{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:32:15Z","timestamp":1793151135800,"version":"4.5.0"},"reference-count":80,"publisher":"Portland Press Ltd.","issue":"14","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["916912"],"award-info":[{"award-number":["916912"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"crossref","award":["DK120493"],"award-info":[{"award-number":["DK120493"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Salt-sensitive hypertension (SSHTN) is associated with M1 macrophage polarization and inflammatory responses, leading to inflammation-associated lymphangiogenesis and functional impairment across multiple organs, including kidneys and gonads. However, it remains unclear whether promoting M2 macrophage polarization can alleviate the hypertension, inflammation, and end organ damage in mice with salt sensitive hypertension (SSHTN). Male and female mice were made hypertensive by administering nitro-L-arginine methyl ester hydrochloride (L-NAME; 0.5 mg\/ml) for 2 weeks in the drinking water, followed by a 2-week interval without any treatments, and a subsequent high salt diet for 3 weeks (SSHTN). AVE0991 (AVE) was intraperitoneally administered concurrently with the high salt diet. Control mice were provided standard diet and tap water. AVE treatment significantly attenuated BP and inflammation in mice with SSHTN. Notably, AVE promoted M2 macrophage polarization, decreased pro-inflammatory immune cell populations, and improved function in renal and gonadal tissues of mice with SSHTN. Additionally, AVE decreased lymphangiogenesis in the kidneys and testes of male SSHTN mice and the ovaries of female SSHTN mice. These findings highlight the effectiveness of AVE in mitigating SSHTN-induced elevated BP, inflammation, and end organ damage by promoting M2 macrophage polarization and suppressing pro-inflammatory immune responses. Targeting macrophage polarization emerges as a promising therapeutic approach for alleviating inflammation and organ damage in SSHTN. Further studies are warranted to elucidate the precise mechanisms underlying AVE-mediated effects and to assess its clinical potential in managing SSHTN.<\/jats:p>","DOI":"10.1042\/cs20240699","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T15:29:56Z","timestamp":1719847796000},"page":"921-940","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages"],"prefix":"10.1042","volume":"138","author":[{"given":"Shobana","family":"Navaneethabalakrishnan","sequence":"first","affiliation":[{"name":"Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany\u00a0L.","family":"Goodlett","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah\u00a0L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Robert\u00a0A.","family":"Montalvo","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-8761","authenticated-orcid":false,"given":"Brett\u00a0M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"2024071607454296400_B1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"2024071607454296400_B2","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"2024071607454296400_B3","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S0140-6736(14)61468-9","article-title":"Hypertension","volume":"386","author":"Poulter","year":"2015","journal-title":"Lancet"},{"key":"2024071607454296400_B4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0140-6736(15)00805-3","article-title":"Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis","volume":"387","author":"Xie","year":"2016","journal-title":"Lancet"},{"key":"2024071607454296400_B5","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1016\/S0140-6736(19)30041-8","article-title":"Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"393","author":"Collaborators G","year":"2019","journal-title":"Lancet"},{"key":"2024071607454296400_B6","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1161\/HYP.0000000000000047","article-title":"Salt sensitivity of blood pressure: a scientific statement from the American Heart Association","volume":"68","author":"Elijovich","year":"2016","journal-title":"Hypertension"},{"key":"2024071607454296400_B7","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 update: a report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"2024071607454296400_B8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.117.032582","article-title":"Potential US Population Impact of the 2017 ACC\/AHA High Blood Pressure Guideline","volume":"137","author":"Muntner","year":"2018","journal-title":"Circulation"},{"key":"2024071607454296400_B9","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"2024071607454296400_B10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/HJH.0b013e328316bb87","article-title":"Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study","volume":"27","author":"He","year":"2009","journal-title":"J. Hypertens."