{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:58:54Z","timestamp":1792673934463,"version":"4.5.0"},"reference-count":41,"publisher":"Portland Press Ltd.","issue":"20","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,22]]},"abstract":"<jats:p>Background: Schistosomiasis is a major cause of pulmonary hypertension (PH) worldwide, and CD4 T cells are critical in disease pathogenesis. The role of dendritic cells (DCs) in Schistosoma-induced PH (SchPH) is unknown. There are two types of conventional DCs, cDC1 and cDC2, that prototypically activate CD8 and CD4 T cells, respectively. Methods: We exposed wildtype, DC reporter, and DC knockout mice to Schistosoma mansoni and quantified PH severity by heart catheterization and cell density by flow cytometry. Results: Experimental S. mansoni exposure increased the density of pulmonary DCs, particularly cDC2s. Deleting both cDC subsets did not significantly modify SchPH disease severity. Deleting only cDC1s caused more severe SchPH, associated with more Th2 CD4 and CD8 T cells. In contrast, deleting only cDC2s reduced SchPH disease severity. Conclusions: cDC1s appear to be protective, whereas cDC2s promote disease in SchPH.<\/jats:p>","DOI":"10.1042\/cs20256896","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:20:51Z","timestamp":1759846851000},"page":"1187-1198","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of conventional dendritic cells in schistosomiasis-induced pulmonary hypertension"],"prefix":"10.1042","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-311X","authenticated-orcid":false,"given":"Claudia","family":"Mickael","sequence":"first","affiliation":[{"name":"1Division of Pulmonary Sciences and Critical Care Medicine \/ Cardiovascular Research Laboratories, Department of Medicine, University of Colorado Anschutz Medical Campus, Colorado, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kumar","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara C.","family":"Fonseca Balladares","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Nolan","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Lee","sequence":"additional","affiliation":[{"name":"4School of Pharmacy, University of California San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biruk","family":"Kassa","sequence":"additional","affiliation":[{"name":"5Division of Respiratory Diseases, Department of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais C.F","family":"Menezes","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Lau-Xiao","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajaypal","family":"Sahota","sequence":"additional","affiliation":[{"name":"1Division of Pulmonary Sciences and Critical Care Medicine \/ Cardiovascular Research Laboratories, Department of Medicine, University of Colorado Anschutz Medical Campus, Colorado, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Sanders","sequence":"additional","affiliation":[{"name":"1Division of Pulmonary Sciences and Critical Care Medicine \/ Cardiovascular Research Laboratories, Department of Medicine, University of Colorado Anschutz Medical Campus, Colorado, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Tuscan","sequence":"additional","affiliation":[{"name":"1Division of Pulmonary Sciences and Critical Care Medicine \/ Cardiovascular Research Laboratories, Department of Medicine, University of Colorado Anschutz Medical Campus, Colorado, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Gandjeva","sequence":"additional","affiliation":[{"name":"6Department of Laboratory Medicine, University of California San Francisco, San Francisco, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Cautivo","sequence":"additional","affiliation":[{"name":"6Department of Laboratory Medicine, University of California San Francisco, San Francisco, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Molofsky","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-2585","authenticated-orcid":false,"given":"Brian B.","family":"Graham","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of California San Francisco, California, U.S.A."},{"name":"3Lung Biology Center, Zuckerberg San Francisco General Hospital, San Francisco, California, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"2025102211365116700_CS-2025-6896C1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1164\/rccm.201410-1820OC","article-title":"The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension","volume":"192","author":"Kumar","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025102211365116700_CS-2025-6896C2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013111","article-title":"Th2 CD4+ T cells are necessary and sufficient for schistosoma-pulmonary hypertension","volume":"8","author":"Kumar","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"2025102211365116700_CS-2025-6896C3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179202","article-title":"Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension","volume":"25","author":"Fonseca Balladares","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2025102211365116700_CS-2025-6896C4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025102211365116700_CS-2025-6896C5","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.4049\/jimmunol.178.11.6861","article-title":"CD103\u2212 and CD103+ Bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T Cells","volume":"178","author":"Rodriguez-Barbosa","year":"2007","journal-title":"The Journal of Immunology"},{"key":"2025102211365116700_CS-2025-6896C6","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5674","article-title":"Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction","volume":"5","author":"Desch","year":"2014","journal-title":"Nat. Commun."