{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:48:54Z","timestamp":1773402534860,"version":"3.50.1"},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondecyt Regular","award":["1220421"],"award-info":[{"award-number":["1220421"]}]},{"name":"Conicyt Beca de Doctorado Nacional","award":["21190567"],"award-info":[{"award-number":["21190567"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"The Wellcome Trust","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypoxia plays a critical role in regulating vascular function, with endothelial mechanosensitive proteins, such as the piezo-type mechanosensitive ion channel component 1 (Piezo1), emerging as key players in maintaining vascular homeostasis. Piezo1 is essential for nitric oxide-mediated vasodilation and vascular tone regulation. However, the impact of hypoxia on endothelial Piezo1 expression and function remains poorly understood. The present study investigated the regulation of Piezo1 and mechanosensitive-related genes (MRGs) during hypoxic development and their role in fetal growth restriction (FGR). Using publicly available datasets, we identified distinct transcriptional profiles in placental endothelial cells from human FGR pregnancies and human umbilical vein endothelial cells (HUVEC) exposed to hypoxia. Functional enrichment analysis revealed significant changes in pathways related to PI3K-Akt, MAPK, and VEGF signaling and responses to mechanical stimuli. Hypoxia-related transcription factors, particularly HIF-1\u03b1 and HIF-1\u03b2, were enriched in the promoter regions of differentially expressed MRGs, including Piezo1, suggesting a conserved regulatory mechanism. In vitro experiments confirmed hypoxia-induced down-regulation of Piezo1 in HUVEC, while ex vivo studies using a chicken embryo model demonstrated impaired Piezo1-mediated vasodilation following hypoxic development. Combined, these findings highlight the critical role of hypoxia in modulating endothelial Piezo1 expression and function, providing mechanistic insights into vascular dysfunction associated with FGR. The present study provides evidence for the potential to target Piezo1 and HIF-1\u03b1 signaling as therapeutic strategies to improve vascular outcomes in offspring of pregnancies complicated by hypoxia and FGR.<\/jats:p>","DOI":"10.1042\/cs20258735","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:35:41Z","timestamp":1772012141000},"page":"493-507","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypoxic development down-regulates endothelial Piezo1 via HIF1-\u03b1 signaling and impairs Piezo1-mediated vasorelaxation"],"prefix":"10.1042","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9251-6759","authenticated-orcid":false,"given":"German\u00a0A.","family":"Arenas","sequence":"first","affiliation":[{"name":"1Facultad de Ciencias Biol\u00f3g\u00adicas, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7763-7322","authenticated-orcid":false,"given":"Anna\u00a0L.K.","family":"Cochrane","sequence":"additional","affiliation":[{"name":"2Physiology, Development & Neuroscience, University of Cambridge, U.K., Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-7671","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Pe\u00f1aloza","sequence":"additional","affiliation":[{"name":"3Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-2748","authenticated-orcid":false,"given":"Adolfo\u00a0A.","family":"Paz","sequence":"additional","affiliation":[{"name":"4Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Med\u00adicina, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matias","family":"Carrasco","sequence":"additional","affiliation":[{"name":"3Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-9897","authenticated-orcid":false,"given":"Rodrigo","family":"Iturriaga","sequence":"additional","affiliation":[{"name":"5Instituto de Ciencias Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-1204","authenticated-orcid":false,"given":"Dino\u00a0A.","family":"Giussani","sequence":"additional","affiliation":[{"name":"2Physiology, Development & Neuroscience, University of Cambridge, U.K., Cambridge"},{"name":"6Loke Centre for Trophoblast Research, University of Cambridge, U.K., Cambridge"},{"name":"7Cambridge Cardiovascular Strategic Research Initiative, University of Cambridge, U.K., Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-6143","authenticated-orcid":false,"given":"Bernardo\u00a0J.","family":"Krause","sequence":"additional","affiliation":[{"name":"3Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"2026031305263619300_B1","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/ki.1997.58","article-title":"Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature","volume":"51","author":"Kourembanas","year":"1997","journal-title":"Kidney Int."},{"key":"2026031305263619300_B2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1046\/j.1440-1681.1999.02992.x","article-title":"Endothelial cell responses to hypoxic stress","volume":"26","author":"Faller","year":"1999","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2026031305263619300_B3","doi-asserted-by":"publisher","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026031305263619300_B4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.atherosclerosis.2010.09.008","article-title":"Role of hemodynamic shear stress in cardiovascular disease","volume":"214","author":"Cecchi","year":"2011","journal-title":"Atherosclerosis"},{"key":"2026031305263619300_B5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1152\/physiol.00007.2016","article-title":"Ion channels in endothelial responses to fluid shear stress","volume":"31","author":"Gerhold","year":"2016","journal-title":"Physiology (Bethesda)."},{"key":"2026031305263619300_B6","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/j.2040-4603.2019.tb00074.x","article-title":"Mechanosensing and mechanoregulation of endothelial cell functions","volume":"9","author":"Fang","year":"2019","journal-title":"Compr. Physiol."},{"key":"2026031305263619300_B7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nature13701","article-title":"Piezo1 integration of vascular architecture with physiological force","volume":"515","author":"Li","year":"2014","journal-title":"Nature"},{"key":"2026031305263619300_B8","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.celrep.2015.09.072","article-title":"Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling","volume":"13","author":"Retailleau","year":"2015","journal-title":"Cell Rep."