{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:52:13Z","timestamp":1790632333508,"version":"4.1.0"},"reference-count":70,"publisher":"Portland Press Ltd.","issue":"23","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gut microbiota dysbiosis has been studied under the pathological conditions of osteoarthritis (OA). However, the effect of antibiotic-induced gut flora dysbiosis on OA remains incompletely understood at present. Herein, we used a mouse (8 weeks) OA model of destabilization of the medial meniscus (DMM) and gut microbiome dysbiosis induced by antibiotic treatment with ampicillin and neomycin for 8 weeks. The results show that antibiotic-induced intestinal microbiota dysbiosis reduced the serum level of lipopolysaccharide (LPS) and the inflammatory response, such as suppression of the levels of tumour necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6), which can lead to decreased matrix metalloprotease-13 (MMP-13) expression and improvement of OA after joint injury. In addition, trabecular thickness (Tb.Th) and osteophyte scores were increased significantly in antibiotic-induced male mice compared with female mice. We further used network correlation analysis to verify the effect of gut microbiota dysbiosis on OA. Therefore, the present study contributes to our understanding of the gut\u2013joint axis in OA and reveals the relationship between the inflammatory response, sex and gut microbiota, which may provide new strategies to prevent the symptoms and long-term sequelae of OA.<\/jats:p>\n               <jats:p>Conclusion: Our data showed that gut microbiome dysbiosis alleviates the progression of OA.<\/jats:p>","DOI":"10.1042\/cs20201224","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T20:53:43Z","timestamp":1606164823000},"page":"3159-3174","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice"],"prefix":"10.1042","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-8998","authenticated-orcid":false,"given":"Zhiyuan","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Spinal Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-9457","authenticated-orcid":false,"given":"Chunli","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University Third Hospital, Beijing, China"},{"name":"Beijing Key Laboratory of Spinal Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"2021113011174369400_B1","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"DALYs, G.B.D. and H. 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