel link between inflammation, diabesity, and cardiovascular disease","volume":"20","author":"Tan","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"2021113012333497000_B101","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1016\/j.jacc.2014.03.032","article-title":"Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms","volume":"63","author":"Kataoka","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B102","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2015.01.032","article-title":"Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species","volume":"457","author":"Kazama","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113012333497000_B103","doi-asserted-by":"publisher","first-page":"e59697","DOI":"10.1371\/journal.pone.0059697","article-title":"Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies","volume":"8","author":"Greulich","year":"2013","journal-title":"PLoS ONE"},{"key":"2021113012333497000_B104","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.yjmcc.2014.11.019","article-title":"Omentin functions to attenuate cardiac hypertrophic response","volume":"79","author":"Matsuo","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B105","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.atherosclerosis.2011.08.017","article-title":"Circulating omentin is associated with coronary artery disease in men","volume":"219","author":"Shibata","year":"2011","journal-title":"Atherosclerosis"},{"key":"2021113012333497000_B106","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1177\/0003319713511322","article-title":"Serum omentin 1 level is associated with coronary artery disease and its severity in postmenopausal women","volume":"65","author":"Onur","year":"2014","journal-title":"Angiology"},{"key":"2021113012333497000_B107","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/aps.2011.26","article-title":"Association of serum omentin-1 levels with coronary artery disease","volume":"32","author":"Zhong","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"2021113012333497000_B108","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3109\/1354750X.2011.622789","article-title":"Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome","volume":"16","author":"Shang","year":"2011","journal-title":"Biomarkers"},{"key":"2021113012333497000_B109","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1475-2840-12-38","article-title":"Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus","volume":"12","author":"Ichikawa","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"2021113012333497000_B110","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1161\/CIRCIMAGING.113.000532","article-title":"Relation of regional fat distribution to left ventricular structure and function","volume":"6","author":"Neeland","year":"2013","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"2021113012333497000_B111","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2021113012333497000_B112","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2021113012333497000_B113","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","volume":"360","author":"Virtanen","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2021113012333497000_B114","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","article-title":"Activation of human brown adipose tissue by a \u03b23-adrenergic receptor agonist","volume":"21","author":"Cypess","year":"2015","journal-title":"Cell Metab."},{"key":"2021113012333497000_B115","first-page":"1500","article-title":"Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans","volume":"31","author":"Thyagarajan","year":"2017","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"2021113012333497000_B116","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1146\/annurev.nutr.28.061807.155357","article-title":"The efficiency of cellular energy transduction and its implications for obesity","volume":"28","author":"Harper","year":"2008","journal-title":"Annu. Rev. Nutr."},{"key":"2021113012333497000_B117","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.yjmcc.2015.05.002","article-title":"Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy","volume":"84","author":"Thoonen","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B118","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrd3138","article-title":"Cellular bioenergetics as a target for obesity therapy","volume":"9","author":"Tseng","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"2021113012333497000_B119","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4161\/adip.18951","article-title":"Brown adipose tissue: recent insights into development, metabolic function and therapeutic potential","volume":"1","author":"Townsend","year":"2012","journal-title":"Adipocyte"},{"key":"2021113012333497000_B120","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"2021113012333497000_B121","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1172\/JCI67803","article-title":"Recruited brown adipose tissue as an antiobesity agent in humans","volume":"123","author":"Yoneshiro","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2021113012333497000_B122","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.cmet.2016.06.011","article-title":"Glucocorticoids acutely increase brown adipose tissue activity in humans, revealing species-specific differences in UCP-1 nbegulation","volume":"24","author":"Ramage","year":"2016","journal-title":"Cell Metab."