{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:41:52Z","timestamp":1791387712173,"version":"4.3.3"},"reference-count":141,"publisher":"Portland Press Ltd.","issue":"21","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sarcopenia is defined as the progressive and generalized loss of skeletal muscle mass and strength, which is associated with increased likelihood of adverse outcomes including falls, fractures, physical disability, and mortality. The etiology of sarcopenia has been postulated to be multifactorial with genetics, aging, immobility, nutritional deficiencies, inflammation, stress, and endocrine factors all contributing to the imbalance of muscle anabolism and catabolism. The prevalence of sarcopenia is estimated to range from 13 to 24% in adults over 60 years of age and up to 50% in persons aged 80 and older. As the population continues to age, the prevalence of sarcopenia continues to increase and is expected to affect 500 million people by the year 2050. Sarcopenia impacts the overall health of patients through limitations in functional status, increase in hospital readmissions, poorer hospital outcomes, and increase in overall mortality. Thus, there exists a need to prevent or reduce the occurrence of sarcopenia. Here, we explore the potential mechanisms and current studies regarding angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors on reducing the development of sarcopenia through the associated changes in cardiovascular function, renal function, muscle fiber composition, inflammation, endothelial dysfunction, metabolic efficiency, and mitochondrial function.<\/jats:p>","DOI":"10.1042\/cs20210719","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T10:51:07Z","timestamp":1636455067000},"page":"2503-2520","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia"],"prefix":"10.1042","volume":"135","author":[{"given":"Jeffrey","family":"Kingsley","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Torimoto","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Barrow Aneurysm and AVM Research Center, Departments of Neurosurgery and Neurobiology, Barrow Neurological Institute, 350 W. Thomas Rd, Phoenix, AZ 85013, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8407-7501","authenticated-orcid":false,"given":"Satoru","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"2021113011243232000_B1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"2021113011243232000_B2","first-page":"10","article-title":"Muscle strength as a predictor of onset of ADL dependence in people aged 75 years","volume":"14","author":"Rantanen","year":"2002","journal-title":"Aging Clin. Exp. Res."},{"key":"2021113011243232000_B3","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1111\/jgs.16517","article-title":"Putative cut-points in sarcopenia components and incident adverse health outcomes: an SDOC analysis","volume":"68","author":"Cawthon","year":"2020","journal-title":"J. Am. Geriatr. Soc."},{"key":"2021113011243232000_B4","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.clnu.2013.01.010","article-title":"Sarcopenia: prevalence and prognostic significance in hospitalized patients","volume":"32","author":"Gariballa","year":"2013","journal-title":"Clin. Nutr."},{"key":"2021113011243232000_B5","doi-asserted-by":"publisher","first-page":"R206","DOI":"10.1186\/cc12901","article-title":"Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients","volume":"17","author":"Moisey","year":"2013","journal-title":"Crit. Care"},{"key":"2021113011243232000_B6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/cc13189","article-title":"Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients","volume":"18","author":"Weijs PJ","year":"2014","journal-title":"Crit. Care"},{"key":"2021113011243232000_B7","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.clnu.2020.10.044","article-title":"The joint association of sarcopenia and frailty with incidence and mortality health outcomes: a prospective study","volume":"40","author":"Petermann-Rocha","year":"2021","journal-title":"Clin. Nutr."},{"key":"2021113011243232000_B8","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072349","article-title":"Nutrition and frailty: opportunities for prevention and treatment","volume":"13","author":"Ni Lochlainn","year":"2021","journal-title":"Nutrients"},{"key":"2021113011243232000_B9","doi-asserted-by":"publisher","first-page":"8031705","DOI":"10.1155\/2019\/8031705","article-title":"Sarcopenia and its implications for metabolic health","volume":"2019","author":"Hunter","year":"2019","journal-title":"J. Obes."