{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:07:31Z","timestamp":1780312051885,"version":"3.54.0"},"reference-count":49,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Army Medical Research and Material Command","award":["PR190829"],"award-info":[{"award-number":["PR190829"]}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["GM152626"],"award-info":[{"award-number":["GM152626"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ASPEN | ASPEN Rhoads Research Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nutritional support is a vital component of the rehabilitation process following sepsis. Essential amino acids (EAA) are recognized as a critical component for stimulating anabolism. However, it remains unclear whether EAA supplementation alone is more effective than providing a complete profile of total amino acids (TAA). We studied amino acid (AA) metabolism in 51 catheterized pigs (\u00b127\u00a0kg) using the pulse tracer approach over a 7-day recovery period following sepsis. Animals were randomly and blindly assigned to receive post-sepsis nutrition containing either an EAA or a TAA mixture based on the composition of pig muscle. Statistical analyses were performed using a generalized linear mixed model. Plasma concentrations of EAA increased substantially in the EAA group post-sepsis (interaction effect, P&amp;lt;0.001), while those of non-essential AA increased in both groups (time effect, P&amp;lt;0.001). Whole-body intracellular production of most AA was reduced on day 3 and remained low on day 7 post-sepsis, with only small differences observed between the two groups. On day 7 post-sepsis, pigs receiving only EAA showed significantly (all P&amp;lt;0.001) lower intracellular production of hydroxyproline (\u221236%), ornithine (\u221211%), and tryptophan (\u221220%) and higher production of arginine (66%), citrulline (18%), glutamine (18%), taurine (22%), and some EAA. The EAA group showed a significantly higher net protein breakdown post-sepsis. In this sepsis-recovery pig model, dietary supplementation of both EAA and TAA failed to normalize the intracellular production of AA. More importantly, providing only EAA resulted in a significantly greater net protein breakdown compared with the TAA group.<\/jats:p>","DOI":"10.1042\/cs20250414","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:34:11Z","timestamp":1778765651000},"page":"1175-1196","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The metabolic effects of post-sepsis feeding of meals with only essential amino acids"],"prefix":"10.1042","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-6447","authenticated-orcid":false,"given":"Nicolaas\u00a0E.P.","family":"Deutz","sequence":"first","affiliation":[{"name":"1Center for Translational Research in Aging and Longevity, Depts of Kinesiology & Sport Management, Texas A&M University, College Station, U.S.A."},{"name":"2Primary Care & Rural Medicine, Texas A&M University, College Station, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella\u00a0A.M.","family":"Ten Have","sequence":"additional","affiliation":[{"name":"1Center for Translational Research in Aging and Longevity, Depts of Kinesiology & Sport Management, Texas A&M University, College Station, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah\u00a0A.","family":"Rice","sequence":"additional","affiliation":[{"name":"1Center for Translational Research in Aging and Longevity, Depts of Kinesiology & Sport Management, Texas A&M University, College Station, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina\u00a0B.W.","family":"Horner","sequence":"additional","affiliation":[{"name":"1Center for Translational Research in Aging and Longevity, Depts of Kinesiology & Sport Management, Texas A&M University, College Station, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Minussi","sequence":"additional","affiliation":[{"name":"1Center for Translational Research in Aging and Longevity, Depts of Kinesiology & Sport Management, Texas A&M University, College Station, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-2553","authenticated-orcid":false,"given":"Marielle\u00a0P.K.J.","family":"Engelen","sequence":"additional","affiliation":[{"name":"1Center for Translational Research in Aging and Longevity, Depts of Kinesiology & Sport Management, Texas A&M University, College Station, U.S.A."},{"name":"2Primary Care & Rural Medicine, Texas A&M University, College Station, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"2026060106361415300_B1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1097\/CCM.0000000000005804","article-title":"Surviving sepsis campaign","volume":"51","author":"Dellinger","year":"2023","journal-title":"Crit. 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