},{"key":"2021113012333497000_B123","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cmet.2017.09.004","article-title":"Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not brown adipose tissue","volume":"26","author":"Schreiber","year":"2017","journal-title":"Cell Metab."},{"key":"2021113012333497000_B124","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.ehj.2004.03.019","article-title":"Changes in autonomic nervous system activity: spontaneous versus balloon-induced myocardial ischaemia","volume":"25","author":"Manfrini","year":"2004","journal-title":"Eur. Heart J."},{"key":"2021113012333497000_B125","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/j.jacc.2004.07.057","article-title":"Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia","volume":"44","author":"Sabatine","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B126","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.yjmcc.2008.12.024","article-title":"Gender differences of echocardiographic and gene expression patterns in human pressure overload left ventricular hypertrophy","volume":"46","author":"Villar","year":"2009","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113012333497000_B127","doi-asserted-by":"publisher","first-page":"e35635","DOI":"10.1371\/journal.pone.0035635","article-title":"Androgens contribute to sex differences in myocardial remodeling under pressure overload by a mechanism involving TGF-\u03b2","volume":"7","author":"Montalvo","year":"2012","journal-title":"PLoS ONE"},{"key":"2021113012333497000_B128","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1067\/S0894-7317(03)00648-5","article-title":"Influence of sex on ventricular remodeling after myocardial infarction in mice","volume":"16","author":"Wu","year":"2003","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"2021113012333497000_B129","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1152\/physrev.00024.2007","article-title":"Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury","volume":"88","author":"Murphy","year":"2008","journal-title":"Physiol. Rev."},{"key":"2021113012333497000_B130","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1172\/JCI62839","article-title":"Signaling effectors underlying pathologic growth and remodeling of the heart","volume":"123","author":"van Berlo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2021113012333497000_B131","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1152\/physrev.00024.2010","article-title":"Myocardial AKT: the omnipresent nexus","volume":"91","author":"Sussman","year":"2011","journal-title":"Physiol. Rev."},{"key":"2021113012333497000_B132","doi-asserted-by":"publisher","first-page":"E567","DOI":"10.1152\/ajpendo.00250.2013","article-title":"An endocrine role for brown adipose tissue?","volume":"305","author":"Villarroya","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021113012333497000_B133","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/305712a0","article-title":"Adrenergic activation of triiodothyronine production in brown adipose tissue","volume":"305","author":"Silva","year":"1983","journal-title":"Nature"},{"key":"2021113012333497000_B134","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1042\/bj2430281","article-title":"Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat","volume":"243","author":"Fernandez","year":"1987","journal-title":"Biochem. J."},{"key":"2021113012333497000_B135","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.tem.2014.03.001","article-title":"FGF21-based pharmacotherapy\u2013potential utility for metabolic disorders","volume":"25","author":"Gimeno","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"2021113012333497000_B136","doi-asserted-by":"publisher","first-page":"H1029","DOI":"10.1152\/ajpheart.00527.2015","article-title":"Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21","volume":"309","author":"Domouzoglou","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113012333497000_B137","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fphys.2019.00037","article-title":"Fibroblast growth factor 21 and browning of white adipose tissue","volume":"10","author":"Cuevas-Ramos","year":"2019","journal-title":"Front. Physiol."},{"key":"2021113012333497000_B138","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.2337\/db09-1878","article-title":"Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats","volume":"59","author":"Sarruf","year":"2010","journal-title":"Diabetes"},{"key":"2021113012333497000_B139","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1038\/srep02767","article-title":"Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue","volume":"3","author":"Liu","year":"2013","journal-title":"Sci. Rep."},{"key":"2021113012333497000_B140","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat. Commun."},{"key":"2021113012333497000_B141","doi-asserted-by":"publisher","first-page":"H1446","DOI":"10.1152\/ajpheart.00362.2012","article-title":"Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia","volume":"303","author":"Liu","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113012333497000_B142","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/icb.2014.16","article-title":"From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation","volume":"92","author":"Pal","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"2021113012333497000_B143","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","article-title":"A switch from white to brown fat increases energy expenditure in cancer-associated cachexia","volume":"20","author":"Petruzzelli","year":"2014","journal-title":"Cell Metab."