{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:21:55Z","timestamp":1782800515300,"version":"3.54.5"},"reference-count":180,"publisher":"Portland Press Ltd.","issue":"24","funder":[{"name":"Grant-in-Aid for Scientific Research","award":["No. J550703552"],"award-info":[{"award-number":["No. J550703552"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The renin-angiotensin system (RAS) is a classically known circulatory regulatory system. In addition to the previously known multi-organ circulatory form of the RAS, the existence of tissue RASs in individual organs has been well established. Skeletal muscle has also been identified as an organ with a distinct RAS. In recent years, the effects of RAS activation on skeletal muscle have been elucidated from several perspectives: differences in motor function due to genetic polymorphisms of RAS components, skeletal muscle dysfunction under conditions of excessive RAS activation such as heart failure, and the effects of the use of RAS inhibitors on muscle strength. In addition, the concept of the RAS itself has recently been expanded with the discovery of a \u2018protective arm\u2019 of the RAS formed by factors such as angiotensin-converting enzyme 2 and angiotensin 1-7. This has led to a new understanding of the physiological function of the RAS in skeletal muscle. This review summarizes the diverse physiological functions of the RAS in skeletal muscle and considers the potential of future therapeutic strategies targeting the RAS to overcome problems such as sarcopenia and muscle weakness associated with chronic disease.<\/jats:p>","DOI":"10.1042\/cs20220501","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T14:01:46Z","timestamp":1735048906000},"page":"1561-1577","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Muscle mass, muscle strength and the renin-angiotensin system"],"prefix":"10.1042","volume":"138","author":[{"given":"Hikari","family":"Takeshita","sequence":"first","affiliation":[{"name":"1Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"},{"name":"2Department of Medical Science Technology, Faculty of Medical Science Technology, Morinomiya University of Medical Sciences, Osaka, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-9315","authenticated-orcid":false,"given":"Koichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"1Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mogi","sequence":"additional","affiliation":[{"name":"3Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4338","authenticated-orcid":false,"given":"Hiromi","family":"Rakugi","sequence":"additional","affiliation":[{"name":"4Osaka Rosai Hospital, Sakai, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"2024122414013919400_B1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1152\/physiologyonline.1999.14.6.271","article-title":"The discovery of Renin 100 years ago","volume":"14","author":"Phillips","year":"1999","journal-title":"News Physiol. 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