{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:22:08Z","timestamp":1791901328141,"version":"4.3.4"},"reference-count":277,"publisher":"Portland Press Ltd.","issue":"15","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and surgical repair is still the unique available therapeutic approach for high-risk patients. Meanwhile, there is no medical alternative for patients with small aneurysms but close surveillance. Clinical trials assessing the efficacy of antihypertensive agents, statins, doxycycline, or anti-platelet drugs, among others, failed to demonstrate a clear benefit limiting AAA growth, while data from ongoing clinical trials addressing the benefit of metformin on aneurysm progression are eagerly awaited. Recent preclinical studies have postulated new therapeutic targets and pharmacological strategies paving the way for the implementation of future clinical studies exploring these novel therapeutic strategies. This review summarises some of the most relevant clinical and preclinical studies in search of new therapeutic approaches for AAA.<\/jats:p>","DOI":"10.1042\/cs20220795","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T01:16:13Z","timestamp":1691630173000},"page":"1167-1194","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Novel pharmacological approaches in abdominal aortic aneurysm"],"prefix":"10.1042","volume":"137","author":[{"given":"L\u00eddia","family":"Puertas-Umbert","sequence":"first","affiliation":[{"name":"1Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, Spain"},{"name":"2CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Almendra-Pegueros","sequence":"additional","affiliation":[{"name":"1Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9034-2041","authenticated-orcid":false,"given":"Francesc","family":"Jim\u00e9nez-Altay\u00f3","sequence":"additional","affiliation":[{"name":"3Department of Pharmacology, Therapeutics and Toxicology, School of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"4Neuroscience Institute, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sirvent","sequence":"additional","affiliation":[{"name":"2CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain"},{"name":"5Departamento de Angiolog\u00eda y Cirug\u00eda Vascular del Hospital Universitari General de Granollers, Granollers, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-8388","authenticated-orcid":false,"given":"Mar\u00eda","family":"Gal\u00e1n","sequence":"additional","affiliation":[{"name":"1Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, Spain"},{"name":"2CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain"},{"name":"6Departamento de Ciencias B\u00e1sicas de la Salud, Universidad Rey Juan Carlos, Alcorc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-7166","authenticated-orcid":false,"given":"Jos\u00e9","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"1Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, Spain"},{"name":"2CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain"},{"name":"7Instituto de Investigaciones Biom\u00e9dicas de Barcelona (IIBB-CSIC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"1Institut d\u2019Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB SANT PAU), Barcelona, Spain"},{"name":"2CIBER de Enfermedades Cardiovasculares, ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"2023081005155240400_B1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nrcardio.2010.180","article-title":"Pathophysiology and epidemiology of abdominal aortic aneurysms","volume":"8","author":"Nordon","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"2023081005155240400_B2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41569-018-0114-9","article-title":"Abdominal aortic aneurysm: update on pathogenesis and medical treatments","volume":"16","author":"Golledge","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"2023081005155240400_B3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1586\/14779072.2015.1052408","article-title":"The pathophysiologic basis of abdominal aortic aneurysm progression: a critical appraisal","volume":"13","author":"Lindeman","year":"2015","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"2023081005155240400_B4","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/bjs.5778","article-title":"Final 12-year follow-up of surgery versus surveillance in the U.K. Small Aneurysm Trial","volume":"94","author":"Powell","year":"2007","journal-title":"Br. J. Surg."},{"key":"2023081005155240400_B5","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1056\/NEJMoa012573","article-title":"Immediate repair compared with surveillance of small abdominal aortic aneurysms","volume":"346","author":"Lederle","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2023081005155240400_B6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.jvs.2009.10.113","article-title":"Endovascular repair compared with surveillance for patients with small abdominal aortic aneurysms","volume":"51","author":"Ouriel","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ejvs.2010.08.026","article-title":"Comparison of surveillance versus aortic endografting for small aneurysm repair (CAESAR): results from a randomised trial","volume":"41","author":"Cao","year":"2011","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B8","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1056\/NEJMcp2108504","article-title":"Management of abdominal aortic aneurysms","volume":"385","author":"Schanzer","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"2023081005155240400_B9","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.2174\/138161207780831220","article-title":"Influence of statin use on endothelial function: from bench to clinics","volume":"13","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"2023081005155240400_B10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.coph.2013.01.004","article-title":"Anti-atherosclerotic mechanisms of statin therapy","volume":"13","author":"Babelova","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"2023081005155240400_B11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.phrs.2014.02.009","article-title":"Cardiovascular effects of statins, beyond lipid-lowering properties","volume":"88","author":"Mihos","year":"2014","journal-title":"Pharmacol. Res."},{"key":"2023081005155240400_B12","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s10557-010-6262-8","article-title":"Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm","volume":"24","author":"Golledge","year":"2010","journal-title":"Cardiovasc. Drugs Ther."},{"key":"2023081005155240400_B13","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ejvs.2007.04.011","article-title":"Simvastatin attenuates the activity of matrix metalloprotease-9 in aneurysmal aortic tissue","volume":"34","author":"Evans","year":"2007","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B14","doi-asserted-by":"publisher","first-page":"e53882","DOI":"10.1371\/journal.pone.0053882","article-title":"A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation","volume":"8","author":"van der Meij","year":"2013","journal-title":"PLoS One"},{"key":"2023081005155240400_B15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijcard.2022.11.058","article-title":"Research advances in drug therapy for abdominal aortic aneurysms over the past five years: An updated narrative review","volume":"372","author":"Li","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"2023081005155240400_B16","doi-asserted-by":"publisher","first-page":"e008657","DOI":"10.1161\/JAHA.118.008657","article-title":"Statins reduce abdominal aortic aneurysm growth, rupture, and perioperative mortality: A systematic review and meta-analysis","volume":"7","author":"Salata","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"2023081005155240400_B17","doi-asserted-by":"publisher","first-page":"10760296221120424","DOI":"10.1177\/10760296221120423","article-title":"Pharmacotherapy in clinical trials for abdominal aortic aneurysms: A systematic review and meta-analysis","volume":"28","author":"Su","year":"2022","journal-title":"Clin. Appl. Thromb. Off. J. Int. Acad. Clin. Appl. Thromb."},{"key":"2023081005155240400_B18","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejvs.2012.06.021","article-title":"Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies","volume":"44","author":"Takagi","year":"2012","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B19","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/bjs.7343","article-title":"Systematic review and meta-analysis of the effects of statin therapy on abdominal aortic aneurysms","volume":"98","author":"Twine","year":"2011","journal-title":"Br. J. Surg."},{"key":"2023081005155240400_B20","doi-asserted-by":"publisher","first-page":"356.e4","DOI":"10.1016\/j.jvs.2021.06.033","article-title":"Meta-analysis suggests statins reduce mortality after abdominal aortic aneurysm repair","volume":"75","author":"Xiong","year":"2022","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B21","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1161\/HYPERTENSIONAHA.113.01986","article-title":"L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects","volume":"62","author":"Mieth","year":"2013","journal-title":"Hypertension"},{"key":"2023081005155240400_B22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.yjmcc.2015.07.031","article-title":"Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications","volume":"87","author":"Miao","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"2023081005155240400_B23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1042\/CS20130382","article-title":"Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model","volume":"127","author":"Seto","year":"2014","journal-title":"Clin. Sci."},{"key":"2023081005155240400_B24","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1161\/HYPERTENSIONAHA.117.09512","article-title":"Perivascular adipose tissue angiotensin II type 1 receptor promotes vascular inflammation and aneurysm formation","volume":"70","author":"Sakaue","year":"2017","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"2023081005155240400_B25","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1097\/HJH.0b013e328313e547","article-title":"Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation","volume":"26","author":"Kaschina","year":"2008","journal-title":"J. Hypertens."