},{"key":"2021113011243232000_B10","doi-asserted-by":"publisher","first-page":"101200","DOI":"10.1016\/j.arr.2020.101200","article-title":"Sarcopenia - molecular mechanisms and open questions","volume":"65","author":"Wiedmer","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"2021113011243232000_B11","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4989","article-title":"Pathophysiology and mechanisms of primary sarcopenia (review)","volume":"48","author":"Nishikawa","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"2021113011243232000_B12","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/ageing\/afaa237","article-title":"Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review","volume":"50","author":"Amarasekera","year":"2021","journal-title":"Age Ageing"},{"key":"2021113011243232000_B13","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.atherosclerosis.2017.01.005","article-title":"Sarcopenia, but not excess weight or increased caloric intake, is associated with coronary subclinical atherosclerosis in the very elderly","volume":"258","author":"Campos","year":"2017","journal-title":"Atherosclerosis"},{"key":"2021113011243232000_B14","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jamda.2016.09.006","article-title":"Sarcopenia and endothelial function in patients with chronic heart failure: results from the Studies Investigating Comorbidities Aggravating Heart Failure (SICA-HF)","volume":"18","author":"Dos Santos","year":"2017","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"2021113011243232000_B15","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/gerona\/glv180","article-title":"endothelial progenitor cell levels predict future physical function: an exploratory analysis from the VA Enhanced Fitness Study","volume":"71","author":"Povsic","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2021113011243232000_B16","first-page":"6","article-title":"Circulating CD34-positive cells are associated with handgrip strength in Japanese older men: The Nagasaki Islands Study","volume":"6","author":"Yamanashi","year":"2017","journal-title":"J. Frailty Aging"},{"key":"2021113011243232000_B17","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10522-010-9292-5","article-title":"Frailty, inflammation and the elderly","volume":"11","author":"Hubbard","year":"2010","journal-title":"Biogerontology"},{"key":"2021113011243232000_B18","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s00395-008-0733-0","article-title":"The role of inflammatory cytokines in endothelial dysfunction","volume":"103","author":"Zhang","year":"2008","journal-title":"Basic Res. Cardiol."},{"key":"2021113011243232000_B19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1152\/japplphysiol.00608.2014","article-title":"Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice","volume":"118","author":"Justice","year":"2015","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2021113011243232000_B20","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.2337\/db06-1228","article-title":"Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial beta-oxidation","volume":"56","author":"Le Gouill","year":"2007","journal-title":"Diabetes"},{"key":"2021113011243232000_B21","doi-asserted-by":"publisher","first-page":"R1399","DOI":"10.1152\/ajpregu.00004.2010","article-title":"Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo","volume":"298","author":"Lee-Young","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113011243232000_B22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s11357-011-9238-0","article-title":"Pulse wave velocity is associated with muscle mass decline: Health ABC study","volume":"34","author":"Abbatecola","year":"2012","journal-title":"Age (Dordr.)"},{"key":"2021113011243232000_B23","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/s41440-020-0404-6","article-title":"Increased arterial velocity pulse index is an independent factor related to skeletal muscle mass reduction and tissue damage in patients with cardiovascular disease","volume":"43","author":"Harada","year":"2020","journal-title":"Hypertens. Res."},{"key":"2021113011243232000_B24","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1161\/HYPERTENSIONAHA.120.15184","article-title":"Unraveling the links underlying arterial stiffness, bone demineralization, and muscle loss","volume":"76","author":"Tap","year":"2020","journal-title":"Hypertension"},{"key":"2021113011243232000_B25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12877-020-01672-y","article-title":"Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis","volume":"20","author":"Bai","year":"2020","journal-title":"BMC Geriatr."},{"key":"2021113011243232000_B26","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/oby.2004.107","article-title":"Sarcopenic obesity: the confluence of two epidemics","volume":"12","author":"Roubenoff","year":"2004","journal-title":"Obes. Res."},{"key":"2021113011243232000_B27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ijcard.2016.07.135","article-title":"Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life","volume":"222","author":"Bekfani","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"2021113011243232000_B28","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/ehf2.12237","article-title":"Muscle wasting and sarcopenia in heart failure and beyond: update 2017","volume":"4","author":"Springer","year":"2017","journal-title":"ESC Heart Fail."},{"key":"2021113011243232000_B29","first-page":"116","article-title":"Sarcopenia in heart failure with reduced ejection fraction","volume":"9","author":"Canteri","year":"2019","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"2021113011243232000_B30","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2147\/DMSO.S186600","article-title":"Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship","volume":"12","author":"Mesinovic","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"2021113011243232000_B31","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.2337\/dc09-2310","article-title":"Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS)","volume":"33","author":"Kim","year":"2010","journal-title":"Diabetes Care"},{"key":"2021113011243232000_B32","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.2337\/dc06-2537","article-title":"Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study","volume":"30","author":"Park","year":"2007","journal-title":"Diabetes Care"},{"key":"2021113011243232000_B33","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1530\/JOE-15-0533","article-title":"Insulin resistance and sarcopenia: mechanistic links between common co-morbidities","volume":"229","author":"Cleasby","year":"2016","journal-title":"J. Endocrinol."