{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:05Z","timestamp":1788447725610,"version":"build-2803163510"},"reference-count":65,"publisher":"Portland Press Ltd.","issue":"22","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of the People\u2019s Republic of China","award":["81900784,82100278, 82270479\uff0c82070460 and HY2021-1"],"award-info":[{"award-number":["81900784,82100278, 82270479\uff0c82070460 and HY2021-1"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2021M700274"],"award-info":[{"award-number":["2021M700274"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Capital Medical University Research Foundation","award":["1220010213"],"award-info":[{"award-number":["1220010213"]}]},{"name":"Beijing Natural Science Foundation","award":["7242084"],"award-info":[{"award-number":["7242084"]}]},{"name":"Peking University Medicine plus X Pilot Program-Platform Construction Project","award":["2024YXXLHPT010"],"award-info":[{"award-number":["2024YXXLHPT010"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,27]]},"abstract":"<jats:p>Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in acyl-esterifying cholesterol intravascularly, but its function in metabolic dysfunction-associated steatotic liver disease (MASLD) or steatohepatitis (MASH) has remained uncertain both in murine models and humans for decades, which is largely attributable to the distinct differences in cholesterol metabolism between mice and humans. Previously, we created a novel golden Syrian hamster model deficient in LCAT activity. Herein, we explored the influence of LCAT on the development of MASLD and MASH. A cross-sectional clinical study of LCAT activity and free cholesterol (FC) levels in healthy and MASLD patients was performed. LCAT knockout (LCAT KO) hamsters were used to explore the characteristics of cholesterol homeostasis and MASLD and MASH development. Lipidomics, mRNA-seq, and qPCR were employed to investigate the underlying mechanisms involved. MASLD patients displayed reduced LCAT activity, elevated FC levels, and ratio of FC\/TC. Serum FC levels were positively correlated with triglyceride (TG), total cholesterol (TC), and apoB100 levels. In hamsters, LCAT deficiency resulted in increased FC levels and decreased high-density lipoprotein levels. Apolipoprotein profiles revealed increased ApoB100\/48 and apoE but decreased apoAI. Increases in serum FC levels were primarily observed in LCAT-deficient hamster. Interestingly, LCAT KO hamsters presented mild TG species deposition in the liver even when fed a chow diet indicated by lipidomics. These increased TG species included TG (16:0\/18:1\/18:2), TG (16:0\/18:1\/18:3), and TG (16:0\/16:1\/18:1). On a high-fat and high-cholesterol diet, LCAT-deficient hamsters developed severe liver ballooning, inflammation, and fibrosis. Using HepG2 cells and primary hepatocytes confirmed that FC increased intracellular lipogenesis and promoted inflammatory response, which was reversed by a NLRP3 inhibitor. In summary, LCAT deficiency in hamsters promotes liver lipid deposition and MASH progression, thus highlighting the therapeutic role of LCAT in MASLD and MASH.<\/jats:p>","DOI":"10.1042\/cs20257764","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:27:12Z","timestamp":1762421232000},"page":"1507-1525","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Loss of LCAT function aggravates metabolic-associated steatohepatitis (MASH) in golden Syrian hamster"],"prefix":"10.1042","volume":"139","author":[{"given":"Yuqing","family":"Zhang","sequence":"first","affiliation":[{"name":"1Department of Clinical Diagnosis, Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Wang","sequence":"additional","affiliation":[{"name":"4Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"},{"name":"5Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China"},{"name":"6State Key Laboratory of Vascular Homeostasis and Remodeling, Institute of Advanced Clinical Medicine; National Health Commission (NHC) Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhao","sequence":"additional","affiliation":[{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"},{"name":"5Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China"},{"name":"6State Key Laboratory of Vascular Homeostasis and Remodeling, Institute of Advanced Clinical Medicine; National Health Commission (NHC) Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhou","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"},{"name":"7Department of Biomedical Informatics, Center for Noncoding RNA