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However, it can be detrimental by increasing susceptibility to secondary bacterial infections and resulting in permanent changes to the lung architecture, in the form of fibrotic sequelae. Here, we review influenza associated bacterial super-infection, the formation of T-cell memory, and persistent lung injury resulting from influenza infection.<\/jats:p>","DOI":"10.1042\/cs20200050","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T10:30:11Z","timestamp":1594377011000},"page":"1697-1714","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Influenza sequelae: from immune modulation to persistent alveolitis"],"prefix":"10.1042","volume":"134","author":[{"given":"Ellyse\u00a0M.","family":"Cipolla","sequence":"first","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brydie\u00a0R.","family":"Huckestein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-7711","authenticated-orcid":false,"given":"John\u00a0F.","family":"Alcorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2021113011142524200_B1","doi-asserted-by":"publisher","first-page":"020421","DOI":"10.7189\/jogh.09.020421","article-title":"Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project","volume":"9","author":"Paget","year":"2019","journal-title":"J. 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