},{"key":"2024071607454296400_B11","doi-asserted-by":"publisher","first-page":"I102","DOI":"10.1161\/01.HYP.17.1_Suppl.I102","article-title":"Salt sensitivity and resistance of blood pressure. Age and race as factors in physiological responses","volume":"17","author":"Luft","year":"1991","journal-title":"Hypertension"},{"key":"2024071607454296400_B12","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/sj.jhh.1002207","article-title":"GenSalt: rationale, design, methods and baseline characteristics of study participants","volume":"21","author":"GenSalt Collaborative Research Group","year":"2007","journal-title":"J. Hum. Hypertens."},{"key":"2024071607454296400_B13","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1161\/01.HYP.22.3.331","article-title":"Divergent hemodynamic and hormonal responses to varying salt intake in normotensive subjects","volume":"22","author":"Overlack","year":"1993","journal-title":"Hypertension"},{"key":"2024071607454296400_B14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jash.2013.01.003","article-title":"Salt sensitivity: a review with a focus on non-Hispanic blacks and Hispanics","volume":"7","author":"Richardson","year":"2013","journal-title":"J. Am. Soc. Hypertens."},{"key":"2024071607454296400_B15","doi-asserted-by":"publisher","first-page":"1096296","DOI":"10.3389\/fphys.2022.1096296","article-title":"Inflammation and oxidative stress in salt sensitive hypertension. The role of the NLRP3 inflammasome","volume":"13","author":"Ertuglu","year":"2022","journal-title":"Front Physiol."},{"key":"2024071607454296400_B16","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1172\/JCI74084","article-title":"DC isoketal-modified proteins activate T cells and promote hypertension","volume":"124","author":"Kirabo","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2024071607454296400_B17","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1161\/CIRCRESAHA.116.303697","article-title":"Inflammation, immunity, and hypertensive end-organ damage","volume":"116","author":"McMaster","year":"2015","journal-title":"Circ. Res."},{"key":"2024071607454296400_B18","doi-asserted-by":"publisher","first-page":"798958","DOI":"10.3389\/fmed.2021.798958","article-title":"Endothelial dysfunction in hypertension: current concepts and clinical implications","volume":"8","author":"Gallo","year":"2021","journal-title":"Front Med. (Lausanne)"},{"key":"2024071607454296400_B19","doi-asserted-by":"publisher","first-page":"1098725","DOI":"10.3389\/fimmu.2022.1098725","article-title":"Role of inflammation, immunity, and oxidative stress in hypertension: new insights and potential therapeutic targets","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol."},{"key":"2024071607454296400_B20","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1111\/bph.14427","article-title":"Role of immune cells in hypertension","volume":"176","author":"Caillon","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"2024071607454296400_B21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nm.1960","article-title":"Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism","volume":"15","author":"Machnik","year":"2009","journal-title":"Nat. Med."},{"key":"2024071607454296400_B22","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2024071607454296400_B23","doi-asserted-by":"publisher","first-page":"4223","DOI":"10.1172\/JCI80919","article-title":"High salt reduces the activation of IL-4- and IL-13-stimulated macrophages","volume":"125","author":"Binger","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2024071607454296400_B24","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/nu13010270","article-title":"Mechanisms of dietary sodium-induced impairments in endothelial function and potential countermeasures","volume":"13","author":"Patik","year":"2021","journal-title":"Nutrients"},{"key":"2024071607454296400_B25","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1093\/ajh\/hpt082","article-title":"The heme oxygenase system selectively suppresses the proinflammatory macrophage m1 phenotype and potentiates insulin signaling in spontaneously hypertensive rats","volume":"26","author":"Ndisang","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"2024071607454296400_B26","doi-asserted-by":"publisher","first-page":"396","DOI":"10.3389\/fphys.2014.00396","article-title":"Angiotensin II-induced endothelial dysfunction is temporally linked with increases in interleukin-6 and vascular macrophage accumulation","volume":"5","author":"Gomolak","year":"2014","journal-title":"Front Physiol."},{"key":"2024071607454296400_B27","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1161\/CIRCRESAHA.116.309402","article-title":"Nicotine mediates CD161a+ renal macrophage infiltration and premature hypertension in the spontaneously hypertensive rat","volume":"119","author":"Harwani","year":"2016","journal-title":"Circ. Res."},{"key":"2024071607454296400_B28","doi-asserted-by":"publisher","first-page":"e0145946","DOI":"10.1371\/journal.pone.0145946","article-title":"Aldosterone induces renal fibrosis and inflammatory M1-macrophage subtype via mineralocorticoid receptor in rats","volume":"11","author":"Mart\u00edn-Fern\u00e1ndez","year":"2016","journal-title":"PLoS ONE"},{"key":"2024071607454296400_B29","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.312765","article-title":"Enhancing renal lymphatic expansion prevents hypertension in mice","volume":"122","author":"Lopez Gelston","year":"2018","journal-title":"Circ. Res."