{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:40:24Z","timestamp":1740138024555,"version":"3.37.3"},"reference-count":10,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We thank Ahmed et al. for their letter regarding our study \u2018Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts\u2019 [1]. As emphasized by Ahmed et al., Prx-4 levels decrease [2] whereas MFN-2, OPA-1 and PGC-1\u03b1 levels increase [3] in dilated cardiomyopathy (DCM). Moreover, Gal-3 expression is also increased in DCM [4]. In our study, we showed in vitro that Gal-3 decreased Prx-4 without modifying MFN-2 or PGC-1\u03b1 levels in human cardiac fibroblasts. Although cardiac Prx-4 decrease could be a direct consequence of Gal-3 effects on cardiac fibroblasts, we cannot exclude the possibility that other factors increase MFN-2, OPA-1 and PGC-1\u03b1 levels in both cardiac fibroblasts or cardiomyocytes in the context of DCM. Further studies are needed to clarify the association between Prx-4 decrease and the increase in other mitochondrial proteins in DCM.<\/jats:p>","DOI":"10.1042\/cs20191184","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T08:59:40Z","timestamp":1578992380000},"page":"73-74","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["(Letter to the Editor) Response to: protective role of peroxiredoxin-4 in heart failure"],"prefix":"10.1042","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-2606","authenticated-orcid":false,"given":"Natalia","family":"L\u00f3pez-Andr\u00e9s","sequence":"first","affiliation":[{"name":"Cardiovascular Translational Research, NavarraBiomed (Miguel Servet Foundation) Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"2021113012342146100_B1","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1042\/CS20171389","article-title":"Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage","volume":"132","author":"Ibarrola","year":"2018","journal-title":"Clin. Sci. (Lond)."},{"key":"2021113012342146100_B2","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.lfs.2007.07.014","article-title":"Isoform-specific downregulation of peroxiredoxin in human failing myocardium","volume":"81","author":"Brixius","year":"2007","journal-title":"Life Sci"},{"key":"2021113012342146100_B3","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1161\/CIRCULATIONAHA.112.001219","article-title":"Divergent mitochondrial biogenesis responses in human cardiomyopathy","volume":"127","author":"Ahuja","year":"2013","journal-title":"Circulation"},{"key":"2021113012342146100_B4","doi-asserted-by":"publisher","first-page":"8213","DOI":"10.1038\/s41598-018-26115-y","article-title":"Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure","volume":"8","author":"Nguyen","year":"2018","journal-title":"Sci. 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Redox Signal."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/134\/1\/73\/866178\/cs-2019-1184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/134\/1\/73\/866178\/cs-2019-1184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:34:32Z","timestamp":1638275672000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/134\/1\/73\/221859\/Letter-to-the-Editor-Response-to-protective-role"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,17]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20191184","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"type":"print","value":"0143-5221"},{"type":"electronic","value":"1470-8736"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2020,1]]}}}