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Several forms of protein lipidation, namely prenylation, S-acylation (e.g, palmitoylation), and N-myristoylation, are involved in many fundamental processes, including cardiovascular development, cardiac electrophysiology\/contractility, blood pressure homeostasis, and angiogenesis. Moreover, aberrant protein lipidation is increasingly linked to a multitude of cardiovascular diseases such as cardiac hypertrophy, hypertension, atherosclerosis, and congenital heart disease. In the present review, we provide an overview of the different types of protein lipidation, the key enzymes that regulate these PTMs, and an in-depth discussion of the mechanisms by which protein lipidation contributes to cardiovascular physiology and disease.<\/jats:p>","DOI":"10.1042\/cs20258047","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:58:41Z","timestamp":1777384721000},"page":"741-770","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protein lipidation in cardiovascular homeostasis, development, and disease"],"prefix":"10.1042","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1536-2357","authenticated-orcid":false,"given":"David","family":"Cully","sequence":"first","affiliation":[{"name":"1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."},{"name":"2Integrated Vascular Biology Training Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."},{"name":"3Curriculum in Genetics & Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-9226","authenticated-orcid":false,"given":"Shenice","family":"Harrison","sequence":"additional","affiliation":[{"name":"1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3597-0247","authenticated-orcid":false,"given":"Matheus","family":"Sadovsky","sequence":"additional","affiliation":[{"name":"1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1124-4217","authenticated-orcid":false,"given":"Gregory\u00a0E.","family":"Miner","sequence":"additional","affiliation":[{"name":"1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5933-8183","authenticated-orcid":false,"given":"Whitney","family":"Edwards","sequence":"additional","affiliation":[{"name":"1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."},{"name":"3Curriculum in Genetics & Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."},{"name":"4McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."},{"name":"5Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"2026042809583640500_B1","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.chembiol.2018.05.003","article-title":"Protein lipidation in cell signaling and diseases: function, regulation, and therapeutic opportunities","volume":"25","author":"Chen","year":"2018","journal-title":"Cell Chem. 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