{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:50:47Z","timestamp":1789829447817,"version":"4.0.1"},"reference-count":160,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cardiometabolic diseases (CMDs) are among the most prevalent and the highest mortality diseases. Single disease etiology such as gene mutation, polymorphisms, or environmental exposure has failed to explain the origin of CMD. This can be evident in the discrepancies in disease susceptibility among individuals exposed to the same environmental insult or who acquire the same genetic variation. Epigenetics is the intertwining of genetic and environmental factors that results in diversity in the disease course, severity, and prognosis among individuals. Environmental exposures modify the epigenome and thus provide a link for translating environmental impact on changes in gene expression and precipitation to pathological conditions. Renin\u2013angiotensin system (RAS) is comprising genes responsible for the regulation of cardiovascular, metabolic, and glycemic functions. Epigenetic modifications of RAS genes can lead to overactivity of the system, increased sympathetic activity and autonomic dysfunction ultimately contributing to the development of CMD. In this review, we describe the three common epigenetic modulations targeting RAS components and their impact on the susceptibility to cardiometabolic dysfunction. Additionally, we highlight the therapeutic efforts of targeting these epigenetic imprints to the RAS and its effects.<\/jats:p>","DOI":"10.1042\/cs20201287","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T21:31:21Z","timestamp":1610573481000},"page":"127-142","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Epigenetic modifications of the renin\u2013angiotensin system in cardiometabolic diseases"],"prefix":"10.1042","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-2789","authenticated-orcid":false,"given":"Mona","family":"Elgazzaz","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, U.S.A."},{"name":"Southeast Louisiana Veterans Health Care System, New Orleans, LA 70119, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-0786","authenticated-orcid":false,"given":"Eric","family":"Lazartigues","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, U.S.A."},{"name":"Southeast Louisiana Veterans Health Care System, New Orleans, LA 70119, U.S.A."},{"name":"Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"2021113011185294400_B1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2017","edition":"8th edn"},{"key":"2021113011185294400_B2","article-title":"Obesity and overweight","year":"2019"},{"key":"2021113011185294400_B3","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0728-6","article-title":"Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007\u20132017","volume":"17","author":"Einarson","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"2021113011185294400_B4","doi-asserted-by":"publisher","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults","volume":"71","author":"Whelton","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113011185294400_B5","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3389\/fnins.2020.00650","article-title":"Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension","volume":"14","author":"Xue","year":"2020","journal-title":"Front. Neurosci."},{"key":"2021113011185294400_B6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00424-012-1096-9","article-title":"Metabolic rate regulation by the renin\u2013angiotensin system: brain vs. body","volume":"465","author":"Grobe","year":"2013","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"key":"2021113011185294400_B7","doi-asserted-by":"publisher","first-page":"R238","DOI":"10.1152\/ajpregu.00486.2014","article-title":"Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ","volume":"308","author":"Coble","year":"2015","journal-title":"Am. J. Physiol.-Regul. Integr. Comparat. Physiol."},{"key":"2021113011185294400_B8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1152\/physiol.00002.2008","article-title":"An Intracellular Renin-Angiotensin System in Neurons: Fact, Hypothesis, or Fantasy","volume":"23","author":"Grobe","year":"2008","journal-title":"Physiology"},{"key":"2021113011185294400_B9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fendo.2020.00425","article-title":"Pathobiological Interactions of Local Bone Marrow Renin-Angiotensin System and Central Nervous System in Systemic Arterial Hypertension","volume":"11","author":"Ciftciler","year":"2020","journal-title":"Front. Endocrinol."},{"key":"2021113011185294400_B10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1113\/jphysiol.2006.126193","article-title":"The physiology of a local renin-angiotensin system in the pancreas: Physiology of the local pancreatic RAS","volume":"580","author":"Leung","year":"2007","journal-title":"J. Physiol."},{"key":"2021113011185294400_B11","first-page":"exd.14159","article-title":"The Role of the Renin-Angiotensin System in Skin Physiology and Pathophysiology","volume":"9","author":"Silva","year":"2020","journal-title":"Exp. Dermatol."},{"key":"2021113011185294400_B12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10286-018-0572-5","article-title":"The renin\u2013angiotensin system in cardiovascular autonomic control: recent developments and clinical implications","volume":"29","author":"Miller","year":"2019","journal-title":"Clin. Auton. Res."