},{"key":"2025102211365116700_CS-2025-6896C7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"key":"2025102211365116700_CS-2025-6896C8","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231282","article-title":"Site-specific regulation of Th2 differentiation within lymph node microenvironments","volume":"221","author":"Lyons-Cohen","year":"2024","journal-title":"J. Exp. Med."},{"key":"2025102211365116700_CS-2025-6896C9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41423-021-00741-5","article-title":"Dendritic cells in cancer immunology","volume":"19","author":"Murphy","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"2025102211365116700_CS-2025-6896C10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/1381612043453414","article-title":"Endothelial expression of MHC class II molecules in autoimmune disease","volume":"10","author":"Turesson","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"2025102211365116700_CS-2025-6896C11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20150235","article-title":"Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12","volume":"213","author":"Everts","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025102211365116700_CS-2025-6896C12","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-017-2250-1","article-title":"Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum","volume":"10","author":"Chen","year":"2017","journal-title":"Parasit. Vectors"},{"key":"2025102211365116700_CS-2025-6896C13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010343","article-title":"Experimental Schistosoma japonicum-induced pulmonary hypertension","volume":"16","author":"Kassa","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2025102211365116700_CS-2025-6896C14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15494","article-title":"TGF-\u03b2 activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension","volume":"8","author":"Kumar","year":"2017","journal-title":"Nat. Commun."},{"key":"2025102211365116700_CS-2025-6896C15","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/CIRCULATIONAHA.113.003072","article-title":"Transforming growth factor-\u03b2 signaling promotes pulmonary hypertension caused by Schistosoma mansoni","volume":"128","author":"Graham","year":"2013","journal-title":"Circulation"},{"key":"2025102211365116700_CS-2025-6896C16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/0471142735.im1901s103","article-title":"Schistosomiasis","volume":"103","author":"Tucker","year":"2013","journal-title":"Curr. Protoc. Immunol."},{"key":"2025102211365116700_CS-2025-6896C17","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1093\/cvr\/cvz304","article-title":"Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension","volume":"116","author":"Kumar","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"2025102211365116700_CS-2025-6896C18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1046\/j.1365-2818.1997.2070765.x","article-title":"The optical rotator","volume":"186","author":"Tandrup","year":"1997","journal-title":"J. Microsc."},{"key":"2025102211365116700_CS-2025-6896C19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.immuni.2013.08.029","article-title":"CD301b","volume":"39","author":"Kumamoto","year":"2013","journal-title":"Immunity"},{"key":"2025102211365116700_CS-2025-6896C20","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf7777","article-title":"Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles","volume":"7","author":"Dick","year":"2022","journal-title":"Sci. Immunol."},{"key":"2025102211365116700_CS-2025-6896C21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1372957","article-title":"Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension","volume":"15","author":"Kumar","year":"2024","journal-title":"Front. Immunol."},{"key":"2025102211365116700_CS-2025-6896C22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.608883","article-title":"schistosomiasis pulmonary arterial Hypertension","volume":"11","author":"Sibomana","year":"2020","journal-title":"Front. Immunol."},{"key":"2025102211365116700_CS-2025-6896C23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jacc.2010.03.065","article-title":"Survival in schistosomiasis-associated pulmonary arterial hypertension","volume":"56","author":"Dos Santos Fernandes","year":"2010","journal-title":"J. Am. Coll. Cardiol"},{"key":"2025102211365116700_CS-2025-6896C24","article-title":"Schistosomiasis-associated pulmonary arterial hypertension: survival in endemic area in Brazil","volume":"25","author":"Piscoya Roncal","year":"2019","journal-title":"Int. J. Cardiol. Heart Vasc"},{"key":"2025102211365116700_CS-2025-6896C25","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00307-2018","article-title":"Survival of patients with schistosomiasis-associated pulmonary arterial hypertension in the modern management era","volume":"51","author":"Fernandes","year":"2018","journal-title":"Eur. Respir. J."