},{"key":"2021113011243232000_B34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4093\/dmj.2016.40.2.140","article-title":"Hyperglycemia is associated with impaired muscle quality in older men with diabetes: The Korean Longitudinal Study on Health and Aging","volume":"40","author":"Yoon","year":"2016","journal-title":"Diabetes Metab. J."},{"key":"2021113011243232000_B35","doi-asserted-by":"publisher","first-page":"M326","DOI":"10.1093\/gerona\/57.5.M326","article-title":"Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study","volume":"57","author":"Visser","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2021113011243232000_B36","doi-asserted-by":"publisher","first-page":"806","DOI":"10.2337\/diabetes.55.03.06.db05-1237","article-title":"Muscle weakness: a progressive late complication in diabetic distal symmetric polyneuropathy","volume":"55","author":"Andreassen","year":"2006","journal-title":"Diabetes"},{"key":"2021113011243232000_B37","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092902","article-title":"Resistance exercise, electrical muscle stimulation, and whole-body vibration in older adults: systematic review and meta-analysis of randomized controlled trials","volume":"9","author":"Sarabon","year":"2020","journal-title":"J. Clin. Med."},{"key":"2021113011243232000_B38","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1249\/00005768-199506000-00017","article-title":"Strength improvements with 1 yr of progressive resistance training in older women","volume":"27","author":"Morganti","year":"1995","journal-title":"Med. Sci. Sports Exerc."},{"key":"2021113011243232000_B39","doi-asserted-by":"publisher","first-page":"M918","DOI":"10.1093\/gerona\/58.10.M918","article-title":"Exercise, aging, and muscle protein metabolism","volume":"58","author":"Yarasheski","year":"2003","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2021113011243232000_B40","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3390\/app10051695","article-title":"Effect of whole-body vibration training on the physical capability, activities of daily living, and sleep quality of older people with sarcopenia","volume":"10","author":"Lin","year":"2020","journal-title":"Appl. Sci."},{"key":"2021113011243232000_B41","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jamda.2010.04.014","article-title":"Nutritional recommendations for the management of sarcopenia","volume":"11","author":"Morley","year":"2010","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"2021113011243232000_B42","first-page":"25","article-title":"Exercise as a remedy for sarcopenia","volume":"17","author":"Landi","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"2021113011243232000_B43","doi-asserted-by":"publisher","first-page":"863","DOI":"10.14336\/AD.2019.1012","article-title":"Exercise programs for muscle mass, muscle strength and physical performance in older adults with sarcopenia: a systematic review and meta-analysis","volume":"11","author":"Bao","year":"2020","journal-title":"Aging Dis."},{"key":"2021113011243232000_B44","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061755","article-title":"Nutrition and sarcopenia-what do we know?","volume":"12","author":"Ganapathy","year":"2020","journal-title":"Nutrients"},{"key":"2021113011243232000_B45","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123601","article-title":"Fighting sarcopenia in ageing European adults: the importance of the amount and source of dietary proteins","volume":"12","author":"Montiel-Rojas","year":"2020","journal-title":"Nutrients"},{"key":"2021113011243232000_B46","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1093\/ajcn\/69.6.1202","article-title":"Protein pulse feeding improves protein retention in elderly women","volume":"69","author":"Arnal","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"2021113011243232000_B47","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/MCO.0b013e32831cef8b","article-title":"Dietary protein recommendations and the prevention of sarcopenia","volume":"12","author":"Paddon-Jones","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"2021113011243232000_B48","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/MCO.0b013e3282fa17fb","article-title":"Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis","volume":"11","author":"Drummond","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"2021113011243232000_B49","doi-asserted-by":"publisher","first-page":"69E","DOI":"10.1016\/j.amjcard.2008.03.004","article-title":"Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia","volume":"101","author":"Solerte","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"2021113011243232000_B50","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3945\/ajcn.115.112359","article-title":"Leucine partially protects muscle mass and function during bed rest in middle-aged adults","volume":"103","author":"English","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"2021113011243232000_B51","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1093\/ajcn\/75.5.944","article-title":"Effect of liquid dietary supplements on energy intake in the elderly","volume":"75","author":"Wilson","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"2021113011243232000_B52","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ejim.2016.07.017","article-title":"Aging of the endocrine system and its potential impact on sarcopenia","volume":"35","author":"Vitale","year":"2016","journal-title":"Eur. J. Intern. Med."