},{"key":"2023081005155240400_B26","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1042\/CS20170131","article-title":"AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice","volume":"131","author":"Krueger","year":"2017","journal-title":"Clin. Sci."},{"key":"2023081005155240400_B27","doi-asserted-by":"publisher","first-page":"e49642","DOI":"10.1371\/journal.pone.0049642","article-title":"Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms","volume":"7","author":"Iida","year":"2012","journal-title":"PloS ONE"},{"key":"2023081005155240400_B28","doi-asserted-by":"publisher","first-page":"573.e2","DOI":"10.1016\/j.jvs.2016.12.110","article-title":"Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms","volume":"67","author":"Xuan","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1067\/mva.2002.121308","article-title":"Propranolol for small abdominal aortic aneurysms: results of a randomized trial","volume":"35","author":"Propanolol Aneurysm Trial Investigators","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B30","first-page":"52","article-title":"Impaired results of a randomised double blinded clinical trial of propranolol versus placebo on the expansion rate of small abdominal aortic aneurysms","volume":"18","author":"Lindholt","year":"1999","journal-title":"Int. Angiol. J. Int. Union Angiol."},{"key":"2023081005155240400_B31","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1001\/jamacardio.2020.3524","article-title":"Efficacy of telmisartan to slow growth of small abdominal aortic aneurysms: A randomized clinical trial","volume":"5","author":"Golledge","year":"2020","journal-title":"JAMA Cardiol."},{"key":"2023081005155240400_B32","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ejvs.2022.07.042","article-title":"Effect of telmisartan on the peak wall stress and peak wall rupture index of small abdominal aortic aneurysms: An exploratory analysis of the TEDY trial","volume":"64","author":"Singh","year":"2022","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B33","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1111\/bph.14906","article-title":"Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice","volume":"177","author":"Xue","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"2023081005155240400_B34","first-page":"e20","article-title":"AT2R (angiotensin AT2 receptor) agonist, compound 21, prevents abdominal aortic aneurysm progression in the rat","volume":"72","author":"Lange","year":"2018","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"2023081005155240400_B35","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S0140-6736(06)69250-7","article-title":"Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study","volume":"368","author":"Hackam","year":"2006","journal-title":"Lancet Lond. Engl."},{"key":"2023081005155240400_B36","doi-asserted-by":"publisher","first-page":"e111952","DOI":"10.1371\/journal.pone.0111952","article-title":"ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm","volume":"9","author":"Kortekaas","year":"2014","journal-title":"PLoS ONE"},{"key":"2023081005155240400_B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jvs.2010.02.264","article-title":"Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms","volume":"52","author":"Sweeting","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B38","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1093\/eurheartj\/ehw257","article-title":"An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled trial (AARDVARK)","volume":"37","author":"Bicknell","year":"2016","journal-title":"Eur. Heart J."},{"key":"2023081005155240400_B39","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"2023081005155240400_B40","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/S0741-5214(96)70279-3","article-title":"Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase","volume":"23","author":"Petrinec","year":"1996","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B41","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S0741-5214(98)70367-2","article-title":"Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease","volume":"27","author":"Boyle","year":"1998","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B42","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B43","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1161\/01.ATV.0000058404.92759.32","article-title":"Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms","volume":"23","author":"Manning","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1749-6632.1999.tb07682.x","article-title":"MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial","volume":"878","author":"Thompson","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2023081005155240400_B45","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0741-5214(00)90163-0","article-title":"Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms","volume":"31","author":"Curci","year":"2000","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B46","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.108.806505","article-title":"Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells","volume":"119","author":"Lindeman","year":"2009","journal-title":"Circulation"},{"key":"2023081005155240400_B47","doi-asserted-by":"publisher","first-page":"e46411","DOI":"10.1371\/journal.pone.0046411","article-title":"Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice","volume":"7","author":"Xie","year":"2012","journal-title":"PLoS ONE"},{"key":"2023081005155240400_B48","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1067\/mva.2001.117891","article-title":"Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study","volume":"34","author":"Mosorin","year":"2001","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B49","doi-asserted-by":"publisher","first-page":"815","DOI":"10.7326\/0003-4819-159-12-201312170-00007","article-title":"Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial","volume":"159","author":"Meijer","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"2023081005155240400_B50","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1001\/jama.2020.5230","article-title":"Effect of doxycycline on aneurysm growth among patients with small infrarenal abdominal aortic aneurysms: A randomized clinical trial","volume":"323","author":"Baxter","year":"2020","journal-title":"JAMA"},{"key":"2023081005155240400_B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1067\/mva.2002.125018","article-title":"Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study","volume":"36","author":"Baxter","year":"2002","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B52","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1161\/ATVBAHA.115.305537","article-title":"Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm","volume":"35","author":"Owens","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B53","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jvs.2008.09.057","article-title":"Effect of blocking platelet activation with AZD6140 on development of abdominal aortic aneurysm in a rat aneurysmal model","volume":"49","author":"Dai","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B54","doi-asserted-by":"publisher","first-page":"e51707","DOI":"10.1371\/journal.pone.0051707","article-title":"Clopidogrel, a platelet P2Y12 receptor inhibitor, reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS ONE"},{"key":"2023081005155240400_B55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2174\/1570161111311030005","article-title":"Anti-platelet treatment of middle-sized abdominal aortic aneurysms","volume":"11","author":"Lindholt","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"key":"2023081005155240400_B56","doi-asserted-by":"publisher","first-page":"616.e4","DOI":"10.1016\/j.jvs.2016.04.061","article-title":"Low-dose aspirin and rupture of abdominal aortic aneurysm","volume":"65","author":"Wemmelund","year":"2017","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B57","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1182\/blood-2017-08-743237","article-title":"Antithrombotic therapy in abdominal aortic aneurysm: beneficial or detrimental?","volume":"132","author":"Cameron","year":"2018","journal-title":"Blood"},{"key":"2023081005155240400_B58","first-page":"450","article-title":"The effect of ticagrelor on growth of small abdominal aortic aneurysms-a randomized controlled trial","volume":"116","author":"Wanhainen","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B59","doi-asserted-by":"publisher","first-page":"55.e2","DOI":"10.1016\/j.jvs.2010.02.012","article-title":"An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance","volume":"52","author":"Thompson","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B60","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.ejvs.2022.07.008","article-title":"Antithrombotic therapy for aortic aneurysms: A systematic review and meta-analysis","volume":"64","author":"Wong","year":"2022","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B61","doi-asserted-by":"publisher","first-page":"437.e2","DOI":"10.1016\/j.jvs.2022.01.144","article-title":"Long-term anticoagulation is associated with type II endoleaks and failure of sac regression after endovascular aneurysm repair","volume":"76","author":"Kong","year":"2022","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B62","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jvs.2010.02.290","article-title":"The effect of warfarin therapy on endoleak development after endovascular aneurysm repair (EVAR) of the abdominal aorta","volume":"52","author":"Bobadilla","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B63","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1161\/ATVBAHA.110.206573","article-title":"Atherosclerosis and abdominal aortic aneurysm: cause, response, or common risk factors?","volume":"30","author":"Golledge","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B64","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/dmrr.2585","article-title":"Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population-based cohort study","volume":"31","author":"Tsai","year":"2015","journal-title":"Diabetes Metab. Res. Rev."