{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:29:19Z","timestamp":1793345359935,"version":"4.5.0"},"reference-count":86,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/15\/41\/31560, FS\/18\/33\/33621, PG\/15\/24\/31367, FS\/19\/24\/34262"],"award-info":[{"award-number":["PG\/15\/41\/31560, FS\/18\/33\/33621, PG\/15\/24\/31367, FS\/19\/24\/34262"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007414","name":"Qassim University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007414","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The three striatins (STRN, STRN3, STRN4) form the core of STRiatin-Interacting Phosphatase and Kinase (STRIPAK) complexes. These place protein phosphatase 2A (PP2A) in proximity to protein kinases thereby restraining kinase activity and regulating key cellular processes. Our aim was to establish if striatins play a significant role in cardiac remodelling associated with cardiac hypertrophy and heart failure. All striatins were expressed in control human hearts, with up-regulation of STRN and STRN3 in failing hearts. We used mice with global heterozygote gene deletion to assess the roles of STRN and STRN3 in cardiac remodelling induced by angiotensin II (AngII; 7 days). Using echocardiography, we detected no differences in baseline cardiac function or dimensions in STRN+\/\u2212 or STRN3+\/\u2212 male mice (8 weeks) compared with wild-type littermates. Heterozygous gene deletion did not affect cardiac function in mice treated with AngII, but the increase in left ventricle mass induced by AngII was inhibited in STRN+\/\u2212 (but not STRN3+\/\u2212) mice. Histological staining indicated that cardiomyocyte hypertrophy was inhibited. To assess the role of STRN in cardiomyocytes, we converted the STRN knockout line for inducible cardiomyocyte-specific gene deletion. There was no effect of cardiomyocyte STRN knockout on cardiac function or dimensions, but the increase in left ventricle mass induced by AngII was inhibited. This resulted from inhibition of cardiomyocyte hypertrophy and cardiac fibrosis. The data indicate that cardiomyocyte striatin is required for early remodelling of the heart by AngII and identify the striatin-based STRIPAK system as a signalling paradigm in the development of pathological cardiac hypertrophy.<\/jats:p>","DOI":"10.1042\/cs20240496","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T20:12:50Z","timestamp":1715199170000},"page":"573-597","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice <i>in vivo<\/i>"],"prefix":"10.1042","volume":"138","author":[{"given":"Joshua\u00a0J.","family":"Cull","sequence":"first","affiliation":[{"name":"1School of Biological Sciences, University of Reading, Reading, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna\u00a0T.E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"2Molecular and Clinical Sciences Institute, St. George\u2019s University of London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajed\u00a0O.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"1School of Biological Sciences, University of Reading, Reading, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia\u00a0P.","family":"Chothani","sequence":"additional","affiliation":[{"name":"3Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen\u00a0J.L.","family":"Rackham","sequence":"additional","affiliation":[{"name":"3Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore"},{"name":"4School of Biological Sciences, University of Southampton, Southampton, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5557-3549","authenticated-orcid":false,"given":"Daniel\u00a0N.","family":"Meijles","sequence":"additional","affiliation":[{"name":"2Molecular and Clinical Sciences Institute, St. George\u2019s University of London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6029-4560","authenticated-orcid":false,"given":"Philip\u00a0R.","family":"Dash","sequence":"additional","affiliation":[{"name":"1School of Biological Sciences, University of Reading, Reading, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Kerkel\u00e4","sequence":"additional","affiliation":[{"name":"5Research Unit of Biomedicine and Internal Medicine, Medical Research Centre Oulu (Oulu University Hospital) and Biocenter Oulu, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Ruparelia","sequence":"additional","affiliation":[{"name":"1School of Biological Sciences, University of Reading, Reading, U.K."},{"name":"6Department of Cardiology, Royal Berkshire Hospital, Reading, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u00a0H.","family":"Sugden","sequence":"additional","affiliation":[{"name":"1School of Biological Sciences, University of Reading, Reading, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5658-0708","authenticated-orcid":false,"given":"Angela","family":"Clerk","sequence":"additional","affiliation":[{"name":"1School of Biological Sciences, University of Reading, Reading, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"2024052210113882900_B1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"2024052210113882900_B2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"2024052210113882900_B3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1161\/HYPERTENSIONAHA.114.04233","article-title":"Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans","volume":"65","author":"Garza","year":"2015","journal-title":"Hypertension"},{"key":"2024052210113882900_B4","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/HYPERTENSIONAHA.115.05600","article-title":"Critical role of striatin in blood pressure and vascular responses to dietary sodium intake","volume":"66","author":"Garza","year":"2015","journal-title":"Hypertension"},{"key":"2024052210113882900_B5","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1530\/JOE-19-0562","article-title":"Striatin heterozygous mice are more sensitive to aldosterone-induced injury","volume":"245","author":"Garza","year":"2020","journal-title":"J. Endocrinol."