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Therefore, the aim of the present study was to investigate whether CS impacts GI function and structure in a mouse model of CS-induced COPD. We also aimed to investigate GI function in the presence of ebselen, an antioxidant that has shown beneficial effects on lung inflammation resulting from CS exposure. Mice were exposed to CS for 2 or 6 months. GI structure was analysed by histology and immunofluorescence. After 2 months of CS exposure, ex vivo gut motility was analysed using video-imaging techniques to examine changes in colonic migrating motor complexes (CMMCs). CS decreased colon length in mice. Mice exposed to CS for 2 months had a higher frequency of CMMCs and a reduced resting colonic diameter but no change in enteric neuron numbers. Ten days cessation after 2 months CS reversed CMMC frequency changes but not the reduced colonic diameter phenotype. Ebselen treatment reversed the CS-induced reduction in colonic diameter. After 6 months CS, the number of myenteric nitric-oxide producing neurons was significantly reduced. This is the first evidence of colonic dysmotility in a mouse model of CS-induced COPD. Dysmotility after 2 months CS is not due to altered neuron numbers; however, prolonged CS-exposure significantly reduced enteric neuron numbers in mice. Further research is needed to assess potential therapeutic applications of ebselen in GI dysfunction in COPD.<\/jats:p>","DOI":"10.1042\/cs20200886","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T10:10:59Z","timestamp":1604052659000},"page":"2943-2957","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice"],"prefix":"10.1042","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-4543","authenticated-orcid":false,"given":"Gayathri\u00a0K.","family":"Balasuriya","sequence":"first","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Mohsenipour","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Brassington","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Dobric","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone\u00a0N.","family":"De Luca","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Mou","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei\u00a0Jiunn","family":"Seow","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalystha Yie\u00a0Qin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madushani","family":"Herath","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Melbourne, Parkville 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley M.H.","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-7071","authenticated-orcid":false,"given":"Ross","family":"Vlahos","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-7198","authenticated-orcid":false,"given":"Elisa\u00a0L.","family":"Hill-Yardin","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"2021113011170191700_B1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3389\/fimmu.2018.00074","article-title":"Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis","volume":"9","author":"Berkowitz","year":"2018","journal-title":"Front. 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