},{"key":"2021113011243232000_B53","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00223-015-0022-5","article-title":"Pharmacologic options for the treatment of sarcopenia","volume":"98","author":"Morley","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"2021113011243232000_B54","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.fertnstert.2013.04.009","article-title":"Scientific overview of hormone treatment used for rejuvenation","volume":"99","author":"Morley","year":"2013","journal-title":"Fertil. Steril."},{"key":"2021113011243232000_B55","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1365-2265.1993.tb02388.x","article-title":"Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations","volume":"39","author":"Cohn","year":"1993","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"2021113011243232000_B56","doi-asserted-by":"publisher","first-page":"104","DOI":"10.7326\/0003-4819-146-2-200701160-00005","article-title":"Systematic review: the safety and efficacy of growth hormone in the healthy elderly","volume":"146","author":"Liu","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"2021113011243232000_B57","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"2021113011243232000_B58","doi-asserted-by":"publisher","first-page":"135","DOI":"10.11138\/ccmbm\/2015.12.2.135","article-title":"Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?","volume":"12","author":"Sartiani","year":"2015","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"2021113011243232000_B59","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.atherosclerosis.2010.05.026","article-title":"Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men","volume":"212","author":"Ochi","year":"2010","journal-title":"Atherosclerosis"},{"key":"2021113011243232000_B60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/10409238.2013.857291","article-title":"Signaling pathways controlling skeletal muscle mass","volume":"49","author":"Egerman","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"2021113011243232000_B61","doi-asserted-by":"publisher","first-page":"82ra37","DOI":"10.1126\/scitranslmed.3002227","article-title":"Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia","volume":"3","author":"Burks","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"2021113011243232000_B62","doi-asserted-by":"publisher","first-page":"35137","DOI":"10.1074\/jbc.M601320200","article-title":"Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells","volume":"281","author":"Wei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2021113011243232000_B63","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1152\/japplphysiol.00898.2018","article-title":"Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle","volume":"126","author":"Silva","year":"2019","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2021113011243232000_B64","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.cellsig.2005.09.009","article-title":"Mechanism of induction of muscle protein degradation by angiotensin II","volume":"18","author":"Russell","year":"2006","journal-title":"Cell. Signal."},{"key":"2021113011243232000_B65","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1161\/CIRCRESAHA.114.305393","article-title":"Angiotensin II induces skeletal muscle atrophy by activating TFEB-mediated MuRF1 expression","volume":"117","author":"Du Bois","year":"2015","journal-title":"Circ. Res."},{"key":"2021113011243232000_B66","doi-asserted-by":"publisher","first-page":"H1565","DOI":"10.1152\/ajpheart.00146.2010","article-title":"IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression","volume":"298","author":"Yoshida","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011243232000_B67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194912","article-title":"Angiotensin-II drives human satellite cells toward hypertrophy and myofibroblast trans-differentiation by two independent pathways","volume":"20","author":"Laurino","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021113011243232000_B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.regpep.2010.02.001","article-title":"Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas","volume":"161","author":"Munoz","year":"2010","journal-title":"Regul. Pept."