},{"key":"2021113011185294400_B13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1056\/NEJM197408222910805","article-title":"The Renin-Angiotensin System","volume":"291","author":"Oparil","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"2021113011185294400_B14","doi-asserted-by":"publisher","first-page":"5643","DOI":"10.1210\/en.2008-0070","article-title":"Renin Inhibition Attenuates Insulin Resistance, Oxidative Stress, and Pancreatic Remodeling in the Transgenic Ren2 Rat","volume":"149","author":"Habibi","year":"2008","journal-title":"Endocrinology"},{"key":"2021113011185294400_B15","doi-asserted-by":"publisher","first-page":"R943","DOI":"10.1152\/ajpregu.00265.2004","article-title":"Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension","volume":"287","author":"Boustany","year":"2004","journal-title":"Am. J. Physiol.-Regul. Integr. Comparati. Physiol."},{"key":"2021113011185294400_B16","doi-asserted-by":"publisher","first-page":"R95","DOI":"10.1093\/hmg\/ddl095","article-title":"The emerging science of epigenomics","volume":"15","author":"Callinan","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2021113011185294400_B17","doi-asserted-by":"publisher","first-page":"30R","DOI":"10.1203\/pdr.0b013e31804575f7","article-title":"Metastable Epialleles, Imprinting, and the Fetal Origins of Adult Diseases","volume":"61","author":"Dolinoy","year":"2007","journal-title":"Pediatr. Res."},{"key":"2021113011185294400_B18","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1161\/CIRCRESAHA.116.306819","article-title":"Epigenetic Changes in Diabetes and Cardiovascular Risk","volume":"118","author":"Keating","year":"2016","journal-title":"Circ. Res."},{"key":"2021113011185294400_B19","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.3390\/ijms19041174","article-title":"DNA Methylation and Histone Modification in Hypertension","volume":"19","author":"Stoll","year":"2018","journal-title":"IJMS"},{"key":"2021113011185294400_B20","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/s41440-019-0248-0","article-title":"Epigenetic modification: a regulatory mechanism in essential hypertension","volume":"42","author":"Arif","year":"2019","journal-title":"Hypertens. Res."},{"key":"2021113011185294400_B21","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3390\/ijms17040451","article-title":"Epigenetic Modifications in Essential Hypertension","volume":"17","author":"Wise","year":"2016","journal-title":"IJMS"},{"key":"2021113011185294400_B22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11906-010-0173-8","article-title":"Epigenetics and Hypertension","volume":"13","author":"Millis","year":"2011","journal-title":"Curr. Hypertens. Rep."},{"key":"2021113011185294400_B23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.metabol.2018.10.007","article-title":"Genetics and epigenetics in obesity","volume":"92","author":"Rohde","year":"2019","journal-title":"Metabolism"},{"key":"2021113011185294400_B24","doi-asserted-by":"publisher","DOI":"10.5772\/67080","article-title":"Renin-Angiotensin System MicroRNAs, Special Focus on the Brain","volume-title":"Renin-Angiotensin System - Past, Present and Future","author":"Gerardo-Aviles","year":"2017"},{"key":"2021113011185294400_B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/896861","article-title":"The ACE2\/Apelin Signaling, MicroRNAs, and Hypertension","volume":"2015","author":"Chen","year":"2015","journal-title":"Int. J. Hypertension"},{"key":"2021113011185294400_B26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.numecd.2017.10.015","article-title":"The clinical potential of adipogenesis and obesity-related microRNAs","volume":"28","author":"Zaiou","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"2021113011185294400_B27","doi-asserted-by":"publisher","first-page":"3608","DOI":"10.3390\/ijms19113608","article-title":"Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity","volume":"19","author":"Improta Caria","year":"2018","journal-title":"IJMS"},{"key":"2021113011185294400_B28","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3109\/08037051.2016.1167355","article-title":"Regulatory mechanisms in arterial hypertension: role of microRNA in pathophysiology and therapy","volume":"26","author":"Klimczak","year":"2017","journal-title":"Blood Press."},{"key":"2021113011185294400_B29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11906-011-0235-6","article-title":"MicroRNAs in Hypertension: Mechanisms and Therapeutic Targets","volume":"14","author":"B\u00e1tkai","year":"2012","journal-title":"Curr. Hypertens. Rep."},{"key":"2021113011185294400_B30","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1161\/HYPERTENSIONAHA.117.08550","article-title":"How Is the Brain Renin\u2013Angiotensin System Regulated?","volume":"70","author":"Nakagawa","year":"2017","journal-title":"Hypertension"},{"key":"2021113011185294400_B31","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/S0140-6736(07)60242-6","article-title":"Renin-angiotensin system and cardiovascular risk","volume":"369","author":"Schmieder","year":"2007","journal-title":"Lancet North Am. Ed."},{"key":"2021113011185294400_B32","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1124\/pr.114.010454","article-title":"International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli","volume":"67","author":"Karnik","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"2021113011185294400_B33","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1210\/en.2003-0150","article-title":"Minireview: Overview of the Renin-Angiotensin System\u2014An Endocrine and Paracrine System","volume":"144","author":"Lavoie","year":"2003","journal-title":"Endocrinology"},{"key":"2021113011185294400_B34","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of Local Renin-Angiotensin Systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol. Rev."