Medicine, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemin","family":"Zheng","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Wang","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Liu","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-0405","authenticated-orcid":false,"given":"Guotao","family":"Lu","sequence":"additional","affiliation":[{"name":"8Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3059-1254","authenticated-orcid":false,"given":"Xunde","family":"Xian","sequence":"additional","affiliation":[{"name":"2Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"},{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2564-4996","authenticated-orcid":false,"given":"Zhao","family":"Dong","sequence":"additional","affiliation":[{"name":"3State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Health Science Center, Beijing, China"},{"name":"9Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"2025112715064047300_CS-2025-7764C1","doi-asserted-by":"crossref","first-page":"155999","DOI":"10.1016\/j.metabol.2024.155999","article-title":"Global burden of metabolic diseases, 1990-2021","volume":"160","author":"Zhang","year":"2024","journal-title":"Metab. Clin. Exp"},{"key":"2025112715064047300_CS-2025-7764C2","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2012.04.001","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology","volume":"142","author":"Chalasani","year":"2012","journal-title":"Gastroenterology"},{"key":"2025112715064047300_CS-2025-7764C3","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology"},{"key":"2025112715064047300_CS-2025-7764C4","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.jhep.2014.07.024","article-title":"Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent","volume":"61","author":"Gan","year":"2014","journal-title":"J. Hepatol."},{"key":"2025112715064047300_CS-2025-7764C5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tem.2015.11.008","article-title":"The role of cholesterol in the pathogenesis of NASH","volume":"27","author":"Ioannou","year":"2016","journal-title":"Trends Endocrinol. Metab"},{"key":"2025112715064047300_CS-2025-7764C6","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2011.06.040","article-title":"Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis","volume":"141","author":"Van Rooyen","year":"2011","journal-title":"Gastroenterology"},{"key":"2025112715064047300_CS-2025-7764C7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.26604","article-title":"Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice","volume":"59","author":"Tomita","year":"2014","journal-title":"Hepatology"},{"key":"2025112715064047300_CS-2025-7764C8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.gastro.2011.09.049","article-title":"A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells","volume":"142","author":"Teratani","year":"2012","journal-title":"Gastroenterology"},{"key":"2025112715064047300_CS-2025-7764C9","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1136\/gutjnl-2020-322509","article-title":"Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis","volume":"70","author":"Koh","year":"2021","journal-title":"Gut"},{"key":"2025112715064047300_CS-2025-7764C10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mad.2016.07.001","article-title":"Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis","volume":"157","author":"Bozaykut","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"2025112715064047300_CS-2025-7764C11","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1161\/CIRCULATIONAHA.111.066589","article-title":"Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport","volume":"125","author":"Rosenson","year":"2012","journal-title":"Circulation"},{"key":"2025112715064047300_CS-2025-7764C12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jacl.2011.07.002","article-title":"Homozygous lecithin:cholesterol acyltransferase (LCAT) deficiency due to a new loss of function mutation and review of the literature","volume":"5","author":"Roshan","year":"2011","journal-title":"J. Clin. Lipidol."},{"key":"2025112715064047300_CS-2025-7764C13","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1194\/jlr.D090233","article-title":"Plasma lipoprotein-X quantification on filipin-stained gels: monitoring recombinant LCAT treatment ex vivo","volume":"60","author":"Freeman","year":"2019","journal-title":"J. Lipid Res."