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Consisting of two antagonistic modules, the pathway plays an integral role in both tumour suppressive and oncogenic processes, generally via regulation of a diverse set of genes involved in a range of biological functions. This review discusses the history of the pathway within the context of cancer and explores some of the most recent discoveries as to how this critical transducer of cellular signalling can influence cancer progression. A special focus is on the various recent efforts to therapeutically target the key effectors of the pathway in both preclinical and clinical settings.<\/jats:p>","DOI":"10.1042\/cs20201474","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T04:27:24Z","timestamp":1643948844000},"page":"197-222","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":301,"title":["The Hippo pathway in cancer: YAP\/TAZ and TEAD as therapeutic targets in cancer"],"prefix":"10.1042","volume":"136","author":[{"given":"Richard","family":"Cunningham","sequence":"first","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Queen\u2019s Medical Research Institute, Edinburgh bioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-7482","authenticated-orcid":false,"given":"Carsten\u00a0Gram","family":"Hansen","sequence":"additional","affiliation":[{"name":"University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Queen\u2019s Medical Research Institute, Edinburgh bioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"2022020409270481300_B1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.tcb.2019.10.005","article-title":"The Hippo pathway, YAP\/TAZ, and the plasma membrane","volume":"30","author":"Rausch","year":"2020","journal-title":"Trends Cell Biol."},{"key":"2022020409270481300_B2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"2022020409270481300_B3","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1042\/BST20200253","article-title":"Cellular feedback dynamics and multilevel regulation driven by the hippo pathway","volume":"49","author":"Park","year":"2021","journal-title":"Biochem. 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