},{"key":"2021113011185294400_B35","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0022-2143(97)90077-9","article-title":"Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart","volume":"129","author":"De Carvalho Frimm","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"2021113011185294400_B36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s001090050123","article-title":"Cardiovascular end-organ damage in Ren-2 transgenic rats compared to spontaneously hypertensive rats","volume":"75","author":"Pinto","year":"1997","journal-title":"J. Mol. Med."},{"key":"2021113011185294400_B37","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1038\/sj.ijo.0801305","article-title":"Gene expression of angiotensinogen in adipose tissue of obese patients","volume":"24","author":"Giacchetti","year":"2000","journal-title":"Int. J. Obes."},{"key":"2021113011185294400_B38","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/00006676-200411000-00004","article-title":"Angiotensin II Mediates Acinar Cell Apoptosis During the Development of Rat Pancreatic Fibrosis by AT1R","volume":"29","author":"Wang","year":"2004","journal-title":"Pancreas"},{"key":"2021113011185294400_B39","doi-asserted-by":"publisher","first-page":"E874","DOI":"10.1152\/ajpendo.00490.2012","article-title":"Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice","volume":"304","author":"Chhabra","year":"2013","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"2021113011185294400_B40","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1161\/HYPERTENSIONAHA.114.03188","article-title":"Increased Expression of Angiotensin II Type 2 Receptors in the Solitary\u2013Vagal Complex Blunts Renovascular Hypertension","volume":"64","author":"Blanch","year":"2014","journal-title":"Hypertension"},{"key":"2021113011185294400_B41","doi-asserted-by":"publisher","first-page":"E357","DOI":"10.1152\/ajpendo.2000.278.3.E357","article-title":"The angiotensin II type 2 receptor: an enigma with multiple variations","volume":"278","author":"Gallinat","year":"2000","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"2021113011185294400_B42","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/377748a0","article-title":"Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor","volume":"377","author":"Ichiki","year":"1995","journal-title":"Nature"},{"key":"2021113011185294400_B43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11906-014-0512-2","article-title":"Neuroprotective Mechanisms of the ACE2\u2013Angiotensin-(1-7)\u2013Mas Axis in Stroke","volume":"17","author":"Bennion","year":"2015","journal-title":"Curr. Hypertens. Rep."},{"key":"2021113011185294400_B44","doi-asserted-by":"publisher","first-page":"383","DOI":"10.2174\/156801605774322373","article-title":"Angiotensin-(1-7): Blood, Heart, and Blood Vessels","volume":"3","author":"Santos","year":"2005","journal-title":"CMCCHA"},{"key":"2021113011185294400_B45","doi-asserted-by":"publisher","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2021113011185294400_B46","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2021113011185294400_B47","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"2021113011185294400_B48","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/hr.2012.161","article-title":"Brain renin\u2013angiotensin system in the nexus of hypertension and aging","volume":"36","author":"Arnold","year":"2013","journal-title":"Hypertens. Res."},{"key":"2021113011185294400_B49","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/ijms19030876","article-title":"Within the Brain: The Renin Angiotensin System","volume":"19","author":"Jackson","year":"2018","journal-title":"IJMS"},{"key":"2021113011185294400_B50","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12974-015-0306-8","article-title":"Brain inflammation and hypertension: the chicken or the egg?","volume":"12","author":"Winklewski","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"2021113011185294400_B51","doi-asserted-by":"publisher","first-page":"11440","DOI":"10.1073\/pnas.88.24.11440","article-title":"Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development","volume":"88","author":"Millan","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2021113011185294400_B52","doi-asserted-by":"publisher","first-page":"R209","DOI":"10.1152\/ajpregu.1991.261.1.R209","article-title":"Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain","volume":"261","author":"Tsutsumi","year":"1991","journal-title":"Am. J. Physiol. Regul. Integrat. Comparat. Physiol."},{"key":"2021113011185294400_B53","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1006\/frne.1997.0155","article-title":"Expression of Angiotensin Type-1 (AT1) and Type-2 (AT2) Receptor mRNAs in the Adult Rat Brain: A Functional Neuroanatomical Review","volume":"18","author":"Lenkei","year":"1997","journal-title":"Front. Neuroendocrinol."},{"key":"2021113011185294400_B54","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1523\/JNEUROSCI.5360-11.2012","article-title":"Angiotensin Type 1A Receptors in C1 Neurons of the Rostral Ventrolateral Medulla Modulate the Pressor Response to Aversive Stress","volume":"32","author":"Chen","year":"2012","journal-title":"J. Neurosci."},{"key":"2021113011185294400_B55","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroscience.2012.08.039","article-title":"Distribution of angiotensin type 1a receptor-containing cells in the brains of bacterial artificial chromosome transgenic mice","volume":"226","author":"Gonzalez","year":"2012","journal-title":"Neuroscience"},{"key":"2021113011185294400_B56","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41440-019-0374-8","article-title":"Brain angiotensin type-1 and type-2 receptors: cellular locations under normal and hypertensive conditions","volume":"43","author":"Sumners","year":"2020","journal-title":"Hypertens. Res."