},{"key":"2021113012333497000_B144","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1172\/JCI62308","article-title":"Brown adipose tissue regulates glucose homeostasis and insulin sensitivity","volume":"123","author":"Stanford","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2021113012333497000_B145","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cyto.2014.12.024","article-title":"The varying faces of IL-6: from cardiac protection to cardiac failure","volume":"74","author":"Fontes","year":"2015","journal-title":"Cytokine"},{"key":"2021113012333497000_B146","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/0300-9629(94)90396-4","article-title":"Production of nerve growth factor by brown fat in culture: relation with the in vivo developmental stage of the tissue","volume":"107","author":"N\u00e9chad","year":"1994","journal-title":"Comp. Biochem. Physiol. Comp. Physiol."},{"key":"2021113012333497000_B147","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/sj.cdd.4402263","article-title":"Identification of the prosurvival activity of nerve growth factor on cardiac myocytes","volume":"15","author":"Caporali","year":"2008","journal-title":"Cell Death Differ."},{"key":"2021113012333497000_B148","doi-asserted-by":"publisher","first-page":"83","DOI":"10.7150\/ijms.10101","article-title":"Nerve growth factor protects the ischemic heart via attenuation of the endoplasmic reticulum stress induced apoptosis by activation of phosphatidylinositol 3-kinase","volume":"12","author":"Wei","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"2021113012333497000_B149","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jdiacomp.2015.01.006","article-title":"Nerve growth factor rescues diabetic mice heart after ischemia\/reperfusion injury via up-regulation of the TRPV1 receptor","volume":"29","author":"Zheng","year":"2015","journal-title":"J. Diabetes Complications"},{"key":"2021113012333497000_B150","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1210\/endo.137.2.8593794","article-title":"Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity","volume":"137","author":"Nisoli","year":"1996","journal-title":"Endocrinology"},{"key":"2021113012333497000_B151","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/j.cellsig.2016.08.005","article-title":"Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy","volume":"28","author":"Slone","year":"2016","journal-title":"Cell. Signal."},{"key":"2021113012333497000_B152","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1172\/jci.insight.121541","article-title":"Human antigen R as a therapeutic target in pathological cardiac hypertrophy","volume":"4","author":"Green","year":"2019","journal-title":"JCI Insight"},{"key":"2021113012333497000_B153","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1038\/onc.2014.225","article-title":"The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1\u03b2-driven IL-6 secretion in glioblastoma cells","volume":"34","author":"Gurgis","year":"2015","journal-title":"Oncogene"},{"key":"2021113012333497000_B154","doi-asserted-by":"publisher","first-page":"5441","DOI":"10.4049\/jimmunol.1301188","article-title":"Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis","volume":"191","author":"Chen","year":"2013","journal-title":"J. Immunol."},{"key":"2021113012333497000_B155","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/ncpcardio0319","article-title":"Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart","volume":"2","author":"Iacobellis","year":"2005","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"2021113012333497000_B156","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/oby.2008.575","article-title":"Epicardial and pericardial fat: close, but very different","volume":"17","author":"Iacobellis","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"2021113012333497000_B157","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.ahj.2007.03.019","article-title":"Human epicardial adipose tissue: a review","volume":"153","author":"Sacks","year":"2007","journal-title":"Am. Heart J."},{"key":"2021113012333497000_B158","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1073\/pnas.1417232112","article-title":"Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPAR\u03b3 activation","volume":"112","author":"Yamaguchi","year":"2015","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021113012333497000_B159","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1532-429X-11-15","article-title":"Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume","volume":"11","author":"Nelson","year":"2009","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"2021113012333497000_B160","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jjcc.2014.07.004","article-title":"Role of pericardial fat: the good, the bad and the ugly","volume":"65","author":"Yamada","year":"2015","journal-title":"J. Cardiol."},{"key":"2021113012333497000_B161","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3389\/fphys.2017.00969","article-title":"The role of perivascular adipose tissue in non- atherosclerotic vascular disease","volume":"8","author":"Horimatsu","year":"2017","journal-title":"Front. Physiol."