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They are more nucleophilic and acidic than thiols and, unlike thiols, they can also be electrophilic. They are especially good one-electron reductants. Methods to detect their formation are under continuous development. In this minireview we describe the pathways of formation of persulfides, their biochemical properties and the techniques available for their detection, and we discuss the possible implications of their formation in biological systems.<\/jats:p>","DOI":"10.1042\/ebc20190049","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T12:46:42Z","timestamp":1580820402000},"page":"155-168","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Persulfides, at the crossroads between hydrogen sulfide and thiols"],"prefix":"10.1042","volume":"64","author":[{"given":"Dayana","family":"Benchoam","sequence":"first","affiliation":[{"name":"Laboratorio de Enzimolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Centro de Investigaciones Biom\u00e9dicas (CEINBIO), Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Cuevasanta","sequence":"additional","affiliation":[{"name":"Laboratorio de Enzimolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Centro de Investigaciones Biom\u00e9dicas (CEINBIO), Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Unidad de Bioqu\u00edmica Anal\u00edtica, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas\u00a0N.","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas (CEINBIO), Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Laboratorio de Fisicoqu\u00edmica Biol\u00f3gica, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias; Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-3132","authenticated-orcid":false,"given":"Beatriz","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Enzimolog\u00eda, Instituto de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Centro de Investigaciones Biom\u00e9dicas (CEINBIO), Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"key":"2021111610292460400_B1","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1248\/bpb.17.1535","article-title":"Tissue and subcellular distribution of bound and acid-labile sulfur, and the enzymic capacity for sulfide production in the rat","volume":"17","author":"Ogasawara","year":"1994","journal-title":"Biol. 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