},{"key":"2024071607454296400_B30","doi-asserted-by":"publisher","first-page":"F361","DOI":"10.1152\/ajprenal.00096.2019","article-title":"Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats","volume":"317","author":"Fehrenbach","year":"2019","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"2024071607454296400_B31","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1042\/CS20220117","article-title":"Hypertension induces gonadal macrophage imbalance, inflammation, lymphangiogenesis, and dysfunction","volume":"136","author":"Navaneethabalakrishnan","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"2024071607454296400_B32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s11906-014-0431-2","article-title":"Angiotensin II and vascular injury","volume":"16","author":"Montezano","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"2024071607454296400_B33","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/MNH.0b013e3283437fcd","article-title":"Angiotensin type 2 receptor in hypertensive cardiovascular disease","volume":"20","author":"Savoia","year":"2011","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"2024071607454296400_B34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00424-012-1120-0","article-title":"ACE2, angiotensin-(1-7), and Mas: the other side of the coin","volume":"465","author":"Bader","year":"2013","journal-title":"Pflugers Archiv: Eur. J. Physiol."},{"key":"2024071607454296400_B35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nrcardio.2014.59","article-title":"Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets","volume":"11","author":"Jiang","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"2024071607454296400_B36","doi-asserted-by":"publisher","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024071607454296400_B37","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.mce.2011.12.010","article-title":"Olmesartan attenuates the development of heart failure after experimental autoimmune myocarditis in rats through the modulation of ANG 1-7 mas receptor","volume":"351","author":"Sukumaran","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"2024071607454296400_B38","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/bph.12318","article-title":"AVE 0991, a non-peptide mimic of angiotensin-(1-7) effects, attenuates pulmonary remodelling in a model of chronic asthma","volume":"170","author":"Rodrigues-Machado","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"2024071607454296400_B39","doi-asserted-by":"publisher","first-page":"4055","DOI":"10.1111\/bph.13685","article-title":"Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis","volume":"174","author":"Skiba","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"2024071607454296400_B40","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2147\/JIR.S392599","article-title":"AVE 0991 suppresses astrocyte-mediated neuroinflammation of Alzheimer's disease by enhancing autophagy","volume":"16","author":"Deng","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"2024071607454296400_B41","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1161\/CIRCRESAHA.115.308111","article-title":"CD70 exacerbates blood pressure elevation and renal damage in response to repeated hypertensive stimuli","volume":"118","author":"Itani","year":"2016","journal-title":"Circ. Res."},{"key":"2024071607454296400_B42","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1042\/CS20220547","article-title":"Genetically inducing renal lymphangiogenesis attenuates hypertension in mice","volume":"136","author":"Goodlett","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"2024071607454296400_B43","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/pharmaceutics14010084","article-title":"A kidney-targeted nanoparticle to augment renal lymphatic density decreases blood pressure in hypertensive mice","volume":"14","author":"Goodlett","year":"2021","journal-title":"Pharmaceutics"},{"key":"2024071607454296400_B44","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1097\/HJH.0000000000003200","article-title":"Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice","volume":"40","author":"Sims","year":"2022","journal-title":"J. Hypertens."},{"key":"2024071607454296400_B45","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2024071607454296400_B46","doi-asserted-by":"publisher","first-page":"9192","DOI":"10.3390\/ijms24119192","article-title":"Indole propionic acid increases T regulatory cells and decreases T Helper 17 cells and blood pressure in mice with salt-sensitive hypertension","volume":"24","author":"Baranwal","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2024071607454296400_B47","doi-asserted-by":"publisher","first-page":"H684","DOI":"10.1152\/ajpheart.00632.2005","article-title":"Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME","volume":"290","author":"Benter","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024071607454296400_B48","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1590\/1806-9282.20220259","article-title":"Evaluation of the cardioprotective and antihypertensive effect of AVE 0991 in normotensive and hypertensive rats","volume":"68","author":"Silva","year":"2002","journal-title":"Rev. Assoc. Med. Bras."