},{"key":"2025112715064047300_CS-2025-7764C14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/clinem\/dgac565","article-title":"Differences in HDL-Bound apolipoproteins in patients with advanced liver fibrosis due to nonalcoholic fatty liver disease","volume":"108","author":"Bril","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025112715064047300_CS-2025-7764C15","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12988","article-title":"Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease","volume":"48","author":"Nass","year":"2018","journal-title":"Eur. J. Clin. Invest"},{"key":"2025112715064047300_CS-2025-7764C16","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.3390\/ijms23158229","article-title":"Unraveling the transcriptional dynamics of NASH Pathogenesis Affecting Atherosclerosis","volume":"23","author":"Van den Hoek","year":"2022","journal-title":"Int. J. Mol. Sci"},{"key":"2025112715064047300_CS-2025-7764C17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bbalip.2016.04.005","article-title":"Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis","volume":"1861","author":"Bashiri","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"2025112715064047300_CS-2025-7764C18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1194\/jlr.M030080","article-title":"LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function","volume":"54","author":"Hoekstra","year":"2013","journal-title":"J. Lipid Res"},{"key":"2025112715064047300_CS-2025-7764C19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ebiom.2017.12.013","article-title":"LDL Receptor gene-ablated hamsters: a rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis","volume":"27","author":"Guo","year":"2018","journal-title":"EBioMedicine"},{"key":"2025112715064047300_CS-2025-7764C20","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/jn\/130.9.2166","article-title":"Regulation of intestinal apolipoprotein B mRNA editing levels by a zinc-deficient diet and cDNA cloning of editing protein in hamsters","volume":"130","author":"Reaves","year":"2000","journal-title":"J. Nutr."},{"key":"2025112715064047300_CS-2025-7764C21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.metabol.2018.03.003","article-title":"Loss of LCAT activity in the golden Syrian hamster elicits pro-atherogenic dyslipidemia and enhanced atherosclerosis","volume":"83","author":"Dong","year":"2018","journal-title":"Metab. Clin. Exp."},{"key":"2025112715064047300_CS-2025-7764C22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/hep.32131","article-title":"Metabolic dysfunction\u2013associated fatty liver disease improves detection of high liver stiffness: the rotterdam study","volume":"75","author":"Van Kleef","year":"2022","journal-title":"Hepatology"},{"key":"2025112715064047300_CS-2025-7764C23","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1194\/jlr.P900015-JLR200","article-title":"Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women","volume":"51","author":"Asztalos","year":"2010","journal-title":"J. Lipid Res."},{"key":"2025112715064047300_CS-2025-7764C24","unstructured":"National Genomics Data Center\n          . RNA seq of liver tissues from LCAT KO hamster with HFHCD. https:\/\/ngdc.cncb.ac.cn\/bioproject\/browse\/PRJCA043111"},{"key":"2025112715064047300_CS-2025-7764C25","unstructured":"National Genomics Data Center\n          . RNA-seq of liver tissue from LCAT KO and WT hamster with HFHCD. https:\/\/ngdc.cncb.ac.cn\/omix\/release\/OMIX010979"},{"key":"2025112715064047300_CS-2025-7764C26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"FOLCH","year":"1957","journal-title":"J. Biol. Chem."},{"key":"2025112715064047300_CS-2025-7764C27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"BLIGH","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"2025112715064047300_CS-2025-7764C28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.chroma.2013.01.078","article-title":"Development of a lipid profiling system using reverse-phase liquid chromatography coupled to high-resolution mass spectrometry with rapid polarity switching and an automated lipid identification software","volume":"1292","author":"Yamada","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"2025112715064047300_CS-2025-7764C29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.talanta.2017.09.046","article-title":"Assessment of potential false positives via orbitrap-based untargeted lipidomics from rat tissues","volume":"178","author":"Xu","year":"2018","journal-title":"Talanta"},{"key":"2025112715064047300_CS-2025-7764C30","doi-asserted-by":"crossref","first-page":"100726","DOI":"10.1016\/j.jhepr.2023.100726","article-title":"Inhibition of phospholipase D1 ameliorates hepatocyte steatosis and non-alcoholic fatty liver disease","volume":"5","author":"Wang","year":"2023","journal-title":"JHEP Reports"},{"key":"2025112715064047300_CS-2025-7764C31","article-title":"Free Cholesterol-Induced Liver Injury in Non-Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I","volume":"12","author":"Shou","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"key":"2025112715064047300_CS-2025-7764C32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166913","article-title":"Exendin-4 Inhibits Hepatic Lipogenesis by Increasing \u03b2-Catenin Signaling","volume":"11","author":"Seo","year":"2016","journal-title":"PLoS ONE"},{"key":"2025112715064047300_CS-2025-7764C33","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.bbadis.2015.05.015","article-title":"Recent insights on the role of cholesterol in