},{"key":"2021113012333497000_B162","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1038\/oby.2008.379","article-title":"Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy","volume":"16","author":"Silaghi","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"2021113012333497000_B163","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1113\/JP273049","article-title":"The role of epicardial adipose tissue in cardiac biology: classic concepts and emerging roles","volume":"595","author":"Antonopoulos","year":"2017","journal-title":"J. Physiol. (Lond.)"},{"key":"2021113012333497000_B164","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.ijcard.2018.09.089","article-title":"Epicardial adipose tissue and cardiovascular diseases","volume":"278","author":"Ansaldo","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"2021113012333497000_B165","doi-asserted-by":"publisher","first-page":"E1448","DOI":"10.1210\/jc.2013-1265","article-title":"Adult epicardial fat exhibits beige features","volume":"98","author":"Sacks","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113012333497000_B166","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1210\/jc.2009-0571","article-title":"Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat","volume":"94","author":"Sacks","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113012333497000_B167","first-page":"416","article-title":"Epicardial adipose tissue: far more than a fat depot","volume":"4","author":"Talman","year":"2014","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"2021113012333497000_B168","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.endonu.2012.08.001","article-title":"Epicardial adipose tissue: more than a simple fat deposit?","volume":"60","author":"Lima-Mart\u00ednez","year":"2013","journal-title":"Endocrinol. Nutr."},{"key":"2021113012333497000_B169","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/oby.2003.45","article-title":"Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction","volume":"11","author":"Iacobellis","year":"2003","journal-title":"Obes. Res."},{"key":"2021113012333497000_B170","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.amjcard.2004.06.075","article-title":"Relation between epicardial adipose tissue and left ventricular mass","volume":"94","author":"Iacobellis","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"2021113012333497000_B171","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.carpath.2004.08.005","article-title":"The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts","volume":"13","author":"Corradi","year":"2004","journal-title":"Cardiovasc. Pathol."},{"key":"2021113012333497000_B172","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.amjcard.2011.03.058","article-title":"Epicardial fat volume in patients with left ventricular systolic dysfunction","volume":"108","author":"Khawaja","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"2021113012333497000_B173","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1532-429X-12-40","article-title":"Epicardial adipose tissue in patients with heart failure","volume":"12","author":"Doesch","year":"2010","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"2021113012333497000_B174","first-page":"490","article-title":"Epicardial fatty tissue of the right ventricle\u2013morphology, morphometry and functional significance","volume":"43","author":"Schejbal","year":"1989","journal-title":"Pneumologie"},{"key":"2021113012333497000_B175","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0021-9150(00)00709-7","article-title":"Pericardial fat accumulation in men as a risk factor for coronary artery disease","volume":"157","author":"Taguchi","year":"2001","journal-title":"Atherosclerosis"},{"key":"2021113012333497000_B176","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.athoracsur.2016.11.034","article-title":"Epicardial adipose tissue removal potentiates outward remodeling and arrests coronary atherogenesis","volume":"103","author":"McKenney-Drake","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"2021113012333497000_B177","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1749-8090-9-2","article-title":"Epicardial adipose excision slows the progression of porcine coronary atherosclerosis","volume":"9","author":"McKenney","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"key":"2021113012333497000_B178","first-page":"251","article-title":"Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease","volume":"29","author":"Iacobellis","year":"2005","journal-title":"Cytokine"},{"key":"2021113012333497000_B179","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1097\/IGC.0000000000001017","article-title":"Utility and actual use of European and Spanish Guidelines on the management of endometrial cancer among gynecologic oncologists in Spain","volume":"27","author":"Zapardiel","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"2021113012333497000_B180","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.jacc.2018.03.509","article-title":"Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium","volume":"71","author":"Packer","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113012333497000_B181","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.atherosclerosis.2016.07.003","article-title":"Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients","volume":"251","author":"Harada","year":"2016","journal-title":"Atherosclerosis"},{"key":"2021113012333497000_B182","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.atherosclerosis.2015.10.100","article-title":"High