},{"key":"2021113011243232000_B69","doi-asserted-by":"publisher","first-page":"e021030","DOI":"10.1161\/JAHA.120.021030","article-title":"Double deletion of Angiotensin II Type 2 and Mas receptors accelerates aging-related muscle weakness in male mice","volume":"10","author":"Takeshita","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"2021113011243232000_B70","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41440-019-0375-7","article-title":"Different effects of the deletion of angiotensin converting enzyme 2 and chronic activation of the renin-angiotensin system on muscle weakness in middle-aged mice","volume":"43","author":"Takeshita","year":"2020","journal-title":"Hypertens. Res."},{"key":"2021113011243232000_B71","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/jcsm.12334","article-title":"Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice","volume":"9","author":"Takeshita","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2021113011243232000_B72","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2018.10.417","article-title":"Mitochondria and cellular senescence: Implications for musculoskeletal ageing","volume":"132","author":"Habiballa","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"2021113011243232000_B73","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ebiom.2019.10.034","article-title":"Skeletal muscle as potential central link between sarcopenia and immune senescence","volume":"49","author":"Nelke","year":"2019","journal-title":"EBioMedicine"},{"key":"2021113011243232000_B74","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1097\/FJC.0000000000000878","article-title":"Senolytic agent Navitoclax inhibits Angiotensin II-induced heart failure in mice","volume":"76","author":"Jia","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021113011243232000_B75","doi-asserted-by":"publisher","first-page":"111416","DOI":"10.1016\/j.exger.2021.111416","article-title":"Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice","volume":"151","author":"Parvizi","year":"2021","journal-title":"Exp. Gerontol."},{"key":"2021113011243232000_B76","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186579","article-title":"Targeting molecular mechanism of vascular smooth muscle senescence induced by Angiotensin II, a potential therapy via senolytics and senomorphics","volume":"21","author":"Okuno","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2021113011243232000_B77","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093112","article-title":"Involvement of senescence and mitochondrial fission in endothelial cell pro-inflammatory phenotype induced by angiotensin II","volume":"21","author":"Miyao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2021113011243232000_B78","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1161\/CIRCRESAHA.111.246876","article-title":"The intersection between aging and cardiovascular disease","volume":"110","author":"North","year":"2012","journal-title":"Circ. Res."},{"key":"2021113011243232000_B79","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/j.1532-5415.2004.52265.x","article-title":"Antihypertensive medications and differences in muscle mass in older persons: the Health, Aging and Body Composition Study","volume":"52","author":"Di Bari","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"2021113011243232000_B80","doi-asserted-by":"publisher","first-page":"H252","DOI":"10.1152\/ajpheart.00149.2014","article-title":"HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling","volume":"307","author":"Demos-Davies","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011243232000_B81","doi-asserted-by":"publisher","first-page":"e0176230","DOI":"10.1371\/journal.pone.0176230","article-title":"Sarcopenia in patients with chronic kidney disease not yet on dialysis: analysis of the prevalence and associated factors","volume":"12","author":"Souza","year":"2017","journal-title":"PLoS ONE"},{"key":"2021113011243232000_B82","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/jhn.12555","article-title":"Differences in the prevalence of sarcopenia in haemodialysis patients: the effects of gender and ethnicity","volume":"31","author":"Yoowannakul","year":"2018","journal-title":"J. Hum. Nutr. Diet."},{"key":"2021113011243232000_B83","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/MNH.0000000000000318","article-title":"Clinical relevance of sarcopenia in chronic kidney disease","volume":"26","author":"Moorthi","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"2021113011243232000_B84","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/med.21343","article-title":"Renin-angiotensin system: an old player with novel functions in skeletal muscle","volume":"35","author":"Cabello-Verrugio","year":"2015","journal-title":"Med. Res. Rev."},{"key":"2021113011243232000_B85","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1056\/NEJM199612193352507","article-title":"Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway","volume":"335","author":"Mitch","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"2021113011243232000_B86","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12882-019-1223-3","article-title":"Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients","volume":"20","author":"Lin YL","year":"2019","journal-title":"BMC Nephrol."