},{"key":"2023081005155240400_B65","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ejvs.2013.12.007","article-title":"Diabetes and abdominal aortic aneurysms","volume":"47","author":"De Rango","year":"2014","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B66","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/eurheartj\/ehm557","article-title":"Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions","volume":"29","author":"Golledge","year":"2008","journal-title":"Eur. Heart J."},{"key":"2023081005155240400_B67","doi-asserted-by":"publisher","first-page":"1095608","DOI":"10.3389\/fendo.2022.1095608","article-title":"Double-edged sword of diabetes mellitus for abdominal aortic aneurysm","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"2023081005155240400_B68","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1161\/ATVBAHA.116.308874","article-title":"Glycated hemoglobin is associated with the growth rate of abdominal aortic aneurysms: A substudy from the VIVA (Viborg Vascular) randomized screening trial","volume":"37","author":"Kristensen","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B69","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1093\/cvr\/cvy174","article-title":"Diabetes and aortic aneurysm: current state of the art","volume":"114","author":"Raffort","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B70","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/bjs.10587","article-title":"Association between metformin prescription and growth rates of abdominal aortic aneurysms","volume":"104","author":"Golledge","year":"2017","journal-title":"Br. J. Surg."},{"key":"2023081005155240400_B71","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.avsg.2021.02.048","article-title":"Association of metformin and abdominal aortic aneurysm repair outcomes","volume":"75","author":"Turowicz","year":"2021","journal-title":"Ann. Vasc. Surg."},{"key":"2023081005155240400_B72","doi-asserted-by":"publisher","first-page":"46.e8","DOI":"10.1016\/j.jvs.2016.02.020","article-title":"Metformin treatment status and abdominal aortic aneurysm disease progression","volume":"64","author":"Fujimura","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B73","doi-asserted-by":"publisher","first-page":"710.e3","DOI":"10.1016\/j.jvs.2018.06.194","article-title":"Metformin prescription status and abdominal aortic aneurysm disease progression in the U.S. veteran population","volume":"69","author":"Itoga","year":"2019","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B74","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejvs.2018.07.035","article-title":"Editor's Choice - Metformin prescription is associated with a reduction in the combined incidence of surgical repair and rupture related mortality in patients with abdominal aortic aneurysm","volume":"57","author":"Golledge","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B75","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.avsg.2020.06.039","article-title":"Metformin prescription associated with reduced abdominal aortic aneurysm growth rate and Reduced chemokine expression in a swedish cohort","volume":"70","author":"Unosson","year":"2021","journal-title":"Ann. Vasc. Surg."},{"key":"2023081005155240400_B76","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1136\/jim-2019-001177","article-title":"Association between metformin and abdominal aortic aneurysm in diabetic and non-diabetic US veterans","volume":"68","author":"Sutton","year":"2020","journal-title":"J. Investig. Med. Off. Publ. Am. Fed. Clin. Res."},{"key":"2023081005155240400_B77","doi-asserted-by":"publisher","first-page":"908747","DOI":"10.3389\/fcvm.2022.908747","article-title":"Association between metformin and abdominal aortic aneurysm: A meta-analysis","volume":"9","author":"Niu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"2023081005155240400_B78","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1089\/ars.2017.7122","article-title":"Does metformin protect diabetic patients from oxidative stress and leukocyte-endothelium interactions?","volume":"27","author":"Diaz-Morales","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"2023081005155240400_B79","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.2337\/db14-1225","article-title":"Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis","volume":"64","author":"Vasamsetti","year":"2015","journal-title":"Diabetes"},{"key":"2023081005155240400_B80","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.bbrc.2012.07.165","article-title":"Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells","volume":"425","author":"Kim","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023081005155240400_B81","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1161\/01.ATV.0000201938.78044.75","article-title":"Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells","volume":"26","author":"Isoda","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B82","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13287-022-02755-w","article-title":"Therapeutic efficacy of mesenchymal stem cells for abdominal aortic aneurysm: a meta-analysis of preclinical studies","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"2023081005155240400_B83","doi-asserted-by":"publisher","first-page":"1305049","DOI":"10.1155\/2019\/1305049","article-title":"Adipose-derived mesenchymal stem cells isolated from patients with abdominal aortic aneurysm exhibit senescence phenomena","volume":"2019","author":"Huang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2023081005155240400_B84","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1161\/ATVBAHA.116.307373","article-title":"Mesenchymal stem cells attenuate NADPH oxidase-dependent high mobility group box 1 production and inhibit abdominal aortic aneurysms","volume":"36","author":"Sharma","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B85","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3727\/096368916X692212","article-title":"Human adipose-derived stem cells suppress elastase-induced murine abdominal aortic inflammation and aneurysm expansion through paracrine factors","volume":"26","author":"Xie","year":"2017","journal-title":"Cell Transplant."},{"key":"2023081005155240400_B86","doi-asserted-by":"publisher","first-page":"fj201701138RR","DOI":"10.1096\/fj.201701138RR","article-title":"Human mesenchymal stromal cell-derived extracellular vesicles attenuate aortic aneurysm formation and macrophage activation via microRNA-147","volume":"32","author":"Spinosa","year":"2018","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"2023081005155240400_B87","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1089\/scd.2020.0058","article-title":"Human umbilical cord mesenchymal stem cells attenuate abdominal aortic aneurysm progression in sprague-dawley rats: Implication of vascular smooth muscle cell phenotypic modulation","volume":"29","author":"Wen","year":"2020","journal-title":"Stem Cells Dev."},{"key":"2023081005155240400_B88","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/1479-5876-11-175","article-title":"Intravenous administration of mesenchymal stem cells prevents angiotensin II-induced aortic aneurysm formation in apolipoprotein E-deficient mouse","volume":"11","author":"Fu","year":"2013","journal-title":"J. Transl. Med."},{"key":"2023081005155240400_B89","doi-asserted-by":"publisher","first-page":"2301.e4","DOI":"10.1016\/j.jtcvs.2018.01.098","article-title":"Intravenously injected human multilineage-differentiating stress-enduring cells selectively engraft into mouse aortic aneurysms and attenuate dilatation by differentiating into multiple cell types","volume":"155","author":"Hosoyama","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"2023081005155240400_B90","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1016\/j.jvs.2019.06.138","article-title":"Allogeneic mesenchymal stem cells induce regulatory T cells and suppress aneurysm inflammation: Interim results of the phase 1 ARREST trial","volume":"70","author":"Leckie","year":"2019","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B91","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1161\/ATVBAHA.110.213157","article-title":"Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms","volume":"31","author":"Swedenborg","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B92","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1172\/JCI31311","article-title":"Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice","volume":"117","author":"Sun","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B93","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.109.849679","article-title":"Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation","volume":"120","author":"Sun","year":"2009","journal-title":"Circulation"},{"key":"2023081005155240400_B94","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1161\/01.ATV.14.6.966","article-title":"Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase\/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas","volume":"14","author":"Kaartinen","year":"1994","journal-title":"Arterioscler. Thromb. J. Vasc. Biol."},{"key":"2023081005155240400_B95","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/bjs.9824","article-title":"Randomized clinical trial of mast cell inhibition in patients with a medium-sized abdominal aortic aneurysm","volume":"102","author":"Sillesen","year":"2015","journal-title":"Br. J. Surg."},{"key":"2023081005155240400_B96","article-title":"A randomized, double-blind, placebo-controlled, multiple dose study of subcutaneous ACZ885 for the treatment of abdominal aortic aneurysm","author":"Novartis Pharmaceuticals","year":"2020","journal-title":"Clinicaltrials.gov"},{"key":"2023081005155240400_B97","doi-asserted-by":"publisher","first-page":"e28903","DOI":"10.1371\/journal.pone.0028903","article-title":"Long term stabilization of expanding aortic aneurysms by a short course of cyclosporine A through transforming growth factor-beta induction","volume":"6","author":"Dai","year":"2011","journal-title":"PLoS One"},{"key":"2023081005155240400_B98","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nm.1958","article-title":"Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms","volume":"15","author":"Satoh","year":"2009","journal-title":"Nat. Med."