},{"key":"2026031305263619300_B9","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1172\/JCI87343","article-title":"Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release","volume":"126","author":"Wang","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2026031305263619300_B10","doi-asserted-by":"publisher","first-page":"8686","DOI":"10.1038\/s41467-024-52969-0","article-title":"Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow","volume":"15","author":"Lim","year":"2024","journal-title":"Nat. Commun."},{"key":"2026031305263619300_B11","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/brv.12814","article-title":"Mechanosensing by Piezo1 and its implications for physiology and various pathologies","volume":"97","author":"Lai","year":"2022","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"2026031305263619300_B12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07369","article-title":"Chemical activation of the mechanotransduction channel Piezo1","volume":"4","author":"Syeda","year":"2015","journal-title":"eLife"},{"key":"2026031305263619300_B13","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1017\/S2040174418000247","article-title":"Isolating the direct effects of adverse developmental conditions on in vivo cardiovascular function at adulthood: the avian model","volume":"9","author":"Skeffington","year":"2018","journal-title":"J. Dev. Orig. Health Dis."},{"key":"2026031305263619300_B14","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1113\/JP274111","article-title":"The highs and lows of programmed cardiovascular disease by developmental hypoxia: studies in the chicken embryo","volume":"596","author":"Itani","year":"2018","journal-title":"J. Physiol."},{"key":"2026031305263619300_B15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/jpi.12283","article-title":"Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo","volume":"60","author":"Itani","year":"2016","journal-title":"J. Pineal Res."},{"key":"2026031305263619300_B16","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101874","article-title":"Transcriptional profiling of human endothelial cells unveils PIEZO1 and mechanosensitive gene regulation by prooxidant and inflammatory inputs","volume":"12","author":"Arenas","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"2026031305263619300_B17","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.1093\/bioinformatics\/btz573","article-title":"TFEA.ChIP: a tool kit for transcription factor binding site enrichment analysis capitalizing on ChIP-seq datasets","volume":"35","author":"Puente-Santamaria","year":"2019","journal-title":"Bioinformatics"},{"key":"2026031305263619300_B18","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1093\/bioinformatics\/bti473","article-title":"MatInspector and beyond: promoter analysis based on transcription factor binding sites","volume":"21","author":"Cartharius","year":"2005","journal-title":"Bioinformatics"},{"key":"2026031305263619300_B19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2006.02.116","article-title":"Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway","volume":"343","author":"Woo","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026031305263619300_B20","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.ejphar.2016.09.027","article-title":"SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis","volume":"791","author":"Wang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"2026031305263619300_B21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT\u00a0method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2026031305263619300_B22","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1113\/JP273393","article-title":"Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo","volume":"595","author":"Itani","year":"2017","journal-title":"J. Physiol."},{"key":"2026031305263619300_B23","doi-asserted-by":"publisher","first-page":"16504","DOI":"10.1096\/fj.202001743R","article-title":"Protective effects of pravastatin on the embryonic cardiovascular system during hypoxic development","volume":"34","author":"Itani","year":"2020","journal-title":"FASEB J."},{"key":"2026031305263619300_B24","doi-asserted-by":"publisher","first-page":"3833","DOI":"10.1113\/JP286266","article-title":"Epigenetic regulation by hypoxia, N-acetylcysteine and hydrogen sulphide of the fetal vasculature in growth restricted offspring: a study in humans and chicken embryos","volume":"602","author":"Krause","year":"2024","journal-title":"J. Physiol."},{"key":"2026031305263619300_B25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/exer.2002.2028","article-title":"Contractility studies on isolated bovine choroidal small arteries: determination of the active and passive wall tension-internal circumference relation","volume":"75","author":"Delaey","year":"2002","journal-title":"Exp. Eye Res."},{"key":"2026031305263619300_B26","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3389\/fphys.2018.00901","article-title":"Chronic intermittent hypoxia-induced vascular dysfunction in rats is reverted by N-acetylcysteine supplementation and arginase inhibition","volume":"9","author":"Krause","year":"2018","journal-title":"Front. Physiol."},{"key":"2026031305263619300_B27","doi-asserted-by":"publisher","first-page":"e00200","DOI":"10.1002\/prp2.200","article-title":"Translational value of mechanical and vasomotor properties of mouse isolated mesenteric resistance-sized arteries","volume":"3","author":"Outzen","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"2026031305263619300_B28","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1111\/bph.14188","article-title":"Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation","volume":"175","author":"Evans","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"2026031305263619300_B29","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1111\/j.1476-5381.1990.tb14151.x","article-title":"Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo","volume":"101","author":"Rees","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"2026031305263619300_B30","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s00424-005-1413-7","article-title":"Hypoxia-responsive transcription factors","volume":"450","author":"Cummins","year":"2005","journal-title":"Pflugers Arch."