{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:41:26Z","timestamp":1793090486099,"version":"4.5.0"},"reference-count":49,"publisher":"Portland Press Ltd.","issue":"11","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470173"],"award-info":[{"award-number":["82470173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To explore the role of gut microbiota and bile acid (BA) metabolism in acute myeloid leukemia (AML), we analyzed samples from 29 patients via 16S rDNA sequencing and LC-QTOF-MS, and performed functional studies on Enterococcus faecalis and hyodeoxycholic acid (HDCA). Results revealed a dynamic shift in gut microbiota diversity during treatment, which recovered after therapy. Notably, the abundance of Enterococcus at baseline was significantly correlated with clinical response after treatment. Furthermore, fecal microbiota transplantation (FMT) using E. faecalis reduced in vivo leukemia burden and increased levels of BAs such as HDCA. In vitro analyses demonstrated that HDCA suppresses AML cell growth and promotes apoptosis through inhibition of NF-\u03baB, mitochondrial dysfunction, and cell cycle arrest. These findings were corroborated in a mouse model, where HDCA delayed leukemia progression and improved survival. Clinically, higher baseline serum HDCA correlated with greater gut microbiota \u03b1 diversity and was associated with complete remission. In summary, Enterococcus levels and baseline HDCA are linked to AML treatment outcomes. E. faecalis FMT ameliorates AML with concurrent rises in fecal HDCA, while HDCA exerts anti-leukemic effects by targeting NF-\u03baB, disrupting mitochondrial integrity, arresting the cell cycle, and triggering apoptosis.<\/jats:p>","DOI":"10.1042\/cs20261592","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:40:40Z","timestamp":1789472440000},"page":"2467-2485","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiota modulates hyodeoxycholic acid to inhibit leukemia development"],"prefix":"10.1042","volume":"140","author":[{"given":"Wanying","family":"Liu","sequence":"first","affiliation":[{"name":"1The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China"},{"name":"2Fujian Medical University Union Hospital, Fuzhou, China"},{"name":"3The Third People\u2019s Hospital of Hubei Province, Affiliated Hospital of Jianghan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Yang","sequence":"additional","affiliation":[{"name":"1The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China"},{"name":"2Fujian Medical University Union Hospital, Fuzhou, China"},{"name":"4Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Chen","sequence":"additional","affiliation":[{"name":"2Fujian Medical University Union Hospital, Fuzhou, China"},{"name":"5Institute of Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhen","family":"Chen","sequence":"additional","affiliation":[{"name":"2Fujian Medical University Union Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazheng","family":"Li","sequence":"additional","affiliation":[{"name":"1The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China"},{"name":"4Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"5Institute of Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China"},{"name":"6Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China"},{"name":"7Department of Hematology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"5Institute of Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China"},{"name":"8School of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China"},{"name":"9Department of Laboratory Medicine, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-2544","authenticated-orcid":false,"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[{"name":"1The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China"},{"name":"2Fujian Medical University Union Hospital, Fuzhou, China"},{"name":"5Institute of Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,10,27]]},"reference":[{"key":"2026102704214884600_B1","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/S0140-6736(23)00108-3","article-title":"Acute myeloid leukaemia","volume":"401","author":"DiNardo","year":"2023","journal-title":"Lancet"},{"key":"2026102704214884600_B2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/ajh.24246","article-title":"Acute myeloid leukemia\u2013major progress over four decades and glimpses into the future","volume":"91","author":"Kantarjian","year":"2016","journal-title":"Am. 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