non-alcoholic fatty liver disease","volume":"1852","author":"Arguello","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"2025112715064047300_CS-2025-7764C34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.plipres.2012.11.002","article-title":"Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis","volume":"52","author":"Musso","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"2025112715064047300_CS-2025-7764C35","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.3390\/ijms20205045","article-title":"Liver x receptors regulate cholesterol metabolism and immunity in hepatic nonparenchymal cells","volume":"20","author":"Endo-Umeda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2025112715064047300_CS-2025-7764C36","doi-asserted-by":"crossref","first-page":"102457","DOI":"10.1016\/j.isci.2021.102457","article-title":"Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease","volume":"24","author":"Li","year":"2021","journal-title":"iScience"},{"key":"2025112715064047300_CS-2025-7764C37","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220681","article-title":"Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH","volume":"220","author":"Itoh","year":"2023","journal-title":"J. Exp. Med."},{"key":"2025112715064047300_CS-2025-7764C38","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/brv.12948","article-title":"Deciphering structural aspects of reverse cholesterol transport: mapping the knowns and unknowns","volume":"98","author":"Sacher","year":"2023","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"2025112715064047300_CS-2025-7764C39","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/0004563219853596","article-title":"The association between lecithin-cholesterol acyltransferase activity and fatty liver index","volume":"56","author":"Janac","year":"2019","journal-title":"Ann. Clin. Biochem."},{"key":"2025112715064047300_CS-2025-7764C40","doi-asserted-by":"crossref","first-page":"11691","DOI":"10.1038\/s41598-018-29639-5","article-title":"Impaired HDL cholesterol efflux capacity in patients with non-alcoholic fatty liver disease is associated with subclinical atherosclerosis","volume":"8","author":"Fadaei","year":"2018","journal-title":"Sci. Rep."},{"key":"2025112715064047300_CS-2025-7764C41","doi-asserted-by":"crossref","first-page":"15777","DOI":"10.1074\/jbc.272.25.15777","article-title":"Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class b type I","volume":"272","author":"Ng","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"2025112715064047300_CS-2025-7764C42","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1074\/jbc.272.11.7506","article-title":"Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency","volume":"272","author":"Sakai","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2025112715064047300_CS-2025-7764C43","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0022-2275(20)37248-5","article-title":"Expression of human lecithin:cholesterol acyltransferase in transgenic mice: effects on cholesterol efflux, esterification, and transport","volume":"38","author":"Francone","year":"1997","journal-title":"J. Lipid Res."},{"key":"2025112715064047300_CS-2025-7764C44","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1074\/jbc.271.8.4396","article-title":"Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits","volume":"271","author":"Hoeg","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2025112715064047300_CS-2025-7764C45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jacl.2013.11.005","article-title":"A kindred with fish eye disease, corneal opacities, marked high-density lipoprotein deficiency, and statin therapy","volume":"8","author":"Dimick","year":"2014","journal-title":"J. Clin. Lipidol."},{"key":"2025112715064047300_CS-2025-7764C46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100232","article-title":"Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans","volume":"63","author":"Pavanello","year":"2022","journal-title":"J. Lipid Res."},{"key":"2025112715064047300_CS-2025-7764C47","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.361","article-title":"Lipoprotein proteome profile: novel insight into hyperlipidemia","volume":"11","author":"Lin","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"2025112715064047300_CS-2025-7764C48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.999470","article-title":"CRISPR\/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Immunol."},{"key":"2025112715064047300_CS-2025-7764C49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jare.2023.10.016","article-title":"Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level","volume":"63","author":"Lin","year":"2024","journal-title":"J. Adv. Res."