},{"key":"2023081005155240400_B99","doi-asserted-by":"publisher","first-page":"e463","DOI":"10.1161\/CIRCULATIONAHA.110.008573","article-title":"Immunosuppression and the abdominal aortic aneurysm: Doctor Jekyll or Mister Hyde?","volume":"124","author":"Lindeman","year":"2011","journal-title":"Circulation"},{"key":"2023081005155240400_B100","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1124\/pr.59.3.1","article-title":"Membrane prostaglandin E synthase-1: a novel therapeutic target","volume":"59","author":"Samuelsson","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"2023081005155240400_B101","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0741-5214(97)70210-6","article-title":"Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms","volume":"25","author":"Holmes","year":"1997","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B102","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1161\/01.CIR.100.1.48","article-title":"Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms","volume":"100","author":"Walton","year":"1999","journal-title":"Circulation"},{"key":"2023081005155240400_B103","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1161\/CIRCULATIONAHA.110.973685","article-title":"Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury","volume":"123","author":"Wang","year":"2011","journal-title":"Circulation"},{"key":"2023081005155240400_B104","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1194\/jlr.M042481","article-title":"Microvascular COX-2\/mPGES-1\/EP-4 axis in human abdominal aortic aneurysm","volume":"54","author":"Camacho","year":"2013","journal-title":"J. Lipid Res."},{"key":"2023081005155240400_B105","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/S0741-5214(99)70216-8","article-title":"Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase","volume":"29","author":"Miralles","year":"1999","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B106","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1161\/01.ATV.0000216119.79008.ac","article-title":"Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice","volume":"26","author":"King","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B107","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2147\/vhrm.1.2.149.64082","article-title":"Nonsteroidal antiinflammatory drugs are associated with increased aortic stiffness","volume":"1","author":"Claridge","year":"2005","journal-title":"Vasc. Health Risk Manag."},{"key":"2023081005155240400_B108","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/1708538119866603","article-title":"Nonsteroidal anti-inflammatory drug use is a risk factor for early Type II endoleak after endovascular abdominal aortic repair","volume":"28","author":"Matsubara","year":"2020","journal-title":"Vascular"},{"key":"2023081005155240400_B109","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1056\/NEJMoa050493","article-title":"Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial","volume":"352","author":"Bresalier","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2023081005155240400_B110","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1161\/CIRCULATIONAHA.107.731398","article-title":"Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation","volume":"117","author":"Wang","year":"2008","journal-title":"Circulation"},{"key":"2023081005155240400_B111","doi-asserted-by":"publisher","first-page":"316150","DOI":"10.1155\/2014\/316150","article-title":"Active smoking increases microsomal PGE2-synthase-1\/PGE-receptor-4 axis in human abdominal aortic aneurysms","volume":"2014","author":"Dilm\u00e9","year":"2014","journal-title":"Mediators Inflamm."},{"key":"2023081005155240400_B112","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13878","article-title":"A selective antagonist of prostaglandin E receptor subtype 4 attenuates abdominal aortic aneurysm","volume":"6","author":"Mamun","year":"2018","journal-title":"Physiol. Rep."},{"key":"2023081005155240400_B113","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ajpath.2012.03.016","article-title":"Prostaglandin receptor EP4 in abdominal aortic aneurysms","volume":"181","author":"Cao","year":"2012","journal-title":"Am. J. Pathol."},{"key":"2023081005155240400_B114","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1161\/ATVBAHA.120.314297","article-title":"Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation","volume":"40","author":"Hiromi","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B115","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1358\/dnp.2008.21.4.1213351","article-title":"Lysyl oxidase as a potential therapeutic target","volume":"21","author":"Rodr\u00edguez","year":"2008","journal-title":"Drug News Perspect."},{"key":"2023081005155240400_B116","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/cvr\/cvn102","article-title":"Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases","volume":"79","author":"Rodr\u00edguez","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B117","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1038\/nm1335","article-title":"Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase","volume":"11","author":"Yoshimura","year":"2005","journal-title":"Nat. Med."},{"key":"2023081005155240400_B118","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1161\/ATVBAHA.110.216580","article-title":"Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation","volume":"31","author":"Tang","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B119","doi-asserted-by":"publisher","first-page":"10594","DOI":"10.1021\/acs.jmedchem.9b02170","article-title":"Advances in the development of phosphodiesterase-4 Inhibitors","volume":"63","author":"Peng","year":"2020","journal-title":"J. Med. Chem."},{"key":"2023081005155240400_B120","doi-asserted-by":"publisher","first-page":"e385","DOI":"10.1016\/j.jss.2011.01.017","article-title":"Suppression of experimental abdominal aortic aneurysm in a rat model by the phosphodiesterase 3 inhibitor cilostazol","volume":"167","author":"Zhang","year":"2011","journal-title":"J. Surg. Res."},{"key":"2023081005155240400_B121","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1161\/ATVBAHA.117.309707","article-title":"Cilostazol Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E-Deficient Mice","volume":"38","author":"Umebayashi","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B122","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3390\/antiox10030460","article-title":"Rolipram prevents the formation of abdominal aortic aneurysm (AAA) in mice: PDE4B as a target in AAA","volume":"10","author":"Varona","year":"2021","journal-title":"Antioxid. Basel Switz."},{"key":"2023081005155240400_B123","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3797\/scipharm.1404-08","article-title":"Selective phosphodiesterase 4B inhibitors: A review","volume":"82","author":"Azam","year":"2014","journal-title":"Sci. Pharm."},{"key":"2023081005155240400_B124","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1124\/mol.56.1.170","article-title":"Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils","volume":"56","author":"Wang","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"2023081005155240400_B125","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/s12276-022-00815-y","article-title":"Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis","volume":"54","author":"Gao","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"2023081005155240400_B126","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1378\/chest.12-2332","article-title":"Cardiovascular safety in patients receiving roflumilast for the treatment of COPD","volume":"144","author":"White","year":"2013","journal-title":"Chest"},{"key":"2023081005155240400_B127","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/j.1476-5381.2011.01729.x","article-title":"Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments","volume":"165","author":"Keravis","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"2023081005155240400_B128","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3390\/ijms23031209","article-title":"Clinical implication of phosphodiesterase-4-inhibition","volume":"23","author":"Schick","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2023081005155240400_B129","doi-asserted-by":"publisher","first-page":"e023053","DOI":"10.1161\/JAHA.121.023053","article-title":"Sildenafil (Viagra) aggravates the development of experimental abdominal aortic aneurysm","volume":"11","author":"Zhang","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"2023081005155240400_B130","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1510\/icvts.2009.205849","article-title":"Aortic dissection due to sildenafil abuse","volume":"9","author":"Tiryakioglu","year":"2009","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"2023081005155240400_B131","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1042\/CS20090557","article-title":"Role of nuclear factor kappaB in cardiovascular health and disease","volume":"118","author":"Van der Heiden","year":"2010","journal-title":"Clin. Sci. Lond. Engl. 1979"},{"key":"2023081005155240400_B132","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.jss.2011.11.1024","article-title":"Increased JNK in males compared with females in a rodent model of abdominal aortic aneurysm","volume":"176","author":"DiMusto","year":"2012","journal-title":"J. Surg. Res."