},{"key":"2025102211365116700_CS-2025-6896C26","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9997.1","article-title":"The role of cDC1s in vivo: CD8 T cell priming through cross-presentation","volume":"6","author":"Theisen","year":"2017","journal-title":"F1000Res."},{"key":"2025102211365116700_CS-2025-6896C27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/eji.201444651","article-title":"Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice","volume":"45","author":"Mart\u00ednez-L\u00f3pez","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"2025102211365116700_CS-2025-6896C28","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.4049\/jimmunol.174.9.5444","article-title":"A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection","volume":"174","author":"Suffia","year":"2005","journal-title":"The Journal of Immunology"},{"key":"2025102211365116700_CS-2025-6896C29","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41577-024-01040-6","article-title":"A guide to adaptive immune memory","volume":"24","author":"Lam","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"2025102211365116700_CS-2025-6896C30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01907","article-title":"Antigen presentation by vascular Cells","volume":"8","author":"Pober","year":"2017","journal-title":"Front. Immunol."},{"key":"2025102211365116700_CS-2025-6896C31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80775","article-title":"Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain","volume":"11","author":"Kovacs","year":"2022","journal-title":"Elife"},{"key":"2025102211365116700_CS-2025-6896C32","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12101262","article-title":"Plasmodium Infection-cure cycles increase the capacity of phagocytosis in conventional dendritic cells","volume":"12","author":"Adachi","year":"2023","journal-title":"Pathogens"},{"key":"2025102211365116700_CS-2025-6896C33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003801","article-title":"Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice","volume":"9","author":"Lantier","year":"2013","journal-title":"PLoS Pathog."},{"key":"2025102211365116700_CS-2025-6896C34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4049\/jimmunol.1900363","article-title":"Cell-Intrinsic Wnt4 Influences conventional dendritic cell fate determination to suppress type 2 immunity","volume":"203","author":"Hung","year":"2019","journal-title":"The Journal of Immunology"},{"key":"2025102211365116700_CS-2025-6896C35","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1084\/jem.20111381","article-title":"Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor","volume":"209","author":"Everts","year":"2012","journal-title":"J. Exp. Med"},{"key":"2025102211365116700_CS-2025-6896C36","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20082460","article-title":"Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses","volume":"206","author":"Everts","year":"2009","journal-title":"Journal of Experimental Medicine"},{"key":"2025102211365116700_CS-2025-6896C37","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.20082462","article-title":"The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)","volume":"206","author":"Steinfelder","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025102211365116700_CS-2025-6896C38","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.4049\/jimmunol.173.4.2419","article-title":"Parasite-induced th2 polarization is associated with down-regulated dendritic cell responsiveness to th1 stimuli and a transient delay in t lymphocyte cycling","volume":"173","author":"Jankovic","year":"2004","journal-title":"The Journal of Immunology"},{"key":"2025102211365116700_CS-2025-6896C39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012457","article-title":"S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration","volume":"20","author":"Patente","year":"2024","journal-title":"PLoS Pathog."},{"key":"2025102211365116700_CS-2025-6896C40","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400338RR","article-title":"Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension","volume":"38","author":"Mickael","year":"2024","journal-title":"FASEB J."},{"key":"2025102211365116700_CS-2025-6896C41","doi-asserted-by":"crossref","first-page":"L609","DOI":"10.1152\/ajplung.00531.2016","article-title":"Central role of T helper 17 cells in chronic hypoxia-induced pulmonary hypertension","volume":"312","author":"Maston","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/doi\/10.1042\/CS20256896\/978754\/cs-2025-6896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/doi\/10.1042\/CS20256896\/978754\/cs-2025-6896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T15:37:03Z","timestamp":1761147423000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/139\/20\/1187\/236610\/Role-of-conventional-dendritic-cells-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":41,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10,22]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20256896","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]}}}