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Colchicine is a medicine used to treat gout and familial Mediterranean fever, and recently, it was approved to reduce the risk of cardiovascular events in adult patients with established atherosclerotic disease. With an AAA mice model created by treatment with porcine pancreatic elastase (PPE) and \u03b2-aminopropionitrile (BAPN), this work was designed to explore whether colchicine could protect against the development of AAA. Here, we showed that colchicine could limit AAA formation, as evidenced by the decreased total aortic weight per body weight, AAA incidence, maximal abdominal aortic diameter and collagen deposition. We also found that colchicine could prevent the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally, it was proved that the protective action of colchicine against AAA formation was mainly mediated by preventing immune cells infiltration to the aortic wall. In summary, our findings demonstrated that colchicine could protect against the development of experimental AAA, providing a potential therapeutic strategy for AAA intervention in the clinic.<\/jats:p>","DOI":"10.1042\/cs20230499","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T18:25:01Z","timestamp":1695666301000},"page":"1533-1545","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Colchicine protects against the development of experimental abdominal aortic aneurysm"],"prefix":"10.1042","volume":"137","author":[{"given":"Yi","family":"Zhao","sequence":"first","affiliation":[{"name":"1Department of Pharmacy, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Rui","family":"Shen","sequence":"additional","affiliation":[{"name":"2Department of Pharmacy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"1Department of Pharmacy, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"1Department of Pharmacy, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bing","family":"Wu","sequence":"additional","affiliation":[{"name":"3Department of Pharmacology, School of Pharmacy, Second Military Medical University\/ Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Li","sequence":"additional","affiliation":[{"name":"4School of Pharmacy, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jie","family":"Li","sequence":"additional","affiliation":[{"name":"1Department of Pharmacy, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1149-315X","authenticated-orcid":false,"given":"Fu-Ming","family":"Shen","sequence":"additional","affiliation":[{"name":"1Department of Pharmacy, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-3301","authenticated-orcid":false,"given":"Hui","family":"Fu","sequence":"additional","affiliation":[{"name":"1Department of Pharmacy, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"2023100307210037400_B1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3390\/biom12040509","article-title":"Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm","volume":"12","author":"DeRoo","year":"2022","journal-title":"Biomolecules"},{"key":"2023100307210037400_B2","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.3390\/ijms21176334","article-title":"Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm","volume":"21","author":"Gurung","year":"2020","journal-title":"Int. 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