{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:55:42Z","timestamp":1791284142504,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360102"],"award-info":[{"award-number":["82360102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"\u6c5f\u897f\u7701\u79d1\u5b66\u6280\u672f\u5385 | Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224BAB206017"],"award-info":[{"award-number":["20224BAB206017"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ganpo Talent Program","award":["gpyc20240195"],"award-info":[{"award-number":["gpyc20240195"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Atherosclerosis is a leading cause of cardiovascular morbidity and mortality, yet the molecular mechanisms driving plaque progression remain incompletely understood. O-GlcNAc transferase (OGT) couples nutrient status to protein O-GlcNAcylation, but its vascular actions appear context dependent. In an exploratory carotid endarterectomy cohort, OGT expression and global O-GlcNAcylation were higher in plaques obtained from symptomatic patients than in plaques from asymptomatic patients. In Western diet-fed ApoE-\/- mice, inducible smooth muscle cell (SMC)-specific OGT deletion was associated with lower aortic lesion burden, lower serum triglyceride and total cholesterol concentrations, and reduced plaque lipid and collagen areas. Proteomic screening identified TEAD1 as an O-GlcNAcylated protein enriched in clinically symptomatic human samples. OGT interacted with TEAD1 and promoted O-GlcNAcylation at Serine 132 (S132); mutation of this residue reduced TEAD1 stability, nuclear accumulation, and reporter activity. In a complementary HUVEC model, OGT knockdown limited ox-LDL-induced injury, inflammation, monocyte adhesion, and endothelial-to-mesenchymal transition, whereas TEAD1 overexpression attenuated these effects. Smooth muscle-targeted TEAD1 overexpression also attenuated the lesion reduction associated with OGT deletion in vivo. These findings support an OGT-TEAD1 pathway in atherosclerosis while indicating that concurrent lipid changes, plaque-cell specificity, and the relative endothelial contribution require further resolution.<\/jats:p>","DOI":"10.1042\/cs20261203","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:35:01Z","timestamp":1791282901000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["OGT-mediated O-GlcNAcylation of TEAD1 at Serine 132 Enhances TEAD1 Stability and Activity and Contributes to Atherosclerosis Progression"],"prefix":"10.1042","author":[{"given":"Xiaojin","family":"Yin","sequence":"first","affiliation":[{"name":"Central People's Hospital of Ji'an, Ji'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Central People's Hospital of Ji'an, Ji'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenling","family":"Gao","sequence":"additional","affiliation":[{"name":"Central People's Hospital of Ji'an, Ji'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengming","family":"Yan","sequence":"additional","affiliation":[{"name":"Central People's Hospital of Ji'an, Ji'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhua","family":"Kuang","sequence":"additional","affiliation":[{"name":"Central People's Hospital of Ji'an, Ji'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jugen","family":"Guo","sequence":"additional","affiliation":[{"name":"Central People's Hospital of Ji'an, Ji'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Zou","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wen","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,10,6]]},"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/doi\/10.1042\/CS20261203\/992689\/cs-2026-1203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/doi\/10.1042\/CS20261203\/992689\/cs-2026-1203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:35:02Z","timestamp":1791282902000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/doi\/10.1042\/CS20261203\/238152\/OGT-mediated-O-GlcNAcylation-of-TEAD1-at-Serine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1042\/cs20261203","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"article-number":"CS20261203"}}