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Vascular remodelling involves changes in vessel structure, including its size, shape, cellular and molecular composition. These changes result from multiple risk factors and may be compensatory adaptations to sustain blood vessel function. They occur in diverse cardiovascular pathologies, from hypertension to heart failure and atherosclerosis. Dynamic changes in the endothelium, fibroblasts, smooth muscle cells, pericytes or other vascular wall cells underlie remodelling. In addition, immune cells, including macrophages and lymphocytes, may infiltrate vessels and initiate inflammatory signalling. They contribute to a dynamic interplay between cell proliferation, apoptosis, migration, inflammation, and extracellular matrix reorganisation, all critical mechanisms of vascular remodelling. Molecular pathways underlying these processes include growth factors (e.g., vascular endothelial growth factor and platelet-derived growth factor), inflammatory cytokines (e.g., interleukin-1\u03b2 and tumour necrosis factor-\u03b1), reactive oxygen species, and signalling pathways, such as Rho\/ROCK, MAPK, and TGF-\u03b2\/Smad, related to nitric oxide and superoxide biology. MicroRNAs and long noncoding RNAs are crucial epigenetic regulators of gene expression in vascular remodelling. We evaluate these pathways for potential therapeutic targeting from a clinical translational perspective. In summary, vascular remodelling, a coordinated modification of vascular structure and function, is crucial in cardiovascular disease pathology.<\/jats:p>","DOI":"10.1042\/cs20220797","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:27:48Z","timestamp":1719376068000},"page":"817-850","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation"],"prefix":"10.1042","volume":"138","author":[{"given":"Justyna","family":"Toto\u0144-\u017bura\u0144ska","sequence":"first","affiliation":[{"name":"1Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz\u00a0P.","family":"Mikolajczyk","sequence":"additional","affiliation":[{"name":"1Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland"},{"name":"2Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessy","family":"Saju","sequence":"additional","affiliation":[{"name":"3BHF Centre for Research Excellence, Centre for Cardiovascular Sciences, The University of Edinburgh, Edinburgh, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz\u00a0J.","family":"Guzik","sequence":"additional","affiliation":[{"name":"1Center for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland"},{"name":"2Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland"},{"name":"3BHF Centre for Research Excellence, Centre for Cardiovascular Sciences, The University of Edinburgh, Edinburgh, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"2024062608273020200_B1","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1056\/NEJM199405193302008","article-title":"The emerging concept of vascular remodeling","volume":"330","author":"Gibbons","year":"1994","journal-title":"N. 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