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Furthermore, some bioactive sphingolipids are implicated in pathological processes including inflammation-associated illnesses such as atherosclerosis, rheumatoid arthritis, inflammatory bowel disease (namely Crohn\u2019s disease and ulcerative colitis), type II diabetes, obesity, and cancer. A major sphingolipid metabolite is ceramide, which is the core of sphingolipid metabolism and can act as second messenger, especially when it is produced at the plasma membrane of cells. Ceramides promote cell cycle arrest and apoptosis. However, ceramide 1-phosphate (C1P), the product of ceramide kinase (CerK), and Sph 1-phosphate (S1P), which is generated by the action of Sph kinases (SphK), stimulate cell proliferation and inhibit apoptosis. Recently, C1P has been implicated in the spontaneous migration of cells from some types of cancer, and can enhance cell migration\/invasion of malignant cells through interaction with a Gi protein-coupled receptor. In addition, CerK and SphK are implicated in inflammatory responses, some of which are associated with cancer progression and metastasis. Hence, targeting these sphingolipid kinases to inhibit C1P or S1P production, or blockade of their receptors might contribute to the development of novel therapeutic strategies to reduce metabolic alterations and disease.<\/jats:p>","DOI":"10.1042\/ebc20190091","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T13:29:47Z","timestamp":1593005387000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Role of bioactive sphingolipids in physiology and pathology"],"prefix":"10.1042","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-2476","authenticated-orcid":false,"given":"Ana","family":"Gomez-Larrauri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), Bilbao 48080, Bizkaia, Spain"},{"name":"Respiratory Department, Cruces University Hospital, Barakaldo 48903, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Presa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), Bilbao 48080, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asier","family":"Dominguez-Herrera","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), Bilbao 48080, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ouro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), Bilbao 48080, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Trueba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), Bilbao 48080, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gomez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV\/EHU), Bilbao 48080, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"2021111610301616700_B1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.plipres.2015.09.002","article-title":"Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate","volume":"61","author":"Gomez-Munoz","year":"2016","journal-title":"Prog. 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