},{"key":"2021113011243232000_B87","doi-asserted-by":"publisher","first-page":"e2500","DOI":"10.1097\/MD.0000000000002500","article-title":"Relationship between sarcopenia and albuminuria: The 2011 Korea National Health and Nutrition Examination Survey","volume":"95","author":"Kim","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2021113011243232000_B88","doi-asserted-by":"publisher","first-page":"e0192990","DOI":"10.1371\/journal.pone.0192990","article-title":"Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease","volume":"13","author":"Ishikawa","year":"2018","journal-title":"PLoS ONE"},{"key":"2021113011243232000_B89","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1681\/ASN.2008060628","article-title":"IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting","volume":"20","author":"Zhang","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011243232000_B90","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/ki.2009.260","article-title":"Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function","volume":"76","author":"Wang","year":"2009","journal-title":"Kidney Int."},{"key":"2021113011243232000_B91","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3109\/00313027109073739","article-title":"Population of muscle satellite cells in relation to age and mitotic activity","volume":"3","author":"Allbrook","year":"1971","journal-title":"Pathology"},{"key":"2021113011243232000_B92","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/mus.10394","article-title":"Effects of endurance training on satellite cell frequency in skeletal muscle of old men","volume":"28","author":"Charifi","year":"2003","journal-title":"Muscle Nerve"},{"key":"2021113011243232000_B93","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"Cohn","year":"2007","journal-title":"Nat. Med."},{"key":"2021113011243232000_B94","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1161\/01.CIR.98.17.1742","article-title":"Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition","volume":"98","author":"Vescovo","year":"1998","journal-title":"Circulation"},{"key":"2021113011243232000_B95","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1034\/j.1399-0004.2003.00029.x","article-title":"The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle","volume":"63","author":"Zhang","year":"2003","journal-title":"Clin. Genet."},{"key":"2021113011243232000_B96","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1113\/expphysiol.2014.084095","article-title":"Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle","volume":"100","author":"Kadoguchi","year":"2015","journal-title":"Exp. Physiol."},{"key":"2021113011243232000_B97","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s11357-012-9428-4","article-title":"Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle","volume":"35","author":"Marzetti","year":"2013","journal-title":"Age (Dordr.)"},{"key":"2021113011243232000_B98","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1469-7793.1999.0189o.x","article-title":"Nitric oxide synthase inhibitors reduce sarcomere addition in rat skeletal muscle","volume":"519","author":"Koh","year":"1999","journal-title":"J. Physiol."},{"key":"2021113011243232000_B99","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1053\/euhj.1998.1446","article-title":"Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure","volume":"20","author":"Anker","year":"1999","journal-title":"Eur. Heart J."},{"key":"2021113011243232000_B100","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1161\/01.ATV.19.7.1623","article-title":"Angiotensin induces inflammatory activation of human vascular smooth muscle cells","volume":"19","author":"Kranzhofer","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113011243232000_B101","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1161\/01.HYP.27.4.849","article-title":"Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans","volume":"27","author":"Gerhard","year":"1996","journal-title":"Hypertension"},{"key":"2021113011243232000_B102","doi-asserted-by":"publisher","first-page":"H425","DOI":"10.1152\/ajpheart.00689.2008","article-title":"Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase","volume":"297","author":"Donato","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011243232000_B103","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1161\/01.HYP.38.2.274","article-title":"Age-related reduction of NO availability and oxidative stress in humans","volume":"38","author":"Taddei","year":"2001","journal-title":"Hypertension"},{"key":"2021113011243232000_B104","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0889-8561(02)00056-5","article-title":"Age-related inflammatory cytokines and disease","volume":"23","author":"Bruunsgaard","year":"2003","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"2021113011243232000_B105","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1161\/01.CIR.100.2.164","article-title":"Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand","volume":"100","author":"Dinenno","year":"1999","journal-title":"Circulation"},{"key":"2021113011243232000_B106","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1152\/jappl.1998.85.1.68","article-title":"Reduced leg blood flow during dynamic exercise in older endurance-trained men","volume":"85","author":"Proctor","year":"1998","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2021113011243232000_B107","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/0735-1097(94)90115-5","article-title":"Effect of angiotensin-converting enzyme inhibitors on endothelium-dependent peripheral vasodilation in patients with chronic heart