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In addition, mutations in the same COQ gene can cause different clinical pictures. Here, we present an updated and comprehensive review of the clinical manifestations associated with each of the pathogenic variants causing primary CoQ deficiencies.<\/jats:p>","DOI":"10.1042\/ebc20170107","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T10:35:16Z","timestamp":1532082916000},"page":"377-398","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Clinical syndromes associated with Coenzyme Q10 deficiency"],"prefix":"10.1042","volume":"62","author":[{"given":"Mar\u00eda","family":"Alc\u00e1zar-Fabra","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-JA, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Trevisson","sequence":"additional","affiliation":[{"name":"Clinical Genetics Unit, Department of Women\u2019s and Children\u2019s Health, University of Padova, Padova 35128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Brea-Calvo","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-JA, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"2021111610261462800_B1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1042\/bj0600274","article-title":"Some minor constituents of liver oils","volume":"60","author":"Cain","year":"1955","journal-title":"Biochem. 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