{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:46:24Z","timestamp":1769053584941,"version":"3.49.0"},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"19","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"funder":[{"DOI":"10.13039\/100010322","name":"Stollery Children\u2019s Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alberta Women\u2019s Health Foundation"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP142396"],"award-info":[{"award-number":["MOP142396"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PS183846"],"award-info":[{"award-number":["PS183846"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heart and Stroke Foundation of Canada","award":["G-20-0029380"],"award-info":[{"award-number":["G-20-0029380"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron deficiency (ID) is common during gestation and in early infancy and has been shown to adversely affect cardiac development and function, which could lead to lasting cardiovascular consequences. Ketone supplementation has been shown to confer cardioprotective effects in numerous disease models. Here, we tested the hypothesis that maternal ketone supplementation during gestation would mitigate cardiac dysfunction in ID neonates. Female Sprague-Dawley rats were fed an iron-restricted or iron-replete diet before and throughout pregnancy. Throughout gestation, iron-restricted dams were given either a daily subcutaneous injection of ketone solution (containing \u03b2-hydroxybutyrate [\u03b2OHB]) or saline (vehicle). Neonatal offspring cardiac function was assessed by echocardiography at postnatal days (PD)3 and 13. Hearts and livers were collected post-mortem for assessments of mitochondrial function and gene expression profiles of markers oxidative stress and inflammation. Maternal iron restriction caused neonatal anemia and asymmetric growth restriction at all time points assessed, and maternal \u03b2OHB treatment had no effect on these outcomes. Echocardiography revealed reduced ejection fraction despite enlarged hearts (relative to body weight) in ID offspring, resulting in impaired oxygen delivery, which was attenuated by maternal \u03b2OHB supplementation. Further, maternal ketone supplementation affected biochemical markers of mitochondrial function, oxidative stress and inflammation in hearts of neonates, implicating these pathways in the protective effects conferred by \u03b2OHB. In summary, \u03b2OHB supplementation confers protection against cardiac dysfunction in ID neonates and could have implications for the treatment of anemic babies.<\/jats:p>","DOI":"10.1042\/cs20241386","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T16:49:26Z","timestamp":1726591766000},"page":"1249-1264","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal ketone supplementation throughout gestation improves neonatal cardiac dysfunction caused by perinatal iron deficiency"],"prefix":"10.1042","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-7840","authenticated-orcid":false,"given":"Ronan\u00a0M.N.","family":"Noble","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, University of Alberta, Edmonton, Canada"},{"name":"2Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, 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Edmonton, Canada"},{"name":"3Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada"},{"name":"5Department of Anesthesiology, University of Alberta, Edmonton, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mourad","family":"Ferdaoussi","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, University of Alberta, Edmonton, Canada"},{"name":"2Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, Canada"},{"name":"3Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Lemieux","sequence":"additional","affiliation":[{"name":"2Women and Children\u2019s Health Research Institute, University of Alberta, Edmonton, Canada"},{"name":"4Faculty Saint-Jean, University of Alberta, Edmonton, AB, 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