},{"key":"2024071607454296400_B49","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.lfs.2012.12.008","article-title":"The nonpeptide ANG-(1-7) mimic AVE 0991 attenuates cardiac remodeling and improves baroreflex sensitivity in renovascular hypertensive rats","volume":"92","author":"Cunha","year":"2013","journal-title":"Life Sci."},{"key":"2024071607454296400_B50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/fcp.12829","article-title":"Activation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II-induced hypertension","volume":"37","author":"Tanr\u0131verdi","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"key":"2024071607454296400_B51","doi-asserted-by":"publisher","first-page":"14109","DOI":"10.1073\/pnas.1612668113","article-title":"Role of the receptor Mas in macrophage-mediated inflammation in vivo","volume":"113","author":"Hammer","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2024071607454296400_B52","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.imbio.2015.07.013","article-title":"Mas receptor deficiency exacerbates lipopolysaccharide-induced cerebral and systemic inflammation in mice","volume":"220","author":"Oliveira-Lima","year":"2015","journal-title":"Immunobiology"},{"key":"2024071607454296400_B53","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molimm.2008.10.022","article-title":"Angiotensin-(1-7) enhances angiotensin II induced phosphorylation of ERK1\/2 in mouse bone marrow-derived dendritic cells","volume":"46","author":"Nie","year":"2009","journal-title":"Mol. Immunol."},{"key":"2024071607454296400_B54","doi-asserted-by":"publisher","first-page":"808726","DOI":"10.1155\/2012\/808726","article-title":"Renoprotective effects of AVE0991, a nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury","volume":"2012","author":"Barroso","year":"2012","journal-title":"Int. J. Hypertens."},{"key":"2024071607454296400_B55","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.bbrc.2015.09.050","article-title":"AVE 0991 attenuates cardiac hypertrophy through reducing oxidative stress","volume":"474","author":"Ma","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024071607454296400_B56","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3390\/ijms21031009","article-title":"IL-20 in acute kidney injury: role in pathogenesis and potential as a therapeutic target","volume":"21","author":"Lin","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2024071607454296400_B57","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jpha.2023.09.003","article-title":"The role of innate immunity in diabetic nephropathy and their therapeutic consequences","volume":"14","author":"Yang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"2024071607454296400_B58","doi-asserted-by":"publisher","first-page":"F450","DOI":"10.1152\/ajprenal.00557.2016","article-title":"The effects of angiotensin-(1-7) on the exchanger NHE3 and on [Ca(2+)](i) in the proximal tubules of spontaneously hypertensive rats","volume":"313","author":"Castelo-Branco","year":"2017","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"2024071607454296400_B59","doi-asserted-by":"publisher","first-page":"F1258","DOI":"10.1152\/ajprenal.00401.2012","article-title":"Dose-dependent effects of angiotensin-(1-7) on the NHE3 exchanger and [Ca(2+)](i) in in vivo proximal tubules","volume":"304","author":"Castelo-Branco","year":"2013","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"2024071607454296400_B60","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s00417-015-2952-z","article-title":"The expression of Mas-receptor of the renin-angiotensin system in the human eye","volume":"253","author":"Vaajanen","year":"2015","journal-title":"Graefe's Archive Clin. Exp. Ophthalmol. = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie"},{"key":"2024071607454296400_B61","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41419-020-03375-z","article-title":"Tubular Mas receptor mediates lipid-induced kidney injury","volume":"12","author":"Kong","year":"2021","journal-title":"Cell Death Dis."},{"key":"2024071607454296400_B62","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.2353\/ajpath.2007.060018","article-title":"Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing","volume":"170","author":"Maruyama","year":"2007","journal-title":"Am. J. Pathol."