},{"key":"2024052210113882900_B6","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00439-010-0855-y","article-title":"Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy","volume":"128","author":"Meurs","year":"2010","journal-title":"Hum. Genet."},{"key":"2024052210113882900_B7","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1111\/jvim.12163","article-title":"Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs","volume":"27","author":"Meurs","year":"2013","journal-title":"J. Vet. Intern. Med."},{"key":"2024052210113882900_B8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/ajh\/hpx146","article-title":"Striatin gene polymorphic variants are associated with salt sensitive blood pressure in normotensives and hypertensives","volume":"31","author":"Gupta","year":"2017","journal-title":"Am. J. Hypertens."},{"key":"2024052210113882900_B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.63.6.29","article-title":"High blood pressure and intraocular pressure: a Mendelian randomization study","volume":"63","author":"Plotnikov","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024052210113882900_B10","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/j.jacc.2016.07.729","article-title":"Genetic loci influencing myocardial mass","volume":"68","author":"van der Harst","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024052210113882900_B11","doi-asserted-by":"publisher","first-page":"2542","DOI":"10.1038\/s41467-020-15706-x","article-title":"Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction","volume":"11","author":"Ntalla","year":"2020","journal-title":"Nat. Commun."},{"key":"2024052210113882900_B12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41588-020-00764-0","article-title":"Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity","volume":"53","author":"Harper","year":"2021","journal-title":"Nat. Genet."},{"key":"2024052210113882900_B13","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.1038\/s41467-022-34216-6","article-title":"Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure","volume":"13","author":"Levin","year":"2022","journal-title":"Nat. Commun."},{"key":"2024052210113882900_B14","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1038\/s41588-020-00713-x","article-title":"Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals","volume":"52","author":"Surendran","year":"2020","journal-title":"Nat. Genet."},{"key":"2024052210113882900_B15","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1161\/CIRCRESAHA.116.308139","article-title":"Recounting cardiac cellular composition","volume":"118","author":"Zhou","year":"2016","journal-title":"Circ. Res."},{"key":"2024052210113882900_B16","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1161\/01.RES.0000077012.11088.BC","article-title":"Phenotyping hypertrophy: eschew obfuscation","volume":"92","author":"Dorn","year":"2003","journal-title":"Circ. Res."},{"key":"2024052210113882900_B17","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/s41401-023-01068-9","article-title":"Regulated cell death pathways in cardiomyopathy","volume":"44","author":"Sheng","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"2024052210113882900_B18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fcvm.2019.00020","article-title":"Angiogenic endothelial cell signaling in cardiac hypertrophy and heart failure","volume":"6","author":"Gogiraju","year":"2019","journal-title":"Front Cardiovasc. Med."},{"key":"2024052210113882900_B19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11897-017-0343-y","article-title":"From inflammation to fibrosis-molecular and cellular mechanisms of myocardial tissue remodelling and perspectives on differential treatment opportunities","volume":"14","author":"Suthahar","year":"2017","journal-title":"Curr. Heart Fail Rep."},{"key":"2024052210113882900_B20","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/s41569-020-00480-6","article-title":"Cellular and molecular pathobiology of heart failure with preserved ejection fraction","volume":"18","author":"Mishra","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"2024052210113882900_B21","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.3390\/cells10071716","article-title":"Cardiac fibrosis and fibroblasts","volume":"10","author":"Kurose","year":"2021","journal-title":"Cells"},{"key":"2024052210113882900_B22","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: JACC State-of-the-Art Review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024052210113882900_B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bbamcr.2018.07.010","article-title":"Physiologic functions of PP2A: lessons from genetically modified mice","volume":"1866","author":"Reynhout","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"2024052210113882900_B24","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00424-009-0674-y","article-title":"The mammalian family of sterile 20p-like protein kinases","volume":"458","author":"Delpire","year":"2009","journal-title":"Pflugers Archives"},{"key":"2024052210113882900_B25","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.biocel.2013.11.021","article-title":"STRIPAK complexes: structure, biological function, and involvement in human diseases","volume":"47","author":"Hwang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2024052210113882900_B26","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1515\/hsz-2019-0173","article-title":"STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases","volume":"400","author":"Kuck","year":"2019","journal-title":"Biol. Chem."