{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:36:43Z","timestamp":1790051803691,"version":"4.0.1"},"reference-count":47,"publisher":"Portland Press Ltd.","issue":"18","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"crossref","award":["P.C006.22"],"award-info":[{"award-number":["P.C006.22"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"crossref","award":["P.C006.22"],"award-info":[{"award-number":["P.C006.22"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"crossref","award":["T.0141.19"],"award-info":[{"award-number":["T.0141.19"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic dysfunction-associated steatohepatitis (MASH) confers a risk for cardiovascular diseases in patients. Animal models may help exploring the mechanisms linking liver and heart diseases. Hence, we explored the cardiac phenotype in two MASH mouse models: foz\/foz mice fed a high-fat diet (HFD) for 24 or 60 weeks and C57BL\/6J mice fed a high-fat-, high-cholesterol-, and high-fructose diet for 60 weeks. Angiotensin II (AngII) was used as an additional cardiovascular stressor for 4 weeks in 10 weeks HFD-fed foz\/foz mice. Foz\/foz mice with fibrosing MASH developed cardiac hypertrophy with adverse cardiac remodelling not seen in WT similarly fed the HFD. AngII caused hypertension and up-regulated the expression of genes contributing to pathological cardiac hypertrophy (Nppa, Myh7) more severely so in foz\/foz mice than in controls. After 60 weeks of HFD, while liver disease had progressed to burn-out non steatotic MASH with hepatocellular carcinoma in 50% of the animals, the cardiomyopathy did not. In an independent model (C57BL\/6J mice fed a fat-, cholesterol- and fructose-rich diet), moderate fibrosing MASH is associated with cardiac fibrosis and dysregulation of genes involved in pathological remodelling (Col1a1, Col3a1, Vim, Myh6, Slc2a1). Thus, animals with MASH present consistent adverse structural changes in the heart with no patent alteration of cardiac function even when stressed with exogenous AngII. Liver disease, and likely not overfeeding or aging alone, is associated with this cardiac phenotype. Our findings support foz\/foz mice as suitable for studying links between MASH and heart structural changes ahead of heart failure.<\/jats:p>","DOI":"10.1042\/cs20240833","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T06:12:29Z","timestamp":1724911949000},"page":"1151-1171","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["When the liver is in poor condition, so is the heart \u2013 cardiac remodelling in MASH mouse models"],"prefix":"10.1042","volume":"138","author":[{"given":"Sebastian","family":"Bott","sequence":"first","affiliation":[{"name":"1Laboratory of Hepato-Gastroenterology, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels"},{"name":"2Pole of Pharmacology and Therapeutics, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Lallement","sequence":"additional","affiliation":[{"name":"1Laboratory of Hepato-Gastroenterology, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels"},{"name":"2Pole of Pharmacology and Therapeutics, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Marino","sequence":"additional","affiliation":[{"name":"3Pole of Cardiovascular Research, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos-Panagiotis","family":"Daskalopoulos","sequence":"additional","affiliation":[{"name":"3Pole of Cardiovascular Research, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Beauloye","sequence":"additional","affiliation":[{"name":"3Pole of Cardiovascular Research, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"},{"name":"4Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrag","family":"Esfahani","sequence":"additional","affiliation":[{"name":"5Platform of Integrated Physiology, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Dessy","sequence":"additional","affiliation":[{"name":"2Pole of Pharmacology and Therapeutics, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-6693","authenticated-orcid":false,"given":"Isabelle\u00a0Anne","family":"Leclercq","sequence":"additional","affiliation":[{"name":"1Laboratory of Hepato-Gastroenterology, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"2024091805205086900_B1","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"2024091805205086900_B2","doi-asserted-by":"publisher","first-page":"391.e3","DOI":"10.1016\/B978-0-323-37591-7.00026-4","article-title":"Epidemiology, natural history, and evaluation of nonalcoholic fatty liver disease","volume-title":"Zakim and Boyer's Hepatology","author":"Anstee","year":"2018","edition":"7th edn"},{"key":"2024091805205086900_B3","doi-asserted-by":"publisher","first-page":"15080","DOI":"10.1038\/nrdp.2015.80","article-title":"Nonalcoholic fatty liver disease","volume":"1","author":"Brunt","year":"2015","journal-title":"Nat. Rev. Dis. Primer"},{"key":"2024091805205086900_B4","first-page":"2809.e28","article-title":"Global NAFLD prevalence: a systematic review and meta-analysis","volume":"20","author":"Le","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"2024091805205086900_B5","doi-asserted-by":"publisher","first-page":"e036663","DOI":"10.1136\/bmjopen-2019-036663","article-title":"Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990-2017: a population-based observational study","volume":"10","author":"Ge","year":"2020","journal-title":"BMJ Open"},{"key":"2024091805205086900_B6","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024091805205086900_B7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/cld.1017","article-title":"Nonalcoholic fatty liver disease and cardiovascular disease","volume":"17","author":"Przybyszewski","year":"2021","journal-title":"Clin. Liver Dis."