},{"key":"2023081005155240400_B133","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1161\/CIRCULATIONAHA.119.044986","article-title":"Lysyl oxidase inhibition ablates sexual dimorphism of abdominal aortic aneurysm formation in mice","volume":"142","author":"Okuyama","year":"2020","journal-title":"Circulation"},{"key":"2023081005155240400_B134","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.3892\/mmr.2019.10017","article-title":"c-Jun\/Ap-1 is upregulated in an Ang II-induced abdominal aortic aneurysm formation model and mediates chop expression in mouse aortic smooth muscle cells","volume":"19","author":"Sun","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"2023081005155240400_B135","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1161\/ATVBAHA.117.309768","article-title":"Genetic ablation of microRNA-33 attenuates inflammation and abdominal aortic aneurysm formation via several anti-inflammatory pathways","volume":"37","author":"Nakao","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B136","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1161\/HYPERTENSIONAHA.119.14442","article-title":"Prevention of progression of aortic aneurysm by peptide vaccine against ang II (angiotensin II) in a rat model","volume":"76","author":"Kurashiki","year":"2020","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"2023081005155240400_B137","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/cvr\/cvt230","article-title":"Zoledronate attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of Rho\/ROCK-dependent JNK and NF-\u03baB pathway","volume":"100","author":"Tsai","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B138","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3400\/avd.oa.17-00086","article-title":"Cytokine profile of human abdominal aortic aneurysm: involvement of JAK\/STAT pathway","volume":"11","author":"Ohno","year":"2018","journal-title":"Ann. Vasc. Dis."},{"key":"2023081005155240400_B139","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.yjmcc.2015.08.014","article-title":"Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3","volume":"87","author":"Qin","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"2023081005155240400_B140","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41419-020-2326-2","article-title":"A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"key":"2023081005155240400_B141","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ijcard.2020.03.072","article-title":"Experimental abdominal aortic aneurysm growth is inhibited by blocking the JAK2\/STAT3 pathway","volume":"312","author":"Xiao","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"2023081005155240400_B142","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/bph.15330","article-title":"Protective effect of suppressor of cytokine signalling 1-based therapy in experimental abdominal aortic aneurysm","volume":"178","author":"Bernal","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"2023081005155240400_B143","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1161\/CIRCGENETICS.111.961235","article-title":"Frequent and widespread vascular abnormalities in human signal transducer and activator of transcription 3 deficiency","volume":"5","author":"Chandesris","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"key":"2023081005155240400_B144","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1161\/ATVBAHA.112.300516","article-title":"Overexpression of SOCS3 in T lymphocytes leads to impaired interleukin-17 production and severe aortic aneurysm formation in mice\u2013brief report","volume":"33","author":"Romain","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B145","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.jjcc.2020.10.010","article-title":"Ying and Yang of Stat3 in pathogenesis of aortic dissection","volume":"77","author":"Aoki","year":"2021","journal-title":"J. Cardiol."},{"issue":"3","key":"2023081005155240400_B146","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.gendis.2022.05.017","article-title":"Activation of Wnt\/\u03b2-catenin signaling in abdominal aortic aneurysm: A potential therapeutic opportunity?","volume":"10","author":"Puertas-Umbert","year":"2022","journal-title":"Genes Dis."},{"key":"2023081005155240400_B147","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1172\/JCI62059","article-title":"\u03b2-Catenin-regulated myeloid cell adhesion and migration determine wound healing","volume":"124","author":"Amini-Nik","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B148","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bbrc.2006.06.082","article-title":"Activation of the canonical Wnt\/beta-catenin pathway enhances monocyte adhesion to endothelial cells","volume":"347","author":"Lee","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023081005155240400_B149","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1161\/01.RES.0000253533.65446.33","article-title":"Regulation of smooth muscle cell proliferation by beta-catenin\/T-cell factor signaling involves modulation of cyclin D1 and p21 expression","volume":"99","author":"Quasnichka","year":"2006","journal-title":"Circ. Res."},{"key":"2023081005155240400_B150","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1161\/CIRCRESAHA.107.166405","article-title":"E-cadherin\/beta-catenin\/T-cell factor pathway is involved in smooth muscle cell proliferation elicited by oxidized low-density lipoprotein","volume":"103","author":"Bedel","year":"2008","journal-title":"Circ. Res."},{"key":"2023081005155240400_B151","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/cvr\/cvs141","article-title":"Wnt signalling in smooth muscle cells and its role in cardiovascular disorders","volume":"95","author":"Mill","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B152","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.immuni.2006.12.007","article-title":"Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration","volume":"26","author":"Wu","year":"2007","journal-title":"Immunity"},{"key":"2023081005155240400_B153","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1161\/ATVBAHA.116.308723","article-title":"Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis","volume":"37","author":"Krishna","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B154","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s12079-021-00623-5","article-title":"Aneurysm severity is suppressed by deletion of CCN4","volume":"15","author":"Williams","year":"2021","journal-title":"J. Cell Commun. Signal."},{"key":"2023081005155240400_B155","doi-asserted-by":"publisher","first-page":"9241959","DOI":"10.1155\/2022\/9241959","article-title":"miR-124a involves in the regulation of Wnt\/\u03b2-Catenin and P53 pathways to inhibit abdominal aortic aneurysm via targeting BRD4","volume":"2022","author":"Li","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"2023081005155240400_B156","doi-asserted-by":"publisher","first-page":"e463","DOI":"10.1002\/ctm2.463","article-title":"Fc\u03b3 receptor activation mediates vascular inflammation and abdominal aortic aneurysm development","volume":"11","author":"Lopez-Sanz","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"2023081005155240400_B157","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.arteri.2022.12.004","article-title":"The presence of activating IgG Fc receptors in macrophages aggravates the development of experimental abdominal aortic aneurysm","volume":"35","author":"L\u00f3pez-Sanz","year":"2023","journal-title":"Clin. E Investig. En Arterioscler. Publ. Soc. Espanola Arterioscler."},{"key":"2023081005155240400_B158","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1161\/01.ATV.18.10.1625","article-title":"Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms","volume":"18","author":"Davis","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B159","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B160","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1172\/JCI118037","article-title":"Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages","volume":"96","author":"Thompson","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B161","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1172\/JCI2182","article-title":"Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms","volume":"102","author":"Curci","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B162","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/nrd4390","article-title":"Is there new hope for therapeutic matrix metalloproteinase inhibition?","volume":"13","author":"Vandenbroucke","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"2023081005155240400_B163","doi-asserted-by":"publisher","first-page":"984","DOI":"10.3390\/cells8090984","article-title":"The rebirth of matrix metalloproteinase inhibitors: moving beyond the dogma","volume":"8","author":"Fields","year":"2019","journal-title":"Cells"},{"key":"2023081005155240400_B164","doi-asserted-by":"publisher","first-page":"809","DOI":"10.2353\/ajpath.2007.060522","article-title":"Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases","volume":"170","author":"Abdul-Hussien","year":"2007","journal-title":"Am. J. Pathol."},{"key":"2023081005155240400_B165","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1196\/annals.1383.028","article-title":"Do cathepsins play a role in abdominal aortic aneurysm pathogenesis?","volume":"1085","author":"Sukhova","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2023081005155240400_B166","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.atherosclerosis.2005.05.012","article-title":"Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells","volume":"184","author":"Liu","year":"2006","journal-title":"Atherosclerosis"},{"key":"2023081005155240400_B167","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1161\/CIRCRESAHA.111.243758","article-title":"Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation","volume":"108","author":"Zhang","year":"2011","journal-title":"Circ. Res."},{"key":"2023081005155240400_B168","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/ATVBAHA.111.235002","article-title":"Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice","volume":"32","author":"Sun","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B169","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1161\/ATVBAHA.111.230201","article-title":"Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice","volume":"31","author":"Sun","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B170","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/cvr\/cvs263","article-title":"Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice","volume":"96","author":"Qin","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B171","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1172\/JCI7709","article-title":"Cystatin C deficiency in human atherosclerosis and aortic aneurysms","volume":"104","author":"Shi","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B172","doi-asserted-by":"publisher","first-page":"e41813","DOI":"10.1371\/journal.pone.0041813","article-title":"Plasma cathepsin S and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population-based study","volume":"7","author":"Lv","year":"2012","journal-title":"PloS ONE"},{"key":"2023081005155240400_B173","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.ejvs.2020.01.008","article-title":"Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice","volume":"59","author":"Lai","year":"2020","journal-title":"Eur. J. Vasc. Endovasc. Surg. Off. J. Eur. Soc. Vasc. Surg."