{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:29:04Z","timestamp":1766507344943,"version":"3.48.0"},"reference-count":75,"publisher":"Portland Press Ltd.","issue":"24","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,23]]},"abstract":"<jats:p>Fetal growth restriction (FGR) arises from chronic hypoxia and increases the risk of cardiovascular dysfunction following perinatal asphyxia, although underlying mechanisms remain unclear. We investigated whether cardiovascular responses to asphyxia are impaired in preterm FGR lambs and whether this arises from \u03b11- and \u03b21-adrenergic receptor dysfunction. Ewes underwent sterile fetal surgery at 89 days\u2019 gestation (d; term=148 d) to induce FGR (single umbilical artery ligation) or sham surgery (control). At 126 d, lambs were delivered, instrumented and randomised to immediate ventilation (ControlVENTn=6; FGRVENTn=6) or asphyxia (ControlASPHYXIAn=12; FGRASPHYXIAn=11) by umbilical cord occlusion until diastolic blood pressure (BP) decreased to 10 mmHg. Lambs were ventilated for 8 hours before baseline ex vivo cardiac function was assessed via Langendorff perfusion to measure left ventricular developed pressure (LVDP), heart rate (HR) and coronary perfusion pressure (CPP). Ex vivo \u03b11- and \u03b21-adrenergic responses were assessed via phenylephrine and dobutamine administration, respectively. FGRASPHYXIA lambs had lower BP during asphyxia and took longer to reach a diastolic BP of 10 mmHg (P&amp;lt;0.05 vs ControlASPHYXIA). FGRASPHYXIA lambs had lower BP in the first 5 minutes after return of spontaneous circulation due to impaired vascular contractility (P&amp;lt;0.05 vs ControlASPHYXIA). Baseline LVDP, HR and CPP were similar between groups. FGRASPHYXIA lambs had increased LVDP responses to phenylephrine and dobutamine (P&amp;lt;0.05 vs FGRVENT and ControlASPHYXIA), without significant changes to HR or CPP. Overall, FGR lambs exhibit impaired vascular contractility and heightened cardiac \u03b11- and \u03b21-adrenergic responsiveness after perinatal asphyxia, consistent with reduced autonomic regulation, potentially increasing susceptibility to cardiovascular dysfunction postnatally.<\/jats:p>","DOI":"10.1042\/cs20258191","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:06:27Z","timestamp":1766498787000},"page":"1709-1732","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vivo<\/i>\n                    and\n                    <i>ex vivo<\/i>\n                    cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia"],"prefix":"10.1042","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-0095","authenticated-orcid":false,"given":"Zahrah","family":"Azman","sequence":"first","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"2Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3264-0996","authenticated-orcid":false,"given":"Beth R.","family":"Piscopo","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"2Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Thiel","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie A.","family":"Zahra","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen","family":"Pham","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Nitsos","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mumu Mahjabin","family":"Hossain","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"2Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-4182","authenticated-orcid":false,"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"3Monash Newborn, Monash Medical Centre, Clayton, VIC, Australia"},{"name":"4Department of Paediatrics, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-8304","authenticated-orcid":false,"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"2Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3846-1414","authenticated-orcid":false,"given":"Kristen J.","family":"Bubb","sequence":"additional","affiliation":[{"name":"5Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia"},{"name":"6Victorian Heart Institute, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-614X","authenticated-orcid":false,"given":"Graeme R.","family":"Polglase","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"4Department of Paediatrics, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-513X","authenticated-orcid":false,"given":"Beth J.","family":"Allison","sequence":"additional","affiliation":[{"name":"1The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia"},{"name":"2Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"2025122309062133400_CS-2025-8191C1","first-page":"409","article-title":"No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths","volume":"83","author":"Lawn","year":"2005","journal-title":"Bull. 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Physiol."},{"key":"2025122309062133400_CS-2025-8191C33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1469-7580.1997.19110107.x","article-title":"Stereological estimates of nuclear number in human ventricular cardiomyocytes before and after birth obtained using physical disectors","volume":"191","author":"Mayhew","year":"1997","journal-title":"J. Anat."},{"key":"2025122309062133400_CS-2025-8191C34","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1164\/rccm.200406-774OC","article-title":"Surfactant and Physiologic Responses of Preterm Lambs to Continuous Positive Airway Pressure","volume":"171","author":"Mulrooney","year":"2005","journal-title":"Am. J. Respir. Crit. 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Physiol."},{"key":"2025122309062133400_CS-2025-8191C39","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.pedneo.2020.12.007","article-title":"Recognition and management of neonatal hemodynamic compromise","volume":"62","author":"Wu","year":"2021","journal-title":"Pediatrics & Neonatology"},{"key":"2025122309062133400_CS-2025-8191C40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41372-019-0337-6","article-title":"The Relationship between blood pressure parameters and left ventricular output in neonates","volume":"39","author":"Kharrat","year":"2019","journal-title":"J. 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Gynecol."},{"key":"2025122309062133400_CS-2025-8191C46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.trsl.2019.03.004","article-title":"Mechanisms of cardiac collagen deposition in experimental models and human disease","volume":"209","author":"Cowling","year":"2019","journal-title":"Transl. Res."},{"key":"2025122309062133400_CS-2025-8191C47","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1113\/JP285572","article-title":"Reduced in utero substrate supply decreases mitochondrial abundance and alters the expression of metabolic signalling molecules in the fetal sheep heart","volume":"602","author":"Dimasi","year":"2024","journal-title":"J. Physiol. 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