{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:24:48Z","timestamp":1790825088159,"version":"4.1.0"},"reference-count":27,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202074"],"award-info":[{"award-number":["82202074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Air Force Medical University","award":["2018HKTS03"],"award-info":[{"award-number":["2018HKTS03"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High-altitude pulmonary hypertension (HAPH) is a severe and progressive disease that can lead to right heart failure. Intermittent short-duration reoxygenation at high altitude is effective in alleviating HAPH; however, the underlying mechanisms are unclear. In the present study, a simulated 5,000-m hypoxia rat model and hypoxic cultured pulmonary artery smooth muscle cells (PASMCs) were used to evaluate the effect and mechanisms of intermittent short-duration reoxygenation. The results showed that intermittent 3-h\/per day reoxygenation (I3) effectively attenuated chronic hypoxia-induced pulmonary hypertension and reduced the content of H2O2 and the expression of NADPH oxidase 4 (NOX4) in lung tissues. In combination with I3, while the NOX inhibitor apocynin did not further alleviate HAPH, the mitochondrial antioxidant MitoQ did. Furthermore, in PASMCs, I3 attenuated hypoxia-induced PASMCs proliferation and reversed the activated HIF-1\u03b1\/NOX4\/PPAR-\u03b3 axis under hypoxia. Targeting this axis offset the protective effect of I3 on hypoxia-induced PASMCs proliferation. The present study is novel in revealing a new mechanism for preventing HAPH and provides insights into the optimization of intermittent short-duration reoxygenation.<\/jats:p>","DOI":"10.1042\/cs20231508","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:21:49Z","timestamp":1705587709000},"page":"103-115","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4\/H2O2\/PPAR-\u03b3 axis"],"prefix":"10.1042","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7412-8787","authenticated-orcid":false,"given":"Shaohua","family":"Li","sequence":"first","affiliation":[{"name":"1Department of Aerospace Physiology, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Lyu","sequence":"additional","affiliation":[{"name":"2Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixin","family":"Shi","sequence":"additional","affiliation":[{"name":"1Department of Aerospace Physiology, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yungang","family":"Bai","sequence":"additional","affiliation":[{"name":"1Department of Aerospace Physiology, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Ren","sequence":"additional","affiliation":[{"name":"3Department of Respiratory and Critical Care Medicine, Shenzhen University General Hospital, Shenzhen 518071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-455X","authenticated-orcid":false,"given":"Jin","family":"Ma","sequence":"additional","affiliation":[{"name":"1Department of Aerospace Physiology, Air Force Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2024013017313613000_B1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1161\/01.RES.0000243584.45145.3f","article-title":"Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms","volume":"99","author":"Stenmark","year":"2006","journal-title":"Circ. 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