},{"key":"2023081005155240400_B174","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1021\/ml500283g","article-title":"Discovery of cathepsin S inhibitor LY3000328 for the treatment of abdominal aortic aneurysm","volume":"5","author":"Jadhav","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"2023081005155240400_B175","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.actbio.2020.05.037","article-title":"Assessing the targeting and fate of cathepsin k antibody-modified nanoparticles in a rat abdominal aortic aneurysm model","volume":"112","author":"Camardo","year":"2020","journal-title":"Acta Biomater."},{"key":"2023081005155240400_B176","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0741-5214(97)70333-1","article-title":"Elevations of tissue-type plasminogen activator and differential expression of urokinase-type plasminogen activator in diseased aorta","volume":"25","author":"Shireman","year":"1997","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B177","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/S0002-9440(10)62532-1","article-title":"Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice","volume":"159","author":"Wang","year":"2001","journal-title":"Am. J. Pathol."},{"key":"2023081005155240400_B178","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1161\/01.RES.0000061571.49375.E1","article-title":"Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm","volume":"92","author":"Deng","year":"2003","journal-title":"Circ. Res."},{"key":"2023081005155240400_B179","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/sj.gt.3303069","article-title":"Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice","volume":"15","author":"Qian","year":"2008","journal-title":"Gene Ther."},{"key":"2023081005155240400_B180","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1161\/ATVBAHA.111.234997","article-title":"Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms","volume":"31","author":"Uchida","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B181","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3390\/biom9100610","article-title":"Emerging roles of lysyl oxidases in the cardiovascular system: New concepts and therapeutic challenges","volume":"9","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2019","journal-title":"Biomolecules"},{"key":"2023081005155240400_B182","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1067\/msy.2000.107379","article-title":"Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms","volume":"128","author":"Huffman","year":"2000","journal-title":"Surgery"},{"key":"2023081005155240400_B183","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1161\/01.CIR.0000038109.84500.1E","article-title":"Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice","volume":"106","author":"M\u00e4ki","year":"2002","journal-title":"Circulation"},{"key":"2023081005155240400_B184","doi-asserted-by":"publisher","first-page":"14387","DOI":"10.1074\/jbc.M210144200","article-title":"Lysyl oxidase is required for vascular and diaphragmatic development in mice","volume":"278","author":"Hornstra","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023081005155240400_B185","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0021-9150(98)00130-0","article-title":"Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats","volume":"140","author":"Br\u00fcel","year":"1998","journal-title":"Atherosclerosis"},{"key":"2023081005155240400_B186","doi-asserted-by":"publisher","first-page":"H1067","DOI":"10.1152\/ajpheart.00217.2012","article-title":"The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms","volume":"303","author":"Remus","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023081005155240400_B187","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1160\/TH14-01-0024","article-title":"Lysyl oxidase (LOX) in vascular remodelling. Insight from a new animal model","volume":"112","author":"Orriols","year":"2014","journal-title":"Thromb. Haemost."},{"key":"2023081005155240400_B188","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.atherosclerosis.2009.07.036","article-title":"Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm","volume":"208","author":"Onoda","year":"2010","journal-title":"Atherosclerosis"},{"key":"2023081005155240400_B189","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0741-5214(97)70185-X","article-title":"Abdominal aortic aneurysm: a general defect in the vasculature with focal manifestations in the abdominal aorta?","volume":"26","author":"Sonesson","year":"1997","journal-title":"J. Vasc. Surg."},{"key":"2023081005155240400_B190","doi-asserted-by":"publisher","first-page":"e0192957","DOI":"10.1371\/journal.pone.0192957","article-title":"Preliminary analysis of proteome alterations in non-aneurysmal, internal mammary artery tissue from patients with abdominal aortic aneurysms","volume":"13","author":"Kidholm","year":"2018","journal-title":"PLoS ONE"},{"key":"2023081005155240400_B191","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.arteri.2016.06.004","article-title":"Inflammation inhibits vascular fibulin-5 expression: Involvement of transcription factor SOX9","volume":"28","author":"Orriols","year":"2016","journal-title":"Clin. E Investig. En Arterioscler. Publ. Soc. Espanola Arterioscler."},{"key":"2023081005155240400_B192","doi-asserted-by":"publisher","first-page":"7093","DOI":"10.1074\/jbc.M110.162917","article-title":"Fibulin-5 is up-regulated by hypoxia in endothelial cells through a hypoxia-inducible factor-1 (HIF-1\u03b1)-dependent mechanism","volume":"286","author":"Guadall","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2023081005155240400_B193","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1161\/ATVBAHA.109.196725","article-title":"Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury","volume":"30","author":"Chapman","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B194","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1073\/pnas.0500058102","article-title":"Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration","volume":"102","author":"Spencer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023081005155240400_B195","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/cvr\/cvw082","article-title":"Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics","volume":"110","author":"Orriols","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B196","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10439-018-02145-5","article-title":"Pentagalloyl glucose and Its functional role in vascular health: biomechanics and drug-delivery characteristics","volume":"47","author":"Patnaik","year":"2019","journal-title":"Ann. Biomed. Eng."},{"key":"2023081005155240400_B197","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1161\/CIRCULATIONAHA.106.672873","article-title":"Elastin stabilization for treatment of abdominal aortic aneurysms","volume":"115","author":"Isenburg","year":"2007","journal-title":"Circulation"},{"key":"2023081005155240400_B198","doi-asserted-by":"publisher","first-page":"e0234409","DOI":"10.1371\/journal.pone.0234409","article-title":"Intraluminal infusion of Penta-Galloyl Glucose reduces abdominal aortic aneurysm development in the elastase rat model","volume":"15","author":"Schack","year":"2020","journal-title":"PLoS ONE"},{"key":"2023081005155240400_B199","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jvssci.2020.04.001","article-title":"Chemical stabilization of the extracellular matrix attenuates growth of experimentally induced abdominal aorta aneurysms in a large animal model","volume":"1","author":"Simionescu","year":"2020","journal-title":"JVS-Vasc. Sci."},{"key":"2023081005155240400_B200","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s12265-016-9709-x","article-title":"Systemic delivery of nanoparticles loaded with pentagalloyl glucose protects elastic lamina and prevents abdominal aortic aneurysm in rats","volume":"9","author":"Nosoudi","year":"2016","journal-title":"J Cardiovasc. Transl. Res."},{"key":"2023081005155240400_B201","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.bbrc.2014.01.027","article-title":"Elasto-regenerative properties of polyphenols","volume":"444","author":"Sinha","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023081005155240400_B202","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2023081005155240400_B203","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1161\/CIRCRESAHA.116.304899","article-title":"Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation","volume":"116","author":"Wang","year":"2015","journal-title":"Circ. Res."},{"key":"2023081005155240400_B204","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41419-019-1468-6","article-title":"Identification of a novel class of RIP1\/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis."},{"key":"2023081005155240400_B205","doi-asserted-by":"publisher","first-page":"1806513","DOI":"10.1155\/2022\/1806513","article-title":"IL-37 Expression in patients with abdominal aortic aneurysm and its role in the necroptosis of vascular smooth muscle cells","volume":"2022","author":"Ding","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"2023081005155240400_B206","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s12079-023-00737-y","article-title":"METTL3-METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneurysms","volume":"17","author":"Li","year":"2023","journal-title":"J. Cell Commun. Signal."