{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:30:25Z","timestamp":1778599825017,"version":"3.51.4"},"reference-count":54,"publisher":"Portland Press Ltd.","issue":"12","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aldosterone, as a major product of renin\u2013angiotensin\u2013aldosterone system (RAAS), determines multiple pathophysiological processes in cardiovascular diseases. The excess inflammatory response is one of the key profiles in aldosterone-mediated cardiac remodeling. However, the potential mechanisms of aldosterone\/inflammatory signaling were still not fully disclosed. The present study aimed to investigate whether TIR-domain-containing adapter-inducing interferon-\u03b2 (Trif) participated in the aldosterone-induced cardiac remodeling, and to explore potential molecular mechanisms. Trif knockout mice and their littermates were osmotically administrated with aldosterone (50 \u03bcg\/kg per day) for 21 and 42 days. The cardiac structural analysis, functional parameters, and mitochondrial function were measured. Aldosterone dose- or time-dependently increased the levels of TRIF in primary mouse cardiomyocytes or mouse heart tissues. Trif deficiency protected against aldosterone-induced cardiac hypertrophy, fibrosis and dysfunction. Moreover, Trif deficiency also suppressed aldosterone-induced cardiac inflammatory response and mitochondrial injuries. Mechanistically, overexpression of cardiac microRNAs (miR)-34a reversed the cardiac benefits of Trif deficiency in aldosterone-treated mice. Taken together, Trif\/miR-34a axis could provide a novel molecular mechanism for explaining aldosterone-induced cardiac hypertrophy, fibrosis and functional disorders.<\/jats:p>","DOI":"10.1042\/cs20200249","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T10:11:08Z","timestamp":1592302268000},"page":"1319-1331","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["TRIF\/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling"],"prefix":"10.1042","volume":"134","author":[{"given":"Shaojun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China"},{"name":"The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, Harbin 150086, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China"},{"name":"The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, Harbin 150086, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China"},{"name":"The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, Harbin 150086, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enbo","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China"},{"name":"The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, Harbin 150086, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China"},{"name":"The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, Harbin 150086, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-796X","authenticated-orcid":false,"given":"Shufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China"},{"name":"The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, Harbin 150086, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"2021113011131854200_B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/postgradmedj-2016-134045","article-title":"The renin-angiotensin-aldosterone system in heart failure for the non-specialist: the past, the present and the future","volume":"93","author":"Orsborne","year":"2017","journal-title":"Postgrad. Med. J."},{"key":"2021113011131854200_B2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.amjcard.2015.03.052","article-title":"Meta-analysis of large-scale randomized trials to determine the effectiveness of inhibition of the renin-angiotensin aldosterone system in heart failure","volume":"116","author":"Emdin","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"2021113011131854200_B3","first-page":"CD012721","article-title":"Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction","volume":"6","author":"Martin","year":"2018","journal-title":"Cochrane Database. Syst. Rev."},{"key":"2021113011131854200_B4","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1056\/NEJMra000050","article-title":"Aldosterone in congestive heart failure","volume":"345","author":"Weber","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2021113011131854200_B5","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/01.HYP.26.6.971","article-title":"Biological determinants of aldosterone-induced cardiac fibrosis in rats","volume":"26","author":"Robert","year":"1995","journal-title":"Hypertension"},{"key":"2021113011131854200_B6","doi-asserted-by":"publisher","first-page":"H1802","DOI":"10.1152\/ajpheart.01096.2001","article-title":"Aldosterone induces a vascular inflammatory phenotype in the rat heart","volume":"283","author":"Rocha","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011131854200_B7","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart: role of oxidative stress","volume":"161","author":"Sun","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2021113011131854200_B8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"2021113011131854200_B9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/CS20070123","article-title":"Aldosterone and end-organ damage","volume":"113","author":"Marney","year":"2007","journal-title":"Clin. Sci."},{"key":"2021113011131854200_B10","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1096\/fj.05-4642fje","article-title":"Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase","volume":"20","author":"Johar","year":"2006","journal-title":"FASEB J."},{"key":"2021113011131854200_B11","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1161\/01.RES.0000102404.81461.25","article-title":"Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface","volume":"93","author":"Ahokas","year":"2003","journal-title":"Circ. Res."