plasma omentin predicts cardiovascular events independently from the presence and extent of angiographically determined atherosclerosis","volume":"244","author":"Saely","year":"2016","journal-title":"Atherosclerosis"},{"key":"2021113012333497000_B183","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1475-2840-13-84","article-title":"Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure","volume":"13","author":"Narumi","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"2021113012333497000_B184","doi-asserted-by":"publisher","first-page":"795a","DOI":"10.1093\/eurheartj\/eht099","article-title":"Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines","volume":"36","author":"Venteclef","year":"2015","journal-title":"Eur. Heart J."},{"key":"2021113012333497000_B185","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/cvr\/cvu045","article-title":"Epicardial adipose tissue and atrial fibrillation","volume":"102","author":"Hatem","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"2021113012333497000_B186","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1038\/s41598-018-21911-y","article-title":"Human epicardial adipose tissue cTGF expression is an independent risk factor for atrial fibrillation and highly associated with atrial fibrosis","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"2021113012333497000_B187","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2174\/1570161114666161024124244","article-title":"Metalloproteinase 2 and 9 activity increase in epicardial adipose tissue of patients with coronary artery disease","volume":"15","author":"Miksztowicz","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"key":"2021113012333497000_B188","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/ehf2.12409","article-title":"The adipo-fibrokine activin A is associated with metabolic abnormalities and left ventricular diastolic dysfunction in obese patients","volume":"6","author":"Zeller","year":"2019","journal-title":"ESC Heart Fail."},{"key":"2021113012333497000_B189","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.amjcard.2014.02.005","article-title":"Relation of proinflammatory activity of epicardial adipose tissue to the occurrence of atrial fibrillation","volume":"113","author":"Mazurek","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"2021113012333497000_B190","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1161\/CIRCEP.109.912055","article-title":"Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study","volume":"3","author":"Thanassoulis","year":"2010","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"2021113012333497000_B191","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1536\/ihj.54.297","article-title":"Epicardial adipose tissue is associated with prevalent atrial fibrillation in patients with hypertrophic cardiomyopathy","volume":"54","author":"Muhib","year":"2013","journal-title":"Int. Heart J."},{"key":"2021113012333497000_B192","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/eurheartj\/ehv625","article-title":"Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria","volume":"38","author":"Haemers","year":"2017","journal-title":"Eur. Heart J."},{"key":"2021113012333497000_B193","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s00059-017-4555-4","article-title":"Removal of epicardial adipose tissue after myocardial infarction improves cardiac function","volume":"43","author":"Chang","year":"2018","journal-title":"Herz"},{"key":"2021113012333497000_B194","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1111\/j.1582-4934.2010.01232.x","article-title":"Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function","volume":"15","author":"Greulich","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"2021113012333497000_B195","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.mce.2015.08.025","article-title":"Differential behaviour of epicardial adipose tissue-secretomes with high and low orosomucoid levels from patients with cardiovascular disease in H9C2 cells","volume":"416","author":"Lage","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021113012333497000_B196","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/nutd.2013.6","article-title":"Human mediastinal adipose tissue displays certain characteristics of brown fat","volume":"3","author":"Cheung","year":"2013","journal-title":"Nutr. Diabetes"},{"key":"2021113012333497000_B197","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1161\/CIRCULATIONAHA.108.828970","article-title":"Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study","volume":"119","author":"Fox","year":"2009","journal-title":"Circulation"},{"key":"2021113012333497000_B198","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.numecd.2013.09.016","article-title":"Pericardial fat, insulin resistance, and left ventricular structure and function in morbid obesity","volume":"24","author":"Pucci","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"2021113012333497000_B199","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.jcmg.2016.10.024","article-title":"Pericardial, but not hepatic, fat by CT is associated with CV outcomes and structure: the multi-ethnic study of