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In this review, we argue that a woman\u2019s pre-conception cardiovascular health drives both the development of placental syndromes and long-term cardiovascular risk but acknowledge that placental syndromes can also contribute to future cardiovascular risk independent of pre-conception health. We describe how preclinical studies in models of preeclampsia inform our understanding of the links with later cardiovascular disease, and how current pre-pregnancy studies may explain relative contributions of both pre-conception factors and the occurrence of placental syndromes to long-term cardiovascular disease.<\/jats:p>","DOI":"10.1042\/cs20211130","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T10:10:55Z","timestamp":1692699055000},"page":"1211-1224","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Placental syndromes and maternal cardiovascular health"],"prefix":"10.1042","volume":"137","author":[{"given":"Helen","family":"Casey","sequence":"first","affiliation":[{"name":"1School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Dennehy","sequence":"additional","affiliation":[{"name":"2Chelsea and Westminster NHS Foundation Trust, London, England, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Fraser","sequence":"additional","affiliation":[{"name":"3Department of Population Health Sciences, Bristol Medical School, and the MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lees","sequence":"additional","affiliation":[{"name":"2Chelsea and Westminster NHS Foundation Trust, London, England, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel\u00a0M.","family":"McEniery","sequence":"additional","affiliation":[{"name":"4Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, England, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayley","family":"Scott","sequence":"additional","affiliation":[{"name":"1School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian\u00a0B.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"4Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, England, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-2612","authenticated-orcid":false,"given":"Christian","family":"Delles","sequence":"additional","affiliation":[{"name":"1School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"2023082210101741200_B1","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The lancet women and cardiovascular disease commission: reducing the global burden by 2030","volume":"397","author":"Vogel","year":"2021","journal-title":"Lancet"},{"key":"2023082210101741200_B2","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1097\/HJH.0000000000001655","article-title":"Sex differences in hypertension and other cardiovascular diseases","volume":"36","author":"Delles","year":"2018","journal-title":"J. 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