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Treatment options are limited to management of edema as there are no specific therapeutics that have demonstrated significant success for ameliorating microvascular leakage or impaired lymphatic function. This review examines current knowledge about the physiological, cellular, and molecular mechanisms that control microvascular permeability and lymphatic clearance, the respective processes for interstitial fluid formation and removal. Clinical conditions featuring edema, along with potential future directions are discussed.<\/jats:p>","DOI":"10.1042\/cs20220314","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T05:15:59Z","timestamp":1695273359000},"page":"1451-1476","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Edema and lymphatic clearance: molecular mechanisms and ongoing challenges"],"prefix":"10.1042","volume":"137","author":[{"given":"Jerome\u00a0W.","family":"Breslin","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"2023092109152837700_B1","article-title":"Chapter 4: Pathophysiology of Edema Formation","volume-title":"Capillary Fluid Exchange: Regulation, Functions, and Pathology","author":"Scallan","year":"2010"},{"key":"2023092109152837700_B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000525787","article-title":"The microvascular-lymphatic interface and tissue homeostasis: critical questions that challenge current understanding","author":"Lampejo","year":"2022","journal-title":"J. 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