{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:12:42Z","timestamp":1768421562014,"version":"3.49.0"},"reference-count":33,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AG054523,R01AG072734,and R01AG061805"],"award-info":[{"award-number":["R01AG054523,R01AG072734,and R01AG061805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017794","name":"Wake Forest Alzheimer\u2019s Disease Research Center","doi-asserted-by":"crossref","award":["P30AG049638 and P30AG072947"],"award-info":[{"award-number":["P30AG049638 and P30AG072947"]}],"id":[{"id":"10.13039\/100017794","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:p>Impaired glucose tolerance (IGT) and insulin resistance (IR), including prediabetes and diabetes, increase risk of developing age-related disorders, such as cardiovascular disorders, kidney disorders, and Alzheimer\u2019s disease. We analyzed mitochondrial bioenergetics of platelets collected from 208 adults, 55 years and older, with IGT and IR and without normoglycemic (NG). Platelets from IGT participants exhibited unique mitochondrial bioenergetic profiles exemplified by higher mitochondrial respiration compared with NG. IGT platelets exhibited higher glucose-dependent maximal respiration (Max) and spare respiratory capacities (SRCs) and higher fatty acid oxidation (FAO)-dependent maximal coupled (MaxOXPHOS) and uncoupled (maximal electron transport system) respiration compared with NG. Correlating mitochondrial bioenergetics from all 208 participants with measures of glucose tolerance (oral glucose tolerance test values measured 120 min after glucose administration, and oral glucose tolerance test area under the curve), and historical glucose measures [hemoglobin A1 (HbA1c)] revealed significant positive associations. Most associations were unaltered with age, sex, and body mass index adjustments. Examining NG and IGT participants separately, we found platelet respiration and HbA1c exhibited positive association in NG participants. Significant positive associations emerged between platelet SRC, FAO, FAO+CI (oxygen flux due to FAO + complex I activities), and HbA1c. No significant associations were observed in the IGT group. Given the utilization of blood-based mitochondrial bioenergetic profiling strategies in clinical research, this work provides new insights into the clinical features of IR that can affect platelet mitochondrial bioenergetics.<\/jats:p>","DOI":"10.1042\/cs20242841","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:54:25Z","timestamp":1764748465000},"page":"65-79","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelets from older adults exhibit differences in mitochondrial function associated with impaired glucose metabolism"],"prefix":"10.1042","volume":"140","author":[{"given":"Gargi","family":"Mahapatra","sequence":"first","affiliation":[{"name":"1Division of Geriatrics, Gerontology, and Palliative Care; Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengrong","family":"Gao","sequence":"additional","affiliation":[{"name":"2Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Bateman","sequence":"additional","affiliation":[{"name":"2Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A."},{"name":"3Department of Neurology, Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Neal","family":"Lockhart","sequence":"additional","affiliation":[{"name":"2Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Bergstrom","sequence":"additional","affiliation":[{"name":"1Division of Geriatrics, Gerontology, and Palliative Care; Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jemima Elizabeth","family":"Piloso","sequence":"additional","affiliation":[{"name":"2Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Craft","sequence":"additional","affiliation":[{"name":"2Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer\u2019s Prevention, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-4622","authenticated-orcid":false,"given":"Anthony J. 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