},{"key":"2026031305263619300_B31","doi-asserted-by":"publisher","first-page":"107290","DOI":"10.1016\/j.phrs.2024.107290","article-title":"Mtnr1b deletion disrupts placental angiogenesis through the VEGF signaling pathway leading to fetal growth restriction","volume":"206","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"2026031305263619300_B32","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1152\/physiolgenomics.00131.2024","article-title":"Maternal-fetal interfaces transcriptome changes associated with placental insufficiency and a novel gene therapy intervention","volume":"57","author":"Jones","year":"2025","journal-title":"Physiol. Genomics"},{"key":"2026031305263619300_B33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/humupd\/dmaa053","article-title":"Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction","volume":"27","author":"Colson","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"2026031305263619300_B34","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1182\/blood-2004-07-2958","article-title":"Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1","volume":"105","author":"Manalo","year":"2005","journal-title":"Blood"},{"key":"2026031305263619300_B35","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1161\/ATVBAHA.117.309249","article-title":"Mechanical activation of hypoxia-inducible factor 1\u03b1 drives endothelial dysfunction at atheroprone sites","volume":"37","author":"Feng","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2026031305263619300_B36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.atherosclerosis.2011.01.009","article-title":"Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function","volume":"215","author":"Ikeda","year":"2011","journal-title":"Atherosclerosis"},{"key":"2026031305263619300_B37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s11658-022-00408-7","article-title":"The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability","volume":"27","author":"Jaskiewicz","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"2026031305263619300_B38","doi-asserted-by":"publisher","first-page":"969.e13","DOI":"10.1016\/j.cell.2021.01.024","article-title":"A role of PIEZO1 in iron metabolism in mice and humans","volume":"184","author":"Ma","year":"2021","journal-title":"Cell"},{"key":"2026031305263619300_B39","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bpc.2015.06.013","article-title":"The biophysics of piezo1 and piezo2 mechanosensitive channels","volume":"208","author":"Soattin","year":"2016","journal-title":"Biophys. Chem."},{"key":"2026031305263619300_B40","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1073\/pnas.1409233111","article-title":"Piezo1, a mechanically activated ion channel, is required for vascular development in mice","volume":"111","author":"Ranade","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026031305263619300_B41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/humrep\/12.1.167","article-title":"Endothelial nitric oxide synthase in placental villous tissue from normal, pre-eclamptic and intrauterine growth restricted pregnancies","volume":"12","author":"Myatt","year":"1997","journal-title":"Hum. Reprod."},{"key":"2026031305263619300_B42","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.placenta.2012.09.015","article-title":"Endothelial eNOS\/arginase imbalance contributes to vascular dysfunction in IUGR umbilical and placental vessels","volume":"34","author":"Krause","year":"2013","journal-title":"Placenta"},{"key":"2026031305263619300_B43","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1113\/JP273396","article-title":"N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs","volume":"595","author":"Herrera","year":"2017","journal-title":"J. Physiol."},{"key":"2026031305263619300_B44","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1113\/JP270495","article-title":"Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction","volume":"593","author":"Jones","year":"2015","journal-title":"J. Physiol."},{"key":"2026031305263619300_B45","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2144\/btn-2019-0124","article-title":"Optimization of western blotting for the detection of proteins of different molecular weight","volume":"68","author":"Heda","year":"2020","journal-title":"BioTechniques"},{"key":"2026031305263619300_B46","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ymeth.2018.02.017","article-title":"The yin and yang of solubilization and stabilization for wild-type and full-length membrane protein","volume":"147","author":"Hardy","year":"2018","journal-title":"Methods"},{"key":"2026031305263619300_B47","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.ab.2008.10.005","article-title":"A modified Western blot protocol for enhanced sensitivity in the detection of a membrane protein","volume":"384","author":"Kaur","year":"2009","journal-title":"Anal. Biochem."},{"key":"2026031305263619300_B48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911873","article-title":"Transcriptional and epigenomic markers of the arterial-venous and micro\/macro-vascular endothelial heterogeneity within the umbilical-placental bed","volume":"23","author":"Arenas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026031305263619300_B49","doi-asserted-by":"publisher","first-page":"16159","DOI":"10.1038\/s41598-023-43142-6","article-title":"Gene regulation for inflammation and inflammation resolution differs between umbilical arterial and venous endothelial cells","volume":"13","author":"Michaeli","year":"2023","journal-title":"Sci. Rep."},{"key":"2026031305263619300_B50","doi-asserted-by":"publisher","first-page":"184","DOI":"10.30802\/AALAS-CM-18-000061","article-title":"Embryonic chicken (Gallus gallus domesticus) as a model of cardiac biology and development","volume":"69","author":"Vilches-Moure","year":"2019","journal-title":"Comp. Med."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/doi\/10.1042\/CS20258735\/985154\/cs-2025-8735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/doi\/10.1042\/CS20258735\/985154\/cs-2025-8735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:26:45Z","timestamp":1773394005000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/140\/4\/493\/237232\/Hypoxic-development-down-regulates-endothelial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,15]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20258735","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,13]]}}}