{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:14:18Z","timestamp":1785294858490,"version":"3.55.0"},"reference-count":80,"publisher":"Portland Press Ltd.","issue":"16","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"funder":[{"name":"Capes\/Probral","award":["BEX 3993\/09-4"],"award-info":[{"award-number":["BEX 3993\/09-4"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["134212\/2007-0"],"award-info":[{"award-number":["134212\/2007-0"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: An unbalance in the renin-angiotensin (Ang) system (RAS) between the Ang II\/AT1 and Ang-(1-7)\/Mas axis appears to be involved in preeclampsia (PE), in which a reduction in Ang-(1-7) was observed. Here, we tested whether the reduction in the activity of the Ang-(1-7)\/Mas axis could be a contributing factor for the development of PE, using Mas-deficient (Mas\u2212\/\u2212) mice. Methods and results: Cardiovascular parameters were evaluated by telemetry before, during pregnancy and 4 days postpartum in 20-week-old Mas\u2212\/\u2212 and wild-type (WT) female mice. Mas\u2212\/\u2212 mice presented reduced arterial blood pressure (BP) at baseline (91.3 \u00b1 0.8 in Mas\u2212\/\u2212 vs. 94.0 \u00b1 0.9 mmHg in WT, Diastolic, P&amp;lt;0.05). However, after the 13th day of gestation, BP in Mas\u2212\/\u2212 mice started to increase, time-dependently, and at day 19 of pregnancy, these animals presented a higher BP in comparison with WT group (90.5 \u00b1 0.7 in Mas\u2212\/\u2212 vs. 80.3 \u00b1 3.5 mmHg in WT, Diastolic D19, P&amp;lt;0.0001). Moreover, pregnant Mas\u2212\/\u2212 mice presented fetal growth restriction, increase in urinary protein excretion as compared with nonpregnant Mas\u2212\/\u2212, oliguria, increase in cytokines, endothelial dysfunction and reduced ACE, AT1R, ACE2, ET-1A, and eNOS placental mRNA, similar to some of the clinical manifestations found in the development of PE. Conclusions: These results show that Mas-deletion produces a PE-like state in FVB\/N mice.<\/jats:p>","DOI":"10.1042\/cs20220819","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T20:20:51Z","timestamp":1690921251000},"page":"1249-1263","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["G-protein-coupled receptor MAS deletion produces a preeclampsia-like phenotype in FVB\/N mice"],"prefix":"10.1042","volume":"137","author":[{"given":"Renata\u00a0L\u00facia","family":"Vieira Pimentel","sequence":"first","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana\u00edna\u00a0F\u00e9lix","family":"Braga","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth\u00a0Portugal\u00a0Pimenta","family":"Velloso","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto\u00a0Queiroga","family":"Lautner","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilene\u00a0Luzia","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail","family":"Todiras","sequence":"additional","affiliation":[{"name":"2Max-Delbr\u00fcck-Center for Molecular Medicine (MDC), Berlin-Buch, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Alenina","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"2Max-Delbr\u00fcck-Center for Molecular Medicine (MDC), Berlin-Buch, Germany"},{"name":"3German Center for Cardiovascular Research (DZHK) site Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bader","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"},{"name":"2Max-Delbr\u00fcck-Center for Molecular Medicine (MDC), Berlin-Buch, Germany"},{"name":"3German Center for Cardiovascular Research (DZHK) site Berlin, Berlin, Germany"},{"name":"4Charit\u00e9 University Medicine Berlin, Germany"},{"name":"5Institute for Biology, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-7820","authenticated-orcid":false,"given":"Felipe\u00a0Gaia","family":"de Sousa","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane\u00a0Lilian","family":"Beier","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5852","authenticated-orcid":false,"given":"RAS","family":"Santos","sequence":"additional","affiliation":[{"name":"1Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"2023082210103281900_B1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy","volume":"183","year":"2000","journal-title":"Am. 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