},{"key":"2021113011185294400_B57","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1152\/advan.00027.2016","article-title":"Central neural control of the cardiovascular system: current perspectives","volume":"40","author":"Dampney","year":"2016","journal-title":"Adv. Physiol. Educ."},{"key":"2021113011185294400_B58","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"2021113011185294400_B59","doi-asserted-by":"publisher","first-page":"R539","DOI":"10.1152\/ajpregu.00594.2004","article-title":"Nuclear localization of angiotensinogen in astrocytes","volume":"288","author":"Sherrod","year":"2005","journal-title":"Am. J. Physiol.-Regul. Integr. Comparat. Physiol."},{"key":"2021113011185294400_B60","doi-asserted-by":"publisher","first-page":"R373","DOI":"10.1152\/ajpregu.00292.2006","article-title":"Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system","volume":"292","author":"Doobay","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comparat. Physiol."},{"key":"2021113011185294400_B61","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1161\/HYPERTENSIONAHA.119.13133","article-title":"ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons","volume":"74","author":"Mukerjee","year":"2019","journal-title":"Hypertension"},{"key":"2021113011185294400_B62","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1161\/HYPERTENSIONAHA.119.12832","article-title":"Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation","volume":"73","author":"Xu","year":"2019","journal-title":"Hypertension"},{"key":"2021113011185294400_B63","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1161\/CIRCRESAHA.109.208645","article-title":"Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension","volume":"106","author":"Feng","year":"2010","journal-title":"Circ. Res."},{"key":"2021113011185294400_B64","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1113\/expphysiol.2009.047407","article-title":"Angiotensin-converting enzyme 2: a new target for neurogenic hypertension: Angiotensin-converting enzyme 2 and hypertension","volume":"95","author":"Feng","year":"2010","journal-title":"Exp. Physiol."},{"key":"2021113011185294400_B65","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1161\/01.RES.0000012460.85923.F0","article-title":"Brain-Selective Overexpression of Angiotensin (AT 1) Receptors Causes Enhanced Cardiovascular Sensitivity in Transgenic Mice","volume":"90","author":"Lazartigues","year":"2002","journal-title":"Circ. Res."},{"key":"2021113011185294400_B66","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1161\/CIRCRESAHA.110.224873","article-title":"Inflammation and Neurogenic Hypertension: A New Role for the Circumventricular Organs?","volume":"107","author":"Lazartigues","year":"2010","journal-title":"Circ. Res."},{"key":"2021113011185294400_B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.01-0457fje","article-title":"Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation","volume":"15","author":"Massi\u00e9ra","year":"2001","journal-title":"FASEB J."},{"key":"2021113011185294400_B68","doi-asserted-by":"publisher","first-page":"E891","DOI":"10.1152\/ajpendo.00551.2003","article-title":"Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity","volume":"286","author":"Rahmouni","year":"2004","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"2021113011185294400_B69","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1056\/NEJM198104163041602","article-title":"The Effect of Weight Reduction on Blood Pressure, Plasma Renin Activity, and Plasma Aldosterone Levels in Obese Patients","volume":"304","author":"Tuck","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"2021113011185294400_B70","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4274\/Jcrpe.1020","article-title":"Effects of ACE Inhibitors on Insulin Resistance and Lipid Profile in Children with Metabolic Syndrome","volume":"5","author":"Bitkin Eda","year":"2013","journal-title":"JCRPE"},{"key":"2021113011185294400_B71","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1475-2840-6-12","article-title":"Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: A sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients","volume":"6","author":"Kintscher","year":"2007","journal-title":"Cardiovasc. Diabetol."},{"key":"2021113011185294400_B72","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1111\/j.1476-5381.2011.01726.x","article-title":"Double blockade of angiotensin II (AT1)-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats: Metabolic outcome after telmisartan","volume":"165","author":"Miesel","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"2021113011185294400_B73","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1056\/NEJM198104163041602","article-title":"The Effect of Weight Reduction on Blood Pressure, Plasma Renin Activity, and Plasma Aldosterone Levels in Obese Patients","volume":"304","author":"Tuck","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"2021113011185294400_B74","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.physbeh.2009.05.009","article-title":"Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL\/6J mice maintained on a high fat diet","volume":"98","author":"Weisinger","year":"2009","journal-title":"Physiol. Behavior"},{"key":"2021113011185294400_B75","doi-asserted-by":"publisher","first-page":"R1223","DOI":"10.1152\/ajpregu.00362.2016","article-title":"High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice","volume":"311","author":"Chodavarapu","year":"2016","journal-title":"Am. J. Physiol. Regulat. Integrat. Comparat. Physiol."