failure","volume":"24","author":"Nakamura","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113011243232000_B108","doi-asserted-by":"publisher","first-page":"660","DOI":"10.7326\/0003-4819-144-9-200605020-00009","article-title":"Brief communication: ramipril markedly improves walking ability in patients with peripheral arterial disease: a randomized trial","volume":"144","author":"Ahimastos","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"2021113011243232000_B109","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1161\/01.CIR.101.14.1653","article-title":"Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan","volume":"101","author":"Schiffrin","year":"2000","journal-title":"Circulation"},{"key":"2021113011243232000_B110","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3317\/jraas.2003.032","article-title":"Effects of ACE inhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients","volume":"4","author":"Yavuz","year":"2003","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"2021113011243232000_B111","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/ajh\/hpt208","article-title":"Effects of an angiotensin II receptor blocker on the impaired function of endothelial progenitor cells in patients with essential hypertension","volume":"27","author":"Suzuki","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"2021113011243232000_B112","doi-asserted-by":"publisher","first-page":"865","DOI":"10.2165\/00002512-200219110-00004","article-title":"Role of hormones in the pathogenesis and management of sarcopenia","volume":"19","author":"Kamel","year":"2002","journal-title":"Drugs Aging"},{"key":"2021113011243232000_B113","doi-asserted-by":"publisher","first-page":"4139","DOI":"10.1210\/jcem.86.9.7868","article-title":"Association of IGF-I levels with muscle strength and mobility in older women","volume":"86","author":"Cappola","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113011243232000_B114","doi-asserted-by":"publisher","first-page":"E481","DOI":"10.1152\/ajpendo.00319.2002","article-title":"Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons","volume":"284","author":"Barbieri","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021113011243232000_B115","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1210\/endo.142.4.8082","article-title":"Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I","volume":"142","author":"Brink","year":"2001","journal-title":"Endocrinology"},{"key":"2021113011243232000_B116","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1172\/JCI118698","article-title":"Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism","volume":"97","author":"Brink","year":"1996","journal-title":"J. Clin. Invest."},{"key":"2021113011243232000_B117","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/j.amjcard.2005.11.089","article-title":"Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects &gt;65 years of age (the InCHIANTI study)","volume":"97","author":"Maggio","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"2021113011243232000_B118","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/jcp.10294","article-title":"Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition","volume":"196","author":"Henriksen","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"2021113011243232000_B119","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1152\/japplphysiol.01102.2001","article-title":"Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia","volume":"92","author":"Bua","year":"2002","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2021113011243232000_B120","doi-asserted-by":"publisher","first-page":"5618","DOI":"10.1073\/pnas.0501559102","article-title":"Decline in skeletal muscle mitochondrial function with aging in humans","volume":"102","author":"Short","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113011243232000_B121","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1469-7793.2000.t01-1-00203.x","article-title":"Oxidative capacity and ageing in human muscle","volume":"526","author":"Conley","year":"2000","journal-title":"J. Physiol."},{"key":"2021113011243232000_B122","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1152\/jappl.2000.89.1.297","article-title":"High-abundance mRNAs in human muscle: comparison between young and old","volume":"89","author":"Welle","year":"2000","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2021113011243232000_B123","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1096\/fj.02-0063fje","article-title":"Enalapril and losartan attenuate mitochondrial dysfunction in aged rats","volume":"17","author":"de Cavanagh","year":"2003","journal-title":"FASEB J."