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Endothelial progenitor cells (EPCs) are a heterogeneous population of cells that differentiate into mature endothelial cells, which influence vascular homeostasis, neovascularization, and endothelial repair. Since their discovery in 1997 by Asahara et al., the role of EPCs in vascular biology has garnered a lot of interest. However, although pregnancy-related conditions are associated with changes in the number and function of EPCs, the reported findings are conflicting. This review discusses the discovery, isolation, and classification of EPCs and highlights discrepancies between current studies. Overviews of how various diseases affect the numbers and functions of EPCs, the role of EPCs as biomarkers of pregnancy disorders, and the potential therapeutic applications involving EPCs are also provided.<\/jats:p>","DOI":"10.1042\/cs20230853","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:01:48Z","timestamp":1700550108000},"page":"1699-1719","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Endothelial progenitor cells in pregnancy-related diseases"],"prefix":"10.1042","volume":"137","author":[{"given":"Yangyang","family":"Chen","sequence":"first","affiliation":[{"name":"1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Wan","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyun","family":"Li","sequence":"additional","affiliation":[{"name":"3The First Clinical School of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhao","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zou","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-5438","authenticated-orcid":false,"given":"Weifang","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"2023112107011000800_B1","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1093\/advances\/nmab070","article-title":"Placental angiogenesis in mammals: a review of the regulatory effects of signaling pathways and functional nutrients","volume":"12","author":"Huang","year":"2021","journal-title":"Adv. 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