},{"key":"2024052210113882900_B27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1074\/mcp.M800266-MCP200","article-title":"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein","volume":"8","author":"Goudreault","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"2024052210113882900_B28","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1126\/science.1221483","article-title":"Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry","volume":"337","author":"Herzog","year":"2012","journal-title":"Science"},{"key":"2024052210113882900_B29","doi-asserted-by":"publisher","first-page":"rs15","DOI":"10.1126\/scisignal.2004712","article-title":"Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions","volume":"6","author":"Couzens","year":"2013","journal-title":"Sci. Signal."},{"key":"2024052210113882900_B30","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00441-014-2053-z","article-title":"Striatins as plaque molecules of zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinoma-derived cells","volume":"357","author":"Franke","year":"2014","journal-title":"Cell Tissue Res."},{"key":"2024052210113882900_B31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13059-017-1286-z","article-title":"Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy","volume":"18","author":"Heinig","year":"2017","journal-title":"Genome Biol."},{"key":"2024052210113882900_B32","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2024052210113882900_B33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1042\/BCJ20210615","article-title":"Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo","volume":"479","author":"Clerk","year":"2022","journal-title":"Biochem. J."},{"key":"2024052210113882900_B34","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1042\/BCJ20220281","article-title":"PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses","volume":"479","author":"Marshall","year":"2022","journal-title":"Biochem. J."},{"key":"2024052210113882900_B35","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1042\/CS20220607","article-title":"Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice","volume":"136","author":"Alharbi","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"2024052210113882900_B36","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ. Res."},{"key":"2024052210113882900_B37","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1161\/HYPERTENSIONAHA.119.14556","article-title":"Redox regulation of cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) controls p38-MAPK (mitogen-activated protein kinase) and orchestrates cardiac remodeling to hypertension","volume":"76","author":"Meijles","year":"2020","journal-title":"Hypertension"},{"key":"2024052210113882900_B38","doi-asserted-by":"publisher","first-page":"e10027","DOI":"10.1371\/journal.pone.0010027","article-title":"ERK1\/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes","volume":"5","author":"Marshall","year":"2010","journal-title":"PLoS ONE"},{"key":"2024052210113882900_B39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1161\/01.RES.0000135483.12297.e4","article-title":"Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system","volume":"95","author":"Zimmerman","year":"2004","journal-title":"Circ. Res."},{"key":"2024052210113882900_B40","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.atherosclerosis.2018.07.019","article-title":"Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice","volume":"276","author":"Patel","year":"2018","journal-title":"Atherosclerosis"},{"key":"2024052210113882900_B41","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1523\/JNEUROSCI.6262-11.2012","article-title":"Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension","volume":"32","author":"Capone","year":"2012","journal-title":"J. Neurosci."},{"key":"2024052210113882900_B42","doi-asserted-by":"publisher","first-page":"R1546","DOI":"10.1152\/ajpregu.00170.2015","article-title":"ANG II-induced hypertension in the VCD mouse model of menopause is prevented by estrogen replacement during perimenopause","volume":"309","author":"Pollow","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2024052210113882900_B43","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1152\/physiol.00057.2014","article-title":"The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome","volume":"31","author":"Brooks","year":"2016","journal-title":"Physiology (Bethesda)."},{"key":"2024052210113882900_B44","doi-asserted-by":"publisher","first-page":"5913","DOI":"10.1038\/s41598-018-24085-9","article-title":"Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia","volume":"8","author":"Jahn","year":"2018","journal-title":"Sci. Rep."},{"key":"2024052210113882900_B45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/BF00877747","article-title":"Elastic properties and Windkessel function of the human aorta","volume":"9","author":"Belz","year":"1995","journal-title":"Cardiovasc. Drugs Ther."},{"key":"2024052210113882900_B46","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1152\/physiol.00035.2021","article-title":"Is it good to have a stiff aorta with aging? Causes and consequences","volume":"37","author":"Pierce","year":"2022","journal-title":"Physiology (Bethesda)."