},{"key":"2021113011243232000_B124","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1152\/japplphysiol.00323.2003","article-title":"Does ACE inhibition enhance endurance performance and muscle energy metabolism in rats?","volume":"96","author":"Bahi","year":"2004","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2021113011243232000_B125","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0140-6736(02)08024-8","article-title":"Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study","volume":"359","author":"Onder","year":"2002","journal-title":"Lancet"},{"key":"2021113011243232000_B126","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1503\/cmaj.061339","article-title":"Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial","volume":"177","author":"Sumukadas","year":"2007","journal-title":"CMAJ"},{"key":"2021113011243232000_B127","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/j.1532-5415.2006.00701.x","article-title":"Meaningful change and responsiveness in common physical performance measures in older adults","volume":"54","author":"Perera","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"2021113011243232000_B128","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s40266-015-0288-3","article-title":"Effect of angiotensin-converting enzyme inhibitors on physical function in elderly subjects: a systematic review and meta-analysis","volume":"32","author":"Zhou","year":"2015","journal-title":"Drugs Aging"},{"key":"2021113011243232000_B129","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s40266-016-0396-8","article-title":"Angiotensin-converting enzyme inhibitors and parameters of sarcopenia: relation to muscle mass, strength and function: data from the Berlin Aging Study-II (BASE-II)","volume":"33","author":"Spira","year":"2016","journal-title":"Drugs Aging"},{"key":"2021113011243232000_B130","doi-asserted-by":"publisher","first-page":"9714","DOI":"10.1007\/s11357-014-9714-4","article-title":"Comparison of quadriceps strength and handgrip strength in their association with health outcomes in older adults in primary care","volume":"36","author":"Chan","year":"2014","journal-title":"Age (Dordr.)"},{"key":"2021113011243232000_B131","doi-asserted-by":"publisher","first-page":"334e1","DOI":"10.1016\/j.ahj.2008.10.026","article-title":"Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study","volume":"157","author":"Cesari","year":"2009","journal-title":"Am. Heart J."},{"key":"2021113011243232000_B132","doi-asserted-by":"publisher","first-page":"258.e1","DOI":"10.1016\/j.ahj.2012.11.008","article-title":"INtensive versus standard ambulatory blood pressure lowering to prevent functional DeclINe in the ElderlY (INFINITY)","volume":"165","author":"White","year":"2013","journal-title":"Am. Heart J."},{"key":"2021113011243232000_B133","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1172\/JCI22324","article-title":"Muscle-specific expression of IGF-1 blocks angiotensin II\u2013induced skeletal muscle wasting","volume":"115","author":"Song","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2021113011243232000_B134","doi-asserted-by":"publisher","first-page":"11877","DOI":"10.1038\/s41598-017-10838-5","article-title":"The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy","volume":"7","author":"Samant","year":"2017","journal-title":"Sci. Rep."},{"key":"2021113011243232000_B135","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.ebiom.2017.01.040","article-title":"Angiotensin-II-induced muscle wasting is mediated by 25-Hydroxycholesterol via GSK3beta signaling pathway","volume":"16","author":"Shen","year":"2017","journal-title":"EBioMedicine"},{"key":"2021113011243232000_B136","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3389\/fphys.2018.00340","article-title":"Possible role of NADPH oxidase 4 in Angiotensin II-induced muscle wasting in mice","volume":"9","author":"Kadoguchi","year":"2018","journal-title":"Front. Physiol."},{"key":"2021113011243232000_B137","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1080\/03008207.2019.1648443","article-title":"Sirtuin 3 deficiency accelerates Angiotensin II-induced skeletal muscle atrophy","volume":"61","author":"Zheng","year":"2020","journal-title":"Connect. Tissue Res."},{"key":"2021113011243232000_B138","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0140-6736(02)08024-8","article-title":"Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study","volume":"359","author":"Onder","year":"2002","journal-title":"Lancet North Am. Ed."},{"key":"2021113011243232000_B139","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1177\/1470320309105338","article-title":"Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial","volume":"10","author":"Bunout","year":"2009","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"2021113011243232000_B140","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/ageing\/afx127","article-title":"The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial","volume":"47","author":"Sumukadas","year":"2018","journal-title":"Age Ageing"},{"key":"2021113011243232000_B141","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1152\/japplphysiol.00106.2018","article-title":"Losartan has no additive effect on the response to heavy-resistance exercise in human elderly skeletal muscle","volume":"125","author":"Heisterberg","year":"2018","journal-title":"J. Appl. Physiol. (1985)"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/135\/21\/2503\/924161\/cs-2021-0719.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/135\/21\/2503\/924161\/cs-2021-0719.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:19:59Z","timestamp":1638274799000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/135\/21\/2503\/230172\/Angiotensin-II-inhibition-a-potential-treatment-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":141,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,11,12]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20210719","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11]]},"published":{"date-parts":[[2021,11]]}}}