},{"key":"2025112715064047300_CS-2025-7764C50","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1161\/ATVBAHA.120.315265","article-title":"Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress-Brief Report","volume":"40","author":"Guo","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025112715064047300_CS-2025-7764C51","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1161\/ATVBAHA.120.315719","article-title":"Correction of Familial LCAT Deficiency by AAV-hLCAT Prevents Renal Injury and Atherosclerosis in Hamsters-Brief Report","volume":"41","author":"Guo","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025112715064047300_CS-2025-7764C52","doi-asserted-by":"crossref","first-page":"26085","DOI":"10.1038\/s41598-024-77104-3","article-title":"Gliflozins, sucrose and flavonoids are allosteric activators of lecithin-cholesterol acyltransferase","volume":"14","author":"Niemel\u00e4","year":"2024","journal-title":"Sci. Rep."},{"key":"2025112715064047300_CS-2025-7764C53","doi-asserted-by":"crossref","DOI":"10.1186\/s12950-019-0211-5","article-title":"Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease","volume":"16","author":"Ho","year":"2019","journal-title":"J. Inflamm. (Lond)."},{"key":"2025112715064047300_CS-2025-7764C54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2014.03.018","article-title":"Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells","volume":"61","author":"Tomita","year":"2014","journal-title":"J. Hepatol"},{"key":"2025112715064047300_CS-2025-7764C55","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1194\/jlr.M034876","article-title":"Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis","volume":"54","author":"Ioannou","year":"2013","journal-title":"J. Lipid Res."},{"key":"2025112715064047300_CS-2025-7764C56","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"2025112715064047300_CS-2025-7764C57","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1073\/pnas.0803933105","article-title":"The Nalp3 inflammasome is essential for the development of silicosis","volume":"105","author":"Cassel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2025112715064047300_CS-2025-7764C58","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"2025112715064047300_CS-2025-7764C59","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/eurheartj\/ehv653","article-title":"Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque","volume":"37","author":"Janoudi","year":"2016","journal-title":"Eur. Heart J."},{"key":"2025112715064047300_CS-2025-7764C60","doi-asserted-by":"crossref","first-page":"1217249","DOI":"10.3389\/fendo.2023.1217249","article-title":"Lean nonalcoholic fatty liver disease and sarcopenia","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2025112715064047300_CS-2025-7764C61","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.3390\/ijms22084156","article-title":"Role of Insulin Resistance in MAFLD","volume":"22","author":"Sakurai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2025112715064047300_CS-2025-7764C62","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10753-021-01559-z","article-title":"Role of inflammatory cytokines, growth factors and adipokines in adipogenesis and insulin resistance","volume":"45","author":"Al-Mansoori","year":"2022","journal-title":"Inflammation"},{"key":"2025112715064047300_CS-2025-7764C63","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1124\/jpet.118.251876","article-title":"LCAT Enzyme replacement therapy reduces lpx and improves kidney function in a mouse model of familial LCAT Deficiency","volume":"368","author":"Vaisman","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2025112715064047300_CS-2025-7764C64","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5551\/jat.32854","article-title":"Role of LCAT in Atherosclerosis","volume":"23","author":"Ossoli","year":"2016","journal-title":"J. Atheroscler. Thromb."},{"key":"2025112715064047300_CS-2025-7764C65","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1161\/01.CIR.94.9.2177","article-title":"Potential gene therapy for lecithin-cholesterol acyltransferase (LCAT)-deficient and hypoalphalipoproteinemic patients with adenovirus-mediated transfer of human LCAT gene","volume":"94","author":"S\u00e9guret-Mac\u00e9","year":"1996","journal-title":"Circulation"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/139\/22\/1507\/979842\/cs-2025-7764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/139\/22\/1507\/979842\/cs-2025-7764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:06:54Z","timestamp":1764274014000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/139\/22\/1507\/236729\/Loss-of-LCAT-function-aggravates-metabolic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":65,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,11,27]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20257764","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,11]]}}}