{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:34:41Z","timestamp":1776760481783,"version":"3.51.2"},"reference-count":38,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polycystic kidney disease (PKD) is an inherited disorder that results in large kidneys, numerous fluid-filled cysts, and ultimately end-stage kidney disease. PKD is either autosomal dominant caused by mutations in PKD1 or PKD2 genes or autosomal recessive caused by mutations in the PKHD1 or DZIP1L genes. While the genetic basis of PKD is known, the downstream molecular mechanisms and signaling pathways that lead to deregulation of proliferation, apoptosis, and differentiation are not completely understood. The Notch pathway plays critical roles during kidney development including directing differentiation of various progenitor cells, and aberrant Notch signaling results in gross alternations in cell fate. In the present study, we generated and studied transgenic mice that have overexpression of an intracellular fragment of mouse Notch1 (\u2018NotchIC\u2019) in renin-expressing cells. Mice with overexpression of NotchIC in renin-expressing cells developed numerous fluid-filled cysts, enlarged kidneys, anemia, renal insufficiency, and early death. Cysts developed in both glomeruli and proximal tubules, had increased proliferation marks, and had increased levels of Myc. The present work implicates the Notch signaling pathway as a central player in PKD pathogenesis and suggests that the Notch-Myc axis may be an important target for therapeutic intervention.<\/jats:p>","DOI":"10.1042\/cs20220496","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T10:08:54Z","timestamp":1670839734000},"page":"35-45","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype"],"prefix":"10.1042","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-7892","authenticated-orcid":false,"given":"Brian\u00a0C.","family":"Belyea","sequence":"first","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Wiltsie","sequence":"additional","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayes","family":"Fountain","sequence":"additional","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Charlton","sequence":"additional","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes\u00a0B.","family":"Fogo","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, U.S.A."},{"name":"3Division of Pediatric Nephrology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-7940","authenticated-orcid":false,"given":"Maria\u00a0Luisa\u00a0Soledad","family":"Sequeira-Lopez","sequence":"additional","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-8255","authenticated-orcid":false,"given":"Roberto\u00a0Ariel","family":"Gomez","sequence":"additional","affiliation":[{"name":"1Child Health Research Center, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA 22908, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"2023010508103737400_B1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","article-title":"Polycystic kidney disease","volume":"4","author":"Bergmann","year":"2018","journal-title":"Nat. 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