},{"key":"2021113011185294400_B76","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.physbeh.2016.11.020","article-title":"The intricacies of the renin-angiotensin-system in metabolic regulation","volume":"178","author":"Bruce","year":"2017","journal-title":"Physiol. Behavior"},{"key":"2021113011185294400_B77","doi-asserted-by":"publisher","first-page":"6235","DOI":"10.1113\/JP276229","article-title":"Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension","volume":"596","author":"Basting","year":"2018","journal-title":"J. Physiol."},{"key":"2021113011185294400_B78","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1161\/CIRCRESAHA.116.310509","article-title":"Clinical Relevance and Role of Neuronal AT 1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension","volume":"121","author":"Xu","year":"2017","journal-title":"Circ. Res."},{"key":"2021113011185294400_B79","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1172\/JCI88641","article-title":"Angiotensin AT1A receptors on leptin receptor\u2013expressing cells control resting metabolism","volume":"127","author":"Claflin","year":"2017","journal-title":"J. Clin. Invest."},{"key":"2021113011185294400_B80","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11906-018-0824-8","article-title":"Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin","volume":"20","author":"Morselli","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"2021113011185294400_B81","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1210\/en.2009-0065","article-title":"The Effect of Angiotensin-Converting Enzyme Inhibition Using Captopril on Energy Balance and Glucose Homeostasis","volume":"150","author":"de Kloet","year":"2009","journal-title":"Endocrinology"},{"key":"2021113011185294400_B82","doi-asserted-by":"publisher","first-page":"E1081","DOI":"10.1152\/ajpendo.00307.2011","article-title":"Central angiotensin II has catabolic action at white and brown adipose tissue","volume":"301","author":"de Kloet","year":"2011","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"2021113011185294400_B83","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.cmet.2010.09.011","article-title":"The Brain Renin-Angiotensin System Controls Divergent Efferent Mechanisms to Regulate Fluid and Energy Balance","volume":"12","author":"Grobe","year":"2010","journal-title":"Cell Metab."},{"key":"2021113011185294400_B84","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1097\/00004872-200410000-00006","article-title":"Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity","volume":"22","author":"Kingston","year":"2004","journal-title":"J. Hypertens."},{"key":"2021113011185294400_B85","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S0006-8993(02)03676-4","article-title":"Effect of central angiotensin II on body weight gain in young rats","volume":"959","author":"Porter","year":"2003","journal-title":"Brain Res."},{"key":"2021113011185294400_B86","doi-asserted-by":"publisher","first-page":"R422","DOI":"10.1152\/ajpregu.00537.2003","article-title":"Effect of intracerebroventricular angiotensin II on body weight and food intake in adult rats","volume":"287","author":"Porter","year":"2004","journal-title":"Am. J. Physiol. Regul. Integrat. Comparat. Physiol."},{"key":"2021113011185294400_B87","doi-asserted-by":"publisher","first-page":"a019133","DOI":"10.1101\/cshperspect.a019133","article-title":"DNA Methylation in Mammals","volume":"6","author":"Li","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"2021113011185294400_B88","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.1038\/sj.onc.1204341","article-title":"DNA methylation, methyltransferases, and cancer","volume":"20","author":"Robertson","year":"2001","journal-title":"Oncogene"},{"key":"2021113011185294400_B89","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1128\/MCB.23.16.5594-5605.2003","article-title":"Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b","volume":"23","author":"Chen","year":"2003","journal-title":"MCB"},{"key":"2021113011185294400_B90","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.stem.2014.06.018","article-title":"Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells","volume":"15","author":"Challen","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2021113011185294400_B91","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"2021113011185294400_B92","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"2021113011185294400_B93","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes Dev."},{"key":"2021113011185294400_B94","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/embor.2011.233","article-title":"DNA methylation: TET proteins\u2014guardians of CpG islands?","volume":"13","author":"Williams","year":"2012","journal-title":"EMBO Rep."},{"key":"2021113011185294400_B95","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1021\/cb2002895","article-title":"The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential","volume":"7","author":"Nabel","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"2021113011185294400_B96","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"2021113011185294400_B97","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1126\/science.1210944","article-title":"Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA","volume":"333","author":"He","year":"2011","journal-title":"Science"},{"key":"2021113011185294400_B98","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"2021113011185294400_B99","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature09934","article-title":"Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells","volume":"473","author":"Wu","year":"2011","journal-title":"Nature"},{"key":"2021113011185294400_B100","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1039\/C3SC51849C","article-title":"A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression","volume":"5","author":"Xu","year":"2014","journal-title":"Chem. Sci."