atherosclerosis","volume":"10","author":"Shah","year":"2017","journal-title":"JACC Cardiovasc. Imaging"},{"key":"2021113012333497000_B200","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.2337\/dc10-0245","article-title":"Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson heart study","volume":"33","author":"Liu","year":"2010","journal-title":"Diabetes Care"},{"key":"2021113012333497000_B201","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1532-429X-16-37","article-title":"The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect","volume":"16","author":"Hua","year":"2014","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"2021113012333497000_B202","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1042\/BC20110033","article-title":"Adipose stem cells originate from perivascular cells","volume":"103","author":"Cai","year":"2011","journal-title":"Biol. Cell."},{"key":"2021113012333497000_B203","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1161\/CIRCULATIONAHA.112.104489","article-title":"Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-\u03b3 deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis","volume":"126","author":"Chang","year":"2012","journal-title":"Circulation"},{"key":"2021113012333497000_B204","first-page":"277","article-title":"Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness","volume":"13","author":"Soltis","year":"1991","journal-title":"Clin. Exp. Hypertens. A"},{"key":"2021113012333497000_B205","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1096\/fj.02-0024com","article-title":"Periadventitial fat releases a vascular relaxing factor","volume":"16","author":"L\u00f6hn","year":"2002","journal-title":"FASEB J."},{"key":"2021113012333497000_B206","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1111\/bph.13650","article-title":"The role of perivascular adipose tissue in obesity-induced vascular dysfunction","volume":"174","author":"Xia","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"2021113012333497000_B207","doi-asserted-by":"publisher","first-page":"e000582","DOI":"10.1161\/JAHA.113.000582","article-title":"Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations","volume":"3","author":"Fitzgibbons","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"2021113012333497000_B208","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1161\/CIRCRESAHA.108.182998","article-title":"Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding","volume":"104","author":"Chatterjee","year":"2009","journal-title":"Circ. Res."},{"key":"2021113012333497000_B209","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11906-018-0835-5","article-title":"Modulation of vascular reactivity by perivascular adipose tissue (PVAT)","volume":"20","author":"Agabiti-Rosei","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"2021113012333497000_B210","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1161\/HYPERTENSIONAHA.116.08451","article-title":"Role of perivascular adipose tissue in vascular physiology and pathology","volume":"69","author":"Huang Cao","year":"2017","journal-title":"Hypertension"},{"key":"2021113012333497000_B211","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.bbrc.2006.01.004","article-title":"Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes","volume":"341","author":"Chen","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113012333497000_B212","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.2337\/diabetes.54.8.2277","article-title":"Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss","volume":"54","author":"Cancello","year":"2005","journal-title":"Diabetes"},{"key":"2021113012333497000_B213","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.108.821181","article-title":"Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients","volume":"119","author":"Greenstein","year":"2009","journal-title":"Circulation"},{"key":"2021113012333497000_B214","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s12170-011-0214-0","article-title":"Perivascular fat and the microcirculation: relevance to insulin resistance, diabetes, and cardiovascular disease","volume":"6","author":"Houben","year":"2012","journal-title":"Curr. Cardiovasc. Risk Rep."},{"key":"2021113012333497000_B215","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.atherosclerosis.2012.08.031","article-title":"Coronary perivascular adipose tissue characteristics are related to atherosclerotic plaque size and composition. A post-mortem study","volume":"225","author":"Verhagen","year":"2012","journal-title":"Atherosclerosis"},{"key":"2021113012333497000_B216","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/hmbci-2015-0010","article-title":"Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease","volume":"22","author":"Lastra","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/22\/2329\/861912\/cs-2019-0578c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/133\/22\/2329\/861912\/cs-2019-0578c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T17:11:47Z","timestamp":1722100307000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/133\/22\/2329\/221338\/Mechanisms-linking-adipose-tissue-inflammation-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":216,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2019,11,29]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20190578","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,11]]}}}