},{"key":"2024071607454296400_B63","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2024071607454296400_B64","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages","volume":"115","author":"Maruyama","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2024071607454296400_B65","doi-asserted-by":"publisher","first-page":"5650","DOI":"10.1182\/blood-2008-09-176776","article-title":"Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution","volume":"113","author":"Kataru","year":"2009","journal-title":"Blood"},{"key":"2024071607454296400_B66","doi-asserted-by":"publisher","first-page":"338","DOI":"10.2353\/ajpath.2007.060589","article-title":"Radiogenic lymphangiogenesis in the skin","volume":"171","author":"Jackowski","year":"2007","journal-title":"Am. J. Pathol."},{"key":"2024071607454296400_B67","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/jnci\/dji003","article-title":"Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody","volume":"97","author":"Pytowski","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"2024071607454296400_B68","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/jid.2008.351","article-title":"Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis","volume":"129","author":"Kajiya","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"2024071607454296400_B69","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI200522037","article-title":"Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation","volume":"115","author":"Baluk","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2024071607454296400_B70","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.jid.2017.04.033","article-title":"An important role of VEGF-C in promoting lymphedema development","volume":"137","author":"Gousopoulos","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"2024071607454296400_B71","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1097\/MIB.0000000000000731","article-title":"A Critical role for monocytes\/macrophages during intestinal inflammation-associated lymphangiogenesis","volume":"22","author":"Becker","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"2024071607454296400_B72","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10456-014-9416-7","article-title":"Inflammation-induced lymphangiogenesis and lymphatic dysfunction","volume":"17","author":"Liao","year":"2014","journal-title":"Angiogenesis"},{"key":"2024071607454296400_B73","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1469-7580.2009.01058.x","article-title":"The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats","volume":"214","author":"Leal","year":"2009","journal-title":"J. Anat."},{"key":"2024071607454296400_B74","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10735-010-9264-8","article-title":"Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility","volume":"41","author":"Reis","year":"2010","journal-title":"J. Mol. Histol."},{"key":"2024071607454296400_B75","doi-asserted-by":"publisher","first-page":"7943","DOI":"10.3390\/ijms21217943","article-title":"Regulation of male fertility by the renin-angiotensin system","volume":"21","author":"Gianzo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2024071607454296400_B76","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1093\/humrep\/dex072","article-title":"Angiotensin-(1-7) in human follicular fluid correlates with oocyte maturation","volume":"32","author":"Cavallo","year":"2017","journal-title":"Hum. Reprod."},{"key":"2024071607454296400_B77","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.3390\/ijms21134572","article-title":"Involvement of ACE2\/Ang-(1-7)\/MAS1 axis in the regulation of ovarian function in mammals","volume":"21","author":"Dominska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2024071607454296400_B78","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1042\/CS20200865","article-title":"Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions","volume":"134","author":"Reis","year":"2020","journal-title":"Clin. Sci. (Lond.)"},{"key":"2024071607454296400_B79","doi-asserted-by":"publisher","first-page":"e48770","DOI":"10.7759\/cureus.48770","article-title":"Effect of angiotensin 1-7 peptide agonist AVE 0991 on diabetic endothelial dysfunction in an experimental animal model: a possible tool to treat diabetic erectile dysfunction","volume":"15","author":"Coskunsever","year":"2023","journal-title":"Cureus"},{"key":"2024071607454296400_B80","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2174\/0929866527666200826104410","article-title":"Angiotensin-(1-7), angiotensin-converting enzyme 2 and Mas receptor in rat polycystic ovaries","volume":"28","author":"Pereira","year":"2021","journal-title":"Protein Pept. Lett."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/138\/14\/921\/959168\/cs-2024-0699.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/138\/14\/921\/959168\/cs-2024-0699.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T07:46:12Z","timestamp":1721115972000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/138\/14\/921\/234654\/Differential-changes-in-end-organ-immune-cells-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":80,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,7,17]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20240699","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,7]]}}}