},{"key":"2024091805205086900_B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1464-5491.2007.02025.x","article-title":"Non-alcoholic fatty liver disease, the metabolic syndrome and the risk of cardiovascular disease: the plot thickens","volume":"24","author":"Targher","year":"2007","journal-title":"Diabet. Med. J. Br. Diabet. Assoc."},{"key":"2024091805205086900_B9","doi-asserted-by":"publisher","first-page":"S300","DOI":"10.21037\/atm.2019.11.13","article-title":"New insights into the association between non-alcoholic fatty liver disease and atherosclerosis","volume":"7","author":"Valencia-Rodr\u00edguez","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"2024091805205086900_B10","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1002\/hep.32072","article-title":"Nonalcoholic fatty liver disease and cardiac remodeling risk: pathophysiological mechanisms and clinical implications","volume":"74","author":"Zhou","year":"2021","journal-title":"Hepatology"},{"key":"2024091805205086900_B11","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1161\/CIRCRESAHA.119.316337","article-title":"Nonalcoholic fatty liver disease pandemic fuels the upsurge in cardiovascular diseases","volume":"126","author":"Cai","year":"2020","journal-title":"Circ. Res."},{"key":"2024091805205086900_B12","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/hep.24376","article-title":"Endpoints and clinical trial design for nonalcoholic steatohepatitis","volume":"54","author":"Sanyal","year":"2011","journal-title":"Hepatology"},{"key":"2024091805205086900_B13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41374-019-0315-9","article-title":"Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD\/NASH","volume":"100","author":"De Rudder","year":"2020","journal-title":"Lab Investig J. Tech. Methods Pathol."},{"key":"2024091805205086900_B14","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1002\/hep.30333","article-title":"Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis","volume":"69","author":"Farrell","year":"2019","journal-title":"Hepatology"},{"key":"2024091805205086900_B15","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1111\/jgh.14122","article-title":"Mouse models of non-alcoholic steatohepatitis: a reflection on recent literature","volume":"33","author":"Haczeyni","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2024091805205086900_B16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ymgme.2017.05.017","article-title":"Characteristics of cardiomyopathy in Alstr\u00f6m syndrome: Prospective single-center data on 38 patients","volume":"121","author":"Brofferio","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"2024091805205086900_B17","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/liv.13163","article-title":"Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alstr\u00f6m syndrome","volume":"36","author":"Gathercole","year":"2016","journal-title":"Liver Int. Off. J. Int. Assoc. Study Liver"},{"key":"2024091805205086900_B18","doi-asserted-by":"publisher","first-page":"G1031","DOI":"10.1152\/ajpgi.00211.2011","article-title":"Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet","volume":"301","author":"Kamada","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2024091805205086900_B19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.5114\/aoms\/157308","article-title":"Menopause and women\u2019s cardiovascular health: is it really an obvious relationship?","volume":"19","author":"Ryczkowska","year":"2023","journal-title":"Arch. Med. Sci. AMS"},{"key":"2024091805205086900_B20","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"2024091805205086900_B21","doi-asserted-by":"publisher","first-page":"e82163","DOI":"10.1371\/journal.pone.0082163","article-title":"Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans","volume":"8","author":"Itoh","year":"2013","journal-title":"PloS ONE"},{"key":"2024091805205086900_B22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/cvr\/cvaa110","article-title":"Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function","volume":"117","author":"Zacchigna","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"2024091805205086900_B23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41374-018-0120-x","article-title":"Activation of brown adipose tissue enhances the efficacy of caloric restriction for treatment of nonalcoholic steatohepatitis","volume":"99","author":"Poekes","year":"2019","journal-title":"Lab. Investig J. Tech. Methods Pathol."},{"key":"2024091805205086900_B24","doi-asserted-by":"publisher","first-page":"100387","DOI":"10.1016\/j.jhepr.2021.100387","article-title":"Bile acids contribute to the development of non-alcoholic steatohepatitis in mice","volume":"4","author":"Gillard","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"2024091805205086900_B25","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nature09130","article-title":"Chromatin regulation by Brg1 underlies heart muscle development and disease","volume":"466","author":"Hang","year":"2010","journal-title":"Nature"},{"key":"2024091805205086900_B26","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.jacc.2016.12.037","article-title":"A test in context: E\/A and E\/e\u2019 to assess diastolic dysfunction and LV filling pressure","volume":"69","author":"Mitter","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024091805205086900_B27","doi-asserted-by":"publisher","first-page":"H771","DOI":"10.1152\/ajpheart.00282.2015","article-title":"A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II","volume":"309","author":"Regan","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024091805205086900_B28","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00392-020-01709-7","article-title":"NAFLD and cardiovascular diseases: a clinical review","volume":"110","author":"Kasper","year":"2021","journal-title":"Clin. Res. Cardiol. Off. J. Ger. Card. Soc."