},{"key":"2021113011185294400_B101","doi-asserted-by":"publisher","first-page":"e008281","DOI":"10.1161\/JAHA.117.008281","article-title":"Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II","volume":"7","author":"Takeda","year":"2018","journal-title":"JAHA"},{"key":"2021113011185294400_B102","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1161\/HYPERTENSIONAHA.113.02303","article-title":"Dynamic CCAAT\/Enhancer Binding Protein\u2013Associated Changes of DNA Methylation in the Angiotensinogen Gene","volume":"63","author":"Wang","year":"2014","journal-title":"Hypertension"},{"key":"2021113011185294400_B103","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000458520","article-title":"Hypomethylation of the Angiotensin II Type I Receptor (AGTR1) Gene Along with Environmental Factors Increases the Risk for Essential Hypertension","volume":"137","author":"Lin","year":"2017","journal-title":"Cardiology"},{"key":"2021113011185294400_B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-014-2295-9","article-title":"Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development","volume":"402","author":"Pei","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"2021113011185294400_B105","doi-asserted-by":"publisher","first-page":"478","DOI":"10.4161\/epi.6.4.14961","article-title":"Epigenetic regulation of somatic angiotensin-converting enzyme by DNA methylation and histone acetylation","volume":"6","author":"Rivi\u00e8re","year":"2011","journal-title":"Epigenetics"},{"key":"2021113011185294400_B106","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/nrendo.2016.87","article-title":"The role of diet and exercise in the transgenerational epigenetic landscape of T2DM","volume":"12","author":"Barr\u00e8s","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"2021113011185294400_B107","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1161\/01.RES.0000258855.60637.58","article-title":"Epigenetic Modification of the Renin-Angiotensin System in the Fetal Programming of Hypertension","volume":"100","author":"Bogdarina","year":"2007","journal-title":"Circ. Res."},{"key":"2021113011185294400_B108","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1530\/REP-13-0219","article-title":"Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring","volume":"146","author":"Zhang","year":"2013","journal-title":"Reproduction"},{"key":"2021113011185294400_B109","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1933719109351935","article-title":"Brain Renin-Angiotensin System: Fetal Epigenetic Programming by Maternal Protein Restriction During Pregnancy","volume":"17","author":"Goyal","year":"2010","journal-title":"Reprod. Sci."},{"key":"2021113011185294400_B110","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.2337\/db09-0782","article-title":"Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice","volume":"59","author":"Bindom","year":"2010","journal-title":"Diabetes"},{"key":"2021113011185294400_B111","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/iub.1190","article-title":"Angiotensin converting enzyme 2: A new important player in the regulation of glycemia: ACE2 in Regulation of Glycemia","volume":"65","author":"Chhabra","year":"2013","journal-title":"IUBMB Life"},{"key":"2021113011185294400_B112","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s10571-017-0502-4","article-title":"Perinatal Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring","volume":"38","author":"Mukerjee","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"2021113011185294400_B113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fasebj.2020.34.s1.02348","article-title":"Perinatal Epigenetic Modulation of the Brain Renin Angiotensin System Programs Cardiometabolic Diseases","volume":"34","author":"Elgazzaz","year":"2020","journal-title":"FASEB J."},{"key":"2021113011185294400_B114","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13148-015-0073-5","article-title":"Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat","volume":"7","author":"Ollikainen","year":"2015","journal-title":"Clin. Epigenet."},{"key":"2021113011185294400_B115","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s11010-019-03509-8","article-title":"Functional relevance of promoter CpG island of human Angiotensin II type 1 receptor (AT1R) gene","volume":"457","author":"Chaudhary","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"2021113011185294400_B116","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.3892\/mmr.2017.8081","article-title":"Effect of prehypertensive losartan therapy on AT1R and ATRAP methylation of adipose tissue in the later life of high-fat-fed spontaneously hypertensive rats","volume":"17","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"2021113011185294400_B117","first-page":"5952","article-title":"Hyperglycemia Induced Methylation Changes In Genes Of Ocular Renin Angiotensin System","volume":"52","author":"Verma","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2021113011185294400_B118","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"2021113011185294400_B119","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021113011185294400_B120","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","article-title":"MicroRNAs in Stress Signaling and Human