},{"key":"2024052210113882900_B47","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"2024052210113882900_B48","doi-asserted-by":"publisher","first-page":"11707","DOI":"10.1073\/pnas.0306880101","article-title":"The mouse kinome: discovery and comparative genomics of all mouse protein kinases","volume":"101","author":"Caenepeel","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024052210113882900_B49","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.tibs.2023.04.004","article-title":"Substrate and phosphorylation site selection by phosphoprotein phosphatases","volume":"48","author":"Nguyen","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"2024052210113882900_B50","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.2174\/092986706777441968","article-title":"Endothelin-1: the yin and yang on vascular function","volume":"13","author":"Marasciulo","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"2024052210113882900_B51","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/ajh.2011.197","article-title":"Activation of the mineralocorticoid receptor increases striatin levels","volume":"25","author":"Pojoga","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"2024052210113882900_B52","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.2174\/138945012802002348","article-title":"Cardiovascular therapeutics targets on the NO-sGC-cGMP signaling pathway: a critical overview","volume":"13","author":"Evora","year":"2012","journal-title":"Curr. Drug Targets"},{"key":"2024052210113882900_B53","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1681\/ASN.2014080816","article-title":"Vascular type 1A angiotensin II receptors control BP by regulating renal blood flow and urinary sodium excretion","volume":"26","author":"Sparks","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"2024052210113882900_B54","doi-asserted-by":"publisher","first-page":"111259","DOI":"10.1016\/j.mce.2021.111259","article-title":"Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease","volume":"529","author":"Rianto","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"2024052210113882900_B55","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/01.ATV.0000046231.17365.9D","article-title":"Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator","volume":"23","author":"Yan","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2024052210113882900_B56","doi-asserted-by":"publisher","first-page":"19087","DOI":"10.1073\/pnas.0602715103","article-title":"Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response","volume":"103","author":"Ramchandran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024052210113882900_B57","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1042\/CS20210192","article-title":"The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension","volume":"135","author":"Meijles","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"key":"2024052210113882900_B58","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.33549\/physiolres.935151","article-title":"Hypertension after the menopause: what can we learn from experimental studies?","volume":"72","author":"Pitha","year":"2023","journal-title":"Physiol. Res."},{"key":"2024052210113882900_B59","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1006\/bbrc.1995.1288","article-title":"A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells","volume":"207","author":"Muro","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024052210113882900_B60","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/ncb3083","article-title":"STRIPAK components determine mode of cancer cell migration and metastasis","volume":"17","author":"Madsen","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2024052210113882900_B61","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.gene.2014.11.045","article-title":"Tissue specific expression of SG2NA is regulated by differential splicing, RNA editing and differential polyadenylation","volume":"556","author":"Jain","year":"2015","journal-title":"Gene"},{"key":"2024052210113882900_B62","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.gene.2008.04.016","article-title":"WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties","volume":"420","author":"Sanghamitra","year":"2008","journal-title":"Gene"},{"key":"2024052210113882900_B63","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jacep.2021.12.002","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin. Electrophysiol."},{"key":"2024052210113882900_B64","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1139\/cjpp-2017-0155","article-title":"Cardiac striatin interacts with caveolin-3 and calmodulin in a calcium sensitive manner and regulates cardiomyocyte spontaneous contraction rate","volume":"95","author":"Nader","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024052210113882900_B65","doi-asserted-by":"publisher","first-page":"H1671","DOI":"10.1152\/ajpheart.01155.2009","article-title":"Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice","volume":"299","author":"Hougen","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024052210113882900_B66","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/ng.716","article-title":"Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction","volume":"42","author":"Sotoodehnia","year":"2010","journal-title":"Nat. Genet."},{"key":"2024052210113882900_B67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41588-018-0303-9","article-title":"Trans-ethnic association study of blood pressure determinants in over 750,000 individuals","volume":"51","author":"Giri","year":"2019","journal-title":"Nat. Genet."