},{"key":"2021113011131854200_B12","doi-asserted-by":"publisher","first-page":"E1154","DOI":"10.1152\/ajpendo.00155.2018","article-title":"MicroRNA-21 ablation exacerbates aldosterone-mediated cardiac injury, remodeling, and dysfunction","volume":"315","author":"Syed","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021113011131854200_B13","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1161\/HYPERTENSIONAHA.113.01102","article-title":"MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex","volume":"62","author":"Robertson","year":"2013","journal-title":"Hypertension"},{"key":"2021113011131854200_B14","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.3390\/ijms19102941","article-title":"MicroRNA-204 is necessary for aldosterone-stimulated T-type calcium channel expression in cardiomyocytes","volume":"19","author":"Koyama","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021113011131854200_B15","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.cyto.2008.07.010","article-title":"Signalling adaptors used by Toll-like receptors: an update","volume":"43","author":"Kenny","year":"2008","journal-title":"Cytokine"},{"key":"2021113011131854200_B16","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/HYPERTENSIONAHA.115.06011","article-title":"Dual activation of TRIF and MyD88 adaptor proteins by angiotensin II evokes opposing effects on pressure, cardiac hypertrophy, and inflammatory gene expression","volume":"66","author":"Singh","year":"2015","journal-title":"Hypertension"},{"key":"2021113011131854200_B17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000452269","article-title":"Protease-activated receptor 1 contributes to angiotensin II-induced cardiovascular remodeling and inflammation","volume":"136","author":"Antoniak","year":"2017","journal-title":"Cardiology"},{"key":"2021113011131854200_B18","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1172\/JCI126428","article-title":"Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation","volume":"130","author":"Li","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2021113011131854200_B19","doi-asserted-by":"publisher","first-page":"3497","DOI":"10.2337\/db13-1577","article-title":"Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy","volume":"63","author":"Pan","year":"2014","journal-title":"Diabetes"},{"key":"2021113011131854200_B20","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1016\/j.bbrc.2018.08.113","article-title":"Exosomal microRNA-194 causes cardiac injury and mitochondrial dysfunction in obese mice","volume":"503","author":"Nie","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113011131854200_B21","doi-asserted-by":"publisher","first-page":"e0150606","DOI":"10.1371\/journal.pone.0150606","article-title":"A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS ONE"},{"key":"2021113011131854200_B22","doi-asserted-by":"publisher","first-page":"e0142456","DOI":"10.1371\/journal.pone.0142456","article-title":"TAK-242, a toll-like receptor 4 antagonist, protects against aldosterone-induced cardiac and renal injury","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS ONE"},{"key":"2021113011131854200_B23","doi-asserted-by":"publisher","first-page":"10877","DOI":"10.1038\/ncomms10877","article-title":"Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases","volume":"7","author":"Cannavo","year":"2016","journal-title":"Nat. Commun."},{"key":"2021113011131854200_B24","doi-asserted-by":"publisher","first-page":"24580","DOI":"10.1038\/srep24580","article-title":"EGFR inhibition blocks palmitic acid-induced inflammation in cardiomyocytes and prevents hyperlipidemia-induced cardiac injury in mice","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"2021113011131854200_B25","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1161\/01.RES.73.1.184","article-title":"Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding","volume":"73","author":"Feldman","year":"1993","journal-title":"Circ. Res."},{"key":"2021113011131854200_B26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijcard.2011.06.066","article-title":"Circulating biomarkers with preventive, diagnostic and prognostic implications in cardiovascular diseases","volume":"157","author":"Battistoni","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"2021113011131854200_B27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jnutbio.2012.03.012","article-title":"Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart","volume":"24","author":"Pan","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"2021113011131854200_B28","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/ni.2346","article-title":"IRF3: a molecular switch in pathogen responses","volume":"13","author":"Takeuchi","year":"2012","journal-title":"Nat. Immunol."},{"key":"2021113011131854200_B29","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0895-7061(02)03199-0","article-title":"Aldosterone-induced cardiac damage: focus on blood pressure independent effects","volume":"16","author":"Schmidt","year":"2003","journal-title":"Am. J. Hypertens."},{"key":"2021113011131854200_B30","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/HYPERTENSIONAHA.108.111211","article-title":"Aldosterone, hypertension, and cardiovascular disease: an endless story","volume":"52","author":"Ruilope","year":"2008","journal-title":"Hypertension"},{"key":"2021113011131854200_B31","doi-asserted-by":"publisher","first-page":"6801","DOI":"10.1038\/s41598-018-25068-6","article-title":"Aldosterone impairs mitochondrial function in human cardiac fibroblasts via A-kinase anchor protein 12","volume":"8","author":"Ibarrola","year":"2018","journal-title":"Sci. Rep."},{"key":"2021113011131854200_B32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nature11919","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nature"},{"key":"2021113011131854200_B33","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1161\/CIRCRESAHA.117.305962","article-title":"MicroRNA-34a plays a key role in cardiac repair and regeneration following myocardial infarction","volume":"117","author":"Yang","year":"2015","journal-title":"Circ. Res."