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This review brings a focus to the importance of inflammatory feedback loops that exist in the initiation and chronic stages of the condition, and how close interaction between the epidermis and both innate and adaptive immune compartments drives psoriatic inflammation. Furthermore, we highlight work done on biomarkers to predict the outcome of therapy as well as the transition from psoriasis to psoriatic arthritis.<\/jats:p>","DOI":"10.1042\/cs20210916","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T07:33:35Z","timestamp":1655883215000},"page":"935-952","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular and cellular regulation of psoriatic inflammation"],"prefix":"10.1042","volume":"136","author":[{"given":"Tom","family":"Macleod","sequence":"first","affiliation":[{"name":"1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bridgewood","sequence":"additional","affiliation":[{"name":"1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hyde","sequence":"additional","affiliation":[{"name":"1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Heague","sequence":"additional","affiliation":[{"name":"1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Helliwell","sequence":"additional","affiliation":[{"name":"1Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom"},{"name":"2National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), The Leeds Teaching Hospitals, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stacey","sequence":"additional","affiliation":[{"name":"3School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-4926","authenticated-orcid":false,"given":"Miriam","family":"Wittmann","sequence":"additional","affiliation":[{"name":"2National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), The Leeds Teaching Hospitals, Leeds, United Kingdom"},{"name":"4Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"2022062207332521800_B1","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1038\/jid.2012.167","article-title":"Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation","volume":"132","author":"Bergboer","year":"2012","journal-title":"J. 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