},{"key":"2023081005155240400_B207","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/ATVBAHA.119.312193","article-title":"Epigenetic regulation of vascular diseases","volume":"39","author":"Zarzour","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B208","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1161\/CIRCRESAHA.118.311597","article-title":"Epigenomes in cardiovascular disease","volume":"122","author":"Rosa-Garrido","year":"2018","journal-title":"Circ. Res."},{"key":"2023081005155240400_B209","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41576-022-00465-w","article-title":"DNA methylation-based predictors of health: applications and statistical considerations","volume":"23","author":"Yousefi","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"2023081005155240400_B210","doi-asserted-by":"publisher","first-page":"11259","DOI":"10.3390\/ijms160511259","article-title":"The potential role of DNA methylation in abdominal aortic aneurysms","volume":"16","author":"Ryer","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"2023081005155240400_B211","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13148-018-0460-9","article-title":"SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells","volume":"10","author":"Toghill","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"2023081005155240400_B212","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1161\/ATVBAHA.118.311917","article-title":"SM22\u03b1 (Smooth muscle 22\u03b1) prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching through suppressing reactive oxygen species\/NF-\u03baB (Nuclear Factor-\u03baB)","volume":"39","author":"Zhong","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B213","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ijcard.2020.06.022","article-title":"Associations of global DNA methylation and homocysteine levels with abdominal aortic aneurysm: A cohort study from a population-based screening program in Sweden","volume":"321","author":"Vats","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"2023081005155240400_B214","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/2211-5463.12643","article-title":"Epigenetic regulation of regulatory T cells in patients with abdominal aortic aneurysm","volume":"9","author":"Xia","year":"2019","journal-title":"FEBS Open Bio"},{"key":"2023081005155240400_B215","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1186\/s12872-022-02882-5","article-title":"DNA methylation alternation in Stanford- A acute aortic dissection","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Cardiovasc. Disord."},{"key":"2023081005155240400_B216","doi-asserted-by":"publisher","first-page":"e20201839","DOI":"10.1084\/jem.20201839","article-title":"Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms","volume":"218","author":"Davis","year":"2021","journal-title":"J. Exp. Med."},{"key":"2023081005155240400_B217","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1242\/dmm.024513","article-title":"Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors","volume":"9","author":"Gal\u00e1n","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"2023081005155240400_B218","doi-asserted-by":"publisher","first-page":"595011","DOI":"10.3389\/fcvm.2020.595011","article-title":"Profiling of histone modifications reveals epigenomic dynamics during abdominal aortic aneurysm formation in mouse models","volume":"7","author":"Greenway","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"2023081005155240400_B219","doi-asserted-by":"publisher","first-page":"7449","DOI":"10.1111\/jcmm.14613","article-title":"Silencing of NONO inhibits abdominal aortic aneurysm in apolipoprotein E-knockout mice via collagen deposition and inflammatory inhibition","volume":"23","author":"Xu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"2023081005155240400_B220","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13148-016-0169-6","article-title":"Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm","volume":"8","author":"Han","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"2023081005155240400_B221","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1093\/cvr\/cvz303","article-title":"Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+\/nicotinamide","volume":"116","author":"Horimatsu","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"2023081005155240400_B222","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jgg.2018.01.002","article-title":"Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation","volume":"45","author":"Zhang","year":"2018","journal-title":"J. Genet. Genomics Yi Chuan Xue Bao"},{"key":"2023081005155240400_B223","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1755-8794-5-25","article-title":"MicroRNA expression signature in human abdominal aortic aneurysms","volume":"5","author":"Pahl","year":"2012","journal-title":"BMC Med. Genomics"},{"key":"2023081005155240400_B224","doi-asserted-by":"publisher","first-page":"e000745","DOI":"10.1161\/JAHA.112.000745","article-title":"Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm","volume":"1","author":"Kin","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"2023081005155240400_B225","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1042\/CS20130599","article-title":"microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155","volume":"126","author":"Biros","year":"2014","journal-title":"Clin. Sci. Lond. Engl. 1979"},{"key":"2023081005155240400_B226","doi-asserted-by":"publisher","first-page":"122ra22","DOI":"10.1126\/scitranslmed.3003441","article-title":"MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion","volume":"4","author":"Maegdefessel","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"2023081005155240400_B227","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1161\/CIRCRESAHA.111.255737","article-title":"MicroRNA-29 in aortic dilation: implications for aneurysm formation","volume":"109","author":"Boon","year":"2011","journal-title":"Circ. Res."},{"key":"2023081005155240400_B228","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1172\/JCI61598","article-title":"Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development","volume":"122","author":"Maegdefessel","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B229","doi-asserted-by":"publisher","first-page":"5214","DOI":"10.1038\/ncomms6214","article-title":"miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development","volume":"5","author":"Maegdefessel","year":"2014","journal-title":"Nat. Commun."},{"key":"2023081005155240400_B230","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1161\/CIRCRESAHA.118.312438","article-title":"Role of noncoding RNAs in the pathogenesis of abdominal aortic aneurysm","volume":"124","author":"Kumar","year":"2019","journal-title":"Circ. Res."},{"key":"2023081005155240400_B231","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.atherosclerosis.2017.03.010","article-title":"A systematic review investigating the association of microRNAs with human abdominal aortic aneurysms","volume":"261","author":"Iyer","year":"2017","journal-title":"Atherosclerosis"},{"key":"2023081005155240400_B232","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.tig.2022.02.006","article-title":"Emerging concepts of miRNA therapeutics: from cells to clinic","volume":"38","author":"Diener","year":"2022","journal-title":"Trends Genet. TIG"},{"key":"2023081005155240400_B233","doi-asserted-by":"publisher","first-page":"571076","DOI":"10.3389\/fcvm.2021.571076","article-title":"Unresolved issues in RNA therapeutics in vascular diseases with a focus on aneurysm disease","volume":"8","author":"Schellinger","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"2023081005155240400_B234","doi-asserted-by":"publisher","first-page":"1153899","DOI":"10.3389\/fgene.2023.1153899","article-title":"The role of long non-coding RNA in abdominal aortic aneurysm","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Genet."},{"key":"2023081005155240400_B235","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.atherosclerosis.2019.11.013","article-title":"Long noncoding RNAs in key cellular processes involved in aortic aneurysms","volume":"292","author":"Wu","year":"2020","journal-title":"Atherosclerosis"},{"key":"2023081005155240400_B236","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.117.032184","article-title":"H19 induces abdominal aortic aneurysm development and progression","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"2023081005155240400_B237","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.yjmcc.2019.04.004","article-title":"LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA","volume":"131","author":"Sun","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"key":"2023081005155240400_B238","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12967-021-03023-w","article-title":"Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm","volume":"19","author":"Le","year":"2021","journal-title":"J. Transl. Med."},{"key":"2023081005155240400_B239","doi-asserted-by":"publisher","first-page":"12583","DOI":"10.1080\/21655979.2021.2010384","article-title":"Long non-coding RNA PVT1\/microRNA miR-3127-5p\/NCK-associated protein 1-like axis participates in the pathogenesis of abdominal aortic aneurysm by regulating vascular smooth muscle cells","volume":"12","author":"Huang","year":"2021","journal-title":"Bioengineered"},{"key":"2023081005155240400_B240","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.vph.2018.06.004","article-title":"The function of long non-coding RNAs in vascular biology and disease","volume":"114","author":"Kok","year":"2019","journal-title":"Vascul. Pharmacol."},{"key":"2023081005155240400_B241","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/CIRCRESAHA.119.315856","article-title":"Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease","volume":"126","author":"Huang","year":"2020","journal-title":"Circ. Res."},{"key":"2023081005155240400_B242","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.ijcard.2016.08.238","article-title":"Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE-\/- mice","volume":"223","author":"Duan","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"2023081005155240400_B243","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1161\/CIRCRESAHA.120.315929","article-title":"BET epigenetic reader proteins in cardiovascular transcriptional programs","volume":"126","author":"Borck","year":"2020","journal-title":"Circ. Res."