},{"key":"2021113011131854200_B34","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1172\/JCI123069","article-title":"Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2021113011131854200_B35","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.109.131110","article-title":"Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone\/salt-induced cardiac fibrosis and increased blood pressure","volume":"54","author":"Rickard","year":"2009","journal-title":"Hypertension"},{"key":"2021113011131854200_B36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1056\/NEJMoa033263","article-title":"Serum aldosterone and the incidence of hypertension in nonhypertensive persons","volume":"351","author":"Vasan","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2021113011131854200_B37","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2021113011131854200_B38","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1161\/CIRCULATIONAHA.106.634626","article-title":"High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction","volume":"114","author":"Beygui","year":"2006","journal-title":"Circulation"},{"key":"2021113011131854200_B39","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.107.748640","article-title":"Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines","volume":"117","author":"Guo","year":"2008","journal-title":"Circulation"},{"key":"2021113011131854200_B40","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1038\/s41598-018-21087-5","article-title":"Vascular dysfunction in obese diabetic db\/db mice involves the interplay between aldosterone\/mineralocorticoid receptor and Rho kinase signaling","volume":"8","author":"Nguyen Dinh Cat","year":"2018","journal-title":"Sci. Rep."},{"key":"2021113011131854200_B41","doi-asserted-by":"publisher","first-page":"e62426","DOI":"10.1371\/journal.pone.0062426","article-title":"Pepsin digest of wheat gliadin fraction increases production of IL-1beta via TLR4\/MyD88\/TRIF\/MAPK\/NF-kappaB signaling pathway and an NLRP3 inflammasome activation","volume":"8","author":"Palova-Jelinkova","year":"2013","journal-title":"PLoS ONE"},{"key":"2021113011131854200_B42","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/jcmm.12175","article-title":"Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy","volume":"18","author":"Pan","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"2021113011131854200_B43","doi-asserted-by":"publisher","first-page":"e000683","DOI":"10.1161\/JAHA.113.000683","article-title":"Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury","volume":"3","author":"Chen","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"2021113011131854200_B44","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system","volume":"83","author":"Weber","year":"1991","journal-title":"Circulation"},{"key":"2021113011131854200_B45","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/BF00877866","article-title":"Left ventricular hypertrophy and diastolic dysfunction: their relation to coronary heart disease","volume":"9","author":"Stork","year":"1995","journal-title":"Cardiovasc. Drugs Ther."},{"key":"2021113011131854200_B46","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1210\/endo.141.5.7529","article-title":"Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy","volume":"141","author":"Takeda","year":"2000","journal-title":"Endocrinology"},{"key":"2021113011131854200_B47","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1161\/01.RES.0000080521.15238.E5","article-title":"Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure","volume":"93","author":"Qin","year":"2003","journal-title":"Circ. Res."},{"key":"2021113011131854200_B48","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1161\/01.HYP.0000203772.78696.67","article-title":"Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats","volume":"47","author":"Nagata","year":"2006","journal-title":"Hypertension"},{"key":"2021113011131854200_B49","doi-asserted-by":"publisher","first-page":"12A","DOI":"10.1016\/0002-9149(93)90239-9","article-title":"Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension","volume":"71","author":"Brilla","year":"1993","journal-title":"Am. J. Cardiol."},{"key":"2021113011131854200_B50","doi-asserted-by":"publisher","first-page":"12103","DOI":"10.1073\/pnas.0811371106","article-title":"miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy","volume":"106","author":"Lin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113011131854200_B51","doi-asserted-by":"publisher","first-page":"e38197","DOI":"10.1371\/journal.pone.0038197","article-title":"Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice","volume":"7","author":"Azibani","year":"2012","journal-title":"PLoS ONE"},{"key":"2021113011131854200_B52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12943-019-0988-0","article-title":"MCT-1\/miR-34a\/IL-6\/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer","volume":"18","author":"Weng","year":"2019","journal-title":"Mol. Cancer"},{"key":"2021113011131854200_B53","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2011.07.020","article-title":"miR-21, miR-210, miR-34a, and miR-146a\/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study","volume":"219","author":"Raitoharju","year":"2011","journal-title":"Atherosclerosis"},{"key":"2021113011131854200_B54","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jhep.2012.08.008","article-title":"miR-34a\/SIRT1\/p53 is suppressed by ursodeoxycholic acid in t he rat liver and activated by disease severity in human non-alcoholic fatty liver disease","volume":"58","author":"Castro","year":"2013","journal-title":"J. Hepatol."}],"updated-by":[{"DOI":"10.1042\/cs-20200249_ret","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"record-id":"24994"},{"DOI":"10.1042\/cs-20200249_eoc","type":"expression_of_concern","label":"Expression of concern","source":"retraction-watch","updated":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"record-id":"24995"},{"DOI":"10.1042\/cs-20200249_ret","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000}},{"DOI":"10.1042\/cs-20200249_eoc","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000}}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/134\/12\/1319\/884626\/cs-2020-0249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/134\/12\/1319\/884626\/cs-2020-0249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:12:06Z","timestamp":1638274326000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/134\/12\/1319\/225309\/TRIF-miR-34a-mediates-aldosterone-induced-cardiac"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6,26]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20200249","relation":{"retraction":[{"id-type":"doi","id":"10.1042\/CS-20200249_RET","asserted-by":"object"}],"expression_of_concern":[{"id-type":"doi","id":"10.1042\/CS-20200249_EOC","asserted-by":"object"}]},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,6]]}}}