{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:32:47Z","timestamp":1791581567946,"version":"4.3.4"},"reference-count":138,"publisher":"Portland Press Ltd.","issue":"13","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["508140"],"award-info":[{"award-number":["508140"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Placental insufficiency is one of the major causes of fetal growth restriction (FGR), a significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. As well as the acute consequences of being born too small, affected offspring are at increased risk of cardiovascular disease, diabetes and other chronic diseases in later life. The placenta and heart develop concurrently, therefore placental maldevelopment and function in FGR may have profound effect on the growth and differentiation of many organ systems, including the heart. Hence, understanding the key molecular players that are synergistically linked in the development of the placenta and heart is critical. This review highlights the key growth factors, angiogenic molecules and transcription factors that are common causes of defective placental and cardiovascular development.<\/jats:p>","DOI":"10.1042\/cs20220428","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:04:02Z","timestamp":1718960642000},"page":"761-775","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular regulators of defective placental and cardiovascular development in fetal growth restriction"],"prefix":"10.1042","volume":"138","author":[{"given":"Anandita","family":"Umapathy","sequence":"first","affiliation":[{"name":"1Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alys","family":"Clark","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand"},{"name":"2Auckland Bioengineering Institute, Bioengineering Institute, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Sehgal","sequence":"additional","affiliation":[{"name":"3Department of Paediatrics, Monash University, Melbourne, VIC, Australia and Monash Newborn, Monash Children\u2019s Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Karanam","sequence":"additional","affiliation":[{"name":"4Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and Royal Women\u2019s Hospital, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri","family":"Rajaraman","sequence":"additional","affiliation":[{"name":"5First year college, Victoria University, St Albans, Victoria 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Kalionis","sequence":"additional","affiliation":[{"name":"4Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and Royal Women\u2019s Hospital, Victoria, Australia"},{"name":"6Department of Maternal Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen\u00a0N.","family":"Jones","sequence":"additional","affiliation":[{"name":"7Department of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL, U.S.A."},{"name":"8Center for Research in Perinatal Outcomes, University of Florida College of Medicine, Gainesville, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"James","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand"},{"name":"2Auckland Bioengineering Institute, Bioengineering Institute, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-5134","authenticated-orcid":false,"given":"Padma","family":"Murthi","sequence":"additional","affiliation":[{"name":"4Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne and Royal Women\u2019s Hospital, Victoria, Australia"},{"name":"6Department of Maternal Fetal Medicine, Pregnancy Research Centre, Royal Women\u2019s Hospital, Victoria, Australia"},{"name":"9Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"2024062715062687900_B1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1093\/ije\/31.6.1235","article-title":"Fetal origins of adult disease: strength of effects and biological basis","volume":"31","author":"Barker","year":"2002","journal-title":"Int. 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