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In rheumatoid arthritis (RA), an autoimmune disease characterized by destructive joint inflammation, metabolic checkpoints have emerged as critical regulators of immune-cell behavior and drivers of tissue pathology. RA CD4+ T cells undergo profound metabolic reprogramming: glycolysis is suppressed, and glucose is redirected into the pentose phosphate pathway, resulting in NADPH accumulation, reduced ROS levels, and a highly reductive intracellular environment. Concurrent defects in mitochondrial DNA repair and electron transport chain function compromise mitochondrial fitness, leading to NAD+ depletion, altered tricarboxylic acid cycle activity, and metabolic exhaustion. The resulting accumulation of citrate and acetyl-CoA promotes lipogenesis and protein acetylation, driving membrane remodeling, tissue invasiveness, and proinflammatory effector functions. Depletion of oxaloacetate and aspartate limits NAD+ regeneration, inducing endoplasmic reticulum expansion and enhanced tumor necrosis factor production. Defective lysosomal coordination of AMPK and mTORC1 signaling uncouples energy sensing from anabolic programs, enabling cellular activation and proliferation despite metabolic insufficiency. Macrophage fate and function are similarly shaped by metabolic state. In synovial macrophages, GLUD1-dependent glutamine oxidation sustains mitochondrial respiration and ATP production, enabling survival under nutrient-deprived conditions while promoting antigen presentation. Conversely, metabolic stress in MerTK+ macrophages activates the NAD+ hydrolase SARM1, triggering NAD+ depletion, mitochondrial collapse, and PANoptotic cell death. Together, these findings identify NAD+ availability, mitochondrial fitness, and organelle-based signaling as central metabolic gatekeepers linking bioenergetic stress to immune-cell dysfunction and chronic inflammation in RA.<\/jats:p>","DOI":"10.1042\/cs20250834","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:44:51Z","timestamp":1792057491000},"page":"2363-2385","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic gatekeepers shape immune cell function in rheumatoid arthritis"],"prefix":"10.1042","volume":"140","author":[{"given":"Li","family":"Jia","sequence":"first","affiliation":[{"name":"1Department of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"2Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"3Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murari\u00a0N.","family":"Kothagundla","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"2Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"3Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-1856","authenticated-orcid":false,"given":"J\u00f6rg\u00a0J.","family":"Goronzy","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"3Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, U.S.A."},{"name":"4Stanford University School of Medicine, Stanford, CA 94305, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-9802","authenticated-orcid":false,"given":"Cornelia\u00a0M.","family":"Weyand","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"2Department of Cardiovascular Medicine, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, U.S.A."},{"name":"3Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, U.S.A."},{"name":"4Stanford University School of Medicine, Stanford, CA 94305, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"2026101505444583900_B1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nri3701","article-title":"Integrating canonical and metabolic signalling programmes in the regulation of T cell responses","volume":"14","author":"Pollizzi","year":"2014","journal-title":"Nat. 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