},{"key":"2024091805205086900_B29","doi-asserted-by":"publisher","first-page":"404","DOI":"10.20524\/aog.2021.0604","article-title":"Epidemiology of nonalcoholic fatty liver disease in Europe: a systematic review and meta-analysis","volume":"34","author":"Cholongitas","year":"2021","journal-title":"Ann. Gastroenterol."},{"key":"2024091805205086900_B30","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1161\/HYPERTENSIONAHA.122.17982","article-title":"Nonalcoholic fatty liver disease and cardiovascular disease: a review of shared cardiometabolic risk factors","volume":"79","author":"Muzurovi\u0107","year":"2022","journal-title":"Hypertension"},{"key":"2024091805205086900_B31","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"2024091805205086900_B32","doi-asserted-by":"publisher","first-page":"e92903","DOI":"10.1371\/journal.pone.0092903","article-title":"A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes","volume":"9","author":"Cox","year":"2014","journal-title":"PloS ONE"},{"key":"2024091805205086900_B33","doi-asserted-by":"publisher","first-page":"e002423","DOI":"10.1161\/JAHA.115.002423","article-title":"Natriuretic peptides in the regulation of cardiovascular physiology and metabolic events","volume":"4","author":"Kerkel\u00e4","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"2024091805205086900_B34","doi-asserted-by":"publisher","first-page":"e007208","DOI":"10.1161\/CIRCHEARTFAILURE.120.007208","article-title":"Natriuretic peptides, inflammation, and sounding the alarm","volume":"13","author":"Ramakrishnan","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"2024091805205086900_B35","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0022-2828(03)00212-8","article-title":"Upregulation of GLUT1 expression is necessary for hypertrophy and survival of neonatal rat cardiomyocytes","volume":"35","author":"Morissette","year":"2003","journal-title":"J. Mol. Cell Cardiol."},{"key":"2024091805205086900_B36","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.jacbts.2021.07.010","article-title":"Relationship of nonalcoholic fatty liver disease and heart failure with preserved ejection fraction","volume":"6","author":"Salah","year":"2021","journal-title":"JACC Basic Transl. Sci."},{"key":"2024091805205086900_B37","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/medicina54050070","article-title":"Cardiac glucolipotoxicity and cardiovascular outcomes","volume":"54","author":"Cerf","year":"2018","journal-title":"Med. Kaunas Lith."},{"key":"2024091805205086900_B38","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.jacc.2009.01.041","article-title":"Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients","volume":"53","author":"Marfella","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024091805205086900_B39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/jcsm.12646","article-title":"Myosteatosis rather than sarcopenia associates with non-alcoholic steatohepatitis in non-alcoholic fatty liver disease preclinical models","volume":"12","author":"Nachit","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2024091805205086900_B40","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1136\/gutjnl-2023-330595","article-title":"MASLD: a systemic metabolic disorder with cardiovascular and malignant complications","volume":"73","author":"Targher","year":"2024","journal-title":"Gut"},{"key":"2024091805205086900_B41","doi-asserted-by":"publisher","first-page":"e006036","DOI":"10.1161\/CIRCIMAGING.117.006036","article-title":"Left Atrial remodeling: more than just left atrial enlargement","volume":"10","author":"Hoit","year":"2017","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"2024091805205086900_B42","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/s41401-024-01249-0","article-title":"Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway","volume":"45","author":"Xu","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"2024091805205086900_B43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1042\/CS20070026","article-title":"Liver fibrosis: a balance of ACEs?","volume":"113","author":"Warner","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"key":"2024091805205086900_B44","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1089\/ars.2015.6498","article-title":"Angiotensin-(1-7) improves liver fibrosis by regulating the NLRP3 inflammasome via redox balance modulation","volume":"24","author":"Cai","year":"2016","journal-title":"Antioxid Redox Signal."},{"key":"2024091805205086900_B45","doi-asserted-by":"publisher","first-page":"100835","DOI":"10.1016\/j.jhepr.2023.100835","article-title":"Non-alcoholic fatty liver disease in women - Current knowledge and emerging concepts","volume":"5","author":"Eng","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"2024091805205086900_B46","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41467-022-28138-6","article-title":"Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis","volume":"13","author":"Lee","year":"2022","journal-title":"Nat. Commun."},{"key":"2024091805205086900_B47","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13293-017-0152-8","article-title":"The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy","volume":"8","author":"Iorga","year":"2017","journal-title":"Biol. Sex Differ."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/138\/18\/1151\/961107\/cs-2024-0833.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/138\/18\/1151\/961107\/cs-2024-0833.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T01:22:01Z","timestamp":1726622521000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/138\/18\/1151\/234923\/When-the-liver-is-in-poor-condition-so-is-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2024,9,18]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20240833","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.01.592038","asserted-by":"object"}]},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9]]}}}