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This wide-reaching capability has generated much interest across a range of disciplines resulting in several clinical trials and studies into the mechanistic basis of VNS. This review discusses current preclinical and clinical evidence supporting the efficacy of VNS in different diseases and highlights recent advancements. Studies that provide insights into the mechanism of VNS are considered.<\/jats:p>","DOI":"10.1042\/cs20210507","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T09:12:54Z","timestamp":1652173974000},"page":"695-709","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Clinical perspectives on vagus nerve stimulation: present and future"],"prefix":"10.1042","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-7726","authenticated-orcid":false,"given":"Eibhlin","family":"Goggins","sequence":"first","affiliation":[{"name":"Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Mitani","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3906-6675","authenticated-orcid":false,"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2022051013124423300_B1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1097\/00005053-193711000-00019","article-title":"Quantitative studies of the vagus nerve in the cat: I. 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