{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:07:04Z","timestamp":1788242824842,"version":"build-2803163510"},"reference-count":45,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous studies of the Caveolin 1 (Cav1) protein and caveolae, which are lipid raft structures found on the plasma membranes of certain cells, are associated with fat metabolism disorders, inflammation, diabetes, and cardiovascular disease. However, there have been no reports linking Cav1 to diabetic cardiomyopathy (DCM). In the present study, we established a relationship between Cav1 and the development of DCM. We found that compared with Cav1+\/+ mice, Cav1\u2212\/\u2212 diabetic mice exhibited more severe cardiac injury, increased activation of NF-\u03baB signaling, and up-regulation of downstream genes, including hypertrophic factors and inflammatory fibrosis factors in heart tissues. Additionally, in vitro results showed that knocking down Cav1 further activated HG-induced NF-\u03baB signaling, increased the expression of downstream target genes, and decreased the expression of inhibitor \u03b1 of NF-\u03baB (i\u03baB\u03b1), all of which have been linked to DCM pathogenesis. In contrast, Cav1 overexpression resulted in the opposite effects. Our study suggests that Cav1 knockdown promotes cardiac injury in DCM by activating the NF-\u03baB signaling pathway, and targeting Cav1 may lead to the development of novel treatments for DCM.<\/jats:p>","DOI":"10.1042\/cs20220874","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T16:27:10Z","timestamp":1678984030000},"page":"511-525","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy"],"prefix":"10.1042","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6950-7545","authenticated-orcid":false,"given":"Wenyan","family":"Gong","sequence":"first","affiliation":[{"name":"1Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310000, China"},{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Jiao","sequence":"additional","affiliation":[{"name":"1Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Yuan","sequence":"additional","affiliation":[{"name":"1Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310000, China"},{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"1Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310000, China"},{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"},{"name":"3Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"4Department of Cardiovascular Ultrasonic Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"},{"name":"3Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Xu","sequence":"additional","affiliation":[{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"},{"name":"5Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, Hangzhou 311121, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Bai","sequence":"additional","affiliation":[{"name":"6Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-8177","authenticated-orcid":false,"given":"Xingwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"1Department of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310000, China"},{"name":"2Hangzhou Institute of Cardiovascular Disease, Hangzhou 310000, China"},{"name":"3Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"2023032410174853200_","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1161\/CIRCULATIONAHA.116.022194","article-title":"Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus - mechanisms, management, and clinical considerations","volume":"133","author":"Low Wang","year":"2016","journal-title":"Circulation"},{"key":"2023032410174853200_","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/CIRCRESAHA.118.314665","article-title":"Diabetic cardiomyopathy","volume":"124","author":"Dillmann","year":"2019","journal-title":"Circ. 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