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The study found that CLU concentrations were significantly lower in ARDS patients, particularly non-survivors, compared with non-ARDS patients and survivors; similarly, serum CLU levels were decreased in mice with lipopolysaccharide-induced ARDS. Both in vivo and in vitro experiments demonstrated that treatment with recombinant CLU protein significantly alleviated organ injury and suppressed the inflammatory response. Mechanistically, CLU improves mitochondrial oxidative phosphorylation by inhibiting the Wnt\/\u03b2-catenin signaling pathway, thereby inhibiting the expression of inflammatory factors, repairing adherens junctions, and reducing vascular leakage, ultimately preserved intercellular junction protein expression. In summary, CLU ameliorates endothelial injury in ARDS models by inhibiting the Wnt\/\u03b2-catenin pathway, playing a crucial protective role in host defense against ARDS.<\/jats:p>","DOI":"10.1042\/cs20251056","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:09:58Z","timestamp":1783084198000},"page":"1635-1652","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt\/\u03b2-catenin pathway"],"prefix":"10.1042","volume":"140","author":[{"given":"Rui","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-7659","authenticated-orcid":false,"given":"Junnan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, No.76 Linjiang Road, Yuzhong District, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026071005465779600_B1","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"key":"2026071005465779600_B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40560-025-00781-3","article-title":"Epidemiological trends of mechanically ventilated acute respiratory distress syndrome in the twenty-first century: a nationwide, population-based retrospective study","volume":"13","author":"Bardaji-Carrillo","year":"2025","journal-title":"J. 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