Disease","volume":"148","author":"Mendell","year":"2012","journal-title":"Cell"},{"key":"2021113011185294400_B121","doi-asserted-by":"publisher","DOI":"10.2174\/15701611113119990012","article-title":"Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease","author":"Araldi","year":"2015"},{"key":"2021113011185294400_B122","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1016\/j.bbalip.2016.01.013","article-title":"MicroRNAs as regulators of endothelial cell functions in cardiometabolic diseases","volume":"1861","author":"Araldi","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Biol. Lipids"},{"key":"2021113011185294400_B123","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.phrs.2013.04.002","article-title":"MicroRNAs as pharmacological targets in endothelial cell function and dysfunction","volume":"75","author":"Chamorro-Jorganes","year":"2013","journal-title":"Pharmacol. Res."},{"key":"2021113011185294400_B124","doi-asserted-by":"publisher","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"2021113011185294400_B125","doi-asserted-by":"publisher","first-page":"H557","DOI":"10.1152\/ajpheart.00711.2013","article-title":"Circulating micrornas as potential biomarkers of aerobic exercise capacity","volume":"306","author":"Mooren","year":"2014","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"key":"2021113011185294400_B126","doi-asserted-by":"publisher","first-page":"11190","DOI":"10.3390\/ijms140611190","article-title":"Angiotensin II Regulates microRNA-132\/-212 in Hypertensive Rats and Humans","volume":"14","author":"Eskildsen","year":"2013","journal-title":"IJMS"},{"key":"2021113011185294400_B127","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.gene.2016.03.015","article-title":"MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes","volume":"585","author":"Li","year":"2016","journal-title":"Gene"},{"key":"2021113011185294400_B128","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.3892\/ijmm.2014.1935","article-title":"Role of microRNA-29b in angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells","volume":"34","author":"Pan","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"2021113011185294400_B129","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708046","article-title":"miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders","volume":"10","author":"Widlansky","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"2021113011185294400_B130","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1086\/519979","article-title":"Human microRNA-155 on Chromosome 21 Differentially Interacts with Its Polymorphic Target in the AGTR1 3\u2032 Untranslated Region: A Mechanism for Functional Single-Nucleotide Polymorphisms Related to Phenotypes","volume":"81","author":"Sethupathy","year":"2007","journal-title":"Am. J. Human Genet."},{"key":"2021113011185294400_B131","first-page":"393","article-title":"microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women","volume":"27","author":"Cheng","year":"2011","journal-title":"Int. J. Mol. Med."},{"key":"2021113011185294400_B132","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1038\/cdd.2009.153","article-title":"The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease","volume":"16","author":"Elia","year":"2009","journal-title":"Cell Death Differ."},{"key":"2021113011185294400_B133","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1161\/HYPERTENSIONAHA.113.01701","article-title":"A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH\/2J Genetically Hypertensive Mice","volume":"62","author":"Jackson","year":"2013","journal-title":"Hypertension"},{"key":"2021113011185294400_B134","doi-asserted-by":"publisher","first-page":"739","DOI":"10.2119\/molmed.2015.00096","article-title":"Signatures of miR-181a on the Renal Transcriptome and Blood Pressure","volume":"21","author":"Marques","year":"2015","journal-title":"Mol. Med."},{"key":"2021113011185294400_B135","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1152\/physiolgenomics.00047.2015","article-title":"MicroRNA network changes in the brain stem underlie the development of hypertension","volume":"47","author":"DeCicco","year":"2015","journal-title":"Physiol. Genomics"},{"key":"2021113011185294400_B136","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/jhh.2013.97","article-title":"Renin-sensitive microRNAs correlate with atherosclerosis plaque progression","volume":"28","author":"Deiuliis","year":"2014","journal-title":"J. Hum. Hypertens."},{"key":"2021113011185294400_B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/173783","article-title":"MicroRNA in Diabetic Nephropathy: Renin Angiotensin, AGE\/RAGE, and Oxidative Stress Pathway","volume":"2013","author":"Hagiwara","year":"2013","journal-title":"J. Diabetes Res."},{"key":"2021113011185294400_B138","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3109\/10408363.2014.937522","article-title":"Relevance of microRNA in metabolic diseases","volume":"51","author":"Price","year":"2014","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"2021113011185294400_B139","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.phrs.2019.01.043","article-title":"Diabetic nephropathy: The regulatory interplay between epigenetics and microRNAs","volume":"141","author":"Sankrityayan","year":"2019","journal-title":"Pharmacol. Res."