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Major neurodegenerative diseases include Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. ABC transporters are highly expressed in the brain and have been implicated in a number of pathological processes underlying neurodegenerative diseases. This review outlines the current understanding of the role of ABC transporters in neurodegenerative diseases, focusing on some of the most important pathways, and also suggests future directions for research in this field.<\/jats:p>","DOI":"10.1042\/ebc20210012","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T09:09:36Z","timestamp":1629450576000},"page":"1013-1024","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["ATP-binding cassette transporters and neurodegenerative diseases"],"prefix":"10.1042","volume":"65","author":[{"given":"Jared\u00a0S.","family":"Katzeff","sequence":"additional","affiliation":[{"name":"The University of Sydney, School of Medical Sciences, Sydney, NSW, Australia"},{"name":"The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-933X","authenticated-orcid":false,"given":"Woojin\u00a0Scott","family":"Kim","sequence":"additional","affiliation":[{"name":"The University of Sydney, School of Medical Sciences, Sydney, NSW, Australia"},{"name":"The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"2021122211022752300_B1","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1002\/1873-3468.13985","article-title":"Evolutionary history of ATP-binding cassette proteins","volume":"594","author":"Srikant","year":"2020","journal-title":"FEBS Lett."},{"key":"2021122211022752300_B2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature22345","article-title":"Structure of the human multidrug transporter ABCG2","volume":"546","author":"Taylor","year":"2017","journal-title":"Nature"},{"key":"2021122211022752300_B3","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1002\/1873-3468.13935","article-title":"Structural and functional diversity calls for a new classification of ABC transporters","volume":"594","author":"Thomas","year":"2020","journal-title":"FEBS Lett."},{"key":"2021122211022752300_B4","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1517\/17425255.2016.1168804","article-title":"ABC transporters at the blood-brain barrier","volume":"12","author":"Mahringer","year":"2016","journal-title":"Expert Opin. 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