},{"key":"2024052210113882900_B68","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/FPC.0000000000000425","article-title":"Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design","volume":"31","author":"Stone","year":"2021","journal-title":"Pharmacogenet Genomics"},{"key":"2024052210113882900_B69","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1042\/BCJ20210003","article-title":"MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins","volume":"478","author":"Fuller","year":"2021","journal-title":"Biochem. J."},{"key":"2024052210113882900_B70","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.cell.2011.10.046","article-title":"Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease","volume":"147","author":"Guettler","year":"2011","journal-title":"Cell"},{"key":"2024052210113882900_B71","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41421-018-0077-3","article-title":"Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling","volume":"5","author":"Tang","year":"2019","journal-title":"Cell Discov."},{"key":"2024052210113882900_B72","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1471-2091-12-54","article-title":"Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3","volume":"12","author":"Gordon","year":"2011","journal-title":"BMC Biochem."},{"key":"2024052210113882900_B73","doi-asserted-by":"publisher","first-page":"25065","DOI":"10.1074\/jbc.M110.214486","article-title":"Structure-function analysis of core STRIPAK proteins: a signaling complex implicated in Golgi polarization","volume":"286","author":"Kean","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2024052210113882900_B74","doi-asserted-by":"publisher","first-page":"25056","DOI":"10.1074\/jbc.M110.213777","article-title":"CCM3\/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization","volume":"286","author":"Ceccarelli","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2024052210113882900_B75","doi-asserted-by":"publisher","first-page":"e201911035","DOI":"10.1083\/jcb.201911035","article-title":"STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity","volume":"219","author":"De Jamblinne","year":"2020","journal-title":"J. Cell Biol."},{"key":"2024052210113882900_B76","doi-asserted-by":"publisher","first-page":"25019","DOI":"10.1074\/jbc.M112.372342","article-title":"Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis","volume":"287","author":"Hyodo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2024052210113882900_B77","doi-asserted-by":"publisher","first-page":"e53003","DOI":"10.7554\/eLife.53003","article-title":"STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells","volume":"9","author":"Kim","year":"2020","journal-title":"Elife"},{"key":"2024052210113882900_B78","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/s42003-022-03708-y","article-title":"Cooperation of striatin 3 and MAP4K4 promotes growth and tissue invasion","volume":"5","author":"Migliavacca","year":"2022","journal-title":"Commun. Biol."},{"key":"2024052210113882900_B79","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/cvr\/cvv210","article-title":"Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts","volume":"108","author":"Fuller","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"2024052210113882900_B80","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","article-title":"The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"2024052210113882900_B81","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.yjmcc.2018.08.028","article-title":"Mst1 knockout enhances cardiomyocyte autophagic flux to alleviate angiotensin II-induced cardiac injury independent of angiotensin II receptors","volume":"125","author":"Cheng","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"2024052210113882900_B82","doi-asserted-by":"publisher","first-page":"12060","DOI":"10.1038\/s41598-020-68907-1","article-title":"Selective protection of human cardiomyocytes from anthracycline cardiotoxicity by small molecule inhibitors of MAP4K4","volume":"10","author":"Golforoush","year":"2020","journal-title":"Sci. Rep."},{"key":"2024052210113882900_B83","doi-asserted-by":"publisher","first-page":"579e512","DOI":"10.1016\/j.stem.2019.01.013","article-title":"MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo","volume":"24","author":"Fiedler","year":"2019","journal-title":"Cell Stem Cell."},{"key":"2024052210113882900_B84","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1042\/BJ20112000","article-title":"A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)","volume":"442","author":"Fuller","year":"2012","journal-title":"Biochem. J."},{"key":"2024052210113882900_B85","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1042\/BJ20130219","article-title":"SOcK, MiSTs, MASK and STicKs: the germinal centre kinase III (GCKIII) kinases and their heterologous protein-protein interactions","volume":"454","author":"Sugden","year":"2013","journal-title":"Biochem. J."},{"key":"2024052210113882900_B86","doi-asserted-by":"publisher","first-page":"19.23.11","DOI":"10.1002\/cpps.51","article-title":"BioID: a screen for protein-protein interactions","volume":"91","author":"Roux","year":"2018","journal-title":"Curr. Protoc. Protein Sci."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/138\/10\/573\/957049\/cs-2024-0496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/138\/10\/573\/957049\/cs-2024-0496.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T10:12:43Z","timestamp":1716372763000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/138\/10\/573\/234422\/Striatin-plays-a-major-role-in-angiotensin-II"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":86,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,5,22]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20240496","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]}}}