},{"key":"2023081005155240400_B244","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.yjmcc.2018.10.012","article-title":"Brg1 trans-activates endothelium-derived colony stimulating factor to promote calcium chloride induced abdominal aortic aneurysm in mice","volume":"125","author":"Zhang","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"2023081005155240400_B245","doi-asserted-by":"publisher","first-page":"e158309","DOI":"10.1172\/JCI158309","article-title":"BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis","volume":"132","author":"Zhao","year":"2022","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B246","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1161\/ATVBAHA.120.314955","article-title":"BAF60a deficiency in vascular smooth muscle cells prevents abdominal aortic aneurysm by reducing inflammation and extracellular matrix degradation","volume":"40","author":"Chang","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B247","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.neuron.2015.06.038","article-title":"Wiring the vascular network with neural cues: A CNS perspective","volume":"87","author":"W\u00e4lchli","year":"2015","journal-title":"Neuron"},{"key":"2023081005155240400_B248","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1093\/eurheartj\/ehs041","article-title":"The human sympathetic nervous system: its relevance in hypertension and heart failure","volume":"33","author":"Parati","year":"2012","journal-title":"Eur. Heart J."},{"key":"2023081005155240400_B249","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1111\/eci.12553","article-title":"Sympathetic activation in cardiovascular disease: evidence, clinical impact and therapeutic implications","volume":"45","author":"Grassi","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"2023081005155240400_B250","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.avsg.2013.11.016","article-title":"Sympathetic hyperactivity and aortic sympathetic nerve sprouting in patients with thoracic aortic dissection","volume":"28","author":"Zhipeng","year":"2014","journal-title":"Ann. Vasc. Surg."},{"key":"2023081005155240400_B251","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12872-016-0375-3","article-title":"Autonomic remodeling may be responsible for decreased incidence of aortic dissection in STZ-induced diabetic rats via down-regulation of matrix metalloprotease 2","volume":"16","author":"Hu","year":"2016","journal-title":"BMC Cardiovasc. Disord."},{"key":"2023081005155240400_B252","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3892\/mmr.2020.11088","article-title":"The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGF\u03b2 by suppressing the expression of the TGF\u03b2 receptor ALK5 in aorta remodeling","volume":"22","author":"Hu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"2023081005155240400_B253","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1161\/HYPERTENSIONAHA.120.16078","article-title":"High NOR-1 (Neuron-derived orphan receptor 1) expression strengthens the vascular wall response to sngiotensin II leading to aneurysm formation in mice","volume":"77","author":"Ca\u00f1es","year":"2021","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"2023081005155240400_B254","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1161\/HYPERTENSIONAHA.121.17517","article-title":"Targeting tyrosine hydroxylase for abdominal aortic aneurysm: impact on inflammation, oxidative stress, and vascular remodeling","volume":"78","author":"Ca\u00f1es","year":"2021","journal-title":"Hypertens. Dallas Tex 1979"},{"key":"2023081005155240400_B255","doi-asserted-by":"publisher","first-page":"11371","DOI":"10.3390\/ijms222111371","article-title":"NR4A3: A key nuclear receptor in vascular biology, cardiovascular remodeling, and beyond","volume":"22","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023081005155240400_B256","doi-asserted-by":"publisher","first-page":"258","DOI":"10.4103\/2141-9248.113672","article-title":"Coexistence of pheochromocytoma with abdominal aortic aneurysm: an untold association","volume":"3","author":"Kota","year":"2013","journal-title":"Ann. Med. Health Sci. Res."},{"key":"2023081005155240400_B257","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/01.ATV.0000013778.72404.30","article-title":"Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling","volume":"22","author":"Miller","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B258","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1161\/01.ATV.0000257552.94483.14","article-title":"Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms","volume":"27","author":"McCormick","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B259","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.atherosclerosis.2015.07.036","article-title":"B lymphocytes in abdominal aortic aneurysms","volume":"242","author":"Zhang","year":"2015","journal-title":"Atherosclerosis"},{"key":"2023081005155240400_B260","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1179\/1351000212Y.0000000012","article-title":"On the potential increase of the oxidative stress status in patients with abdominal aortic aneurysm","volume":"17","author":"Pincemail","year":"2012","journal-title":"Redox Rep. Commun. Free Radic. Res."},{"key":"2023081005155240400_B261","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1042\/CS20190399","article-title":"Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm","volume":"133","author":"Navas-Madro\u00f1al","year":"2019","journal-title":"Clin. Sci."},{"key":"2023081005155240400_B262","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1161\/CIRCULATIONAHA.105.607168","article-title":"Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice","volume":"114","author":"Thomas","year":"2006","journal-title":"Circulation"},{"key":"2023081005155240400_B263","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.3390\/antiox11091830","article-title":"NADPH oxidases in aortic aneurysms","volume":"11","author":"Salmon","year":"2022","journal-title":"Antioxid. Basel Switz."},{"key":"2023081005155240400_B264","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis","volume":"297","author":"Bjelakovic","year":"2007","journal-title":"JAMA"},{"key":"2023081005155240400_B265","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.bbamcr.2014.02.009","article-title":"Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction","volume":"1843","author":"Gal\u00e1n","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2023081005155240400_B266","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"Kassan","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023081005155240400_B267","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nm0410-396","article-title":"Endoplasmic reticulum stress and atherosclerosis","volume":"16","author":"Hotamisligil","year":"2010","journal-title":"Nat. Med."},{"key":"2023081005155240400_B268","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbadis.2018.10.029","article-title":"A FBN1 3\u2032UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in Marfan syndrome","volume":"1865","author":"Siegert","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"17","key":"2023081005155240400_B269","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1111\/bph.16077","article-title":"Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress","volume":"180","author":"Navas-Madro\u00f1al","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"2023081005155240400_B270","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12020-018-1657-6","article-title":"Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice","volume":"62","author":"Ni","year":"2018","journal-title":"Endocrine"},{"key":"2023081005155240400_B271","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1172\/JCI38857","article-title":"Calcium\/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways","volume":"119","author":"Timmins","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2023081005155240400_B272","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cell.2008.01.007","article-title":"Mitochondria\u2013a nexus for aging, calorie restriction, and sirtuins?","volume":"132","author":"Guarente","year":"2008","journal-title":"Cell"},{"key":"2023081005155240400_B273","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000446653","article-title":"Altered PPAR\u03b3 coactivator-1 alpha expression in abdominal aortic aneurysm: possible effects on mitochondrial biogenesis","volume":"53","author":"Gabrielson","year":"2016","journal-title":"J. Vasc. Res."},{"key":"2023081005155240400_B274","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.surg.2005.07.011","article-title":"Mitochondrial-dependent apoptosis in experimental rodent abdominal aortic aneurysms","volume":"138","author":"Sinha","year":"2005","journal-title":"Surgery"},{"key":"2023081005155240400_B275","doi-asserted-by":"publisher","first-page":"17224","DOI":"10.1073\/pnas.1413624111","article-title":"Comparison of the transcriptional landscapes between human and mouse tissues","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023081005155240400_B276","first-page":"2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"2023081005155240400_B277","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1161\/ATVBAHA.116.308534","article-title":"Translational relevance and recent advances of animal models of abdominal aortic aneurysm","volume":"37","author":"S\u00e9n\u00e9maud","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/137\/15\/1167\/948772\/cs-2022-0795c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/137\/15\/1167\/948772\/cs-2022-0795c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T01:16:24Z","timestamp":1691630184000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/137\/15\/1167\/233360\/Novel-pharmacological-approaches-in-abdominal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":277,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,8,14]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20220795","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,8]]}}}