},{"key":"2021113011185294400_B140","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1751-7176.2011.00449.x","article-title":"Renin-Angiotensin-Aldosterone System in Diabetes and Hypertension","volume":"13","author":"Hsueh","year":"2011","journal-title":"J. Clin. Hypertension"},{"key":"2021113011185294400_B141","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"2021113011185294400_B142","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nature03714","article-title":"A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response","volume":"436","author":"Masumoto","year":"2005","journal-title":"Nature"},{"key":"2021113011185294400_B143","doi-asserted-by":"publisher","first-page":"25949","DOI":"10.1074\/jbc.C500181200","article-title":"Characterization of Lysine 56 of Histone H3 as an Acetylation Site in Saccharomyces cerevisiae","volume":"280","author":"Ozdemir","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021113011185294400_B144","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cell.2005.03.011","article-title":"Acetylation in Histone H3 Globular Domain Regulates Gene Expression in Yeast","volume":"121","author":"Xu","year":"2005","journal-title":"Cell"},{"key":"2021113011185294400_B145","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nrm3890","article-title":"Histone core modifications regulating nucleosome structure and dynamics","volume":"15","author":"Tessarz","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021113011185294400_B146","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/35065132","article-title":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins","volume":"410","author":"Lachner","year":"2001","journal-title":"Nature"},{"key":"2021113011185294400_B147","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1101\/gad.12.5.599","article-title":"Histone acetylation and transcriptional regulatory mechanisms","volume":"12","author":"Struhl","year":"1998","journal-title":"Genes Dev."},{"key":"2021113011185294400_B148","doi-asserted-by":"publisher","first-page":"11621","DOI":"10.1074\/jbc.C200045200","article-title":"Histone H3 Lysine 4 Methylation Disrupts Binding of Nucleosome Remodeling and Deacetylase (NuRD) Repressor Complex","volume":"277","author":"Zegerman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021113011185294400_B149","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbamcr.2004.09.019","article-title":"Ubiquitin: structures, functions, mechanisms","volume":"1695","author":"Pickart","year":"2004","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"2021113011185294400_B150","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"2021113011185294400_B151","volume-title":"Epigenetics in human disease.","author":"Tollefsbol","year":"2018","edition":"2nd edn"},{"key":"2021113011185294400_B152","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/ijo.2017.166","article-title":"Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1\/angiotensin II axis","volume":"41","author":"Choi","year":"2017","journal-title":"Int. J. Obes."},{"key":"2021113011185294400_B153","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/HYPERTENSIONAHA.115.05962","article-title":"Human GRK4\u03b3 142V Variant Promotes Angiotensin II Type I Receptor\u2013Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition","volume":"67","author":"Wang","year":"2016","journal-title":"Hypertension"},{"key":"2021113011185294400_B154","doi-asserted-by":"publisher","first-page":"H699","DOI":"10.1152\/ajpheart.01152.2007","article-title":"Identity of the renin cell is mediated by cAMP and chromatin remodeling: an in vitro model for studying cell recruitment and plasticity","volume":"294","author":"Pentz","year":"2008","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"key":"2021113011185294400_B155","doi-asserted-by":"publisher","first-page":"H2545","DOI":"10.1152\/ajpheart.00782.2011","article-title":"Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype","volume":"302","author":"Pentz","year":"2012","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"key":"2021113011185294400_B156","doi-asserted-by":"publisher","first-page":"e12270","DOI":"10.14814\/phy2.12270","article-title":"Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life","volume":"3","author":"Wang","year":"2015","journal-title":"Physiol. Rep."},{"key":"2021113011185294400_B157","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/ki.2013.387","article-title":"Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db\/db mice","volume":"85","author":"Reddy","year":"2014","journal-title":"Kidney Int."},{"key":"2021113011185294400_B158","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jff.2015.05.017","article-title":"Esculetin reverses histone H2A\/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy","volume":"17","author":"Kadakol","year":"2015","journal-title":"J. Funct. Foods"},{"key":"2021113011185294400_B159","doi-asserted-by":"publisher","first-page":"39469","DOI":"10.1038\/srep39469","article-title":"Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"2021113011185294400_B160","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1161\/HYPERTENSIONAHA.111.182428","article-title":"Tissue-Specific Upregulation of Angiotensin-Converting Enzyme 1 in Spontaneously Hypertensive Rats Through Histone Code Modifications","volume":"59","author":"Lee","year":"2012","journal-title":"Hypertension"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/135\/1\/127\/901455\/cs-2020-1287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/135\/1\/127\/901455\/cs-2020-1287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:16:49Z","timestamp":1638274609000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/135\/1\/127\/227535\/Epigenetic-modifications-of-the-renin-angiotensin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":160,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,15]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20201287","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1]]},"published":{"date-parts":[[2021,1]]}}}